Adam Snook

TitleAsst Professor
InstitutionThomas Jefferson University
DepartmentPharmacology & Exp Therapeutic
Address1020 Locust St.
Philadelphia PA 19107
vCardDownload vCard

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Bashir B, Flickinger JC, Snook AE. Vaccines and immune checkpoint inhibitors: a promising combination strategy in gastrointestinal cancers. Immunotherapy. 2021 May; 13(7):561-564. PMID: 33724866.
      Citations:    
    2. Zalewski A, Snook AE, Waldman SA. Stem cells as therapeutic targets in colorectal cancer. Per Med. 2021 Mar; 18(2):171-183. PMID: 33565332.
      Citations:    
    3. Barton JR, Snook AE, Waldman SA. From leptin to lasers: the past and present of mouse models of obesity. Expert Opin Drug Discov. 2021 Jan 29; 1-14. PMID: 33472452.
      Citations:    
    4. Flickinger JC, Rappaport JA, Barton JR, Baybutt TR, Pattison AM, Snook AE, Waldman SA. Guanylyl cyclase C as a biomarker for immunotherapies for the treatment of gastrointestinal malignancies. Biomark Med. 2021 Feb; 15(3):201-217. PMID: 33470843.
      Citations:    
    5. Flickinger JC, Singh J, Carlson R, Leong E, Baybutt TR, Barton J, Caparosa E, Pattison A, Rappaport JA, Roh J, Zhan T, Bashir B, Waldman SA, Snook AE. Chimeric Ad5.F35 vector evades anti-adenovirus serotype 5 neutralization opposing GUCY2C-targeted antitumor immunity. J Immunother Cancer. 2020 Aug; 8(2). PMID: 32819976.
      Citations:    
    6. Pattison AM, Barton JR, Entezari AA, Zalewski A, Rappaport JA, Snook AE, Waldman SA. Silencing the intestinal GUCY2C tumor suppressor axis requires APC loss of heterozygosity. Cancer Biol Ther. 2020 Jun 28; 1-7. PMID: 32594830.
      Citations:    
    7. Kopenhaver J, Carlson RD, Snook AE. Mobilizing Toxins for Cancer Treatment: Historical Perspectives and Current Strategies. Toxins (Basel). 2020 Jun 23; 12(6). PMID: 32585926.
      Citations:    
    8. Carlson RD, Flickinger JC, Snook AE. Talkin' Toxins: From Coley's to Modern Cancer Immunotherapy. Toxins (Basel). 2020 Apr 09; 12(4). PMID: 32283684.
      Citations:    
    9. Wehr J, Sikorski EL, Bloch E, Feigman MS, Ferraro NJ, Baybutt TR, Snook AE, Pires MM, Thévenin D. pH-Dependent Grafting of Cancer Cells with Antigenic Epitopes Promotes Selective Antibody-Mediated Cytotoxicity. J Med Chem. 2020 Apr 09; 63(7):3713-3722. PMID: 32196345.
      Citations:    
    10. Blomain ES, Rappaport JA, Pattison AM, Bashir B, Caparosa E, Stem J, Snook AE, Waldman SA. APC-ß-catenin-TCF signaling silences the intestinal guanylin-GUCY2C tumor suppressor axis. Cancer Biol Ther. 2020 Feb 09; 1-11. PMID: 32037952.
      Citations:    
    11. Caparosa EM, Stem J, Snook AE, Waldman SA. Biomarker targeting of colorectal cancer stem cells. Biomark Med. 2019 Aug; 13(11):891-894. PMID: 31385523.
      Citations:    
    12. Khalili M, Daniels L, Lin A, Krebs FC, Snook AE, Bekeschus S, Bowne WB, Miller V. Non-Thermal Plasma-Induced Immunogenic Cell Death in Cancer: A Topical Review. J Phys D Appl Phys. 2019 Oct 22; 52(42). PMID: 31485083.
