Thomas Jefferson University

Yohei Kirino

TitleProfessor
InstitutionThomas Jefferson University
DepartmentComputational Med Center
Address1020 Locust St.
Philadelphia PA 19107
Phone215-503-8648
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Kirino Y, Maeda A, Asano T, Migita K, Hidaka Y, Ida H, Kobayashi D, Oda N, Rokutanda R, Fujieda Y, Atsumi T, Kishida D, Kobayashi H, Shiratsuchi M, Shimizu T, Kawakami A, Tanaka K, Tsuji T, Mishima K, Miyamae T, Hasegawa A, Ikeda K, Watanabe T, Yamaguchi Y, Nishikomori R, Ohara O, Nakajima H. Low remission rates and high incidence of adverse events in a prospective VEXAS syndrome registry. Rheumatology (Oxford). 2025 Jun 01; 64(6):3872-3878. PMID: 39340799.
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    2. Shigematsu M, Matsubara R, Gumas J, Kawamura T, Kirino Y. Angiogenin-catalyzed cleavage within tRNA anticodon-loops identified by cP-RNA-seq. Biosci Biotechnol Biochem. 2025 Feb 20; 89(3):398-405. PMID: 39658364.
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    3. Ichikawa K, Adachi S, Takase-Minegishi K, Nakayama Y, Nagasawa Y, Iizuka Y, Maeda A, Hirahara L, Soejima Y, Ohashi T, Kunimoto H, Horita N, Yoshimi R, Kirino Y, Nakajima H. Distinct features of trisomy 8-associated autoinflammatory disease from Beh?et's disease: case series and systematic review. Clin Exp Rheumatol. 2025 Oct; 43(10):1718-1725. PMID: 39907597.
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    4. Miyagi Y, Kobayashi H, Umebayashi Y, Okimura A, Nakatsugawa M, Maeda A, Kirino Y, Aoki A. A Japanese case of VEXAS syndrome after COVID-19 vaccination: Comparison with previously reported cases. Mod Rheumatol Case Rep. 2025 Jan 16; 9(1):218-223. PMID: 39242354.
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    5. Kashino K, Tsuchida N, Maeda A, Uchiyama Y, Kirino Y, Matsumoto N, Hamada T. VEXAS syndrome initially presenting as relapsing polychondritis and progressing into neutrophilic dermatosis with systemic symptoms over a 5-year period. Int J Dermatol. 2025 Jul; 64(7):1307-1309. PMID: 39739863.
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    6. Shigematsu M, Kawamura T, Kirino Y. TaqMan RT-qPCR for tRNA half quantification. Methods Enzymol. 2025; 711:155-170. PMID: 39952703.
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    7. Shigematsu M, Gumas J, Kirino Y. cP-RNA-seq for tRNA half sequencing. Methods Enzymol. 2025; 711:135-153. PMID: 39952701.
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    8. Shirahama Y, Kokuzawa A, Yamauchi Y, Kirino Y, Nagai H, Inoue Y, Ota T, Chifu Y, Mitoma H, Akahoshi M, Sakai M, Maruyama A, Ohta A, Iwamoto M, Tada Y. Cluster analysis defines four groups of Japanese patients with adult-onset Still's disease. Mod Rheumatol. 2024 Oct 15; 34(6):1213-1220. PMID: 38564322.
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    9. Sakurai N, Yoshimi R, Yajima N, Hidekawa C, Kunishita Y, Kishimoto D, Sugiyama YK, Kojitani N, Suzuki N, Yoshioka Y, Komiya T, Takase-Minegishi K, Kirino Y, Sada KE, Miyawaki Y, Ichinose K, Ohno S, Kajiyama H, Sato S, Shimojima Y, Fujiwara M, Nakajima H. Characteristic features of late-onset systemic lupus erythematosus: An observational study of data from the Lupus Registry of Nationwide Institutions. Lupus. 2024 Oct; 33(12):1306-1316. PMID: 39226537.
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    10. Yoshimi R, Yajima N, Hidekawa C, Sakurai N, Oguro N, Shidahara K, Hayashi K, Ichikawa T, Kishida D, Miyawaki Y, Sada KE, Shimojima Y, Ishikawa Y, Yoshioka Y, Kunishita Y, Kishimoto D, Takase-Minegishi K, Kirino Y, Ohno S, Kurita N, Nakajima H. Effect of Shared Decision-Making on Trust in Physicians in the Management of Systemic Lupus Erythematosus: The Trust Measurement for Physicians and Patients With Systemic Lupus Erythematosus Prospective Cohort Study. Arthritis Care Res (Hoboken). 2024 Dec; 76(12):1597-1605. PMID: 39099215.
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    11. Maeda A, Tsuchida N, Uchiyama Y, Horita N, Kobayashi S, Kishimoto M, Kobayashi D, Matsumoto H, Asano T, Migita K, Kato A, Mori I, Morita H, Matsubara A, Marumo Y, Ito Y, Machiyama T, Shirai T, Ishii T, Kishibe M, Yoshida Y, Hirata S, Akao S, Higuchi A, Rokutanda R, Nagahata K, Takahashi H, Katsuo K, Ohtani T, Fujiwara H, Nagano H, Hosokawa T, Ito T, Haji Y, Yamaguchi H, Hagino N, Shimizu T, Koga T, Kawakami A, Kageyama G, Kobayashi H, Aoki A, Mizokami A, Takeuchi Y, Motohashi R, Hagiyama H, Itagane M, Teruya H, Kato T, Miyoshi Y, Kise T, Yokogawa N, Ishida T, Umeda N, Isogai S, Naniwa T, Yamabe T, Uchino K, Kanasugi J, Takami A, Kondo Y, Furuhashi K, Saito K, Ohno S, Kishimoto D, Yamamoto M, Fujita Y, Fujieda Y, Araki S, Tsushima H, Misawa K, Katagiri A, Kobayashi T, Hashimoto K, Sone T, Hidaka Y, Ida H, Nishikomori R, Doi H, Fujimaki K, Akasaka K, Amano M, Matsushima H, Kashino K, Ohnishi H, Miwa Y, Takahashi N, Takase-Minegishi K, Yoshimi R, Kirino Y, Nakajima H, Matsumoto N. Efficient detection of somatic UBA1 variants and clinical scoring system predicting patients with variants in VEXAS syndrome. Rheumatology (Oxford). 2024 08 01; 63(8):2056-2064. PMID: 37606963.
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    12. Tsuchida N, Uchiyama Y, Maeda A, Horita N, Kirino Y, Matsumoto N. Comment on: Efficient detection of somatic UBA1 variants and clinical scoring system predicting patients with variants in VEXAS syndrome: reply. Rheumatology (Oxford). 2024 08 01; 63(8):e229-e230. PMID: 38059601.
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    13. Shigematsu M, Kawamura T, Deshpande DA, Kirino Y. Immunoactive signatures of circulating tRNA- and rRNA-derived RNAs in chronic obstructive pulmonary disease. Mol Ther Nucleic Acids. 2024 Sep 10; 35(3):102285. PMID: 39220268.
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    14. Shigematsu M, Kawamura T, Deshpande DA, Kirino Y. Immunoactive signatures of circulating tRNA- and rRNA-derived RNAs in chronic obstructive pulmonary disease. bioRxiv. 2024 Jun 19. PMID: 38948719.
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    15. Adachi S, Kirino Y, Higashitani K, Hirahara L, Maeda A, Horita N, Takase-Minegishi K, Yoshimi R, Nakajima H. Targeting enhanced cell death represents a potential therapeutic strategy for VEXAS syndrome. Rheumatol Adv Pract. 2024; 8(2):rkae065. PMID: 38854419.
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    16. Pawar K, Kawamura T, Kirino Y. The tRNAVal half: A strong endogenous Toll-like receptor 7 ligand with a 5'-terminal universal sequence signature. Proc Natl Acad Sci U S A. 2024 May 07; 121(19):e2319569121. PMID: 38683985.
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    17. Hirahara L, Kirino Y, Soejima Y, Iizuka Y, Yoshimi R, Fujieda Y, Atsumi T, Tono T, Kobayashi D, Meguro A, Takeuchi M, Sakamaki K, Takeno M, Mizuki N, Nakajima H. Association of high disease activity and serum IL-6 levels with the incidence of inflammatory major organ events in Beh?et disease: a prospective registry study. Front Immunol. 2024; 15:1354969. PMID: 38686380.
