Thomas Jefferson University

Joel Rosenbloom

TitleVolunteer Faculty
InstitutionThomas Jefferson University
DepartmentDermatology
Address233 S. 10th Street
Philadelphia PA 19107
Phone215-503-5785
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Tartaglia G, Park PH, Alexander MH, Nystr?m A, Rosenbloom J, South AP. Trametinib-Induced Epidermal Thinning Accelerates a Mouse Model of Junctional Epidermolysis Bullosa. Biomolecules. 2023 04 25; 13(5). PMID: 37238610.
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    2. Basta MD, Petruk S, Summer R, Rosenbloom J, Wermuth PJ, Macarak E, Levin AV, Mazo A, Walker JL. Changes in nascent chromatin structure regulate activation of the pro-fibrotic transcriptome and myofibroblast emergence in organ fibrosis. iScience. 2023 May 19; 26(5):106570. PMID: 37250334.
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    3. Rosenbloom J. Joel Rosenbloom and the revolution in biomedical research. Connect Tissue Res. 2022 05; 63(3):200-209. PMID: 35321605.
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    4. Macarak EJ, Wermuth PJ, Rosenbloom J, Uitto J. Keloid disorder: Fibroblast differentiation and gene expression profile in fibrotic skin diseases. Exp Dermatol. 2021 01; 30(1):132-145. PMID: 33211348.
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    5. Gelbard MK, Rosenbloom J. Fibroproliferative disorders and diabetes: Understanding the pathophysiologic relationship between Peyronie's disease, Dupuytren disease and diabetes. Endocrinol Diabetes Metab. 2021 04; 4(2):e00195. PMID: 33855203.
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    6. Macarak EJ, Rosenbloom J. Therapeutic Approaches to Radiation-Induced Fibrosis. J Cancer Treatment Diagn. 2018; 2(4):7-9. PMID: 30949622.
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    7. Wermuth PJ, Piera-Velazquez S, Rosenbloom J, Jimenez SA. Existing and novel biomarkers for precision medicine in systemic sclerosis. Nat Rev Rheumatol. 2018 07; 14(7):421-432. PMID: 29789665.
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    8. Macarak EJ, Lotto CE, Koganti D, Jin X, Wermuth PJ, Olsson AK, Montgomery M, Rosenbloom J. Trametinib prevents mesothelial-mesenchymal transition and ameliorates abdominal adhesion formation. J Surg Res. 2018 07; 227:198-210. PMID: 29804854.
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    9. Rosenbloom J, Macarak E, Piera-Velazquez S, Jimenez SA. Human Fibrotic Diseases: Current Challenges in Fibrosis Research. Methods Mol Biol. 2017; 1627:1-23. PMID: 28836191.
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    10. Andrews JP, Marttala J, Macarak E, Rosenbloom J, Uitto J. Keloids: The paradigm of skin fibrosis - Pathomechanisms and treatment. Matrix Biol. 2016 04; 51:37-46. PMID: 26844756.
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    11. Marttala J, Andrews JP, Rosenbloom J, Uitto J. Keloids: Animal models and pathologic equivalents to study tissue fibrosis. Matrix Biol. 2016 04; 51:47-54. PMID: 26827712.
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    12. Jin X, Ren S, Macarak E, Rosenbloom J. Pathobiological mechanisms of peritoneal adhesions: The mesenchymal transition of rat peritoneal mesothelial cells induced by TGF-?1 and IL-6 requires activation of Erk1/2 and Smad2 linker region phosphorylation. Matrix Biol. 2016 04; 51:55-64. PMID: 26825317.
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    13. Rosenbloom J, Ren S, Macarak E. New frontiers in fibrotic disease therapies: The focus of the Joan and Joel Rosenbloom Center for Fibrotic Diseases at Thomas Jefferson University. Matrix Biol. 2016 04; 51:14-25. PMID: 26807756.
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    14. Andrews JP, Marttala J, Macarak E, Rosenbloom J, Uitto J. Keloid Pathogenesis: Potential Role of Cellular Fibronectin with the EDA Domain. J Invest Dermatol. 2015 Jul; 135(7):1921-1924. PMID: 25685931.
