Thomas Jefferson University

Thomas Rushmore

TitleAdjunct Faculty
InstitutionThomas Jefferson University
DepartmentJefferson College of Life Scie
Address1020 Locust St.
Philadelphia PA 19107
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    F32CA007806     (RUSHMORE, THOMAS H)Feb 8, 1986
    NIH
    STUDIES ON THE INDUCTION OF CANCER BY A DIETARY MODEL
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Davydov DR, Davydova NY, Rodgers JT, Rushmore TH, Jones JP. Toward a systems approach to the human cytochrome P450 ensemble: interactions between CYP2D6 and CYP2E1 and their functional consequences. Biochem J. 2017 10 10; 474(20):3523-3542. PMID: 28904078.
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    2. Frederick DM, Jacinto EY, Patel NN, Rushmore TH, Tchao R, Harvison PJ. Cytotoxicity of 3-(3,5-dichlorophenyl)-2,4-thiazolidinedione (DCPT) and analogues in wild type and CYP3A4 stably transfected HepG2 cells. Toxicol In Vitro. 2011 Dec; 25(8):2113-9. PMID: 21964476.
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    3. Yang X, Zhang B, Molony C, Chudin E, Hao K, Zhu J, Gaedigk A, Suver C, Zhong H, Leeder JS, Guengerich FP, Strom SC, Schuetz E, Rushmore TH, Ulrich RG, Slatter JG, Schadt EE, Kasarskis A, Lum PY. Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver. Genome Res. 2010 Aug; 20(8):1020-36. PMID: 20538623.
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    4. Wenning LA, Petry AS, Kost JT, Jin B, Breidinger SA, DeLepeleire I, Carlini EJ, Young S, Rushmore T, Wagner F, Lunde NM, Bieberdorf F, Greenberg H, Stone JA, Wagner JA, Iwamoto M. Pharmacokinetics of raltegravir in individuals with UGT1A1 polymorphisms. Clin Pharmacol Ther. 2009 Jun; 85(6):623-7. PMID: 19279563.
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    5. Schadt EE, Molony C, Chudin E, Hao K, Yang X, Lum PY, Kasarskis A, Zhang B, Wang S, Suver C, Zhu J, Millstein J, Sieberts S, Lamb J, GuhaThakurta D, Derry J, Storey JD, Avila-Campillo I, Kruger MJ, Johnson JM, Rohl CA, van Nas A, Mehrabian M, Drake TA, Lusis AJ, Smith RC, Guengerich FP, Strom SC, Schuetz E, Rushmore TH, Ulrich R. Mapping the genetic architecture of gene expression in human liver. PLoS Biol. 2008 May 06; 6(5):e107. PMID: 18462017.
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    6. Slatter JG, Cheng O, Cornwell PD, de Souza A, Rockett J, Rushmore T, Hartley D, Evers R, He Y, Dai X, Hu R, Caguyong M, Roberts CJ, Castle J, Ulrich RG. Microarray-based compendium of hepatic gene expression profiles for prototypical ADME gene-inducing compounds in rats and mice in vivo. Xenobiotica. 2006 Oct-Nov; 36(10-11):902-37. PMID: 17118914.
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    7. Slatter JG, Templeton IE, Castle JC, Kulkarni A, Rushmore TH, Richards K, He Y, Dai X, Cheng OJ, Caguyong M, Ulrich RG. Compendium of gene expression profiles comprising a baseline model of the human liver drug metabolism transcriptome. Xenobiotica. 2006 Oct-Nov; 36(10-11):938-62. PMID: 17118915.
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    8. Li SX, Pequignot E, Panebianco D, Lupinacci P, Majumdar A, Rosen L, Ahmed T, Royalty JE, Rushmore TH, Murphy MG, Petty KJ. Lack of effect of aprepitant on hydrodolasetron pharmacokinetics in CYP2D6 extensive and poor metabolizers. J Clin Pharmacol. 2006 Jul; 46(7):792-801. PMID: 16809805.