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    18. Gumas J, Kawamura T, Shigematsu M, Kirino Y. Immunostimulatory short non-coding RNAs in the circulation of patients with tuberculosis infection. Mol Ther Nucleic Acids. 2024 Mar 12; 35(1):102156. PMID: 38481936.
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    19. Kirino Y. Clinical Challenges of Emerging Acquired Autoinflammatory Diseases, Including VEXAS Syndrome. Intern Med. 2025 Jan 01; 64(1):25-30. PMID: 38296470.
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    20. Hirahara Y, Yamaguchi M, Takase-Minegishi K, Kirino Y, Aoki S, Hirahara L, Obata S, Kasai M, Maeda A, Tsuchida N, Yoshimi R, Horita N, Nakajima H, Miyagi E. Pregnancy outcomes in patients with familial Mediterranean fever: systematic review and meta-analysis. Rheumatology (Oxford). 2024 02 01; 63(2):277-284. PMID: 37594755.
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    21. Fukuda N, Kanai D, Hoshino K, Fukuda Y, Morita R, Ishikawa Y, Kanaoka T, Toya Y, Kirino Y, Wakui H, Tamura K. Vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) syndrome presenting as recurrent aseptic peritonitis in a patient receiving peritoneal dialysis: a case report. BMC Nephrol. 2024 01 11; 25(1):18. PMID: 38212709.
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    22. Miyoshi Y, Kise T, Morita K, Okada H, Imadome KI, Tsuchida N, Maeda A, Uchiyama Y, Kirino Y, Matsumoto N, Yokogawa N. Long-term remission of?VEXAS syndrome achieved by a single course of?CHOP therapy: A case report. Mod Rheumatol Case Rep. 2023 12 29; 8(1):199-204. PMID: 37548220.
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    23. Nagafuchi H, Kikuchi H, Ishibash H, Maeda H, Ogino H, Kirino Y, Sawada T, Saito K, Kuwana M, Hirohata S, Ishigatsubo Y, Niimi M, Okita Y, Miyata T, Shigematsu H, Takeno M. Recommendations for the management of the vascular involvement in Beh?et's disease by the Japanese National Research Committee for Beh?et's disease-secondary publication. Mod Rheumatol. 2023 Dec 22; 34(1):182-193. PMID: 36658731.
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    24. Adachi S, Takase-Minegishi K, Maeda A, Nagai H, Horita N, Yoshimi R, Kirino Y, Nakajima H. Risk of Macrophage Activation Syndrome in Patients with Adult-Onset Still's Disease Treated with IL-1 and IL-6 Inhibitors: A Meta-analysis and Single-Center Experience. Rheumatol Ther. 2023 Dec; 10(6):1623-1636. PMID: 37794210.
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    25. Hidekawa C, Yoshimi R, Saigusa Y, Tamura J, Kojitani N, Suzuki N, Sakurai N, Yoshioka Y, Sugiyama-Kawahara Y, Kunishita Y, Kishimoto D, Higashitani K, Sato Y, Komiya T, Nagai H, Hamada N, Maeda A, Tsuchida N, Hirahara L, Soejima Y, Takase-Minegishi K, Kirino Y, Yajima N, Sada KE, Miyawaki Y, Ichinose K, Ohno S, Kajiyama H, Sato S, Shimojima Y, Fujiwara M, Nakajima H. Protective effect of hydroxychloroquine on infections in patients with systemic lupus erythematosus: an observational study using the LUNA registry. Front Immunol. 2023; 14:1227403. PMID: 37720209.
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    26. Hirohata S, Kikuchi H, Sawada T, Kuwana M, Kawachi I, Kirino Y, Ishigatsubo Y, Takeno M. Effect of Infliximab on Chronic Progressive Neuro-Beh?et's Disease: Influence of the Timing of Introduction on the Patient Outcome. Intern Med. 2024 Feb 15; 63(4):481-486. PMID: 37344428.
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    27. Ohashi T, Takase-Minegishi K, Maeda A, Hamada N, Yoshimi R, Kirino Y, Teranaka H, Kunimoto H, Hagihara M, Matsumoto K, Namkoong H, Horita N, Nakajima H. Incidence and Risk of Hematological Adverse Events Associated With Immune Checkpoint Inhibitors: A Systematic Literature Review and Meta-Analysis. J Hematol. 2023 Apr; 12(2):66-74. PMID: 37187501.
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    28. Kunimoto H, Miura A, Maeda A, Tsuchida N, Uchiyama Y, Kunishita Y, Nakajima Y, Takase-Minegishi K, Yoshimi R, Miyazaki T, Hagihara M, Yamazaki E, Kirino Y, Matsumoto N, Nakajima H. Clinical and genetic features of Japanese cases of MDS associated with VEXAS syndrome. Int J Hematol. 2023 Oct; 118(4):494-502. PMID: 37062784.
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    29. Maeda A, Takase-Minegishi K, Kirino Y, Hamada N, Kunishita Y, Yoshimi R, Meguro A, Namkoong H, Horita N, Nakajima H. Immune checkpoint inhibitor-induced arthralgia is tightly associated with improved overall survival in cancer patients. Rheumatology (Oxford). 2023 04 03; 62(4):1451-1459. PMID: 36069626.
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    30. Motegi H, Kirino Y, Morishita R, Nishino I, Suzuki S. Overlap syndrome with antibodies against multiple transfer-RNA components presenting antisynthetase syndrome. Neuromuscul Disord. 2023 05; 33(5):405-409. PMID: 37037049.
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    31. Higashitani K, Takase-Minegishi K, Yoshimi R, Kirino Y, Hamada N, Nagai H, Hagihara M, Matsumoto K, Namkoong H, Horita N, Nakajima H. Benefits and risks of haematopoietic stem cell transplantation for systemic sclerosis: A systematic review and meta-analysis. Mod Rheumatol. 2023 Mar 02; 33(2):330-337. PMID: 35285885.
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    32. Teshigawara T, Meguro A, Takeuchi M, Ishido M, Soejima Y, Hirahara L, Kirino Y, Ohno S, Mizuki N. Replication Study of the Association of GAS6 and PROS1 Polymorphisms with Beh?et's Disease in a Japanese Population. Ocul Immunol Inflamm. 2024 May; 32(4):447-453. PMID: 37133403.
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    33. Yamaguchi H, Kobayashi D, Nakamura G, Aida R, Horii Y, Okamoto T, Murakami S, Kondo D, Tsuchida N, Uchiyama Y, Maeda A, Kirino Y, Matsumoto N, Kurosawa Y, Hasegawa E, Wakamatsu A, Narita I. Acute heart failure due to left common iliac arteriovenous fistula: A case of VEXAS syndrome. Mod Rheumatol Case Rep. 2023 01 03; 7(1):327-333. PMID: 36264203.
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    34. Samukawa S, Yoshimi R, Kojitani N, Uzawa Y, Takase-Minegishi K, Kirino Y, Soejima Y, Kato H, Nakajima H. Cryptococcal meningitis with atypical paradoxical inflammatory reactions after antifungal treatment in acquired immune deficiency syndrome: A case report. J Infect Chemother. 2023 Mar; 29(3):347-352. PMID: 36384196.
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    35. Iizuka Y, Takase-Minegishi K, Hirahara L, Kirino Y, Soejima Y, Namkoong HO, Horita N, Yoshimi R, Takeuchi M, Takeno M, Mizuki N, Nakajima H. Beneficial effects of apremilast on genital ulcers, skin lesions, and arthritis in patients with Beh?et's disease: A systematic review and meta-analysis. Mod Rheumatol. 2022 Oct 15; 32(6):1153-1162. PMID: 34752620.
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    36. Tono T, Kikuchi H, Sawada T, Takeno M, Nagafuchi H, Kirino Y, Tanaka Y, Yamaoka K, Hirohata S. Clinical features of Beh?et's disease patients with joint symptoms in Japan: A national multicenter study. Mod Rheumatol. 2022 Oct 15; 32(6):1146-1152. PMID: 34850090.
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    37. Clemente P, Calvo-Garrido J, Pearce SF, Schober FA, Shigematsu M, Siira SJ, Laine I, Sp?hr H, Steinmetzger C, Petzold K, Kirino Y, Wibom R, Rackham O, Filipovska A, Rorbach J, Freyer C, Wredenberg A. ANGEL2 phosphatase activity is required for non-canonical mitochondrial RNA processing. Nat Commun. 2022 09 30; 13(1):5750. PMID: 36180430.
