Yohei Kirino

TitleAssoc Professor
InstitutionThomas Jefferson University
DepartmentComputational Med Center
Address1020 Locust St.
Philadelphia PA 19107
Phone215-503-8648
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Kawamura T, Shigematsu M, Kirino Y. In vitro production and multiplex quantification of 2',3'-cyclic phosphate-containing 5'-tRNA half molecules. Methods. 2021 May 04. PMID: 33962012.
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    2. Tsuchida N, Kunishita Y, Uchiyama Y, Kirino Y, Enaka M, Yamaguchi Y, Taguri M, Yamanaka S, Takase-Minegishi K, Yoshimi R, Fujii S, Nakajima H, Matsumoto N. Pathogenic UBA1 variants associated with VEXAS syndrome in Japanese patients with relapsing polychondritis. Ann Rheum Dis. 2021 Mar 31. PMID: 33789873.
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    3. Ichikawa K, Kirino Y, Kunishita Y, Kishimoto D, Takase-Minegishi K, Yoshimi R, Nakajima H. Initial hydroxychloroquine monotherapy in systemic lupus erythematosus: report of three cases. Mod Rheumatol Case Rep. 2021 Feb 18; 1-9. PMID: 33533686.
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    4. Nagai H, Kirino Y, Nakano H, Kunishita Y, Henmi R, Szymanski AM, Yoshimi R, Ombrello MJ, Nakajima H. Elevated serum gasdermin D N-terminal implicates monocyte and macrophage pyroptosis in adult-onset Still's disease. Rheumatology (Oxford). 2021 Feb 07. PMID: 33550379.
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    5. Soejima Y, Kirino Y, Takeno M, Kurosawa M, Takeuchi M, Yoshimi R, Sugiyama Y, Ohno S, Asami Y, Sekiguchi A, Igarashi T, Nagaoka S, Ishigatsubo Y, Nakajima H, Mizuki N. Changes in the proportion of clinical clusters contribute to the phenotypic evolution of Behçet's disease in Japan. Arthritis Res Ther. 2021 02 01; 23(1):49. PMID: 33522943.
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    6. Vrettos N, Maragkakis M, Alexiou P, Sgourdou P, Ibrahim F, Palmieri D, Kirino Y, Mourelatos Z. Modulation of Aub-TDRD interactions elucidates piRNA amplification and germplasm formation. Life Sci Alliance. 2021 03; 4(3). PMID: 33376130.
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    7. Abe K, Chiba Y, Katsuse O, Takahashi Y, Suda A, Hattori S, Yoshimi R, Kirino Y, Kunii M, Yoshimi A, Asami T, Hishimoto A. Exploratory investigation on antibodies to GluN1 and cognitive dysfunction in patients with chronic autoimmune psychosis. Neurosci Lett. 2021 01 19; 743:135588. PMID: 33359543.
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    8. Pawar K, Shigematsu M, Sharbati S, Kirino Y. Infection-induced 5'-half molecules of tRNAHisGUG activate Toll-like receptor 7. PLoS Biol. 2020 12; 18(12):e3000982. PMID: 33332353.
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    9. Gono T, Masui K, Nishina N, Kawaguchi Y, Kawakami A, Ikeda K, Kirino Y, Sugiyama Y, Tanino Y, Nunokawa T, Kaneko Y, Sato S, Asakawa K, Ukichi T, Kaieda S, Naniwa T, Okano Y, Kuwana M. Risk prediction modeling based on a combination of initial serum biomarkers in myositis-associated interstitial lung disease. Arthritis Rheumatol. 2020 Oct 29. PMID: 33118321.
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    10. Hirahara L, Kirino Y, Soejima Y, Takeno M, Takase-Minegishi K, Yoshimi R, Takeuchi M, Mizuki N, Nakajima H. Efficacy and safety of apremilast for 3 months in Behçet's disease: A prospective observational study. Mod Rheumatol. 2020 Oct 16; 1-6. PMID: 32996801.
