"Prolactin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A lactogenic hormone secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). It is a polypeptide of approximately 23 kD. Besides its major action on lactation, in some species prolactin exerts effects on reproduction, maternal behavior, fat metabolism, immunomodulation and osmoregulation. Prolactin receptors are present in the mammary gland, hypothalamus, liver, ovary, testis, and prostate.
| Descriptor ID |
D011388
|
| MeSH Number(s) |
D06.472.699.322.576.773 D06.472.699.631.525.525 D12.644.548.691.525.525
|
| Concept/Terms |
Prolactin- Prolactin
- Mammotropic Hormone, Pituitary
- Hormone, Pituitary Mammotropic
- Pituitary Mammotropic Hormone
- PRL (Prolactin)
- Lactogenic Hormone, Pituitary
- Hormone, Pituitary Lactogenic
- Pituitary Lactogenic Hormone
- Mammotropin
|
Below are MeSH descriptors whose meaning is more general than "Prolactin".
Below are MeSH descriptors whose meaning is more specific than "Prolactin".
This graph shows the total number of publications written about "Prolactin" by people in this website by year, and whether "Prolactin" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 1 | 0 | 1 |
| 2001 | 1 | 0 | 1 |
| 2002 | 4 | 2 | 6 |
| 2003 | 0 | 1 | 1 |
| 2004 | 1 | 2 | 3 |
| 2005 | 4 | 0 | 4 |
| 2007 | 2 | 1 | 3 |
| 2008 | 1 | 0 | 1 |
| 2009 | 2 | 2 | 4 |
| 2010 | 3 | 2 | 5 |
| 2011 | 3 | 2 | 5 |
| 2012 | 2 | 1 | 3 |
| 2014 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
| 2022 | 1 | 1 | 2 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Prolactin" by people in Profiles.
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Amin M, Gragnoli C. The prolactin receptor gene (PRLR) is linked and associated with the risk of polycystic ovarian syndrome. J Ovarian Res. 2023 Nov 22; 16(1):222.
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Clevenger CV, Rui H. Breast Cancer and Prolactin - New Mechanisms and Models. Endocrinology. 2022 10 01; 163(10).
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Paul DA, Rodrigue A, Contento N, Haber S, Hoang R, Rahmani R, Hirad A, Shafiq I, Williams Z, Vates GE. Prolactin at moderately increased levels confers a neuroprotective effect in non-secreting pituitary macroadenomas. PLoS One. 2022; 17(8):e0271690.
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Popnikolov N, Brzezinska K, Platoff RM, Binnebose R, Rothstein-Rubin R, Komarnicky LT, Woodworth A. Upregulation of Prolactin Receptor Expression and Activation of Prolactin Signaling in an Aggressive Triple-Negative Breast Carcinoma During Pregnancy: A Case Report. Clin Breast Cancer. 2020 10; 20(5):e529-e539.
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Rahman T, Clevenger CV, Kaklamani V, Lauriello J, Campbell A, Malwitz K, Kirkland RS. Antipsychotic treatment in breast cancer patients. Am J Psychiatry. 2014 Jun; 171(6):616-21.
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Xu J, Sun D, Jiang J, Deng L, Zhang Y, Yu H, Bahl D, Langenheim JF, Chen WY, Fuchs SY, Frank SJ. The role of prolactin receptor in GH signaling in breast cancer cells. Mol Endocrinol. 2013 Feb; 27(2):266-79.
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Oberweis B, Gragnoli C. Potential role of prolactin in antipsychotic-mediated association of schizophrenia and type 2 diabetes. J Cell Physiol. 2012 Aug; 227(8):3001-6.
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Xu C, Langenheim JF, Chen WY. Stromal-epithelial interactions modulate cross-talk between prolactin receptor and HER2/Neu in breast cancer. Breast Cancer Res Treat. 2012 Jul; 134(1):157-69.
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Goffin V, Hoang DT, Bogorad RL, Nevalainen MT. Prolactin regulation of the prostate gland: a female player in a male game. Nat Rev Urol. 2011 Nov; 8(11):597-607.
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Aksamitiene E, Achanta S, Kolch W, Kholodenko BN, Hoek JB, Kiyatkin A. Prolactin-stimulated activation of ERK1/2 mitogen-activated protein kinases is controlled by PI3-kinase/Rac/PAK signaling pathway in breast cancer cells. Cell Signal. 2011 Nov; 23(11):1794-805.