Adenomatous Polyposis Coli

"Adenomatous Polyposis Coli" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A polyposis syndrome due to an autosomal dominant mutation of the APC genes (GENES, APC) on CHROMOSOME 5. The syndrome is characterized by the development of hundreds of ADENOMATOUS POLYPS in the COLON and RECTUM of affected individuals by early adulthood.

Descriptor ID	D011125
MeSH Number(s)	C04.557.470.035.215.100 C04.588.274.476.411.307.089 C04.700.100 C06.301.371.411.307.090 C06.405.249.411.307.090 C06.405.469.158.356.090 C06.405.469.491.307.090 C06.405.469.578.249 C16.320.700.100
Concept/Terms	Adenomatous Polyposis Coli Adenomatous Polyposis Coli Adenomatous Polyposis Colus Coli, Adenomatous Polyposis Colus, Adenomatous Polyposis Polyposis Coli, Adenomatous Polyposis Colus, Adenomatous Polyposis Syndrome, Familial Familial Polyposis Syndromes Familial Adenomatous Polyposis Coli Adenomatous Polyposis Coli, Familial Adenomatous Polyposis of the Colon Familial Adenomatous Polyposis Adenomatous Polyposes, Familial Adenomatous Polyposis, Familial Familial Adenomatous Polyposes Polyposes, Familial Adenomatous Polyposis, Familial Adenomatous Familial Polyposis Coli Familial Adenomatous Polyposis of the Colon Familial Multiple Polyposi Familial Multiple Polyposus Multiple Polyposi, Familial Multiple Polyposus, Familial Polyposi, Familial Multiple Polyposus, Familial Multiple Familial Polyposis of the Colon Hereditary Polyposis Coli Coli, Hereditary Polyposis Colus, Hereditary Polyposis Hereditary Polyposis Colus Polyposis Coli, Hereditary Polyposis Colus, Hereditary Familial Multiple Polyposis Familial Multiple Polyposes Multiple Polyposes, Familial Multiple Polyposis, Familial Polyposes, Familial Multiple Polyposis, Familial Multiple Familial Multiple Polyposis Syndrome Familial Polyposis Syndrome Myh-Associated Polyposis Myh Associated Polyposis Myh-Associated Polyposes Polyposes, Myh-Associated Polyposis, Myh-Associated Polyposis Coli Coli, Polyposis Colus, Polyposis Polyposis Colus Polyposis Coli, Familial Coli, Familial Polyposis Colus, Familial Polyposis Familial Polyposis Colus Polyposis Colus, Familial Familial Intestinal Polyposis Familial Intestinal Polyposis Familial Intestinal Polyposes Intestinal Polyposes, Familial Intestinal Polyposis, Familial Polyposis, Adenomatous Intestinal Polyposis, Adenomatous Intestinal Adenomatous Intestinal Polyposes Adenomatous Intestinal Polyposis Intestinal Polyposis, Adenomatous

Below are MeSH descriptors whose meaning is more general than "Adenomatous Polyposis Coli".

Diseases [C]
Neoplasms [C04]
Neoplasms by Histologic Type [C04.557]
Neoplasms, Glandular and Epithelial [C04.557.470]
Adenoma [C04.557.470.035]
Adenomatous Polyps [C04.557.470.035.215]
Adenomatous Polyposis Coli [C04.557.470.035.215.100]
Neoplasms by Site [C04.588]
Digestive System Neoplasms [C04.588.274]
Gastrointestinal Neoplasms [C04.588.274.476]
Intestinal Neoplasms [C04.588.274.476.411]
Colorectal Neoplasms [C04.588.274.476.411.307]
Adenomatous Polyposis Coli [C04.588.274.476.411.307.089]
Neoplastic Syndromes, Hereditary [C04.700]
Adenomatous Polyposis Coli [C04.700.100]
Digestive System Diseases [C06]
Digestive System Neoplasms [C06.301]
Gastrointestinal Neoplasms [C06.301.371]
Intestinal Neoplasms [C06.301.371.411]
Colorectal Neoplasms [C06.301.371.411.307]
Adenomatous Polyposis Coli [C06.301.371.411.307.090]
Gastrointestinal Diseases [C06.405]
Gastrointestinal Neoplasms [C06.405.249]
Intestinal Neoplasms [C06.405.249.411]
Colorectal Neoplasms [C06.405.249.411.307]
Adenomatous Polyposis Coli [C06.405.249.411.307.090]
Intestinal Diseases [C06.405.469]
Colonic Diseases [C06.405.469.158]
Colorectal Neoplasms [C06.405.469.158.356]
Adenomatous Polyposis Coli [C06.405.469.158.356.090]
Intestinal Neoplasms [C06.405.469.491]
Colorectal Neoplasms [C06.405.469.491.307]
Adenomatous Polyposis Coli [C06.405.469.491.307.090]
Intestinal Polyposis [C06.405.469.578]
Adenomatous Polyposis Coli [C06.405.469.578.249]
Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
Genetic Diseases, Inborn [C16.320]
Neoplastic Syndromes, Hereditary [C16.320.700]
Adenomatous Polyposis Coli [C16.320.700.100]

Below are MeSH descriptors whose meaning is more specific than "Adenomatous Polyposis Coli".