      Citations:    
    13. Chen T, Lin R, Avula L, Sarker R, Yang J, Cha B, Tse CM, McNamara G, Seidler U, Waldman S, Snook A, Bijvelds MJC, de Jonge HR, Li X, Donowitz M. NHERF3 is Necessary for E. coli Heat Stable Enterotoxin (ST)-induced Inhibition of NHE3 - Differences in Signaling in Mouse Small Intestine and Caco-2 Cells. Am J Physiol Cell Physiol. 2019 Jul 31. PMID: 31365292.
      Citations:    
    14. Stem J, Flickinger JC, Merlino D, Caparosa EM, Snook AE, Waldman SA. Therapeutic targeting of gastrointestinal cancer stem cells. Regen Med. 2019 Apr 26. PMID: 31025613.
      Citations:    
    15. Snook AE, Baybutt TR, Xiang B, Abraham TS, Flickinger JC, Hyslop T, Zhan T, Kraft WK, Sato T, Waldman SA. Split tolerance permits safe Ad5-GUCY2C-PADRE vaccine-induced T-cell responses in colon cancer patients. J Immunother Cancer. 2019 Apr 23; 7(1):104. PMID: 31010434.
      Citations:    
    16. Bashir B, Merlino DJ, Rappaport JA, Gnass E, Palazzo JP, Feng Y, Fearon ER, Snook AE, Waldman SA. Silencing the GUCA2A-GUCY2C tumor suppressor axis in CIN, serrated and MSI colorectal neoplasia. Hum Pathol. 2019 Feb 01. PMID: 30716341.
      Citations:    
    17. Abraham TS, Flickinger JC, Waldman SA, Snook AE. TCR Retrogenic Mice as a Model To Map Self-Tolerance Mechanisms to the Cancer Mucosa Antigen GUCY2C. J Immunol. 2019 Feb 15; 202(4):1301-1310. PMID: 30642983.
      Citations:    
    18. Huang J, Snook AE, Uitto J, Li Q. Adenovirus-mediated ABCC6 Gene Therapy for Heritable Ectopic Mineralization Disorders. J Invest Dermatol. 2019 Jan 10. PMID: 30639429.
      Citations:    
    19. Baybutt TR, Flickinger JC, Caparosa EM, Snook AE. Advances in Chimeric Antigen Receptor T-Cell Therapies for Solid Tumors. Clin Pharmacol Ther. 2019 Jan; 105(1):71-78. PMID: 30406956.
      Citations:    
    20. Lin AG, Xiang B, Merlino DJ, Baybutt TR, Sahu J, Fridman A, Snook AE, Miller V. Non-thermal plasma induces immunogenic cell death in vivo in murine CT26 colorectal tumors. Oncoimmunology. 2018; 7(9):e1484978. PMID: 30228954.
      Citations:    
    21. Flickinger JC, Rodeck U, Snook AE. Listeria monocytogenes as a Vector for Cancer Immunotherapy: Current Understanding and Progress. Vaccines (Basel). 2018 Jul 25; 6(3). PMID: 30044426.
      Citations:    
    22. Magee MS, Abraham TS, Baybutt TR, Flickinger JC, Ridge NA, Marszalowicz GP, Prajapati P, Hersperger AR, Waldman SA, Snook AE. Human GUCY2C-Targeted Chimeric Antigen Receptor (CAR)-Expressing T Cells Eliminate Colorectal Cancer Metastases. Cancer Immunol Res. 2018 Apr 03. PMID: 29615399.
      Citations:    
    23. Bashir B, Snook AE. Immunotherapy regimens for metastatic colorectal carcinomas. Hum Vaccin Immunother. 2018 Feb 01; 14(2):250-254. PMID: 29083978.
      Citations:    
    24. Kraft CL, Rappaport JA, Snook AE, Pattison AM, Lynch JP, Waldman SA. GUCY2C maintains intestinal LGR5+ stem cells by opposing ER stress. Oncotarget. 2017 Nov 28; 8(61):102923-102933. PMID: 29262534.
      Citations:    
    25. Baybutt TR, Aka AA, Snook AE. The Heat-Stable Enterotoxin Receptor, Guanylyl Cyclase C, as a Pharmacological Target in Colorectal Cancer Immunotherapy: A Bench-to-Bedside Current Report. Toxins (Basel). 2017 Sep 15; 9(9). PMID: 28914772.