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    15. Rosenbloom J, Mendoza FA, Jimenez SA. Strategies for anti-fibrotic therapies. Biochim Biophys Acta. 2013 Jul; 1832(7):1088-103. PMID: 23266403.
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    16. Rosenbloom J, Castro SV, Jimenez SA. Narrative review: fibrotic diseases: cellular and molecular mechanisms and novel therapies. Ann Intern Med. 2010 Feb 02; 152(3):159-66. PMID: 20124232.
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    17. Jim?nez SA, Rosenbloom J. Angiotensin II blockade in Marfan's syndrome. N Engl J Med. 2008 Oct 16; 359(16):1732-3; author reply 1733-4. PMID: 18927953.
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    18. Rosenbloom J, Jim?nez SA. Molecular ablation of transforming growth factor beta signaling pathways by tyrosine kinase inhibition: the coming of a promising new era in the treatment of tissue fibrosis. Arthritis Rheum. 2008 Aug; 58(8):2219-24. PMID: 18668575.
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    19. Larsson A, Peng S, Persson H, Rosenbloom J, Abrams WR, Wassberg E, Thelin S, Sletten K, Gerwins P, Westermark P. Lactadherin binds to elastin--a starting point for medin amyloid formation? Amyloid. 2006 Jun; 13(2):78-85. PMID: 16911961.
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    20. Zhou D, Herrick DJ, Rosenbloom J, Chaqour B. Cyr61 mediates the expression of VEGF, alphav-integrin, and alpha-actin genes through cytoskeletally based mechanotransduction mechanisms in bladder smooth muscle cells. J Appl Physiol (1985). 2005 Jun; 98(6):2344-54. PMID: 15649872.
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    21. Patterson CE, Abrams WR, Wolter NE, Rosenbloom J, Davis EC. Developmental regulation and coordinate reexpression of FKBP65 with extracellular matrix proteins after lung injury suggest a specialized function for this endoplasmic reticulum immunophilin. Cell Stress Chaperones. 2005; 10(4):285-95. PMID: 16333983.
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    22. Shimo T, Kanyama M, Wu C, Sugito H, Billings PC, Abrams WR, Rosenbloom J, Iwamoto M, Pacifici M, Koyama E. Expression and roles of connective tissue growth factor in Meckel's cartilage development. Dev Dyn. 2004 Sep; 231(1):136-47. PMID: 15305294.
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    23. Han JS, Macarak E, Rosenbloom J, Chung KC, Chaqour B. Regulation of Cyr61/CCN1 gene expression through RhoA GTPase and p38MAPK signaling pathways. Eur J Biochem. 2003 Aug; 270(16):3408-21. PMID: 12899698.
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    24. Kirsch AJ, Macarak EJ, Chaqour B, Quinn T, Zderic S, Flake A, Crombleholme T, Adzick NS, Canning D, Hubbard AM, Rosenbloom J, Snyder HM, Howard PS. Molecular response of the bladder to obstruction. Adv Exp Med Biol. 2003; 539(Pt A):195-216. PMID: 15088906.
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    25. Lazaar AL, Plotnick MI, Kucich U, Crichton I, Lotfi S, Das SK, Kane S, Rosenbloom J, Panettieri RA, Schechter NM, Pur? E. Mast cell chymase modifies cell-matrix interactions and inhibits mitogen-induced proliferation of human airway smooth muscle cells. J Immunol. 2002 Jul 15; 169(2):1014-20. PMID: 12097409.
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    26. Shimo T, Wu C, Billings PC, Piddington R, Rosenbloom J, Pacifici M, Koyama E. Expression, gene regulation, and roles of Fisp12/CTGF in developing tooth germs. Dev Dyn. 2002 Jul; 224(3):267-78. PMID: 12112457.
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    27. Billings PC, Whitbeck JC, Adams CS, Abrams WR, Cohen AJ, Engelsberg BN, Howard PS, Rosenbloom J. The transforming growth factor-beta-inducible matrix protein (beta)ig-h3 interacts with fibronectin. J Biol Chem. 2002 Aug 02; 277(31):28003-9. PMID: 12034705.