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    11. Maruyama A, Kokuzawa A, Yamauchi Y, Kirino Y, Nagai H, Inoue Y, Ota T, Chifu Y, Inokuchi S, Koarada S, Ohta A, Iwamoto M, Tada Y. Clinical features of elderly-onset Adult-onset Still's disease. Mod Rheumatol. 2020 Oct 13; 1-7. PMID: 32990106.
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    12. Suzuki T, Yashiro Y, Kikuchi I, Ishigami Y, Saito H, Matsuzawa I, Okada S, Mito M, Iwasaki S, Ma D, Zhao X, Asano K, Lin H, Kirino Y, Sakaguchi Y, Suzuki T. Complete chemical structures of human mitochondrial tRNAs. Nat Commun. 2020 08 28; 11(1):4269. PMID: 32859890.
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    13. Shigematsu M, Kirino Y. Oxidative stress enhances the expression of 2',3'-cyclic phosphate-containing RNAs. RNA Biol. 2020 Jun 18; 1-10. PMID: 32397797.
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    14. Kunishita Y, Yoshimi R, Kamiyama R, Kishimoto D, Yoshida K, Hashimoto E, Komiya T, Sakurai N, Sugiyama Y, Kirino Y, Ozato K, Nakajima H. TRIM21 Dysfunction Enhances Aberrant B-Cell Differentiation in Autoimmune Pathogenesis. Front Immunol. 2020; 11:98. PMID: 32117252.
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    15. Kato H, Takeuchi M, Horita N, Ishido T, Mizuki R, Kawagoe T, Shibuya E, Yuda K, Ishido M, Mizuki Y, Hayashi T, Meguro A, Kirino Y, Minegishi K, Nakano H, Yoshimi R, Kurosawa M, Fukumoto T, Takeno M, Hotta K, Kaneko T, Mizuki N. HLA-A26 is a risk factor for Behçet's disease ocular lesions. Mod Rheumatol. 2020 Jan 04; 1-5. PMID: 31851572.
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    16. Shigematsu M, Morichika K, Kawamura T, Honda S, Kirino Y. Genome-wide identification of short 2',3'-cyclic phosphate-containing RNAs and their regulation in aging. PLoS Genet. 2019 Nov; 15(11):e1008469. PMID: 31721758.
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    17. Pawar K, Shigematsu M, Loher P, Honda S, Rigoutsos I, Kirino Y. Exploration of CCA-added RNAs revealed the expression of mitochondrial non-coding RNAs regulated by CCA-adding enzyme. RNA Biol. 2019 Sep 12; 1-9. PMID: 31512554.
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    18. Komiya T, Takase-Minegishi K, Sakurai N, Nagai H, Hamada N, Soejima Y, Sugiyama Y, Tsuchida N, Kunishita Y, Kishimoto D, Kobayashi K, Kamiyama R, Yoshimi R, Kirino Y, Ohno S, Nakajima H. Dose down-titration of biological disease-modifying antirheumatic drugs in daily clinical practice: Shared decision-making and patient treatment preferences in Japanese patients with rheumatoid arthritis. Int J Rheum Dis. 2019 Sep 12. PMID: 31515933.
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    19. Sugiyama Y, Yoshimi R, Takeno M, Kunishita Y, Kishimoto D, Kamiyama R, Kirino Y, Ohno S, Nakajima H. miR-1 Is a Novel Biomarker for Polymyositis/dermatomyositis-associated Interstitial Lung Disease. Mod Rheumatol. 2019 Sep 04; 1-16. PMID: 31483179.
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    20. Mitsuhashi M, Yoshimi R, Kishimoto D, Hidekawa C, Iizuka Y, Sakurai N, Kamiyama R, Kirino Y, Kondo Y, Mizuki N, Nakajima H. Refractory optic perineuritis related to granulomatosis with polyangiitis treated with intensive immunosuppressive therapy combined with plasma exchange. Mod Rheumatol Case Rep. 2020 01; 4(1):84-89. PMID: 33086977.
