Claudia Gragnoli

TitleAssoc Prof CHP
InstitutionThomas Jefferson University
DepartmentNursing - Undergraduate
Address1020 Locust St.
Philadelphia PA 19107
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Perrelli M, Goparaju P, Postolache TT, Del Bosque-Plata L, Gragnoli C. Stress and the CRH System, Norepinephrine, Depression, and Type 2 Diabetes. Biomedicines. 2024 May 27; 12(6). PMID: 38927393.
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    2. Postolache TT, Al Tinawi QM, Gragnoli C. The melatonin receptor genes are linked and associated with the risk of polycystic ovary syndrome. J Ovarian Res. 2024 Jan 13; 17(1):17. PMID: 38217063.
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    3. Syed S, Gragnoli C. The glucocorticoid receptor gene (NR3C1) is linked to and associated with polycystic ovarian syndrome in Italian families. J Ovarian Res. 2024 Jan 12; 17(1):13. PMID: 38217051.
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    4. Del Bosque-Plata L, Amin M, Gonz?lez-Ram?rez R, Wu R, Postolache TT, Vergare M, Gordon D, Gragnoli C. LD block disorder-specific pleiotropic roles of novel CRHR1 in type 2 diabetes and depression disorder comorbidity. Eur Arch Psychiatry Clin Neurosci. 2023 Dec 14. PMID: 38092990.
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    5. Amin M, Gragnoli C. The prolactin receptor gene (PRLR) is linked and associated with the risk of polycystic ovarian syndrome. J Ovarian Res. 2023 Nov 22; 16(1):222. PMID: 37993904.
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    6. Wu S, Liu X, Dong A, Gragnoli C, Griffin C, Wu J, Yau ST, Wu R. The metabolomic physics of complex diseases. Proc Natl Acad Sci U S A. 2023 Oct 17; 120(42):e2308496120. PMID: 37812720.
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    7. Wang Y, Sang M, Feng L, Gragnoli C, Griffin C, Wu R. A pleiotropic-epistatic entangelement model of drug response. Drug Discov Today. 2023 Sep 26; 28(11):103790. PMID: 37758020.
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    8. Amin M, Wu R, Postolache TT, Gragnoli C. Author Correction: Linkage and association of novel DRD2 variants to the comorbidity of type 2 diabetes and depression. Eur Rev Med Pharmacol Sci. 2023 Sep; 27(18):8322. PMID: 37782147.
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    9. Amin M, Horst N, Gragnoli C. Linkage and association of variants in the dopamine receptor 2 gene (DRD2) with polycystic ovary syndrome. J Ovarian Res. 2023 Aug 10; 16(1):158. PMID: 37563671.
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    10. Amin M, Horst N, Wu R, Gragnoli C. Novel corticotropin-releasing hormone receptor genes (CRHR1 and CRHR2) linkage to and association with polycystic ovary syndrome. J Ovarian Res. 2023 Aug 05; 16(1):155. PMID: 37543650.
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    11. Amin M, Rafla B, Wu R, Postolache TT, Gragnoli C. The role of melatonin receptor 1B gene (MTNR1B) in the susceptibility to depression and type 2 diabetes comorbidity. Genes Dis. 2024 May; 11(3):101067. PMID: 38292205.
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    12. Amin M, Del Bosque-Plata L, Gragnoli C. Novel linkage and association of TCF7L2 variants with PCOS in Italian families. Eur Rev Med Pharmacol Sci. 2023 Aug; 27(15):7346-7351. PMID: 37606143.
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    13. Amin M, Wu R, Postolache TT, Gragnoli C. The prolactin receptor (PRLR) gene is linked to and associated with the comorbidity of depression and type 2 diabetes in Italian families. Genes Dis. 2024 May; 11(3):101048. PMID: 38274369.