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    9. Booth-Genthe CL, Louie SW, Carlini EJ, Li B, Leake BF, Eisenhandler R, Hochman JH, Mei Q, Kim RB, Rushmore TH, Yamazaki M. Development and characterization of LLC-PK1 cells containing Sprague-Dawley rat Abcb1a (Mdr1a): comparison of rat P-glycoprotein transport to human and mouse. J Pharmacol Toxicol Methods. 2006 Jul-Aug; 54(1):78-89. PMID: 16545584.
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    10. Gibson CR, Lin C, Singh R, Brown CM, Richards K, Brunner J, Michel K, Adelsberger J, Carlini E, Boothe-Genthe C, Raab C, Luu M, Michael A, Parikh M, Ciecko P, Subramanian R, Krolikowski P, Rodrigues AD, Baillie TA, Rushmore TH. Induction of CYP1A in the beagle dog by an inhibitor of kinase insert domain-containing receptor: differential effects in vitro and in vivo on mRNA and functional activity. Drug Metab Dispos. 2005 Jul; 33(7):1044-51. PMID: 15833927.
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    11. Lu P, Singh SB, Carr BA, Fang Y, Xiang CD, Rushmore TH, Rodrigues AD, Shou M. Selective inhibition of dog hepatic CYP2B11 and CYP3A12. J Pharmacol Exp Ther. 2005 May; 313(2):518-28. PMID: 15677349.
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    12. Schrag ML, Cui D, Rushmore TH, Shou M, Ma B, Rodrigues AD. Sulfotransferase 1E1 is a low km isoform mediating the 3-O-sulfation of ethinyl estradiol. Drug Metab Dispos. 2004 Nov; 32(11):1299-303. PMID: 15483196.
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    13. Chen Q, Tan E, Strauss JR, Zhang Z, Fenyk-Melody JE, Booth-Genthe C, Rushmore TH, Stearns RA, Evans DC, Baillie TA, Tang W. Effect of quinidine on the 10-hydroxylation of R-warfarin: species differences and clearance projection. J Pharmacol Exp Ther. 2004 Oct; 311(1):307-14. PMID: 15163679.
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    14. Hartley DP, Dai X, He YD, Carlini EJ, Wang B, Huskey SE, Ulrich RG, Rushmore TH, Evers R, Evans DC. Activators of the rat pregnane X receptor differentially modulate hepatic and intestinal gene expression. Mol Pharmacol. 2004 May; 65(5):1159-71. PMID: 15102944.
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    15. Miller KK, Cai J, Ripp SL, Pierce WM, Rushmore TH, Prough RA. Stereo- and regioselectivity account for the diversity of dehydroepiandrosterone (DHEA) metabolites produced by liver microsomal cytochromes P450. Drug Metab Dispos. 2004 Mar; 32(3):305-13. PMID: 14977864.
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    16. Shou M, Norcross R, Sandig G, Lu P, Li Y, Lin Y, Mei Q, Rodrigues AD, Rushmore TH. Substrate specificity and kinetic properties of seven heterologously expressed dog cytochromes p450. Drug Metab Dispos. 2003 Sep; 31(9):1161-9. PMID: 12920172.
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    17. Rushmore TH, Kong AN. Pharmacogenomics, regulation and signaling pathways of phase I and II drug metabolizing enzymes. Curr Drug Metab. 2002 Oct; 3(5):481-90. PMID: 12369894.
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    18. Mei Q, Tang C, Lin Y, Rushmore TH, Shou M. Inhibition kinetics of monoclonal antibodies against cytochromes P450. Drug Metab Dispos. 2002 Jun; 30(6):701-8. PMID: 12019198.
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    19. Rodrigues AD, Rushmore TH. Cytochrome P450 pharmacogenetics in drug development: in vitro studies and clinical consequences. Curr Drug Metab. 2002 Jun; 3(3):289-309. PMID: 12083322.