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    38. Itagane M, Teruya H, Kato T, Tsuchida N, Maeda A, Kirino Y, Uchiyama Y, Matsumoto N, Kinjo M. Clinical images: VEXAS syndrome presenting as treatment-refractory polyarteritis nodosa. Arthritis Rheumatol. 2022 11; 74(11):1863-1864. PMID: 35696330.
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    39. Koga T, Sato S, Hagimori N, Yamamoto H, Ishimura M, Yasumi T, Kirino Y, Ikeda K, Yachie A, Migita K, Kishida D, Atsumi T, Kawakami A. A randomised, double-blind, placebo-controlled phase III trial on the efficacy and safety of tocilizumab in patients with familial Mediterranean fever. Clin Exp Rheumatol. 2022 Sep; 40(8):1535-1542. PMID: 36106542.
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    40. Uchino K, Kanasugi J, Enomoto M, Kitamura F, Tsuchida N, Uchiyama Y, Maeda A, Kirino Y, Matsumoto N, Takami A. VEXAS syndrome. Int J Hematol. 2022 10; 116(4):463-464. PMID: 36056988.
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    41. Maruyama A, Kokuzawa A, Yamauchi Y, Kirino Y, Nagai H, Inoue Y, Ota T, Chifu Y, Inokuchi S, Mitoma H, Akahoshi M, Sakai M, Ohta A, Iwamoto M, Tada Y. Usefulness of the severity classification for predicting drug-free remission in Japanese patients with adult-onset Still's disease. Mod Rheumatol. 2022 Aug 20; 32(5):953-959. PMID: 34918141.
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    42. Kunishita Y, Kirino Y, Tsuchida N, Maeda A, Sato Y, Takase-Minegishi K, Yoshimi R, Nakajima H. Case Report: Tocilizumab Treatment for VEXAS Syndrome With Relapsing Polychondritis: A Single-Center, 1-Year Longitudinal Observational Study In Japan. Front Immunol. 2022; 13:901063. PMID: 35769485.
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    43. Matsumoto H, Fujita Y, Fukatsu M, Ikezoe T, Yokose K, Asano T, Tsuchida N, Maeda A, Yoshida S, Hashimoto H, Temmoku J, Matsuoka N, Yashiro-Furuya M, Sato S, Murakami M, Sato H, Sakuma C, Kawashima K, Shakespear N, Uchiyama Y, Watanabe H, Kirino Y, Matsumoto N, Migita K. Case Report: Coexistence of Multiple Myeloma and Auricular Chondritis in VEXAS Syndrome. Front Immunol. 2022; 13:897722. PMID: 35757758.
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    44. Shigematsu M, Kirino Y. Making Invisible RNA Visible: Discriminative Sequencing Methods for RNA Molecules with Specific Terminal Formations. Biomolecules. 2022 04 20; 12(5). PMID: 35625540.
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    45. Matsumoto H, Asano T, Tsuchida N, Maeda A, Yoshida S, Yokose K, Fujita Y, Temmoku J, Matsuoka N, Yashiro-Furuya M, Sato S, Irie K, Norikawa N, Yamamoto T, Endo M, Fukuchi K, Ohkawara H, Ikezoe T, Uchiyama Y, Kirino Y, Matsumoto N, Watanabe H, Migita K. Beh?et's disease with a somatic UBA1 variant:Expanding spectrum of autoinflammatory phenotypes of VEXAS syndrome. Clin Immunol. 2022 05; 238:108996. PMID: 35398520.
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    46. Hirahara L, Takase-Minegishi K, Kirino Y, Iizuka-Iribe Y, Soejima Y, Yoshimi R, Nakajima H. The Roles of Monocytes and Macrophages in Beh?et's Disease With Focus on M1 and M2 Polarization. Front Immunol. 2022; 13:852297. PMID: 35359926.
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    47. Nagano A, Takeuchi M, Horita N, Teshigawara T, Kawagoe T, Mizuki Y, Meguro A, Nakano H, Kirino Y, Takase-Minegishi K, Yoshimi R, Kurosawa M, Fukumoto T, Takeno M, Kaneko T, Mizuki N. Beh?et's disease and activities of daily living. Rheumatology (Oxford). 2022 03 02; 61(3):1133-1140. PMID: 34146088.
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    48. Matsubara A, Tsuchida N, Sakurai M, Maeda A, Uchiyama Y, Sasaki K, Haji Y, Kirino Y, Matsumoto N, Morita A. A case of VEXAS syndrome with Sweet's disease and pulmonary involvement. J Dermatol. 2022 05; 49(5):e177-e178. PMID: 35166394.
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    49. Hidekawa C, Yoshimi R, Kishimoto D, Kato H, Mitsuhashi M, Sakurai N, Sato Y, Uehara T, Iizuka Y, Komiya T, Hamada N, Nagai H, Soejima Y, Kamiyama R, Takase-Minegishi K, Kirino Y, Sakagami T, Nakajima H. Anti-interferon-? Antibody-seropositive Disseminated Nontuberculous Mycobacterial Infection Mimicking POEMS and TAFRO Syndromes. Intern Med. 2022 Aug 01; 61(15):2377-2385. PMID: 35022342.
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    50. Samukawa S, Yoshimi R, Kirino Y, Nakajima H. The PRY/SPRY domain of pyrin/TRIM20 interacts with ?2-microglobulin to promote inflammasome formation. Sci Rep. 2021 12 08; 11(1):23613. PMID: 34880353.
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    51. Hamada N, Maeda A, Takase-Minegishi K, Kirino Y, Sugiyama Y, Namkoong H, Horita N, Yoshimi R, Nakajima H. Incidence and Distinct Features of Immune Checkpoint Inhibitor-Related Myositis From Idiopathic Inflammatory Myositis: A Single-Center Experience With Systematic Literature Review and Meta-Analysis. Front Immunol. 2021; 12:803410. PMID: 34938300.
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    52. Kunishita Y, Yoshimi R, Kamiyama R, Kishimoto D, Komiya T, Sakurai N, Sugiyama Y, Takase-Minegishi K, Kirino Y, Nagaoka S, Nakajima H. Anti-TRIM21 antibody is associated with aberrant B-cell function and type I interferon production in systemic lupus erythematosus. Lupus. 2021 Nov; 30(13):2054-2065. PMID: 34565210.
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    53. Nagai H, Kirino Y, Nakano H, Kunishita Y, Henmi R, Szymanski AM, Yoshimi R, Ombrello MJ, Nakajima H. Elevated serum gasdermin D N-terminal implicates monocyte and macrophage pyroptosis in adult-onset Still's disease. Rheumatology (Oxford). 2021 08 02; 60(8):3888-3895. PMID: 33550379.
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    54. Shigematsu M, Kawamura T, Morichika K, Izumi N, Kiuchi T, Honda S, Pliatsika V, Matsubara R, Rigoutsos I, Katsuma S, Tomari Y, Kirino Y. RNase ? promotes robust piRNA production by generating 2',3'-cyclic phosphate-containing precursors. Nat Commun. 2021 07 23; 12(1):4498. PMID: 34301931.
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    55. Ban T, Kikuchi M, Sato GR, Manabe A, Tagata N, Harita K, Nishiyama A, Nishimura K, Yoshimi R, Kirino Y, Yanai H, Matsumoto Y, Suzuki S, Hihara H, Ito M, Tsukahara K, Yoshimatsu K, Yamamoto T, Taniguchi T, Nakajima H, Ito S, Tamura T. Genetic and chemical inhibition of IRF5 suppresses pre-existing mouse lupus-like disease. Nat Commun. 2021 07 19; 12(1):4379. PMID: 34282144.
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    56. Kirino Y, Takase-Minegishi K, Tsuchida N, Hirahara L, Kunishita Y, Yoshimi R, Nakajima H. Tocilizumab in VEXAS relapsing polychondritis: a single-center pilot study in Japan. Ann Rheum Dis. 2021 11; 80(11):1501-1502. PMID: 34260381.
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    57. Zouboulis CC, van Laar JAM, Schirmer M, Emmi G, Fortune F, G?l A, Kirino Y, Lee ES, Sfikakis PP, Shahram F, Wallace GR. Adamantiades-Beh?et's disease (Beh?et's disease) and COVID-19. J Eur Acad Dermatol Venereol. 2021 09; 35(9):e541-e543. PMID: 33914986.
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    58. Kawamura T, Shigematsu M, Kirino Y. In vitro production and multiplex quantification of 2',3'-cyclic phosphate-containing 5'-tRNA half molecules. Methods. 2022 07; 203:335-341. PMID: 33962012.