      Citations:    
    26. Li P, Wuthrick E, Rappaport JA, Kraft C, Lin JE, Marszalowicz G, Snook AE, Zhan T, Hyslop TM, Waldman SA. GUCY2C Signaling Opposes the Acute Radiation-Induced GI Syndrome. Cancer Res. 2017 Sep 15; 77(18):5095-5106. PMID: 28916678.
      Citations:    
    27. Li P, Lin JE, Snook AE, Waldman SA. ST-Producing E. coli Oppose Carcinogen-Induced Colorectal Tumorigenesis in Mice. Toxins (Basel). 2017 Sep 12; 9(9). PMID: 28895923.
      Citations:    
    28. Abraham TS, Snook AE. The swinging pendulum of cancer immunotherapy personalization. Per Med. 2017 May; 14(3):259-270. PMID: 29767586.
      Citations:    
    29. Aka AA, Rappaport JA, Pattison AM, Sato T, Snook AE, Waldman SA. Guanylate cyclase C as a target for prevention, detection, and therapy in colorectal cancer. Expert Rev Clin Pharmacol. 2017 May; 10(5):549-557. PMID: 28162021.
      Citations:    
    30. Xiang B, Baybutt TR, Berman-Booty L, Magee MS, Waldman SA, Alexeev VY, Snook AE. Prime-Boost Immunization Eliminates Metastatic Colorectal Cancer by Producing High-Avidity Effector CD8+ T Cells. J Immunol. 2017 May 01; 198(9):3507-3514. PMID: 28341670.
      Citations:    
    31. Perepelyuk M, Shoyele O, Birbe R, Thangavel C, Liu Y, Den RB, Snook AE, Lu B, Shoyele SA. siRNA-Encapsulated Hybrid Nanoparticles Target Mutant K-ras and Inhibit Metastatic Tumor Burden in a Mouse Model of Lung Cancer. Mol Ther Nucleic Acids. 2017 Mar 17; 6:259-268. PMID: 28325292.
      Citations:    
    32. Thangavel C, Boopathi E, Liu Y, Haber A, Ertel A, Bhardwaj A, Addya S, Williams N, Ciment S, Cotzia P, Dean JL, Snook AE, McNair C, Price MA, Hernandez JR, Zhao SG, Birbe R, McCarthy JB, Turely EA, Pienta KJ, Feng FY, Dicker AP, Knudsen KE, Den RB. RB loss promotes prostate cancer metastasis. Cancer Res. 2016 Dec 06. PMID: 27923835.
      Citations:    
    33. Snook AE, Baybutt TR, Hyslop T, Waldman SA. Preclinical Evaluation of a Replication-Deficient Recombinant Adenovirus Serotype 5 Vaccine Expressing Guanylate Cyclase C and the PADRE T-helper Epitope. Hum Gene Ther Methods. 2016 Dec; 27(6):238-250. PMID: 27903079.
      Citations:    
    34. Pattison AM, Blomain ES, Merlino DJ, Wang F, Crissey MA, Kraft CL, Rappaport JA, Snook AE, Lynch JP, Waldman SA. Intestinal Enteroids Model Guanylate Cyclase C-Dependent Secretion Induced by Heat-Stable Enterotoxins. Infect Immun. 2016 Oct; 84(10):3083-91. PMID: 27481254.
      Citations:    
    35. Magee MS, Kraft CL, Abraham TS, Baybutt TR, Marszalowicz GP, Li P, Waldman SA, Snook AE. GUCY2C-directed CAR-T cells oppose colorectal cancer metastases without autoimmunity. Oncoimmunology. 2016; 5(10):e1227897. PMID: 27853651.
      Citations:    
    36. Blomain ES, Merlino DJ, Pattison AM, Snook AE, Waldman SA. Guanylyl Cyclase C Hormone Axis at the Intersection of Obesity and Colorectal Cancer. Mol Pharmacol. 2016 Sep; 90(3):199-204. PMID: 27251363.