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    20. Lu P, Lin Y, Rodrigues AD, Rushmore TH, Baillie TA, Shou M. Testosterone, 7-benzyloxyquinoline, and 7-benzyloxy-4-trifluoromethyl-coumarin bind to different domains within the active site of cytochrome P450 3A4. Drug Metab Dispos. 2001 Nov; 29(11):1473-9. PMID: 11602524.
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    21. Gerhold D, Lu M, Xu J, Austin C, Caskey CT, Rushmore T. Monitoring expression of genes involved in drug metabolism and toxicology using DNA microarrays. Physiol Genomics. 2001 Apr 27; 5(4):161-70. PMID: 11328961.
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    22. Tang C, Shou M, Rushmore TH, Mei Q, Sandhu P, Woolf EJ, Rose MJ, Gelmann A, Greenberg HE, De Lepeleire I, Van Hecken A, De Schepper PJ, Ebel DL, Schwartz JI, Rodrigues AD. In-vitro metabolism of celecoxib, a cyclooxygenase-2 inhibitor, by allelic variant forms of human liver microsomal cytochrome P450 2C9: correlation with CYP2C9 genotype and in-vivo pharmacokinetics. Pharmacogenetics. 2001 Apr; 11(3):223-35. PMID: 11337938.
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    23. Lin Y, Lu P, Tang C, Mei Q, Sandig G, Rodrigues AD, Rushmore TH, Shou M. Substrate inhibition kinetics for cytochrome P450-catalyzed reactions. Drug Metab Dispos. 2001 Apr; 29(4 Pt 1):368-74. PMID: 11259318.
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    24. Shou M, Lin Y, Lu P, Tang C, Mei Q, Cui D, Tang W, Ngui JS, Lin CC, Singh R, Wong BK, Yergey JA, Lin JH, Pearson PG, Baillie TA, Rodrigues AD, Rushmore TH. Enzyme kinetics of cytochrome P450-mediated reactions. Curr Drug Metab. 2001 Mar; 2(1):17-36. PMID: 11465149.
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    25. Shou M, Dai R, Cui D, Korzekwa KR, Baillie TA, Rushmore TH. A kinetic model for the metabolic interaction of two substrates at the active site of cytochrome P450 3A4. J Biol Chem. 2001 Jan 19; 276(3):2256-62. PMID: 11054425.
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    26. Tang C, Shou M, Mei Q, Rushmore TH, Rodrigues AD. Major role of human liver microsomal cytochrome P450 2C9 (CYP2C9) in the oxidative metabolism of celecoxib, a novel cyclooxygenase-II inhibitor. J Pharmacol Exp Ther. 2000 May; 293(2):453-9. PMID: 10773015.
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    27. Lightning LK, Jones JP, Friedberg T, Pritchard MP, Shou M, Rushmore TH, Trager WF. Mechanism-based inactivation of cytochrome P450 3A4 by L-754,394. Biochemistry. 2000 Apr 18; 39(15):4276-87. PMID: 10757976.
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    28. Rushmore TH, Reider PJ, Slaughter D, Assang C, Shou M. Bioreactor systems in drug metabolism: synthesis of cytochrome P450-generated metabolites. Metab Eng. 2000 Apr; 2(2):115-25. PMID: 10935727.
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    29. Mei Q, Tang C, Assang C, Lin Y, Slaughter D, Rodrigues AD, Baillie TA, Rushmore TH, Shou M. Role of a potent inhibitory monoclonal antibody to cytochrome P-450 3A4 in assessment of human drug metabolism. J Pharmacol Exp Ther. 1999 Nov; 291(2):749-59. PMID: 10525096.
