Christine Eischen

TitleProfessor
InstitutionThomas Jefferson University
DepartmentCancer Biology
Address233 S. 10th Street
Philadelphia PA 19107
Phone615-343-2303
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    F32CA081695     (EISCHEN, CHRISTINE M)Nov 10, 1999
    NIH
    MEDIATORS OF MYC INDUCED MYELOID LEUKEMIA AND APOPTOSIS
    Role: Principal Investigator

    R01CA098139     (EISCHEN, CHRISTINE M)Jul 1, 2003 - Apr 30, 2009
    NIH
    The Role of Mdm2 in Lymphoma Development
    Role: Principal Investigator

    R01CA117935     (EISCHEN, CHRISTINE M)Apr 9, 2007 - Feb 28, 2013
    NIH
    p53-Independent Pathways in Mdm2-Mediated Transformation
    Role: Principal Investigator

    R01CA148950     (EISCHEN, CHRISTINE M.)Jan 1, 2011 - Jun 30, 2017
    NIH
    Regulation of Myc-Mediated Tumorigenesis
    Role: Principal Investigator

    R01CA160432     (EISCHEN, CHRISTINE M.)Jul 26, 2012 - May 31, 2018
    NIH
    SMARCAL1 function in replication stress and disease
    Role: Principal Investigator

    R01CA181204     (EISCHEN, CHRISTINE M.)Jul 18, 2014 - May 31, 2020
    NIH
    Novel oncogenic functions of Mdm2 and Mdmx
    Role: Principal Investigator

    R01CA177786     (EISCHEN, CHRISTINE M.)Sep 15, 2014 - Aug 31, 2021
    NIH
    Novel mechanisms of oncogenic transformation in lung cancer
    Role: Principal Investigator

    R21CA184352     (EISCHEN, CHRISTINE M.)Apr 7, 2015 - Mar 31, 2018
    NIH
    Myc-induced pathways in B cell lymphoma initiation and survival
    Role: Principal Investigator

    R01CA226432     (EISCHEN, CHRISTINE M.)Dec 1, 2018 - Nov 30, 2023
    NIH
    Replication stress in hematopoiesis and lymphomagenesis
    Role: Principal Investigator