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    14. Reis DJ, Yen P, Tizenberg B, Gottipati A, Postolache SY, De Riggs D, Nance M, Dagdag A, Plater L, Federline A, Grassmeyer R, Dagdag A, Akram F, Ozorio Dutra SV, Gragnoli C, RachBeisel JA, Volkov J, Bahraini NH, Stiller JW, Brenner LA, Postolache TT. Longitude-based time zone partitions and rates of suicide. J Affect Disord. 2023 Jul 20; 339:933-942. PMID: 37481129.
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    15. Feng L, Yang W, Ding M, Hou L, Gragnoli C, Griffin C, Wu R. A personalized pharmaco-epistatic network model of precision medicine. Drug Discov Today. 2023 May 04; 28(7):103608. PMID: 37149282.
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    16. Amin M, Wu R, Postolache TT, Gragnoli C. Novel implication of the prolactin (PRL) gene in the comorbidity of type 2 diabetes and depression. Eur Rev Med Pharmacol Sci. 2023 May; 27(9):4080-4084. PMID: 37203833.
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    17. Amin M, Gragnoli C. Melatonin receptor 1A (MTNR1A) gene linkage and association to type 2 diabetes in Italian families. Eur Rev Med Pharmacol Sci. 2023 May; 27(10):4688-4692. PMID: 37259752.
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    18. Amin M, Gragnoli C. Genome-wide linkage and association study identifies novel genes and pathways implicated in polycystic ovarian syndrome. Eur Rev Med Pharmacol Sci. 2023 Apr; 27(8):3719-3732. PMID: 37140321.
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    19. Amin M, Wu R, Gragnoli C. Novel Risk Variants in the Oxytocin Receptor Gene (OXTR) Possibly Linked to and Associated with Familial Type 2 Diabetes. Int J Mol Sci. 2023 Mar 27; 24(7). PMID: 37047255.
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    20. Amin M, Horst N, Wu R, Gragnoli C. Oxytocin receptor (OXTR) is a risk gene for polycystic ovarian syndrome. Eur Rev Med Pharmacol Sci. 2023 03; 27(6):2634-2639. PMID: 37013781.
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    21. Amin M, Perrelli M, Wu R, Gragnoli C. The mineralocorticoid receptor gene (NR3C2) is linked to and associated with polycystic ovarian syndrome in Italian families. Eur Rev Med Pharmacol Sci. 2023 Feb; 27(3):942-948. PMID: 36808340.
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    22. Del Bosque-Plata L, Amin M, Wu R, Postolache TT, Gragnoli C. Novel TCF7L2 familial linkage and association with Type 2 diabetes, depression, and their comorbidity. Eur Rev Med Pharmacol Sci. 2023 Jan; 27(2):694-703. PMID: 36734726.
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    23. Del Bosque-Plata L, Amin M, Gragnoli C. PSMD9 is linked to T2D age of onset, years of isolated and combined insulin therapy, irregular menses, and hot flashes. Eur Rev Med Pharmacol Sci. 2022 12; 26(23):8873-8878. PMID: 36524506.
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    24. Perrelli M, Wu R, Liu DJ, Lucchini RG, Del Bosque-Plata L, Vergare MJ, Akhter MP, Ott J, Gragnoli C. Heavy metals as risk factors for human diseases - a Bayesian network approach. Eur Rev Med Pharmacol Sci. 2022 12; 26(24):9275-9310. PMID: 36591839.
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    25. Amin M, Wu R, Postolache TT, Gragnoli C. Linkage and association of novel DRD2 variants to the comorbidity of type 2 diabetes and depression. Eur Rev Med Pharmacol Sci. 2022 11; 26(22):8370-8375. PMID: 36459020.
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    26. Wang Q, Dong A, Zhao J, Wang C, Griffin C, Gragnoli C, Xue F, Wu R. Vaginal microbiota networks as a mechanistic predictor of aerobic vaginitis. Front Microbiol. 2022; 13:998813. PMID: 36338093.
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    27. Amin M, Syed S, Wu R, Postolache TT, Gragnoli C. Familial Linkage and Association of the NR3C1 Gene with Type 2 Diabetes and Depression Comorbidity. Int J Mol Sci. 2022 Oct 08; 23(19). PMID: 36233250.