      Citations:    
    37. Perepelyuk M, Thangavel C, Liu Y, Den RB, Lu B, Snook AE, Shoyele SA. Biodistribution and Pharmacokinetics Study of siRNA-loaded Anti-NTSR1-mAb-functionalized Novel Hybrid Nanoparticles in a Metastatic Orthotopic Murine Lung Cancer Model. Mol Ther Nucleic Acids. 2016; 5:e282. PMID: 26812654.
      Citations:    
    38. Lin JE, Colon-Gonzalez F, Blomain E, Kim GW, Aing A, Stoecker B, Rock J, Snook AE, Zhan T, Hyslop TM, Tomczak M, Blumberg RS, Waldman SA. Obesity-Induced Colorectal Cancer Is Driven by Caloric Silencing of the Guanylin-GUCY2C Paracrine Signaling Axis. Cancer Res. 2016 Jan 15; 76(2):339-46. PMID: 26773096.
      Citations:    
    39. Joelsson AC, Brown AS, Puri A, Keough MP, Gaudioso ZE, Siciliano NA, Snook AE. Comparative Evaluation of Veriflow® Listeria monocytogenes to USDA and AOAC Culture Based Methods for the Detection of Listeria monocytogenes in Food. J AOAC Int. 2015 Sep-Oct; 98(5):1325-34. PMID: 26525251.
      Citations:    
    40. Goodwin JF, Kothari V, Drake JM, Zhao S, Dylgjeri E, Dean JL, Schiewer MJ, McNair C, Jones JK, Aytes A, Magee MS, Snook AE, Zhu Z, Den RB, Birbe RC, Gomella LG, Graham NA, Vashisht AA, Wohlschlegel JA, Graeber TG, Karnes RJ, Takhar M, Davicioni E, Tomlins SA, Abate-Shen C, Sharifi N, Witte ON, Feng FY, Knudsen KE. DNA-PKcs-Mediated Transcriptional Regulation Drives Prostate Cancer Progression and Metastasis. Cancer Cell. 2015 Jul 13; 28(1):97-113. PMID: 26175416.
      Citations:    
    41. Krishnan V, Xu X, Kelly D, Snook A, Waldman SA, Mason RW, Jia X, Rajasekaran AK. CD19-Targeted Nanodelivery of Doxorubicin Enhances Therapeutic Efficacy in B-Cell Acute Lymphoblastic Leukemia. Mol Pharm. 2015 Jun 1; 12(6):2101-11. PMID: 25898125.
      Citations:    
    42. Witek M, Siglin J, Malatesta T, Snook A, Gressen E, Rudoler S, Bar-Ad V, Fisher S. Is financial literacy necessary for radiation oncology residents? Int J Radiat Oncol Biol Phys. 2014 Dec 1; 90(5):986-7. PMID: 25539362.
      Citations:    
    43. Magee MS, Snook AE. Challenges to chimeric antigen receptor (CAR)-T cell therapy for cancer. Discov Med. 2014 Nov; 18(100):265-71. PMID: 25425467.
      Citations:    
    44. Marszalowicz GP, Snook AE, Magee MS, Merlino D, Berman-Booty LD, Waldman SA. GUCY2C lysosomotropic endocytosis delivers immunotoxin therapy to metastatic colorectal cancer. Oncotarget. 2014 Oct 15; 5(19):9460-71. PMID: 25294806.
      Citations:    
    45. Wilson C, Lin JE, Li P, Snook AE, Gong J, Sato T, Liu C, Girondo MA, Rui H, Hyslop T, Waldman SA. The Paracrine Hormone for the GUCY2C Tumor Suppressor, Guanylin, Is Universally Lost in Colorectal Cancer. Cancer Epidemiol Biomarkers Prev. 2014 Nov; 23(11):2328-37. PMID: 25304930.
      Citations:    
    46. Witek ME, Snook AE, Lin JE, Blomain ES, Xiang B, Magee M, Waldman SA. A Novel CDX2 Isoform Regulates Alternative Splicing. PLoS One. 2014; 9(8):e104293. PMID: 25101906.