    R01CA236853     (EISCHEN, CHRISTINE M.)Dec 1, 2019 - Nov 30, 2024
    NIH
    BCLW in lymphoma survival and resistance to targeted BCL2 family therapies
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Popay TM, Wang J, Adams CM, Howard GC, Codreanu SG, Sherrod SD, McLean JA, Thomas LR, Lorey SL, Machida YJ, Weissmiller AM, Eischen CM, Liu Q, Tansey WP. MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor-1. Elife. 2021 Jan 08; 10. PMID: 33416496.
      Citations:    
    2. Wohlberedt K, Klusmann I, Derevyanko PK, Henningsen K, Choo JAMY, Manzini V, Magerhans A, Giansanti C, Eischen CM, Jochemsen AG, Dobbelstein M. Mdm4 supports DNA replication in a p53-independent fashion. Oncogene. 2020 Jun; 39(25):4828-4843. PMID: 32427989.
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    3. Mitra R, Adams CM, Jiang W, Greenawalt E, Eischen CM. Pan-cancer analysis reveals cooperativity of both strands of microRNA that regulate tumorigenesis and patient survival. Nat Commun. 2020 Feb 20; 11(1):968. PMID: 32080184.
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    4. Qin G, Mallik S, Mitra R, Li A, Jia P, Eischen CM, Zhao Z. MicroRNA and transcription factor co-regulatory networks and subtype classification of seminoma and non-seminoma in testicular germ cell tumors. Sci Rep. 2020 Jan 21; 10(1):852. PMID: 31965022.
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    5. Thomas LR, Adams CM, Fesik SW, Eischen CM, Tansey WP. Targeting MYC through WDR5. Mol Cell Oncol. 2020; 7(2):1709388. PMID: 32158922.
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    6. Thomas LR, Adams CM, Wang J, Weissmiller AM, Creighton J, Lorey SL, Liu Q, Fesik SW, Eischen CM, Tansey WP. Interaction of the oncoprotein transcription factor MYC with its chromatin cofactor WDR5 is essential for tumor maintenance. Proc Natl Acad Sci U S A. 2019 Dec 10; 116(50):25260-25268. PMID: 31767764.
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    7. Adams CM, Mitra R, Vogel AN, Liu J, Gong JZ, Eischen CM. Targeting BCL-W and BCL-XL as a therapeutic strategy for Hodgkin lymphoma. Leukemia. 2019 Oct 21. PMID: 31636344.
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    8. Stier MT, Mitra R, Nyhoff LE, Goleniewska K, Zhang J, Puccetti MV, Casanova HC, Seegmiller AC, Newcomb DC, Kendall PL, Eischen CM, Peebles RS. IL-33 Is a Cell-Intrinsic Regulator of Fitness during Early B Cell Development. J Immunol. 2019 Aug 07. PMID: 31391233.
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    9. Puccetti MV, Adams CM, Dan TD, Palagani A, Simone BA, DeAngelis T, Eischen CM, Simone NL. miR-21 is required for hematopoietic cell viability following radiation exposure. Int J Radiat Oncol Biol Phys. 2019 Apr 27. PMID: 31039423.
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    10. McBride A, Houtmann S, Wilde L, Vigil C, Eischen CM, Kasner M, Palmisiano N. The Role of Inhibition of Apoptosis in Acute Leukemias and Myelodysplastic Syndrome. Front Oncol. 2019; 9:192. PMID: 30972300.
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    11. Adams CM, Clark-Garvey S, Porcu P, Eischen CM. Targeting the Bcl-2 Family in B Cell Lymphoma. Front Oncol. 2018; 8:636. PMID: 30671383.
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    12. Puccetti MV, Adams CM, Kushinsky S, Eischen CM. Smarcal1 and Zranb3 protect replication forks from Myc-induced DNA replication stress. Cancer Res. 2019 Jan 04. PMID: 30610086.
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    13. Greenawalt EJ, Edmonds MD, Jain N, Adams CM, Mitra R, Eischen CM. Targeting of SGK1 by miR-576-3p inhibits lung adenocarcinoma migration and invasion. Mol Cancer Res. 2018 Sep 26. PMID: 30257988.
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    14. Olivos DJ, Perrien DS, Hooker A, Cheng YH, Fuchs RK, Hong JM, Bruzzaniti A, Chun K, Eischen CM, Kacena MA, Mayo LD. The proto-oncogene function of Mdm2 in bone. J Cell Biochem. 2018 Nov; 119(11):8830-8840. PMID: 30011084.
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    15. Mitra R, Chen X, Greenawalt EJ, Maulik U, Jiang W, Zhao Z, Eischen CM. Decoding critical long non-coding RNA in ovarian cancer epithelial-to-mesenchymal transition. Nat Commun. 2017 Nov 17; 8(1):1604. PMID: 29150601.