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    28. Amin M, Ott J, Gordon D, Wu R, Postolache TT, Vergare M, Gragnoli C. Comorbidity of Novel CRHR2 Gene Variants in Type 2 Diabetes and Depression. Int J Mol Sci. 2022 Aug 29; 23(17). PMID: 36077219.
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    29. Amin M, Ott J, Wu R, Postolache TT, Gragnoli C. Implication of Melanocortin Receptor Genes in the Familial Comorbidity of Type 2 Diabetes and Depression. Int J Mol Sci. 2022 Jul 28; 23(15). PMID: 35955479.
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    30. Del Bosque-Plata L, Hernández-Cortés EP, Gragnoli C. The broad pathogenetic role of TCF7L2 in human diseases beyond type 2 diabetes. J Cell Physiol. 2021 Oct 06. PMID: 34612510.
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    31. Del Bosque-Plata L, Martínez-Martínez E, Espinoza-Camacho MÁ, Gragnoli C. The Role of TCF7L2 in Type 2 Diabetes. Diabetes. 2021 06; 70(6):1220-1228. PMID: 34016596.
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    32. Jiang L, Liu X, He X, Jin Y, Cao Y, Zhan X, Griffin CH, Gragnoli C, Wu R. A behavioral model for mapping the genetic architecture of gut-microbiota networks. Gut Microbes. 2020 Nov 01; 1-15. PMID: 33131416.
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    33. Sun L, Jiang L, Grant CN, Wang HG, Gragnoli C, Liu Z, Wu R. Computational Identification of Gene Networks as a Biomarker of Neuroblastoma Risk. Cancers (Basel). 2020 Jul 28; 12(8). PMID: 32731407.
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    34. Akram F, Gragnoli C, Raheja UK, Snitker S, Lowry CA, Stearns-Yoder KA, Hoisington AJ, Brenner LA, Saunders E, Stiller JW, Ryan KA, Rohan KJ, Mitchell BD, Postolache TT. Seasonal affective disorder and seasonal changes in weight and sleep duration are inversely associated with plasma adiponectin levels. J Psychiatr Res. 2020 Mar; 122:97-104. PMID: 31981963.
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    35. Sang M, Rice S, Jiang L, Liu X, Gragnoli C, Belani CP, Wu R. A rewiring model of intratumoral interaction networks. Comput Struct Biotechnol J. 2020; 18:45-51. PMID: 31890143.
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    36. Jiang L, Xu J, Sang M, Zhang Y, Ye M, Zhang H, Wu B, Zhu Y, Xu P, Tai R, Zhao Z, Jiang Y, Dong C, Sun L, Griffin CH, Gragnoli C, Wu R. A Drive to Driven Model of Mapping Intraspecific Interaction Networks. iScience. 2019 Dec 20; 22:109-122. PMID: 31765992.
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    37. Postolache TT, Del Bosque-Plata L, Jabbour S, Vergare M, Wu R, Gragnoli C. Co-shared genetics and possible risk gene pathway partially explain the comorbidity of schizophrenia, major depressive disorder, type 2 diabetes, and metabolic syndrome. Am J Med Genet B Neuropsychiatr Genet. 2019 Apr; 180(3):186-203. PMID: 30729689.
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    38. Wang Q, Gan J, Wei K, Berceli SA, Gragnoli C, Wu R. A unified mapping framework of multifaceted pharmacodynamic responses to hypertension interventions. Drug Discov Today. 2019 Jan 25. PMID: 30690194.
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    39. Wei K, Wang Q, Gan J, Zhang S, Ye M, Gragnoli C, Wu R. Mapping genes for drug chronotherapy. Drug Discov Today. 2018 Jun 28. PMID: 29964181.
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    40. Gragnoli C, Wu R, Ahmed I. Breastfeeding and Future Maternal Health-No Causal Evidence. JAMA Intern Med. 2018 Jun 01; 178(6):869-870. PMID: 29868740.