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    59. Tsuchida N, Kunishita Y, Uchiyama Y, Kirino Y, Enaka M, Yamaguchi Y, Taguri M, Yamanaka S, Takase-Minegishi K, Yoshimi R, Fujii S, Nakajima H, Matsumoto N. Pathogenic UBA1 variants associated with VEXAS syndrome in Japanese patients with relapsing polychondritis. Ann Rheum Dis. 2021 08; 80(8):1057-1061. PMID: 33789873.
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    60. Gono T, Masui K, Nishina N, Kawaguchi Y, Kawakami A, Ikeda K, Kirino Y, Sugiyama Y, Tanino Y, Nunokawa T, Kaneko Y, Sato S, Asakawa K, Ukichi T, Kaieda S, Naniwa T, Okano Y, Kuwana M. Risk Prediction Modeling Based on a Combination of Initial Serum Biomarker Levels in Polymyositis/Dermatomyositis-Associated Interstitial Lung Disease. Arthritis Rheumatol. 2021 04; 73(4):677-686. PMID: 33118321.
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    61. Ichikawa K, Kirino Y, Kunishita Y, Kishimoto D, Takase-Minegishi K, Yoshimi R, Nakajima H. Initial hydroxychloroquine monotherapy in systemic lupus erythematosus: report of three cases. Mod Rheumatol Case Rep. 2021 07; 5(2):259-264. PMID: 33533686.
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    62. Soejima Y, Kirino Y, Takeno M, Kurosawa M, Takeuchi M, Yoshimi R, Sugiyama Y, Ohno S, Asami Y, Sekiguchi A, Igarashi T, Nagaoka S, Ishigatsubo Y, Nakajima H, Mizuki N. Changes in the proportion of clinical clusters contribute to the phenotypic evolution of Beh?et's disease in Japan. Arthritis Res Ther. 2021 02 01; 23(1):49. PMID: 33522943.
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    63. Vrettos N, Maragkakis M, Alexiou P, Sgourdou P, Ibrahim F, Palmieri D, Kirino Y, Mourelatos Z. Modulation of Aub-TDRD interactions elucidates piRNA amplification and germplasm formation. Life Sci Alliance. 2021 03; 4(3). PMID: 33376130.
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    64. Abe K, Chiba Y, Katsuse O, Takahashi Y, Suda A, Hattori S, Yoshimi R, Kirino Y, Kunii M, Yoshimi A, Asami T, Hishimoto A. Exploratory investigation on antibodies to GluN1 and cognitive dysfunction in patients with chronic autoimmune psychosis. Neurosci Lett. 2021 01 19; 743:135588. PMID: 33359543.
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    65. Pawar K, Shigematsu M, Sharbati S, Kirino Y. Infection-induced 5'-half molecules of tRNAHisGUG activate Toll-like receptor 7. PLoS Biol. 2020 12; 18(12):e3000982. PMID: 33332353.
      Citations:    
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    73. Sugiyama Y, Yoshimi R, Takeno M, Kunishita Y, Kishimoto D, Kamiyama R, Kirino Y, Ohno S, Nakajima H. miR-1 is a novel biomarker for polymyositis/dermatomyositis-associated interstitial lung disease. Mod Rheumatol. 2020 Sep; 30(5):878-883. PMID: 31483179.
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    77. Mizuki Y, Horita N, Horie Y, Takeuchi M, Ishido T, Mizuki R, Kawagoe T, Shibuya E, Yuda K, Ishido M, Minegishi K, Yoshimi R, Kirino Y, Kato S, Arimoto J, Fukumoto T, Kurosawa M, Kitaichi N, Takeno M, Kaneko T, Mizuki N. The influence of HLA-B51 on clinical manifestations among Japanese patients with Beh?et's disease: A nationwide survey. Mod Rheumatol. 2020 Jul; 30(4):708-714. PMID: 31386589.
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    79. Tsuchida N, Kirino Y, Soejima Y, Onodera M, Arai K, Tamura E, Ishikawa T, Kawai T, Uchiyama T, Nomura S, Kobayashi D, Taguri M, Mitsuhashi S, Mizuguchi T, Takata A, Miyake N, Nakajima H, Miyatake S, Matsumoto N. Haploinsufficiency of A20 caused by a novel nonsense variant or entire deletion of TNFAIP3 is clinically distinct from Beh?et's disease. Arthritis Res Ther. 2019 06 04; 21(1):137. PMID: 31164164.
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    80. Telonis AG, Loher P, Magee R, Pliatsika V, Londin E, Kirino Y, Rigoutsos I. tRNA Fragments Show Intertwining with mRNAs of Specific Repeat Content and Have Links to Disparities. Cancer Res. 2019 06 15; 79(12):3034-3049. PMID: 30996049.
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    85. Nakano H, Kirino Y, Takeno M, Higashitani K, Nagai H, Yoshimi R, Yamaguchi Y, Kato I, Aoki I, Nakajima H. GWAS-identified CCR1 and IL10 loci contribute to M1 macrophage-predominant inflammation in Beh?et's disease. Arthritis Res Ther. 2018 06 12; 20(1):124. PMID: 29895319.
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    86. Suwa A, Horita N, Ishido T, Takeuchi M, Kawagoe T, Shibuya E, Yamane T, Hayashi T, Meguro A, Ishido M, Minegishi K, Yoshimi R, Kirino Y, Kato S, Arimoto J, Fukumoto T, Ishigatsubo Y, Kurosawa M, Kaneko T, Takeno M, Mizuki N. The ocular involvement did not accompany with the genital ulcer or the gastrointestinal symptoms at the early stage of Beh?et's disease. Mod Rheumatol. 2019 Mar; 29(2):357-362. PMID: 29583036.
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    87. Kishimoto D, Kirino Y, Tamura M, Takeno M, Kunishita Y, Takase-Minegishi K, Nakano H, Kato I, Nagahama K, Yoshimi R, Igarashi K, Aoki I, Nakajima H. Dysregulated heme oxygenase-1low M2-like macrophages augment lupus nephritis via Bach1 induced by type I interferons. Arthritis Res Ther. 2018 04 10; 20(1):64. PMID: 29636091.
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    90. Kirino Y, Kawaguchi Y, Tada Y, Tsukamoto H, Ota T, Iwamoto M, Takahashi H, Nagasawa K, Takei S, Horiuchi T, Ichida H, Minota S, Ueda A, Ohta A, Ishigatsubo Y. Beneficial use of serum ferritin and heme oxygenase-1 as biomarkers in adult-onset Still's disease: A multicenter retrospective study. Mod Rheumatol. 2018 Sep; 28(5):858-864. PMID: 29278009.
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    91. Pliatsika V, Loher P, Magee R, Telonis AG, Londin E, Shigematsu M, Kirino Y, Rigoutsos I. MINTbase v2.0: a comprehensive database for tRNA-derived fragments that includes nuclear and mitochondrial fragments from all The Cancer Genome Atlas projects. Nucleic Acids Res. 2018 01 04; 46(D1):D152-D159. PMID: 29186503.
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    93. Takase-Minegishi K, Horita N, Kobayashi K, Yoshimi R, Kirino Y, Ohno S, Kaneko T, Nakajima H, Wakefield RJ, Emery P. Diagnostic test accuracy of ultrasound for synovitis in rheumatoid arthritis: systematic review and meta-analysis. Rheumatology (Oxford). 2018 01 01; 57(1):49-58. PMID: 28340066.
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    97. Honda S, Loher P, Morichika K, Shigematsu M, Kawamura T, Kirino Y, Rigoutsos I, Kirino Y. Increasing cell density globally enhances the biogenesis of Piwi-interacting RNAs in Bombyx mori germ cells. Sci Rep. 2017 06 23; 7(1):4110. PMID: 28646211.
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    98. Saito T, Tamura M, Chiba Y, Katsuse O, Suda A, Kamada A, Ikura T, Abe K, Ogawa M, Minegishi K, Yoshimi R, Kirino Y, Ihata A, Hirayasu Y. Regional cerebral glucose metabolism in systemic lupus erythematosus patients with major depressive disorder. J Neurol Sci. 2017 Aug 15; 379:127-130. PMID: 28716225.
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    107. Sakai H, Kirino Y, Katsuma S, Aoki F, Suzuki MG. Morphological and histomorphological structures of testes and ovaries in early developmental stages of the silkworm, Bombyx mori. J Insect Biotechnol Sericology. 2016; 85(1):15-20. PMID: 28943775.