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    21. Mizuki Y, Horita N, Horie Y, Takeuchi M, Ishido T, Mizuki R, Kawagoe T, Shibuya E, Yuda K, Ishido M, Minegishi K, Yoshimi R, Kirino Y, Kato S, Arimoto J, Fukumoto T, Kurosawa M, Kitaichi N, Takeno M, Kaneko T, Mizuki N. The influence of HLA-B51 on clinical manifestations among Japanese patients with Behçet's disease: A nationwide survey. Mod Rheumatol. 2019 Aug 06; 1-7. PMID: 31386589.
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    22. Rigoutsos I, Londin E, Kirino Y. Short RNA regulators: the past, the present, the future, and implications for precision medicine and health disparities. Curr Opin Biotechnol. 2019 Aug; 58:202-210. PMID: 31323485.
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    23. Tsuchida N, Kirino Y, Soejima Y, Onodera M, Arai K, Tamura E, Ishikawa T, Kawai T, Uchiyama T, Nomura S, Kobayashi D, Taguri M, Mitsuhashi S, Mizuguchi T, Takata A, Miyake N, Nakajima H, Miyatake S, Matsumoto N. Haploinsufficiency of A20 caused by a novel nonsense variant or entire deletion of TNFAIP3 is clinically distinct from Behçet's disease. Arthritis Res Ther. 2019 Jun 04; 21(1):137. PMID: 31164164.
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    24. Telonis AG, Loher P, Magee R, Pliatsika V, Londin E, Kirino Y, Rigoutsos I. tRNA Fragments Show Intertwining with mRNAs of Specific Repeat Content and Have Links to Disparities. Cancer Res. 2019 Apr 17. PMID: 30996049.
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    25. Kirino Y, Nakajima H. Clinical and Genetic Aspects of Behçet's Disease in Japan. Intern Med. 2019 Jan 10. PMID: 30626832.
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    26. Terao C, Yoshifuji H, Matsumura T, Naruse TK, Ishii T, Nakaoka Y, Kirino Y, Matsuo K, Origuchi T, Shimizu M, Maejima Y, Amiya E, Tamura N, Kawaguchi T, Takahashi M, Setoh K, Ohmura K, Watanabe R, Horita T, Atsumi T, Matsukura M, Miyata T, Kochi Y, Suda T, Tanemoto K, Meguro A, Okada Y, Ogimoto A, Yamamoto M, Takahashi H, Nakayamada S, Saito K, Kuwana M, Mizuki N, Tabara Y, Ueda A, Komuro I, Kimura A, Isobe M, Mimori T, Matsuda F. Genetic determinants and an epistasis of LILRA3 and HLA-B*52 in Takayasu arteritis. Proc Natl Acad Sci U S A. 2018 12 18; 115(51):13045-13050. PMID: 30498034.
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    27. Shigematsu M, Kawamura T, Kirino Y. Generation of 2',3'-Cyclic Phosphate-Containing RNAs as a Hidden Layer of the Transcriptome. Front Genet. 2018; 9:562. PMID: 30538719.
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    28. Suzuki T, Horita N, Takeuchi M, Ishido T, Mizuki Y, Mizuki R, Kawagoe T, Shibuya E, Yuta K, Yamane T, Hayashi T, Meguro A, Ishido M, Minegishi K, Yoshimi R, Kirino Y, Kato S, Arimoto J, Fukumoto T, Ishigatsubo Y, Kurosawa M, Takeno M, Kaneko T, Mizuki N. Clinical features of early-stage possible Behçet's disease patients with a variant-type major organ involvement in Japan. Mod Rheumatol. 2018 Jun 28; 1-18. PMID: 29954241.
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    29. Nakano H, Kirino Y, Takeno M, Higashitani K, Nagai H, Yoshimi R, Yamaguchi Y, Kato I, Aoki I, Nakajima H. GWAS-identified CCR1 and IL10 loci contribute to M1 macrophage-predominant inflammation in Behçet's disease. Arthritis Res Ther. 2018 Jun 12; 20(1):124. PMID: 29895319.