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    41. Mohyuddin H, Georgiou P, Wadhawan A, Daue ML, Brenner LA, Gragnoli C, Saunders EFH, Fuchs D, Lowry CA, Postolache TT. Seasonality of blood neopterin levels in the Old Order Amish. Pteridines. 2017; 28(3-4):163-176. PMID: 29657362.
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    42. Ahmad Z, Moustafa YW, Stiller JW, Pavlovich MA, Raheja UK, Gragnoli C, Snitker S, Nazem S, Dagdag A, Fang B, Fuchs D, Lowry CA, Postolache TT. Sleep onset insomnia, daytime sleepiness and sleep duration in relationship to Toxoplasma gondii IgG seropositivity and serointensity. Pteridines. 2017; 28(3-4):195-204. PMID: 29657364.
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    43. Mathai AJ, Kanwar J, Okusaga O, Fuchs D, Lowry CA, Peng X, Giegling I, Hartmann AM, Konte B, Friedl M, Gragnoli C, Reeves GM, Groer MW, Rosenthal RN, Rujescu D, Postolache TT. Blood Levels of Monoamine Precursors and Smoking in Patients with Schizophrenia. Front Public Health. 2016; 4:182. PMID: 27626030.
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    44. Gragnoli C, Reeves GM, Reazer J, Postolache TT. Dopamine-prolactin pathway potentially contributes to the schizophrenia and type 2 diabetes comorbidity. Transl Psychiatry. 2016 Apr 19; 6:e785. PMID: 27093067; PMCID: PMC4872408.
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    45. Zhu X, Jiang L, Ye M, Sun L, Gragnoli C, Wu R. Integrating Evolutionary Game Theory into Mechanistic Genotype-Phenotype Mapping. Trends Genet. 2016 May; 32(5):256-68. PMID: 27017185.
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    46. Hao H, Haas MJ, Wu R, Gragnoli C. T2D and Depression Risk Gene Proteasome Modulator 9 is Linked to Insomnia. Sci Rep. 2015; 5:12032. PMID: 26166263.
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    47. Gragnoli C. Proteasome modulator 9 gene SNPs, responsible for anti-depressant response, are in linkage with generalized anxiety disorder. J Cell Physiol. 2014 Sep; 229(9):1157-9. PMID: 24648162.
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    48. Gragnoli C. Hypothesis of the neuroendocrine cortisol pathway gene role in the comorbidity of depression, type 2 diabetes, and metabolic syndrome. Appl Clin Genet. 2014; 7:43-53. PMID: 24817815.
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    49. Gragnoli C. Overweight condition and waist circumference and a candidate gene within the 12q24 locus. Cardiovasc Diabetol. 2013; 12:2. PMID: 23282078.
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    50. Oberweis B, Gragnoli C. Potential role of prolactin in antipsychotic-mediated association of schizophrenia and type 2 diabetes. J Cell Physiol. 2012 Aug; 227(8):3001-6. PMID: 22105468.
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    51. Gragnoli C. Proteasome modulator 9 is linked to microvascular pathology of T2D. J Cell Physiol. 2012 Aug; 227(8):3116-8. PMID: 22015693.
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    52. Gragnoli C. Depression and type 2 diabetes: cortisol pathway implication and investigational needs. J Cell Physiol. 2012 Jun; 227(6):2318-22. PMID: 21898408.
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    53. Gragnoli C. Proteasome modulator 9 and depression in type 2 diabetes. Curr Med Chem. 2012; 19(30):5178-80. PMID: 22934761.
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    54. Gragnoli C. Proteasome modulator 9 and carpal tunnel syndrome. Diabetes Res Clin Pract. 2011 Nov; 94(2):e47-9. PMID: 21862167.
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    55. Gragnoli C. Proteasome modulator 9 SNPs are linked to hypertension in type 2 diabetes families. Cardiovasc Diabetol. 2011; 10:77. PMID: 21871126.
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    56. Gragnoli C. PSMD9 is linked to type 2 diabetes neuropathy. J Diabetes Complications. 2011 Sep-Oct; 25(5):329-31. PMID: 21813292.
