Nucleic Acid Heteroduplexes
"Nucleic Acid Heteroduplexes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Double-stranded nucleic acid molecules (DNA-DNA or DNA-RNA) which contain regions of nucleotide mismatches (non-complementary). In vivo, these heteroduplexes can result from mutation or genetic recombination; in vitro, they are formed by nucleic acid hybridization. Electron microscopic analysis of the resulting heteroduplexes facilitates the mapping of regions of base sequence homology of nucleic acids.
| Descriptor ID |
D009692
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| MeSH Number(s) |
D13.444.500
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Nucleic Acid Heteroduplexes".
Below are MeSH descriptors whose meaning is more specific than "Nucleic Acid Heteroduplexes".
This graph shows the total number of publications written about "Nucleic Acid Heteroduplexes" by people in this website by year, and whether "Nucleic Acid Heteroduplexes" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 1 | 2 |
| 1996 | 0 | 1 | 1 |
| 1997 | 0 | 3 | 3 |
| 1998 | 0 | 2 | 2 |
| 1999 | 1 | 1 | 2 |
| 2000 | 0 | 3 | 3 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 3 | 3 |
| 2006 | 1 | 0 | 1 |
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Below are the most recent publications written about "Nucleic Acid Heteroduplexes" by people in Profiles.
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Miranda KC, Huynh T, Tay Y, Ang YS, Tam WL, Thomson AM, Lim B, Rigoutsos I. A pattern-based method for the identification of MicroRNA binding sites and their corresponding heteroduplexes. Cell. 2006 Sep 22; 126(6):1203-17.
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Gamper HB, Gewirtz A, Edwards J, Hou YM. Modified bases in RNA reduce secondary structure and enhance hybridization. Biochemistry. 2004 Aug 10; 43(31):10224-36.
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Igoucheva O, Alexeev V, Yoon K. Oligonucleotide-directed mutagenesis and targeted gene correction: a mechanistic point of view. Curr Mol Med. 2004 Aug; 4(5):445-63.
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Chakrabarti A, Desai P, Wickstrom E. Transposon Tn7 protein TnsD binding to Escherichia coli attTn7 DNA and its eukaryotic orthologs. Biochemistry. 2004 Mar 16; 43(10):2941-6.
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Gamper HB, Nulf CJ, Corey DR, Kmiec EB. The synaptic complex of RecA protein participates in hybridization and inverse strand exchange reactions. Biochemistry. 2003 Mar 11; 42(9):2643-55.
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Gamper HB, Hou YM, Kmiec EB. Evidence for a four-strand exchange catalyzed by the RecA protein. Biochemistry. 2000 Dec 12; 39(49):15272-81.
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Gamper HB, Parekh H, Rice MC, Bruner M, Youkey H, Kmiec EB. The DNA strand of chimeric RNA/DNA oligonucleotides can direct gene repair/conversion activity in mammalian and plant cell-free extracts. Nucleic Acids Res. 2000 Nov 01; 28(21):4332-9.
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Gamper HB, Cole-Strauss A, Metz R, Parekh H, Kumar R, Kmiec EB. A plausible mechanism for gene correction by chimeric oligonucleotides. Biochemistry. 2000 May 16; 39(19):5808-16.
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Frank J, McGrath JA, Poh-Fitzpatrick MB, Hawk JL, Christiano AM. Mutations in the translation initiation codon of the protoporphyrinogen oxidase gene underlie variegate porphyria. Clin Exp Dermatol. 1999 Jul; 24(4):296-301.
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Cole-Strauss A, Gamper H, Holloman WK, Mu?oz M, Cheng N, Kmiec EB. Targeted gene repair directed by the chimeric RNA/DNA oligonucleotide in a mammalian cell-free extract. Nucleic Acids Res. 1999 Mar 01; 27(5):1323-30.