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    30. Kishimoto D, Kirino Y, Tamura M, Takeno M, Kunishita Y, Takase-Minegishi K, Nakano H, Kato I, Nagahama K, Yoshimi R, Igarashi K, Aoki I, Nakajima H. Dysregulated heme oxygenase-1low M2-like macrophages augment lupus nephritis via Bach1 induced by type I interferons. Arthritis Res Ther. 2018 Apr 10; 20(1):64. PMID: 29636091.
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    31. Suwa A, Horita N, Ishido T, Takeuchi M, Kawagoe T, Shibuya E, Yamane T, Hayashi T, Meguro A, Ishido M, Minegishi K, Yoshimi R, Kirino Y, Kato S, Arimoto J, Fukumoto T, Ishigatsubo Y, Kurosawa M, Kaneko T, Takeno M, Mizuki N. The ocular involvement did not accompany with the genital ulcer or the gastrointestinal symptoms at the early stage of Behçet's disease. Mod Rheumatol. 2018 Mar 27; 1-17. PMID: 29583036.
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    32. Kamiyama R, Yoshimi R, Takeno M, Iribe Y, Tsukahara T, Kishimoto D, Kunishita Y, Sugiyama Y, Tsuchida N, Nakano H, Minegishi K, Tamura M, Asami Y, Kirino Y, Ishigatsubo Y, Ozato K, Nakajima H. Dysfunction of TRIM21 in interferon signature of systemic lupus erythematosus. Mod Rheumatol. 2018 Feb 23; 1-11. PMID: 29385873.
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    33. Sugiyama Y, Yoshimi R, Tamura M, Takeno M, Kunishita Y, Kishimoto D, Yoshioka Y, Kobayashi K, Takase-Minegishi K, Watanabe T, Hamada N, Nagai H, Tsuchida N, Soejima Y, Nakano H, Kamiyama R, Uehara T, Kirino Y, Sekiguchi A, Ihata A, Ohno S, Nagaoka S, Nakajima H. The predictive prognostic factors for polymyositis/dermatomyositis-associated interstitial lung disease. Arthritis Res Ther. 2018 Jan 11; 20(1):7. PMID: 29325580.
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    34. Kirino Y, Kawaguchi Y, Tada Y, Tsukamoto H, Ota T, Iwamoto M, Takahashi H, Nagasawa K, Takei S, Horiuchi T, Ichida H, Minota S, Ueda A, Ohta A, Ishigatsubo Y. Beneficial use of serum ferritin and heme oxygenase-1 as biomarkers in adult-onset Still's disease: A multicenter retrospective study. Mod Rheumatol. 2018 Jan 11; 1-7. PMID: 29278009.
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    35. Pliatsika V, Loher P, Magee R, Telonis AG, Londin E, Shigematsu M, Kirino Y, Rigoutsos I. MINTbase v2.0: a comprehensive database for tRNA-derived fragments that includes nuclear and mitochondrial fragments from all The Cancer Genome Atlas projects. Nucleic Acids Res. 2018 Jan 04; 46(D1):D152-D159. PMID: 29186503.
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    36. Shigematsu M, Honda S, Kirino Y. Dumbbell-PCR for Discriminative Quantification of a Small RNA Variant. Methods Mol Biol. 2018; 1680:65-73. PMID: 29030841.
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    37. Ishido T, Horita N, Takeuchi M, Kawagoe T, Shibuya E, Yamane T, Hayashi T, Meguro A, Ishido M, Minegishi K, Yoshimi R, Kirino Y, Kato S, Arimoto J, Ishigatsubo Y, Takeno M, Kurosawa M, Kaneko T, Mizuki N. Clinical manifestations of Behçet's disease depending on sex and age: results from Japanese nationwide registration. Rheumatology (Oxford). 2017 Nov 01; 56(11):1918-1927. PMID: 28968732.