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    57. Gragnoli C. Proteasome modulator 9 gene is linked to diabetic and non-diabetic retinopathy in T2D. Ophthalmic Genet. 2011 Nov; 32(4):228-30. PMID: 21728808.
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    58. Gragnoli C. Hypercholesterolemia and a candidate gene within the 12q24 locus. Cardiovasc Diabetol. 2011; 10:38. PMID: 21554682.
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    59. Gragnoli C. Proteasome modulator 9 and macrovascular pathology of T2D. Cardiovasc Diabetol. 2011; 10:32. PMID: 21496327.
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    60. Gragnoli C. T2D-nephropathy linkage within 12q24 locus. Diabetes Res Clin Pract. 2011 Jun; 92(3):e73-5. PMID: 21439668.
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    61. Gragnoli C. PSMD9 is linked to MODY3. J Cell Physiol. 2010 Apr; 223(1):1-5. PMID: 20069546.
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    62. Gragnoli C. PSMD9 gene in the NIDDM2 locus is linked to type 2 diabetes in Italians. J Cell Physiol. 2010 Feb; 222(2):265-7. PMID: 19877155.
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    63. Meenakshisundaram R, Gragnoli C. CDK4 IVS4-nt40G-->A and T2D-associated obesity in Italians. J Cell Physiol. 2009 Nov; 221(2):273-5. PMID: 19634152.
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    64. Meenakshisundaram R, Piumelli N, Pierpaoli L, Gragnoli C. CDK4 IVS4-nt40G-->A SNP and type 2 diabetes in Italians. Diabetes Res Clin Pract. 2009 Nov; 86(2):e28-30. PMID: 19695727.
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    65. Meenakshisundaram R, Piumelli N, Pierpaoli L, Gragnoli C. CHOP 5'UTR-c.279T>C and +nt30C>T variants are not associated with overweight condition or with tumors/cancer in Italians - a case-control study. J Exp Clin Cancer Res. 2009 Jun 26; 28:90. PMID: 19558691.
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    66. Spanakis E, Gragnoli C. Successful medical management of status post-Roux-en-Y-gastric-bypass hyperinsulinemic hypoglycemia. Obes Surg. 2009 Sep; 19(9):1333-4. PMID: 19551453.
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    67. Meenakshisundaram R, Gragnoli C. CDK4 IVS4-nt40 AA genotype and obesity-associated tumors/cancer in Italians - a case-control study. J Exp Clin Cancer Res. 2009 Mar 28; 28:42. PMID: 19327170.
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    68. Spanakis E, Milord E, Gragnoli C. AVPR2 variants and mutations in nephrogenic diabetes insipidus: review and missense mutation significance. J Cell Physiol. 2008 Dec; 217(3):605-17. PMID: 18726898.
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    69. Jonnakuty C, Gragnoli C. What do we know about serotonin? J Cell Physiol. 2008 Nov; 217(2):301-6. PMID: 18651566.
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    70. Gragnoli C. CHOP T/C and C/T haplotypes contribute to early-onset type 2 diabetes in Italians. J Cell Physiol. 2008 Nov; 217(2):291-5. PMID: 18680108.
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    71. Spanakis E, Gragnoli C. Bariatric surgery, safety and type 2 diabetes. Obes Surg. 2009 Mar; 19(3):363-8. PMID: 18830788.
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    72. Gragnoli C. The CM cell line derived from liver metastasis of malignant human insulinoma is not a valid beta cell model for in vitro studies. J Cell Physiol. 2008 Aug; 216(2):569-70. PMID: 18384119.
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    73. Jonnakuty C, Gragnoli C. Karyotype of the human insulinoma CM cell line--beta cell model in vitro? J Cell Physiol. 2007 Dec; 213(3):661-2. PMID: 17492774.
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    74. Gragnoli C, Pierpaoli L, Piumelli N, Chiaramonte F. Linkage studies for T2D in Chop and C/EBPbeta chromosomal regions in Italians. J Cell Physiol. 2007 Nov; 213(2):552-5. PMID: 17620318.