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    30. Shou M, Mei Q, Ettore MW, Dai R, Baillie TA, Rushmore TH. Sigmoidal kinetic model for two co-operative substrate-binding sites in a cytochrome P450 3A4 active site: an example of the metabolism of diazepam and its derivatives. Biochem J. 1999 Jun 15; 340 ( Pt 3):845-53. PMID: 10359672.
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    31. Gerhold D, Rushmore T, Caskey CT. DNA chips: promising toys have become powerful tools. Trends Biochem Sci. 1999 May; 24(5):168-73. PMID: 10322428.
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    32. Tang W, Stearns RA, Bandiera SM, Zhang Y, Raab C, Braun MP, Dean DC, Pang J, Leung KH, Doss GA, Strauss JR, Kwei GY, Rushmore TH, Chiu SH, Baillie TA. Studies on cytochrome P-450-mediated bioactivation of diclofenac in rats and in human hepatocytes: identification of glutathione conjugated metabolites. Drug Metab Dispos. 1999 Mar; 27(3):365-72. PMID: 10064567.
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    33. McCrea JB, Cribb A, Rushmore T, Osborne B, Gillen L, Lo MW, Waldman S, Bjornsson T, Spielberg S, Goldberg MR. Phenotypic and genotypic investigations of a healthy volunteer deficient in the conversion of losartan to its active metabolite E-3174. Clin Pharmacol Ther. 1999 Mar; 65(3):348-52. PMID: 10096267.
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    34. Koenigs LL, Peter RM, Hunter AP, Haining RL, Rettie AE, Friedberg T, Pritchard MP, Shou M, Rushmore TH, Trager WF. Electrospray ionization mass spectrometric analysis of intact cytochrome P450: identification of tienilic acid adducts to P450 2C9. Biochemistry. 1999 Feb 23; 38(8):2312-9. PMID: 10029524.
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    35. Wang RW, Newton DJ, Liu NY, Shou M, Rushmore T, Lu AY. Inhibitory anti-CYP3A4 peptide antibody: mapping of inhibitory epitope and specificity toward other CYP3A isoforms. Drug Metab Dispos. 1999 Feb; 27(2):167-72. PMID: 9929498.
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    36. Falkner KC, Rushmore TH, Linder MW, Prough RA. Negative regulation of the rat glutathione S-transferase A2 gene by glucocorticoids involves a canonical glucocorticoid consensus sequence. Mol Pharmacol. 1998 Jun; 53(6):1016-26. PMID: 9614203.
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    37. Silva JM, Morin PE, Day SH, Kennedy BP, Payette P, Rushmore T, Yergey JA, Nicoll-Griffith DA. Refinement of an in vitro cell model for cytochrome P450 induction. Drug Metab Dispos. 1998 May; 26(5):490-6. PMID: 9571231.
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    38. Steward DJ, Haining RL, Henne KR, Davis G, Rushmore TH, Trager WF, Rettie AE. Genetic association between sensitivity to warfarin and expression of CYP2C9*3. Pharmacogenetics. 1997 Oct; 7(5):361-7. PMID: 9352571.
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    39. Fei P, Matwyshyn GA, Rushmore TH, Kong AN. Transcription regulation of rat glutathione S-transferase Ya subunit gene expression by chemopreventive agents. Pharm Res. 1996 Jul; 13(7):1043-8. PMID: 8842042.
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    40. Abramovitz M, Adam M, Boie Y, Grygorczyk R, Rushmore TH, Nguyen T, Funk CD, Bastien L, Sawyer N, Rochette C, et al. Human prostanoid receptors: cloning and characterization. Adv Prostaglandin Thromboxane Leukot Res. 1995; 23:499-504. PMID: 7732897.
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    41. Cribb AE, Griffin GP, Spielberg SP, Rushmore TH, Chauret N, Nicoll-Griffith DA. Increased cosedimentation of cytosolic glutathione S-transferases with microsomal fractions prepared from frozen rat liver. Drug Metab Dispos. 1994 Nov-Dec; 22(6):969-72. PMID: 7895617.