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    108. Yamazaki W, Uemura R, Sekiguchi S, Dong JB, Watanabe S, Kirino Y, Mekata H, Nonaka N, Norimine J, Sueyoshi M, Goto Y, Horii Y, Kurogi M, Yoshino S, Misawa N. Campylobacter and Salmonella are prevalent in broiler farms in Kyushu, Japan: results of a 2-year distribution and circulation dynamics audit. J Appl Microbiol. 2016 Jun; 120(6):1711-22. PMID: 27005691.
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    136. Kirino Y, Bertsias G, Ishigatsubo Y, Mizuki N, Tugal-Tutkun I, Seyahi E, Ozyazgan Y, Sacli FS, Erer B, Inoko H, Emrence Z, Cakar A, Abaci N, Ustek D, Satorius C, Ueda A, Takeno M, Kim Y, Wood GM, Ombrello MJ, Meguro A, G?l A, Remmers EF, Kastner DL. Genome-wide association analysis identifies new susceptibility loci for Beh?et's disease and epistasis between HLA-B*51 and ERAP1. Nat Genet. 2013 Feb; 45(2):202-7. PMID: 23291587.
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    137. Suzuki R, Honda S, Kirino Y. PIWI Expression and Function in Cancer. Front Genet. 2012; 3:204. PMID: 23087701.
      Citations:    
    138. Vourekas A, Zheng Q, Alexiou P, Maragkakis M, Kirino Y, Gregory BD, Mourelatos Z. Mili and Miwi target RNA repertoire reveals piRNA biogenesis and function of Miwi in spermiogenesis. Nat Struct Mol Biol. 2012 Aug; 19(8):773-81. PMID: 22842725.
      Citations:    
    139. Hama M, Kirino Y, Takeno M, Takase K, Miyazaki T, Yoshimi R, Ueda A, Itoh-Nakadai A, Muto A, Igarashi K, Ishigatsubo Y. Bach1 regulates osteoclastogenesis in a mouse model via both heme oxygenase 1-dependent and heme oxygenase 1-independent pathways. Arthritis Rheum. 2012 May; 64(5):1518-28. PMID: 22127667.
      Citations:    
    140. Takase K, Ohno S, Takeno M, Hama M, Kirino Y, Ihata A, Ideguchi H, Mochida Y, Tateishi U, Shizukuishi K, Nagashima Y, Aoki I, Ishigatsubo Y. Simultaneous evaluation of long-lasting knee synovitis in patients undergoing arthroplasty by power Doppler ultrasonography and contrast-enhanced MRI in comparison with histopathology. Clin Exp Rheumatol. 2012 Jan-Feb; 30(1):85-92. PMID: 22325923.
      Citations:    
    141. Kirino Y. [Role of arginine methylation in the Piwi-interacting RNA pathway]. Seikagaku. 2011 Apr; 83(4):312-6. PMID: 21626884.
      Citations:    
    142. Kirino Y, Vourekas A, Khandros E, Mourelatos Z. Immunoprecipitation of piRNPs and directional, next generation sequencing of piRNAs. Methods Mol Biol. 2011; 725:281-93. PMID: 21528460.
      Citations:    
    143. Mimaki M, Hatakeyama H, Komaki H, Yokoyama M, Arai H, Kirino Y, Suzuki T, Nishino I, Nonaka I, Goto Y. Reversible infantile respiratory chain deficiency: a clinical and molecular study. Ann Neurol. 2010 Dec; 68(6):845-54. PMID: 21194154.
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    144. Vourekas A, Kirino Y, Mourelatos Z. Elective affinities: a Tudor-Aubergine tale of germline partnership. Genes Dev. 2010 Sep 15; 24(18):1963-6. PMID: 20844011.
      Citations:    
    145. Remmers EF, Cosan F, Kirino Y, Ombrello MJ, Abaci N, Satorius C, Le JM, Yang B, Korman BD, Cakiris A, Aglar O, Emrence Z, Azakli H, Ustek D, Tugal-Tutkun I, Akman-Demir G, Chen W, Amos CI, Dizon MB, Kose AA, Azizlerli G, Erer B, Brand OJ, Kaklamani VG, Kaklamanis P, Ben-Chetrit E, Stanford M, Fortune F, Ghabra M, Ollier WE, Cho YH, Bang D, O'Shea J, Wallace GR, Gadina M, Kastner DL, G?l A. Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Beh?et's disease. Nat Genet. 2010 Aug; 42(8):698-702. PMID: 20622878.
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    146. Ideguchi H, Ohno S, Takase K, Kirino Y, Suda A, Ihata A, Ueda A, Takeno M, Nagaoka S, Ishigatsubo Y. Completion rate and compliance of anti-tuberculosis chemoprophylaxis in patients with rheumatic disease receiving tumor necrosis factor antagonists. Clin Exp Rheumatol. 2010 Mar-Apr; 28(2):294-5. PMID: 20483059.
      Citations:    
    147. Miyazaki T, Kirino Y, Takeno M, Samukawa S, Hama M, Tanaka M, Yamaji S, Ueda A, Tomita N, Fujita H, Ishigatsubo Y. Expression of heme oxygenase-1 in human leukemic cells and its regulation by transcriptional repressor Bach1. Cancer Sci. 2010 Jun; 101(6):1409-16. PMID: 20345481.
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    148. Ishigatsubo Y, Ihata A, Kobayashi H, Hama M, Kirino Y, Ueda A, Takeno M, Shirai A, Ohno S. Therapeutic angiogenesis in patients with systemic sclerosis by autologous transplantation of bone-marrow-derived cells. Mod Rheumatol. 2010 Jun; 20(3):263-72. PMID: 20169390.
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    149. Ideguchi H, Suda A, Takeno M, Kirino Y, Ihata A, Ueda A, Ohno S, Baba Y, Kuroiwa Y, Ishigatsubo Y. Neurological manifestations of Beh?et's disease in Japan: a study of 54 patients. J Neurol. 2010 Jun; 257(6):1012-20. PMID: 20127350.
      Citations:    
    150. Miyazaki T, Kirino Y, Takeno M, Hama M, Ushihama A, Watanabe R, Takase K, Tachibana T, Matsumoto K, Tanaka M, Yamaji S, Ideguchi H, Tomita N, Fujita H, Ohno S, Ueda A, Ishigatsubo Y. Serum HO-1 is useful to make differential diagnosis of secondary hemophagocytic syndrome from other similar hematological conditions. Int J Hematol. 2010 Mar; 91(2):229-37. PMID: 20091384.
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    151. Kirino Y, Vourekas A, Kim N, de Lima Alves F, Rappsilber J, Klein PS, Jongens TA, Mourelatos Z. Arginine methylation of vasa protein is conserved across phyla. J Biol Chem. 2010 Mar 12; 285(11):8148-54. PMID: 20080973.
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    152. Kirino Y, Vourekas A, Sayed N, de Lima Alves F, Thomson T, Lasko P, Rappsilber J, Jongens TA, Mourelatos Z. Arginine methylation of Aubergine mediates Tudor binding and germ plasm localization. RNA. 2010 Jan; 16(1):70-8. PMID: 19926723.
      Citations:    
    153. Kirino Y, Ihata A, Shizukuishi K, Hama M, Takase K, Suda A, Ueda A, Ohno S, Takeno M, Ishigatsubo Y. Multiple extra-articular synovial cysts complicated with rheumatoid arthritis. Mod Rheumatol. 2009; 19(5):563-6. PMID: 19526305.
      Citations:    
    154. Kirino Y, Kim N, de Planell-Saguer M, Khandros E, Chiorean S, Klein PS, Rigoutsos I, Jongens TA, Mourelatos Z. Arginine methylation of Piwi proteins catalysed by dPRMT5 is required for Ago3 and Aub stability. Nat Cell Biol. 2009 May; 11(5):652-8. PMID: 19377467.
      Citations:    
    155. Murakami S, Takeno M, Kirino Y, Kobayashi M, Watanabe R, Kudo M, Ihata A, Ueda A, Ohno S, Watanuki Y, Kaneko T, Ishigatsubo Y. Screening of tuberculosis by interferon-gamma assay before biologic therapy for rheumatoid arthritis. Tuberculosis (Edinb). 2009 Mar; 89(2):136-41. PMID: 19211305.
      Citations:    
    156. Kobayashi M, Miyazawa N, Takeno M, Murakami S, Kirino Y, Okouchi A, Kaneko T, Ishigatsubo Y. Circulating carbon monoxide level is elevated after sleep in patients with obstructive sleep apnea. Chest. 2008 Nov; 134(5):904-910. PMID: 18988776.