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    28. Kucich U, Rosenbloom JC, Abrams WR, Rosenbloom J. Transforming growth factor-beta stabilizes elastin mRNA by a pathway requiring active Smads, protein kinase C-delta, and p38. Am J Respir Cell Mol Biol. 2002 Feb; 26(2):183-8. PMID: 11804868.
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    29. Kucich U, Rosenbloom JC, Herrick DJ, Abrams WR, Hamilton AD, Sebti SM, Rosenbloom J. Signaling events required for transforming growth factor-beta stimulation of connective tissue growth factor expression by cultured human lung fibroblasts. Arch Biochem Biophys. 2001 Nov 01; 395(1):103-12. PMID: 11673871.
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    30. Jimenez SA, Gaidarova S, Saitta B, Sandorfi N, Herrich DJ, Rosenbloom JC, Kucich U, Abrams WR, Rosenbloom J. Role of protein kinase C-delta in the regulation of collagen gene expression in scleroderma fibroblasts. J Clin Invest. 2001 Nov; 108(9):1395-403. PMID: 11696585.
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    31. Rosenbloom J, Saitta B, Gaidarova S, Sandorfi N, Rosenbloom JC, Abrams WR, Hamilton AD, Sebti SM, Kucich U, Jimenez SA. Inhibition of type I collagen gene expression in normal and systemic sclerosis fibroblasts by a specific inhibitor of geranylgeranyl transferase I. Arthritis Rheum. 2000 Jul; 43(7):1624-32. PMID: 10902768.
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    32. Kucich U, Rosenbloom JC, Shen G, Abrams WR, Hamilton AD, Sebti SM, Rosenbloom J. TGF-beta1 stimulation of fibronectin transcription in cultured human lung fibroblasts requires active geranylgeranyl transferase I, phosphatidylcholine-specific phospholipase C, protein kinase C-delta, and p38, but not erk1/erk2. Arch Biochem Biophys. 2000 Feb 15; 374(2):313-24. PMID: 10666313.
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    33. Kucich U, Rosenbloom JC, Shen G, Abrams WR, Blaskovich MA, Hamilton AD, Ohkanda J, Sebti SM, Rosenbloom J. Requirement for geranylgeranyl transferase I and acyl transferase in the TGF-beta-stimulated pathway leading to elastin mRNA stabilization. Biochem Biophys Res Commun. 1998 Nov 09; 252(1):111-6. PMID: 9813154.
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    34. Kucich U, Rosenbloom JC, Abrams WR, Bashir MM, Rosenbloom J. Stabilization of elastin mRNA by TGF-beta: initial characterization of signaling pathway. Am J Respir Cell Mol Biol. 1997 Jul; 17(1):10-6. PMID: 9224204.
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    35. Lally ET, Golub EE, Kieba IR, Taichman NS, Rosenbloom J, Rosenbloom JC, Gibson CW, Demuth DR. Analysis of the Actinobacillus actinomycetemcomitans leukotoxin gene. Delineation of unique features and comparison to homologous toxins. J Biol Chem. 1989 Sep 15; 264(26):15451-6. PMID: 2670940.
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    36. Indik Z, Yeh H, Ornstein-Goldstein N, Kucich U, Abrams W, Rosenbloom JC, Rosenbloom J. Structure of the elastin gene and alternative splicing of elastin mRNA: implications for human disease. Am J Med Genet. 1989 Sep; 34(1):81-90. PMID: 2683784.
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    37. Bashir MM, Indik Z, Yeh H, Ornstein-Goldstein N, Rosenbloom JC, Abrams W, Fazio M, Uitto J, Rosenbloom J. Characterization of the complete human elastin gene. Delineation of unusual features in the 5'-flanking region. J Biol Chem. 1989 May 25; 264(15):8887-91. PMID: 2722804.
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    38. Yeh H, Anderson N, Ornstein-Goldstein N, Bashir MM, Rosenbloom JC, Abrams W, Indik Z, Yoon K, Parks W, Mecham R, et al. Structure of the bovine elastin gene and S1 nuclease analysis of alternative splicing of elastin mRNA in the bovine nuchal ligament. Biochemistry. 1989 Mar 21; 28(6):2365-70. PMID: 2543440.
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