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    42. Nguyen T, Rushmore TH, Pickett CB. Transcriptional regulation of a rat liver glutathione S-transferase Ya subunit gene. Analysis of the antioxidant response element and its activation by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate. J Biol Chem. 1994 May 06; 269(18):13656-62. PMID: 8175801.
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    43. Boie Y, Rushmore TH, Darmon-Goodwin A, Grygorczyk R, Slipetz DM, Metters KM, Abramovitz M. Cloning and expression of a cDNA for the human prostanoid IP receptor. J Biol Chem. 1994 Apr 22; 269(16):12173-8. PMID: 7512962.
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    44. Adam M, Boie Y, Rushmore TH, M?ller G, Bastien L, McKee KT, Metters KM, Abramovitz M. Cloning and expression of three isoforms of the human EP3 prostanoid receptor. FEBS Lett. 1994 Jan 31; 338(2):170-4. PMID: 8307176.
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    45. Abramovitz M, Boie Y, Nguyen T, Rushmore TH, Bayne MA, Metters KM, Slipetz DM, Grygorczyk R. Cloning and expression of a cDNA for the human prostanoid FP receptor. J Biol Chem. 1994 Jan 28; 269(4):2632-6. PMID: 8300593.
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    46. Rushmore TH, Pickett CB. Glutathione S-transferases, structure, regulation, and therapeutic implications. J Biol Chem. 1993 Jun 05; 268(16):11475-8. PMID: 8505281.
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    47. Rushmore TH, Morton MR, Pickett CB. The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity. J Biol Chem. 1991 Jun 25; 266(18):11632-9. PMID: 1646813.
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    48. Rushmore TH, Pickett CB. Xenobiotic responsive elements controlling inducible expression by planar aromatic compounds and phenolic antioxidants. Methods Enzymol. 1991; 206:409-20. PMID: 1784226.
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    49. Quinn BA, Crane TL, Kocal TE, Best SJ, Cameron RG, Rushmore TH, Farber E, Hayes MA. Protective activity of different hepatic cytosolic glutathione S-transferases against DNA-binding metabolites of aflatoxin B1. Toxicol Appl Pharmacol. 1990 Sep 15; 105(3):351-63. PMID: 2173169.
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    50. Rushmore TH, Pickett CB. Transcriptional regulation of the rat glutathione S-transferase Ya subunit gene. Characterization of a xenobiotic-responsive element controlling inducible expression by phenolic antioxidants. J Biol Chem. 1990 Aug 25; 265(24):14648-53. PMID: 2387873.
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    51. Rushmore TH, King RG, Paulson KE, Pickett CB. Regulation of glutathione S-transferase Ya subunit gene expression: identification of a unique xenobiotic-responsive element controlling inducible expression by planar aromatic compounds. Proc Natl Acad Sci U S A. 1990 May; 87(10):3826-30. PMID: 2160079.
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    52. Paulson KE, Darnell JE, Rushmore T, Pickett CB. Analysis of the upstream elements of the xenobiotic compound-inducible and positionally regulated glutathione S-transferase Ya gene. Mol Cell Biol. 1990 May; 10(5):1841-52. PMID: 2325638.
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    53. Rushmore TH, Harris L, Nagai M, Sharma RN, Hayes MA, Cameron RG, Murray RK, Farber E. Purification and characterization of P-52 (glutathione S-transferase-P or 7-7) from normal liver and putative preneoplastic liver nodules. Cancer Res. 1988 May 15; 48(10):2805-12. PMID: 3359441.
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    54. Rushmore TH, Sharma RN, Roomi MW, Harris L, Satoh K, Sato K, Murray RK, Farber E. Identification of a characteristic cytosolic polypeptide of rat preneoplastic hepatocyte nodules as placental glutathione S-transferase. Biochem Biophys Res Commun. 1987 Feb 27; 143(1):98-103. PMID: 3827932.
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