      Citations:    
    157. Kirino Y, Mourelatos Z. Site-specific crosslinking of human microRNPs to RNA targets. RNA. 2008 Oct; 14(10):2254-9. PMID: 18719246.
      Citations:    
    158. Kirino M, Kirino Y, Takeno M, Nagashima Y, Takahashi K, Kobayashi M, Murakami S, Hirasawa T, Ueda A, Aihara M, Ikezawa Z, Ishigatsubo Y. Heme oxygenase 1 attenuates the development of atopic dermatitis-like lesions in mice: implications for human disease. J Allergy Clin Immunol. 2008 Aug; 122(2):290-7, 297.e1-8. PMID: 18582925.
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    159. Kurata S, Weixlbaumer A, Ohtsuki T, Shimazaki T, Wada T, Kirino Y, Takai K, Watanabe K, Ramakrishnan V, Suzuki T. Modified uridines with C5-methylene substituents at the first position of the tRNA anticodon stabilize U.G wobble pairing during decoding. J Biol Chem. 2008 Jul 04; 283(27):18801-11. PMID: 18456657.
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    160. Kirino Y, Takeno M, Watanabe R, Murakami S, Kobayashi M, Ideguchi H, Ihata A, Ohno S, Ueda A, Mizuki N, Ishigatsubo Y. Association of reduced heme oxygenase-1 with excessive Toll-like receptor 4 expression in peripheral blood mononuclear cells in Beh?et's disease. Arthritis Res Ther. 2008; 10(1):R16. PMID: 18234118.
      Citations:    
    161. Ideguchi H, Ohno S, Takase K, Hattori H, Kirino Y, Takeno M, Ishigatsubo Y. Successful treatment of refractory lupus-associated haemophagocytic lymphohistiocytosis with infliximab. Rheumatology (Oxford). 2007 Oct; 46(10):1621-2. PMID: 17726035.
      Citations:    
    162. Kirino Y, Mourelatos Z. The mouse homolog of HEN1 is a potential methylase for Piwi-interacting RNAs. RNA. 2007 Sep; 13(9):1397-401. PMID: 17652135.
      Citations:    
    163. Kirino Y, Mourelatos Z. Mouse Piwi-interacting RNAs are 2'-O-methylated at their 3' termini. Nat Struct Mol Biol. 2007 Apr; 14(4):347-8. PMID: 17384647.
      Citations:    
    164. Kirino Y, Takeno M, Murakami S, Kobayashi M, Kobayashi H, Miura K, Ideguchi H, Ohno S, Ueda A, Ishigatsubo Y. Tumor necrosis factor alpha acceleration of inflammatory responses by down-regulating heme oxygenase 1 in human peripheral monocytes. Arthritis Rheum. 2007 Feb; 56(2):464-75. PMID: 17265482.
      Citations:    
    165. Kirino Y, Mourelatos Z. 2'-O-methyl modification in mouse piRNAs and its methylase. Nucleic Acids Symp Ser (Oxf). 2007; (51):417-8. PMID: 18029764.
      Citations:    
    166. Noma A, Kirino Y, Ikeuchi Y, Suzuki T. Biosynthesis of wybutosine, a hyper-modified nucleoside in eukaryotic phenylalanine tRNA. EMBO J. 2006 May 17; 25(10):2142-54. PMID: 16642040.
      Citations:    
    167. Kobayashi H, Takeno M, Saito T, Takeda Y, Kirino Y, Noyori K, Hayashi T, Ueda A, Ishigatsubo Y. Regulatory role of heme oxygenase 1 in inflammation of rheumatoid arthritis. Arthritis Rheum. 2006 Apr; 54(4):1132-42. PMID: 16572448.
      Citations:    
    168. Kirino Y, Yasukawa T, Marjavaara SK, Jacobs HT, Holt IJ, Watanabe K, Suzuki T. Acquisition of the wobble modification in mitochondrial tRNALeu(CUN) bearing the G12300A mutation suppresses the MELAS molecular defect. Hum Mol Genet. 2006 Mar 15; 15(6):897-904. PMID: 16446307.
      Citations:    
    169. Yoshimi R, Takeno M, Yamanaka S, Shiina M, Kirino Y, Takeda Y, Sekiguchi A, Kobayashi H, Ihata A, Motoji K, Ohno S, Ueda A, Soga T, Ishigatsubo Y. Systemic sclerosis and pseudomesotheliomatous adenocarcinoma of the lung. Mod Rheumatol. 2006; 16(3):165-8. PMID: 16767555.
      Citations:    
    170. Yasukawa T, Kirino Y, Ishii N, Holt IJ, Jacobs HT, Makifuchi T, Fukuhara N, Ohta S, Suzuki T, Watanabe K. Wobble modification deficiency in mutant tRNAs in patients with mitochondrial diseases. FEBS Lett. 2005 May 23; 579(13):2948-52. PMID: 15893315.
      Citations:    
    171. Kirino Y, Goto Y, Campos Y, Arenas J, Suzuki T. Specific correlation between the wobble modification deficiency in mutant tRNAs and the clinical features of a human mitochondrial disease. Proc Natl Acad Sci U S A. 2005 May 17; 102(20):7127-32. PMID: 15870203.
      Citations:    
    172. Kirino Y, Suzuki T. Human mitochondrial diseases associated with tRNA wobble modification deficiency. RNA Biol. 2005 Apr; 2(2):41-4. PMID: 17132941.
      Citations:    
    173. Kirino Y, Takeno M, Iwasaki M, Ueda A, Ohno S, Shirai A, Kanamori H, Tanaka K, Ishigatsubo Y. Increased serum HO-1 in hemophagocytic syndrome and adult-onset Still's disease: use in the differential diagnosis of hyperferritinemia. Arthritis Res Ther. 2005; 7(3):R616-24. PMID: 15899048.
      Citations:    
    174. Aoki A, Kirino Y, Ishigatsubo Y, Senuma A, Nagaoka S. [Liver involvement in primary Sjogren's syndrome]. Nihon Rinsho Meneki Gakkai Kaishi. 2004 Dec; 27(6):397-401. PMID: 15678893.
      Citations:    
    175. Takeda Y, Takeno M, Iwasaki M, Kobayashi H, Kirino Y, Ueda A, Nagahama K, Aoki I, Ishigatsubo Y. Chemical induction of HO-1 suppresses lupus nephritis by reducing local iNOS expression and synthesis of anti-dsDNA antibody. Clin Exp Immunol. 2004 Nov; 138(2):237-44. PMID: 15498032.
      Citations:    
    176. Kirino Y, Yasukawa T, Ohta S, Akira S, Ishihara K, Watanabe K, Suzuki T. Codon-specific translational defect caused by a wobble modification deficiency in mutant tRNA from a human mitochondrial disease. Proc Natl Acad Sci U S A. 2004 Oct 19; 101(42):15070-5. PMID: 15477592.
      Citations:    
    177. Limongelli A, Schaefer J, Jackson S, Invernizzi F, Kirino Y, Suzuki T, Reichmann H, Zeviani M. Variable penetrance of a familial progressive necrotising encephalopathy due to a novel tRNA(Ile) homoplasmic mutation in the mitochondrial genome. J Med Genet. 2004 May; 41(5):342-9. PMID: 15121771.
      Citations:    
    178. Kirino Y, Tsuji T, Ohno S, Yoshimi R, Takeda Y, Misumi M, Inoue Y, Ueda A, Takeno M, Ishigatsubo Y. [A solitary lung lesion in Wegener's granulomatosis, which was difficult to differentiate from lung neoplasm]. Ryumachi. 2003 Feb; 43(1):39-43. PMID: 12692988.
      Citations:    
    179. Kurata S, Ohtsuki T, Wada T, Kirino Y, Takai K, Saigo K, Watanabe K, Suzuki T. Decoding property of C5 uridine modification at the wobble position of tRNA anticodon. Nucleic Acids Res Suppl. 2003; (3):245-6. PMID: 14510472.
      Citations:    
    180. Shimozono S, Watanabe S, Inoue T, Kirino Y. Identification and characterization of an output neuron from the oscillatory molluscan olfactory network. Brain Res. 2001 Dec 07; 921(1-2):98-105. PMID: 11720715.
      Citations:    
    181. Muto Y, Matsuoka T, Kida A, Okano Y, Kirino Y. Blepharismins, produced by the protozoan, Blepharisma japonicum, form ion-permeable channels in planar lipid bilayer membranes. FEBS Lett. 2001 Nov 23; 508(3):423-6. PMID: 11728465.