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    16. Adams CM, Mitra R, Gong JZ, Eischen CM. Non-Hodgkin and Hodgkin Lymphomas Select for Overexpression of BCLW. Clin Cancer Res. 2017 Nov 15; 23(22):7119-7129. PMID: 28855351.
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    17. Feeley KP, Adams CM, Mitra R, Eischen CM. Mdm2 Is Required for Survival and Growth of p53-Deficient Cancer Cells. Cancer Res. 2017 Jun 02. PMID: 28576884.
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    18. Adams CM, Kim AS, Mitra R, Choi JK, Gong JZ, Eischen CM. BCL-W has a fundamental role in B cell survival and lymphomagenesis. J Clin Invest. 2017 Feb 01; 127(2):635-650. PMID: 28094768.
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    19. Eischen CM. Role of MDM2 and MDMX in DNA repair. J Mol Cell Biol. 2016 Dec 08. PMID: 27932484.
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    20. Oran AR, Adams CM, Zhang XY, Gennaro VJ, Pfeiffer HK, Mellert HS, Seidel HE, Mascioli K, Kaplan J, Gaballa MR, Shen C, Rigoutsos I, King MP, Cotney JL, Arnold JJ, Sharma SD, Martinez-Outschoorn UE, Vakoc CR, Chodosh LA, Thompson JE, Bradner JE, Cameron CE, Shadel GS, Eischen CM, McMahon SB. Multi-focal control of mitochondrial gene expression by oncogenic MYC provides potential therapeutic targets in cancer. Oncotarget. 2016 Nov 08; 7(45):72395-72414. PMID: 27590350.
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    21. Grieb BC, Boyd K, Mitra R, Eischen CM. Haploinsufficiency of the Myc regulator Mtbp extends survival and delays tumor development in aging mice. Aging (Albany NY). 2016 Oct 30; 8(10):2590-2602. PMID: 27803394.
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    22. Liu S, Mitra R, Zhao MM, Fan W, Eischen CM, Yin F, Zhao Z. The Potential Roles of Long Noncoding RNAs (lncRNA) in Glioblastoma Development. Mol Cancer Ther. 2016 Dec; 15(12):2977-2986. PMID: 27784795.
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    23. Eischen CM. Genome Stability Requires p53. Cold Spring Harb Perspect Med. 2016; 6(6). PMID: 27252396.
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    24. Adams CM, Eischen CM. Molecular underpinnings of HDAC inhibition revealed. Cell Cycle. 2016 Aug 2; 15(15):1943-4. PMID: 27153392.
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    25. Adams CM, Hiebert SW, Eischen CM. Myc Induces miRNA-Mediated Apoptosis in Response to HDAC Inhibition in Hematologic Malignancies. Cancer Res. 2016 Feb 1; 76(3):736-48. PMID: 26676759.
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    26. Edmonds MD, Boyd KL, Moyo T, Mitra R, Duszynski R, Arrate MP, Chen X, Zhao Z, Blackwell TS, Andl T, Eischen CM. MicroRNA-31 initiates lung tumorigenesis and promotes mutant KRAS-driven lung cancer. J Clin Invest. 2016 Jan; 126(1):349-64. PMID: 26657862.
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    27. Thompson MA, Edmonds MD, Liang S, McClintock-Treep S, Wang X, Li S, Eischen CM. miR-31 and miR-17-5p levels change during transformation of follicular lymphoma. Hum Pathol. 2016 Apr; 50:118-26. PMID: 26997445.
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    28. Poole LA, Zhao R, Glick GG, Lovejoy CA, Eischen CM, Cortez D. SMARCAL1 maintains telomere integrity during DNA replication. Proc Natl Acad Sci U S A. 2015 Dec 1; 112(48):14864-9. PMID: 26578802.
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    29. Tonsing-Carter E, Bailey BJ, Saadatzadeh MR, Ding J, Wang H, Sinn AL, Peterman KM, Spragins TK, Silver JM, Sprouse AA, Georgiadis TM, Gunter TZ, Long EC, Minto RE, Marchal CC, Batuello CN, Safa AR, Hanenberg H, Territo PR, Sandusky GE, Mayo LD, Eischen CM, Shannon HE, Pollok KE. Potentiation of Carboplatin-Mediated DNA Damage by the Mdm2 Modulator Nutlin-3a in a Humanized Orthotopic Breast-to-Lung Metastatic Model. Mol Cancer Ther. 2015 Dec; 14(12):2850-63. PMID: 26494859.
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    30. McGirt LY, Jia P, Baerenwald DA, Duszynski RJ, Dahlman KB, Zic JA, Zwerner JP, Hucks D, Dave U, Zhao Z, Eischen CM. Whole-genome sequencing reveals oncogenic mutations in mycosis fungoides. Blood. 2015 Jul 23; 126(4):508-19. PMID: 26082451.
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    31. Carrillo AM, Hicks M, Khabele D, Eischen CM. Pharmacologically Increasing Mdm2 Inhibits DNA Repair and Cooperates with Genotoxic Agents to Kill p53-Inactivated Ovarian Cancer Cells. Mol Cancer Res. 2015 Aug; 13(8):1197-205. PMID: 25964101.