      Citations:    
    47. Hersperger AR, Siciliano NA, DeHaven BC, Snook AE, Eisenlohr LC. Epithelial Immunization Induces Polyfunctional CD8+ T Cells and Optimal Mousepox Protection. J Virol. 2014 Aug 15; 88(16):9472-5. PMID: 24899206.
      Citations:    
    48. Snook AE, Magee MS, Schulz S, Waldman SA. Selective antigen-specific CD4(+) T-cell, but not CD8(+) T- or B-cell, tolerance corrupts cancer immunotherapy. Eur J Immunol. 2014 Jul; 44(7):1956-66. PMID: 24771148.
      Citations:    
    49. Witek M, Blomain ES, Magee MS, Xiang B, Waldman SA, Snook AE. Tumor Radiation Therapy Creates Therapeutic Vaccine Responses to the Colorectal Cancer Antigen GUCY2C. Int J Radiat Oncol Biol Phys. 2014 Apr 1; 88(5):1188-95. PMID: 24661671.
      Citations:    
    50. Snook AE. Could targeting T-helper cells aid the development of effective cancer vaccines? Immunotherapy. 2014; 6(9):959-61. PMID: 25341117.
      Citations:    
    51. Hayes CS, Shicora AC, Keough MP, Snook AE, Burns MR, Gilmour SK. Polyamine-blocking therapy reverses immunosuppression in the tumor microenvironment. Cancer Immunol Res. 2014 Mar; 2(3):274-85. PMID: 24778323.
      Citations:    
    52. Gibbons AV, Lin JE, Kim GW, Marszalowicz GP, Li P, Stoecker BA, Blomain ES, Rattan S, Snook AE, Schulz S, Waldman SA. Intestinal GUCY2C Prevents TGF-ß Secretion Coordinating Desmoplasia and Hyperproliferation in Colorectal Cancer. Cancer Res. 2013 Nov 15; 73(22):6654-66. PMID: 24085786.
      Citations:    
    53. Blomain ES, Lin JE, Kraft CL, Trela UT, Rock JM, Aing AS, Snook AE, Waldman SA. Translating colorectal cancer prevention through the guanylyl cyclase C signaling axis. Expert Rev Clin Pharmacol. 2013 Sep; 6(5):557-64. PMID: 23971873.
      Citations:    
    54. Xiang B, Snook AE, Magee MS, Waldman SA. Colorectal cancer immunotherapy. Discov Med. 2013 May; 15(84):301-8. PMID: 23725603.
      Citations:    
    55. Snook AE, Waldman SA. Advances in cancer immunotherapy. Discov Med. 2013 Feb; 15(81):120-5. PMID: 23449114.
      Citations:    
    56. Magee MS, Snook AE, Marszalowicz GP, Waldman SA. Immunotherapeutic strategies to target prognostic and predictive markers of cancer. Biomark Med. 2013 Feb; 7(1):23-35. PMID: 23387482.
      Citations:    
    57. Lin JE, Snook AE, Li P, Stoecker BA, Kim GW, Magee MS, Garcia AV, Valentino MA, Hyslop T, Schulz S, Waldman SA. GUCY2C opposes systemic genotoxic tumorigenesis by regulating AKT-dependent intestinal barrier integrity. PLoS One. 2012; 7(2):e31686. PMID: 22384056.
      Citations:    
    58. Snook AE, Magee MS, Waldman SA. GUCY2C-targeted cancer immunotherapy: past, present and future. Immunol Res. 2011 Dec; 51(2-3):161-9. PMID: 22038530.
      Citations:    
    59. Snook AE, Magee MS, Marszalowicz GP, Schulz S, Waldman SA. Epitope-targeted cytotoxic T cells mediate lineage-specific antitumor efficacy induced by the cancer mucosa antigen GUCY2C. Cancer Immunol Immunother. 2012 May; 61(5):713-23. PMID: 22057677.
      Citations:    
    60. Valentino MA, Lin JE, Snook AE, Li P, Kim GW, Marszalowicz G, Magee MS, Hyslop T, Schulz S, Waldman SA. A uroguanylin-GUCY2C endocrine axis regulates feeding in mice. J Clin Invest. 2011 Sep; 121(9):3578-88. PMID: 21865642.