      Citations:    
    182. Kishimoto Y, Suzuki M, Kawahara S, Kirino Y. Age-dependent impairment of delay and trace eyeblink conditioning in mice. Neuroreport. 2001 Oct 29; 12(15):3349-52. PMID: 11711884.
      Citations:    
    183. Kishimoto Y, Hirono M, Sugiyama T, Kawahara S, Nakao K, Kishio M, Katsuki M, Yoshioka T, Kirino Y. Impaired delay but normal trace eyeblink conditioning in PLCbeta4 mutant mice. Neuroreport. 2001 Sep 17; 12(13):2919-22. PMID: 11588603.
      Citations:    
    184. Hirono M, Sugiyama T, Kishimoto Y, Sakai I, Miyazawa T, Kishio M, Inoue H, Nakao K, Ikeda M, Kawahara S, Kirino Y, Katsuki M, Horie H, Ishikawa Y, Yoshioka T. Phospholipase Cbeta4 and protein kinase Calpha and/or protein kinase CbetaI are involved in the induction of long term depression in cerebellar Purkinje cells. J Biol Chem. 2001 Nov 30; 276(48):45236-42. PMID: 11551922.
      Citations:    
    185. Ando K, Iijima KI, Elliott JI, Kirino Y, Suzuki T. Phosphorylation-dependent regulation of the interaction of amyloid precursor protein with Fe65 affects the production of beta-amyloid. J Biol Chem. 2001 Oct 26; 276(43):40353-61. PMID: 11517218.
      Citations:    
    186. Satoh Y, Hirakura Y, Shibayama S, Hirashima N, Suzuki T, Kirino Y. Beta-amyloid peptides inhibit acetylcholine release from cholinergic presynaptic nerve endings isolated from an electric ray. Neurosci Lett. 2001 Apr 20; 302(2-3):97-100. PMID: 11290396.
      Citations:    
    187. Watanabe S, Inoue T, Murakami M, Inokuma Y, Kawahara S, Kirino Y. Modulation of oscillatory neural activities by cholinergic activation of interneurons in the olfactory center of a terrestrial slug. Brain Res. 2001 Mar 30; 896(1-2):30-5. PMID: 11277969.
      Citations:    
    188. Kishimoto Y, Kawahara S, Mori H, Mishina M, Kirino Y. Long-trace interval eyeblink conditioning is impaired in mutant mice lacking the NMDA receptor subunit epsilon 1. Eur J Neurosci. 2001 Mar; 13(6):1221-7. PMID: 11285019.
      Citations:    
    189. Kishimoto Y, Kawahara S, Suzuki M, Mori H, Mishina M, Kirino Y. Classical eyeblink conditioning in glutamate receptor subunit delta 2 mutant mice is impaired in the delay paradigm but not in the trace paradigm. Eur J Neurosci. 2001 Mar; 13(6):1249-53. PMID: 11285022.
      Citations:    
    190. Shindo K, Takahashi H, Shinozaki K, Kami K, Anzai K, Lee S, Aoyagi H, Kirino Y, Shimada I. Solution structure of micelle-bound H5 peptide (427-452): a primary structure corresponding to the pore forming region of the voltage dependent potassium channel. Biochim Biophys Acta. 2001 Feb 09; 1545(1-2):153-9. PMID: 11342041.
      Citations:    
    191. Nakaya T, Kawahara S, Watanabe S, Lee D, Suzuki T, Kirino Y. Identification and expression of a novel gene in odour-taste associative learning in the terrestrial slug. Genes Cells. 2001 Jan; 6(1):43-56. PMID: 11168596.
      Citations:    
    192. Mio M, Kirino Y, Kamei C. Desensitization of beta2-adrenoceptor and hypersensitization to phosphodiesterase inhibitors elicited by beta2-agonists in guinea pig eosinophils. J Allergy Clin Immunol. 2000 Nov; 106(5):896-903. PMID: 11080712.
      Citations:    
    193. Toda S, Kawahara S, Kirino Y. Image analysis of olfactory responses in the procerebrum of the terrestrial slug Limax marginatus. J Exp Biol. 2000 Oct; 203(Pt 19):2895-905. PMID: 10976027.
      Citations:    
    194. Lee D, Hirashima N, Kirino Y. Rapid transbilayer phospholipid redistribution associated with exocytotic release of neurotransmitters from cholinergic nerve terminals isolated from electric ray Narke japonica. Neurosci Lett. 2000 Sep 08; 291(1):21-4. PMID: 10962144.
      Citations:    
    195. Iijima K, Ando K, Takeda S, Satoh Y, Seki T, Itohara S, Greengard P, Kirino Y, Nairn AC, Suzuki T. Neuron-specific phosphorylation of Alzheimer's beta-amyloid precursor protein by cyclin-dependent kinase 5. J Neurochem. 2000 Sep; 75(3):1085-91. PMID: 10936190.
      Citations:    
    196. Lee DS, Tomita S, Kirino Y, Suzuki T. Regulation of X11L-dependent amyloid precursor protein metabolism by XB51, a novel X11L-binding protein. J Biol Chem. 2000 Jul 28; 275(30):23134-8. PMID: 10833507.
      Citations:    
    197. Tomita S, Fujita T, Kirino Y, Suzuki T. PDZ domain-dependent suppression of NF-kappaB/p65-induced Abeta42 production by a neuron-specific X11-like protein. J Biol Chem. 2000 Apr 28; 275(17):13056-60. PMID: 10777610.
      Citations:    
    198. Ando K, Oishi M, Takeda S, Iijima K, Isohara T, Nairn AC, Kirino Y, Greengard P, Suzuki T. Role of phosphorylation of Alzheimer's amyloid precursor protein during neuronal differentiation. J Neurosci. 1999 Jun 01; 19(11):4421-7. PMID: 10341243.
      Citations:    
    199. Tomita S, Ozaki T, Taru H, Oguchi S, Takeda S, Yagi Y, Sakiyama S, Kirino Y, Suzuki T. Interaction of a neuron-specific protein containing PDZ domains with Alzheimer's amyloid precursor protein. J Biol Chem. 1999 Jan 22; 274(4):2243-54. PMID: 9890987.
      Citations:    
    200. Hirakura Y, Satoh Y, Hirashima N, Suzuki T, Kagan BL, Kirino Y. Membrane perturbation by the neurotoxic Alzheimer amyloid fragment beta 25-35 requires aggregation and beta-sheet formation. Biochem Mol Biol Int. 1998 Nov; 46(4):787-94. PMID: 9844740.
      Citations:    
    201. Lee DS, Anzai K, Hirashima N, Kirino Y. Phospholipid translocation from the outer to the inner leaflet of synaptic vesicle membranes isolated from the electric organ of Japanese electric ray Narke japonica. J Biochem. 1998 Oct; 124(4):798-803. PMID: 9756626.
      Citations:    
    202. Tomita S, Kirino Y, Suzuki T. A basic amino acid in the cytoplasmic domain of Alzheimer's beta-amyloid precursor protein (APP) is essential for cleavage of APP at the alpha-site. J Biol Chem. 1998 Jul 24; 273(30):19304-10. PMID: 9668120.
      Citations:    
    203. Kim YI, Middlekauff EH, Viglione MP, Okutsu J, Satoh Y, Hirashima N, Kirino Y. An autoimmune animal model of the Lambert-Eaton syndrome. Ann N Y Acad Sci. 1998 May 13; 841:670-6. PMID: 9668312.
      Citations:    
    204. Watanabe S, Takagi H, Miyasho T, Inoue M, Kirino Y, Kudo Y, Miyakawa H. Differential roles of two types of voltage-gated Ca2+ channels in the dendrites of rat cerebellar Purkinje neurons. Brain Res. 1998 Apr 27; 791(1-2):43-55. PMID: 9593816.
      Citations:    
    205. Satoh Y, Hirashima N, Tokumaru H, Takahashi MP, Kang J, Viglione MP, Kim YI, Kirino Y. Lambert-Eaton syndrome antibodies inhibit acetylcholine release and P/Q-type Ca2+ channels in electric ray nerve endings. J Physiol. 1998 Apr 15; 508 ( Pt 2):427-38. PMID: 9508807.
      Citations:    
    206. Tomita S, Kirino Y, Suzuki T. Cleavage of Alzheimer's amyloid precursor protein (APP) by secretases occurs after O-glycosylation of APP in the protein secretory pathway. Identification of intracellular compartments in which APP cleavage occurs without using toxic agents that interfere with protein metabolism. J Biol Chem. 1998 Mar 13; 273(11):6277-84. PMID: 9497354.