Adenomatous Polyposis Coli
Gardner Syndrome

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Adenomatous Polyposis Coli" by people in this website by year, and whether "Adenomatous Polyposis Coli" was a major or minor topic of these publications.

Bar chart showing 23 publications over 14 distinct years, with a maximum of 4 publications in 2004

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	1	0	1
1996	1	1	2
2000	0	1	1
2001	1	0	1
2002	3	0	3
2004	4	0	4
2005	1	0	1
2008	1	1	2
2010	1	0	1
2011	2	0	2
2012	1	0	1
2018	1	0	1
2020	0	1	1
2021	2	0	2

Below are the most recent publications written about "Adenomatous Polyposis Coli" by people in Profiles.

Mokhashi N, Cai LZ, Shields CL, Benson WE, Ho AC. Systemic considerations with pigmented fundus lesions and retinal pigment epithelium hamartomas in Turcot syndrome. Curr Opin Ophthalmol. 2021 Nov 01; 32(6):567-573.

View in: PubMed
Flahive CB, Onwuka A, Bass LM, MacFarland SP, Minneci PC, Erdman SH. Characterizing Pediatric Familial Adenomatous Polyposis in Patients Undergoing Colectomy in the United States. J Pediatr. 2022 06; 245:117-122.

View in: PubMed
Zhang T, Ahn K, Emerick B, Modarai SR, Opdenaker LM, Palazzo J, Schleiniger G, Fields JZ, Boman BM. APC mutations in human colon lead to decreased neuroendocrine maturation of ALDH+ stem cells that alters GLP-2 and SST feedback signaling: Clue to a link between WNT and retinoic acid signalling in colon cancer development. PLoS One. 2020; 15(10):e0239601.

View in: PubMed
Dukleska K, Berman L, Aka AA, Vinocur CD, Teeple EA. Short-term outcomes in children undergoing restorative proctocolectomy with ileal-pouch anal anastomosis. J Pediatr Surg. 2018 Jun; 53(6):1154-1159.

View in: PubMed
Birsner ML, Hoover-Fong J, Bytyci Telegrafi A, Hueppchen NA. Perinatal detection of familial adenomatous polyposis. Obstet Gynecol. 2012 Aug; 120(2 Pt 2):500-3.

View in: PubMed
Trufant J, Kurz W, Frankel A, Muthusamy V, McKinnon W, Greenblatt M, Lazar A, Cook D, Bosenberg M. Familial multiple pilomatrixomas as a presentation of attenuated adenomatosis polyposis coli. J Cutan Pathol. 2012 Apr; 39(4):440-3.

View in: PubMed
Patel BB, Li XM, Dixon MP, Blagoi EL, Nicolas E, Seeholzer SH, Cheng D, He YA, Coudry RA, Howard SD, Riddle DM, Cooper HC, Boman BM, Conrad P, Crowell JA, Bellacosa A, Knudson A, Yeung AT, Kopelovich L. APC +/- alters colonic fibroblast proteome in FAP. Oncotarget. 2011 Mar; 2(3):197-208.

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Crist RC, Roth JJ, Baran AA, McEntee BJ, Siracusa LD, Buchberg AM. The armadillo repeat domain of Apc suppresses intestinal tumorigenesis. Mamm Genome. 2010 Oct; 21(9-10):450-7.

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Yeung AT, Patel BB, Li XM, Seeholzer SH, Coudry RA, Cooper HS, Bellacosa A, Boman BM, Zhang T, Litwin S, Ross EA, Conrad P, Crowell JA, Kopelovich L, Knudson A. One-hit effects in cancer: altered proteome of morphologically normal colon crypts in familial adenomatous polyposis. Cancer Res. 2008 Sep 15; 68(18):7579-86.

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Boman BM, Huang E. Human colon cancer stem cells: a new paradigm in gastrointestinal oncology. J Clin Oncol. 2008 Jun 10; 26(17):2828-38.

View in: PubMed

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