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    32. Mitra R, Lin CC, Eischen CM, Bandyopadhyay S, Zhao Z. Concordant dysregulation of miR-5p and miR-3p arms of the same precursor microRNA may be a mechanism in inducing cell proliferation and tumorigenesis: a lung cancer study. RNA. 2015 Jun; 21(6):1055-65. PMID: 25852169.
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    33. Thomas LR, Wang Q, Grieb BC, Phan J, Foshage AM, Sun Q, Olejniczak ET, Clark T, Dey S, Lorey S, Alicie B, Howard GC, Cawthon B, Ess KC, Eischen CM, Zhao Z, Fesik SW, Tansey WP. Interaction with WDR5 promotes target gene recognition and tumorigenesis by MYC. Mol Cell. 2015 May 7; 58(3):440-52. PMID: 25818646.
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    34. Edmonds MD, Eischen CM. Differences in miRNA expression in early stage lung adenocarcinomas that did and did not relapse. PLoS One. 2014; 9(7):e101802. PMID: 25028925.
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    35. Mitra R, Edmonds MD, Sun J, Zhao M, Yu H, Eischen CM, Zhao Z. Reproducible combinatorial regulatory networks elucidate novel oncogenic microRNAs in non-small cell lung cancer. RNA. 2014 Sep; 20(9):1356-68. PMID: 25024357.
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    36. Adams CM, Eischen CM. Cell survival is dicey without Dicer. Mol Cell Oncol. 2014 Jun; 1(2). PMID: 25558471.
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    37. Grieb BC, Chen X, Eischen CM. MTBP is overexpressed in triple-negative breast cancer and contributes to its growth and survival. Mol Cancer Res. 2014 Sep; 12(9):1216-24. PMID: 24866769.
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    38. Adams CM, Eischen CM. Inactivation of p53 is insufficient to allow B cells and B-cell lymphomas to survive without Dicer. Cancer Res. 2014 Jul 15; 74(14):3923-34. PMID: 24840646.
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    39. Grieb BC, Gramling MW, Arrate MP, Chen X, Beauparlant SL, Haines DS, Xiao H, Eischen CM. Oncogenic protein MTBP interacts with MYC to promote tumorigenesis. Cancer Res. 2014 Jul 1; 74(13):3591-602. PMID: 24786788.
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    40. Eischen CM, Lozano G. The Mdm network and its regulation of p53 activities: a rheostat of cancer risk. Hum Mutat. 2014 Jun; 35(6):728-37. PMID: 24488925.
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    41. Zhang X, Hagen J, Muniz VP, Smith T, Coombs GS, Eischen CM, Mackie DI, Roman DL, Van Rheeden R, Darbro B, Tompkins VS, Quelle DE. RABL6A, a novel RAB-like protein, controls centrosome amplification and chromosome instability in primary fibroblasts. PLoS One. 2013; 8(11):e80228. PMID: 24282525; PMCID: PMC3839920.
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    42. McGirt LY, Adams CM, Baerenwald DA, Zwerner JP, Zic JA, Eischen CM. miR-223 regulates cell growth and targets proto-oncogenes in mycosis fungoides/cutaneous T-cell lymphoma. J Invest Dermatol. 2014 Apr; 134(4):1101-7. PMID: 24304814.
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    43. Wells CE, Bhaskara S, Stengel KR, Zhao Y, Sirbu B, Chagot B, Cortez D, Khabele D, Chazin WJ, Cooper A, Jacques V, Rusche J, Eischen CM, McGirt LY, Hiebert SW. Inhibition of histone deacetylase 3 causes replication stress in cutaneous T cell lymphoma. PLoS One. 2013; 8(7):e68915. PMID: 23894374.
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    44. Eischen CM, Boyd K. Decreased Mdm2 expression inhibits tumor development and extends survival independent of Arf and dependent on p53. PLoS One. 2012; 7(9):e46148. PMID: 23029416.
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    45. Anderson PD, McKissic SA, Logan M, Roh M, Franco OE, Wang J, Doubinskaia I, van der Meer R, Hayward SW, Eischen CM, Eltoum IE, Abdulkadir SA. Nkx3.1 and Myc crossregulate shared target genes in mouse and human prostate tumorigenesis. J Clin Invest. 2012 May; 122(5):1907-19. PMID: 22484818.
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    46. Melo AN, Eischen CM. Protecting the genome from mdm2 and mdmx. Genes Cancer. 2012 Mar; 3(3-4):283-90. PMID: 23150761.