      Citations:    
    207. Iijima K, Lee DS, Okutsu J, Tomita S, Hirashima N, Kirino Y, Suzuki T. cDNA isolation of Alzheimer's amyloid precursor protein from cholinergic nerve terminals of the electric organ of the electric ray. Biochem J. 1998 Feb 15; 330 ( Pt 1):29-33. PMID: 9461486.
      Citations:    
    208. Kojima H, Sakurai K, Kikuchi K, Kawahara S, Kirino Y, Nagoshi H, Hirata Y, Akaike T, Maeda H, Nagano T. Development of a fluorescent indicator for the bioimaging of nitric oxide. Biol Pharm Bull. 1997 Dec; 20(12):1229-32. PMID: 9448093.
      Citations:    
    209. Ishizuka T, Saisu H, Suzuki T, Kirino Y, Abe T. Molecular cloning of synaphins/complexins, cytosolic proteins involved in transmitter release, in the electric organ of an electric ray (Narke japonica). Neurosci Lett. 1997 Aug 29; 232(2):107-10. PMID: 9302098.
      Citations:    
    210. Tokumaru H, Satoh Y, Hirashima N, Shojaku S, Yamamoto H, Kirino Y. Involvement of calciseptine-sensitive calcium channels in the evoked acetylcholine release from electric organ synaptosomes. Biol Pharm Bull. 1997 Jun; 20(6):641-5. PMID: 9212982.
      Citations:    
    211. Suzuki T, Ando K, Isohara T, Oishi M, Lim GS, Satoh Y, Wasco W, Tanzi RE, Nairn AC, Greengard P, Gandy SE, Kirino Y. Phosphorylation of Alzheimer beta-amyloid precursor-like proteins. Biochemistry. 1997 Apr 15; 36(15):4643-9. PMID: 9109675.
      Citations:    
    212. Tomita A, Yoshida S, Yano M, Kirino Y, Kawahara S, Shimizu H. Removal after addition of NO-generating agents and 8-bromo-cyclic GMP causes morphological change of cultured cerebellar astrocytes: a new mode of NO action. Brain Res. 1997 Jan 09; 744(2):344-6. PMID: 9027395.
      Citations:    
    213. Hirakura Y, Alvarez-Bravo J, Kurata S, Natori S, Kirino Y. Selective interaction of synthetic antimicrobial peptides derived from sapecin B with lipid bilayers. J Biochem. 1996 Dec; 120(6):1130-40. PMID: 9010761.
      Citations:    
    214. Watanabe S, Jimbo Y, Kamioka H, Kirino Y, Kawana A. Development of low magnesium-induced spontaneous synchronized bursting and GABAergic modulation in cultured rat neocortical neurons. Neurosci Lett. 1996 May 24; 210(1):41-4. PMID: 8762187.
      Citations:    
    215. Fujiwara-Hirashima C, Anzai K, Takahashi M, Kirino Y. A voltage-dependent chloride channel from Tetrahymena ciliary membrane incorporated into planar lipid bilayers. Biochim Biophys Acta. 1996 Apr 26; 1280(2):207-16. PMID: 8639695.
      Citations:    
    216. Anzai K, Yoshioka Y, Hatanaka K, Nakagawa Y, Kirino Y. Phosphatidylserine-specific transbilayer lipid translocation in synaptosomal plasma membranes from Narke japonica. J Biochem. 1995 Jun; 117(6):1232-7. PMID: 7490265.
      Citations:    
    217. Anzai K, Takano C, Tanaka K, Kirino Y. Asymmetrical lipid charge changes the subconducting state of the potassium channel from sarcoplasmic reticulum. Biochem Biophys Res Commun. 1994 Mar 15; 199(2):1081-7. PMID: 8135782.
      Citations:    
    218. Tokumaru H, Wang CY, Hirashima N, O'Hori T, Yamamoto H, Kirino Y. Action and binding of calcium channel blockers on the putative calcium channel of synaptosomal plasma membrane from the electric organ of Narke japonica. Ann N Y Acad Sci. 1993 Dec 20; 707:410-2. PMID: 9163314.
      Citations:    
    219. Anzai K, Yoshioka Y, Kirino Y. Novel radioactive phospholipid probes as a tool for measurement of phospholipid translocation across biomembranes. Biochim Biophys Acta. 1993 Sep 05; 1151(1):69-75. PMID: 8357821.
      Citations:    
    220. Agawa Y, Lee S, Ono S, Aoyagi H, Ohno M, Taniguchi T, Anzai K, Kirino Y. Interaction with phospholipid bilayers, ion channel formation, and antimicrobial activity of basic amphipathic alpha-helical model peptides of various chain lengths. J Biol Chem. 1991 Oct 25; 266(30):20218-22. PMID: 1718959.
      Citations:    
    221. Nishie I, Anzai K, Yamamoto T, Kirino Y. Measurement of steady-state Ca2+ pump current caused by purified Ca2(+)-ATPase of sarcoplasmic reticulum incorporated into a planar bilayer lipid membrane. J Biol Chem. 1990 Feb 15; 265(5):2488-91. PMID: 2137447.
      Citations:    
    222. Wakamatsu M, Yamamoto M, Kirino Y, Katoh H, Shimonaka H, Nozawa Y. Effects of anesthetic and related agents on calcium-induced calcium release from sarcoplasmic reticulum isolated from rabbit skeletal muscle. J Anesth. 1989 Mar 01; 3(1):1-9. PMID: 15236048.
      Citations:    
    223. Kyoi K, Kirino Y, Sakaki T, Tsunoda S, Hashimoto H, Hiramatsu K, Utsumi S. [Therapeutic irradiation of brain tumor and cerebrovasculopathy]. No Shinkei Geka. 1989 Feb; 17(2):163-70. PMID: 2660007.
      Citations:    
    224. Tanaka Y, Tada T, Utsumi S, Kirino Y, Miyamoto S, Kyoi K. Lidocaine for convulsion. Jpn J Psychiatry Neurol. 1988 Sep; 42(3):622. PMID: 3241489.
      Citations:    
    225. Fujiwara C, Anzai K, Kirino Y, Nagao S, Nozawa Y, Takahashi M. Cation channels from ciliary membrane of Tetrahymena reconstituted into planar lipid bilayer. Comparison between the channels from the wild T. thermophila and from its mutant which does not show ciliary reversal. J Biochem. 1988 Sep; 104(3):344-8. PMID: 2467903.
      Citations:    
    226. Higashi K, Suzuki S, Fujii H, Kirino Y. Preparation and some properties of giant liposomes and proteoliposomes. J Biochem. 1987 Feb; 101(2):433-40. PMID: 3294817.
      Citations:    
    227. Homma S, Nagamori S, Hasumura S, Fujise K, Sujino H, Kameda H, Kirino Y, Hataba Y, Suzuki T. The morphological studies on characteristics of isolated parenchymal and non-parenchymal cells of the rat liver. J Electron Microsc (Tokyo). 1982; 31(4):389-96. PMID: 6927339.
      Citations:    
    228. Ishikawa E, Tanaka H, Kakimoto S, Takasaki S, Kirino Y, Sakata A, Suzuki M. A pathological study on eosinophilic lymphfolliculoid granuloma (Kimura's disease). Acta Pathol Jpn. 1981 Sep; 31(5):767-81. PMID: 7304168.
      Citations:    
    229. Hataba Y, Kirino Y, Suzuki T. Scanning electron microscopic study of the red pulp of mouse spleen. J Electron Microsc (Tokyo). 1981; 30(1):46-56. PMID: 7288349.
      Citations:    
    230. Suchi T, Tajima K, Nanba K, Wakasa H, Mikata A, Kikuchi M, Mori S, Watanabe S, Mohri N, Shamoto M, Harigaya K, Itagaki T, Matsuda M, Kirino Y, Takagi K, Fukunaga S. Some problems on the histopathological diagnosis of non-Hodgkin's malignant lymphoma -- a proposal of a new type. Acta Pathol Jpn. 1979 Sep; 29(5):755-76. PMID: 386708.
      Citations:    
    231. Kirino Y, Anzai K, Shimizu H, Ohta S, Nakanishi M, Tsuboi M. Thermotropic transition in the states of proteins in sarcoplasmic reticulum vesicles. J Biochem. 1977 Oct; 82(4):1181-4. PMID: 924990.
      Citations:    
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