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    75. Gragnoli C, Cronsell J. PSMD9 gene variants within NIDDM2 may rarely contribute to type 2 diabetes. J Cell Physiol. 2007 Sep; 212(3):568-71. PMID: 17516568.
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    76. Gragnoli C, Cronsell J. Meta-analysis of the IPF1 D76N polymorphism in a worldwide type 2 diabetes population. Minerva Med. 2007 Jun; 98(3):163-6. PMID: 17592437.
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    77. Milord E, Gragnoli C. NEUROG3 variants and type 2 diabetes in Italians. Minerva Med. 2006 Oct; 97(5):373-8. PMID: 17146417.
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    78. Gragnoli C, Stanojevic V, Gorini A, Von Preussenthal GM, Thomas MK, Habener JF. IPF-1/MODY4 gene missense mutation in an Italian family with type 2 and gestational diabetes. Metabolism. 2005 Aug; 54(8):983-8. PMID: 16092045.
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    79. Gragnoli C, Gragnoli C, Milord E, Habener JF. Linkage study of the glucagon receptor gene with type 2 diabetes mellitus in Italians. Metabolism. 2005 Jun; 54(6):786-7. PMID: 15931615.
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    80. Gragnoli C, Menzinger Von Preussenthal G, Habener JF. Triple genetic variation in the HNF-4alpha gene is associated with early-onset type 2 diabetes mellitus in a philippino family. Metabolism. 2004 Aug; 53(8):959-63. PMID: 15281001.
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    81. Gragnoli C, Cockburn BN, Chiaramonte F, Gorini A, Marietti G, Marozzi G, Signorini AM. Early-onset Type II diabetes mellitus in Italian families due to mutations in the genes encoding hepatic nuclear factor 1 alpha and glucokinase. Diabetologia. 2001 Oct; 44(10):1326-9. PMID: 11692182.
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    82. Godart F, Bellanné-Chantelot C, Clauin S, Gragnoli C, Abderrahmani A, Blanché H, Boutin P, Chèvre JC, Froguel P, Bailleul B. Identification of seven novel nucleotide variants in the hepatocyte nuclear factor-1alpha (TCF1) promoter region in MODY patients. Hum Mutat. 2000; 15(2):173-80. PMID: 10649494.
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    83. Gragnoli C, Lindner T, Cockburn BN, Kaisaki PJ, Gragnoli F, Marozzi G, Bell GI. Maturity-onset diabetes of the young due to a mutation in the hepatocyte nuclear factor-4 alpha binding site in the promoter of the hepatocyte nuclear factor-1 alpha gene. Diabetes. 1997 Oct; 46(10):1648-51. PMID: 9313764.
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    84. Lindner T, Gragnoli C, Furuta H, Cockburn BN, Petzold C, Rietzsch H, Weiss U, Schulze J, Bell GI. Hepatic function in a family with a nonsense mutation (R154X) in the hepatocyte nuclear factor-4alpha/MODY1 gene. J Clin Invest. 1997 Sep 15; 100(6):1400-5. PMID: 9294105; PMCID: PMC508318.
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    85. Lindner T, Gragnoli C, Schulze J, Rietzsch H, Petzold C, Schröder HE, Cox NJ, Bell GI. The 31-cM region of chromosome 11 including the obesity gene tubby and ATP-sensitive potassium channel genes, SUR1 and Kir6.2, does not contain a major susceptibility locus for NIDDM in 127 non-Hispanic white affected sibships. Diabetes. 1997 Jul; 46(7):1227-9. PMID: 9200660.
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    86. Baroni MG, Alcolado JC, Gragnoli C, Franciosi AM, Cavallo MG, Fiore V, Pozzilli P, Galton DJ. Affected sib-pair analysis of the GLUT1 glucose transporter gene locus in non-insulin-dependent diabetes mellitus (NIDDM): evidence for no linkage. Hum Genet. 1994 Jun; 93(6):675-80. PMID: 7516306.
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