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    47. Cho SH, Ahn AK, Bhargava P, Lee CH, Eischen CM, McGuinness O, Boothby M. Glycolytic rate and lymphomagenesis depend on PARP14, an ADP ribosyltransferase of the B aggressive lymphoma (BAL) family. Proc Natl Acad Sci U S A. 2011 Sep 20; 108(38):15972-7. PMID: 21911376.
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    48. Eischen CM. Decreased Mdm2 levels after DNA damage: antibody masking or protein degradation? Cell Cycle. 2011 May 1; 10(9):1347. PMID: 21460638.
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    49. Arrate MP, Vincent T, Odvody J, Kar R, Jones SN, Eischen CM. MicroRNA biogenesis is required for Myc-induced B-cell lymphoma development and survival. Cancer Res. 2010 Jul 15; 70(14):6083-92. PMID: 20587524.
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    50. Sluss HK, Gannon H, Coles AH, Shen Q, Eischen CM, Jones SN. Phosphorylation of p53 serine 18 upregulates apoptosis to suppress Myc-induced tumorigenesis. Mol Cancer Res. 2010 Feb; 8(2):216-22. PMID: 20145032.
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    51. Bouska A, Eischen CM. Murine double minute 2: p53-independent roads lead to genome instability or death. Trends Biochem Sci. 2009 Jun; 34(6):279-86. PMID: 19447627.
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    52. Eischen CM, Lozano G. p53 and MDM2: antagonists or partners in crime? Cancer Cell. 2009 Mar 3; 15(3):161-2. PMID: 19249672.
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    53. Bouska A, Eischen CM. Mdm2 affects genome stability independent of p53. Cancer Res. 2009 Mar 1; 69(5):1697-701. PMID: 19244108.
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    54. Cho SH, Goenka S, Henttinen T, Gudapati P, Reinikainen A, Eischen CM, Lahesmaa R, Boothby M. PARP-14, a member of the B aggressive lymphoma family, transduces survival signals in primary B cells. Blood. 2009 Mar 12; 113(11):2416-25. PMID: 19147789.
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    55. Humbey O, Pimkina J, Zilfou JT, Jarnik M, Dominguez-Brauer C, Burgess DJ, Eischen CM, Murphy ME. The ARF tumor suppressor can promote the progression of some tumors. Cancer Res. 2008 Dec 1; 68(23):9608-13. PMID: 19047137.
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    56. Mudhasani R, Zhu Z, Hutvagner G, Eischen CM, Lyle S, Hall LL, Lawrence JB, Imbalzano AN, Jones SN. Loss of miRNA biogenesis induces p19Arf-p53 signaling and senescence in primary cells. J Cell Biol. 2008 Jun 30; 181(7):1055-63. PMID: 18591425.
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    57. Bouska A, Lushnikova T, Plaza S, Eischen CM. Mdm2 promotes genetic instability and transformation independent of p53. Mol Cell Biol. 2008 Aug; 28(15):4862-74. PMID: 18541670.
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    58. Tompkins VS, Hagen J, Frazier AA, Lushnikova T, Fitzgerald MP, di Tommaso A, Ladeveze V, Domann FE, Eischen CM, Quelle DE. A novel nuclear interactor of ARF and MDM2 (NIAM) that maintains chromosomal stability. J Biol Chem. 2007 Jan 12; 282(2):1322-33. PMID: 17110379.
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    59. Alt JR, Bouska A, Fernandez MR, Cerny RL, Xiao H, Eischen CM. Mdm2 binds to Nbs1 at sites of DNA damage and regulates double strand break repair. J Biol Chem. 2005 May 13; 280(19):18771-81. PMID: 15734743.
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    60. Eischen CM, Alt JR, Wang P. Loss of one allele of ARF rescues Mdm2 haploinsufficiency effects on apoptosis and lymphoma development. Oncogene. 2004 Nov 25; 23(55):8931-40. PMID: 15467748.
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    61. Alt JR, Greiner TC, Cleveland JL, Eischen CM. Mdm2 haplo-insufficiency profoundly inhibits Myc-induced lymphomagenesis. EMBO J. 2003 Mar 17; 22(6):1442-50. PMID: 12628936.
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    62. Eischen CM, Rehg JE, Korsmeyer SJ, Cleveland JL. Loss of Bax alters tumor spectrum and tumor numbers in ARF-deficient mice. Cancer Res. 2002 Apr 1; 62(7):2184-91. PMID: 11929842.
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    63. Dang J, Kuo ML, Eischen CM, Stepanova L, Sherr CJ, Roussel MF. The RING domain of Mdm2 can inhibit cell proliferation. Cancer Res. 2002 Feb 15; 62(4):1222-30. PMID: 11861407.
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