      Citations:    
    61. Comber JD, Robinson TM, Siciliano NA, Snook AE, Eisenlohr LC. Functional macroautophagy induction by influenza A virus without a contribution to major histocompatibility complex class II-restricted presentation. J Virol. 2011 Jul; 85(13):6453-63. PMID: 21525345.
      Citations:    
    62. Lin JE, Valentino M, Marszalowicz G, Magee MS, Li P, Snook AE, Stoecker BA, Chang C, Waldman SA. Bacterial heat-stable enterotoxins: translation of pathogenic peptides into novel targeted diagnostics and therapeutics. Toxins (Basel). 2010 Aug; 2(8):2028-54. PMID: 22069671.
      Citations:    
    63. Lin JE, Li P, Snook AE, Schulz S, Dasgupta A, Hyslop TM, Gibbons AV, Marszlowicz G, Pitari GM, Waldman SA. The hormone receptor GUCY2C suppresses intestinal tumor formation by inhibiting AKT signaling. Gastroenterology. 2010 Jan; 138(1):241-54. PMID: 19737566.
      Citations:    
    64. Gong L, Debruyne PR, Witek M, Nielsen K, Snook A, Lin JE, Bombonati A, Palazzo J, Schulz S, Waldman SA. Bile acids initiate lineage-addicted gastroesophageal tumorigenesis by suppressing the EGF receptor-AKT axis. Clin Transl Sci. 2009 Aug; 2(4):286-93. PMID: 20443907.
      Citations:    
    65. Snook AE, Li P, Stafford BJ, Faul EJ, Huang L, Birbe RC, Bombonati A, Schulz S, Schnell MJ, Eisenlohr LC, Waldman SA. Lineage-specific T-cell responses to cancer mucosa antigen oppose systemic metastases without mucosal inflammatory disease. Cancer Res. 2009 Apr 15; 69(8):3537-44. PMID: 19351847.
      Citations:    
    66. Chang C, Marszlowicz G, Waldman Z, Li P, Snook AE, Lin JE, Schulz S, Waldman SA. Guanylyl cyclase C as a biomarker for targeted imaging and therapy of metastatic colorectal cancer. Biomark Med. 2009 Feb; 3(1):33-45. PMID: 20477494.
      Citations:    
    67. Snook AE, Waldman SA. CANCER MUCOSA ANTIGENS A NOVEL PARADIGM IN CANCER IMMUNOTHERAPEUTICS. Bioforum Eur. 2009; 3:14-16. PMID: 26855637.
      Citations:    
    68. Snook AE, Huang L, Schulz S, Eisenlohr LC, Waldman SA. Cytokine adjuvanation of therapeutic anti-tumor immunity targeted to cancer mucosa antigens. Clin Transl Sci. 2008 Dec; 1(3):263-4. PMID: 19956776.
      Citations:    
    69. Snook AE, Stafford BJ, Li P, Tan G, Huang L, Birbe R, Schulz S, Schnell MJ, Thakur M, Rothstein JL, Eisenlohr LC, Waldman SA. Guanylyl cyclase C-induced immunotherapeutic responses opposing tumor metastases without autoimmunity. J Natl Cancer Inst. 2008 Jul 2; 100(13):950-61. PMID: 18577748.
      Citations:    
    70. Plesa G, Snook AE, Waldman SA, Eisenlohr LC. Derivation and fluidity of acutely induced dysfunctional CD8+ T cells. J Immunol. 2008 Apr 15; 180(8):5300-8. PMID: 18390711.
      Citations:    
    71. Snook AE, Stafford BJ, Eisenlohr LC, Rothstein JL, Waldman SA. Mucosally restricted antigens as novel immunological targets for antitumor therapy. Biomark Med. 2007 Jun; 1(1):187-202. PMID: 20477468.
      Citations:    
    Snook's Networks
    Click the
    Explore
    buttons for more information and interactive visualizations!
    Concepts (158)
    Explore
    _
    Co-Authors (30)
    Explore
    _
    Similar People (60)
    Explore
    _
    Same Department Expand Description
    Explore
    _