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    38. Ishido M, Horita N, Takeuchi M, Shibuya E, Yamane T, Kawagoe T, Ishido T, Minegishi K, Yoshimi R, Kirino Y, Hirohata S, Ishigatsubo Y, Takeno M, Kaneko T, Mizuki N. Distinct clinical features between acute and chronic progressive parenchymal neuro-Behçet disease: meta-analysis. Sci Rep. 2017 Aug 31; 7(1):10196. PMID: 28860590.
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    39. Honda S, Loher P, Morichika K, Shigematsu M, Kawamura T, Kirino Y, Rigoutsos I, Kirino Y. Increasing cell density globally enhances the biogenesis of Piwi-interacting RNAs in Bombyx mori germ cells. Sci Rep. 2017 Jun 23; 7(1):4110. PMID: 28646211.
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    40. Honda S, Kawamura T, Loher P, Morichika K, Rigoutsos I, Kirino Y. The biogenesis pathway of tRNA-derived piRNAs in Bombyx germ cells. Nucleic Acids Res. 2017 Jun 22. PMID: 28645172.
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    41. Saito T, Tamura M, Chiba Y, Katsuse O, Suda A, Kamada A, Ikura T, Abe K, Ogawa M, Minegishi K, Yoshimi R, Kirino Y, Ihata A, Hirayasu Y. Regional cerebral glucose metabolism in systemic lupus erythematosus patients with major depressive disorder. J Neurol Sci. 2017 Aug 15; 379:127-130. PMID: 28716225.
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    42. Shigematsu M, Honda S, Loher P, Telonis AG, Rigoutsos I, Kirino Y. YAMAT-seq: an efficient method for high-throughput sequencing of mature transfer RNAs. Nucleic Acids Res. 2017 May 19; 45(9):e70. PMID: 28108659.
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    43. Takase-Minegishi K, Horita N, Kobayashi K, Yoshimi R, Kirino Y, Ohno S, Kaneko T, Nakajima H, Wakefield RJ, Emery P. Diagnostic test accuracy of ultrasound for synovitis in rheumatoid arthritis: systematic review and meta-analysis. Rheumatology (Oxford). 2017 Mar 03. PMID: 28340066.
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    44. Takeuchi M, Mizuki N, Meguro A, Ombrello MJ, Kirino Y, Satorius C, Le J, Blake M, Erer B, Kawagoe T, Ustek D, Tugal-Tutkun I, Seyahi E, Ozyazgan Y, Sousa I, Davatchi F, Francisco V, Shahram F, Abdollahi BS, Nadji A, Shafiee NM, Ghaderibarmi F, Ohno S, Ueda A, Ishigatsubo Y, Gadina M, Oliveira SA, Gül A, Kastner DL, Remmers EF. Dense genotyping of immune-related loci implicates host responses to microbial exposure in Behçet's disease susceptibility. Nat Genet. 2017 Mar; 49(3):438-443. PMID: 28166214.
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    45. Shigematsu M, Kirino Y. 5'-terminal nucleotide variations in human cytoplasmic tRNAHisGUG and its 5'-halves. RNA. 2016 Nov 22. PMID: 27879434.
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    46. Kirino Y, Ideguchi H, Takeno M, Suda A, Higashitani K, Kunishita Y, Takase-Minegishi K, Tamura M, Watanabe T, Asami Y, Uehara T, Yoshimi R, Yamazaki T, Sekiguchi A, Ihata A, Ohno S, Ueda A, Igarashi T, Nagaoka S, Ishigatsubo Y, Nakajima H. Continuous evolution of clinical phenotype in 578 Japanese patients with Behçet's disease: a retrospective observational study. Arthritis Res Ther. 2016 Oct 3; 18(1):217. PMID: 27716399.
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    47. Kunishita Y, Yoshimi R, Takeno M, Yamanaka S, Sugiyama Y, Tsuchida N, Kishimoto D, Kamiyama R, Minegishi K, Hama M, Kirino Y, Ishigatsubo Y, Ueda A, Nakajima H. Non-IgG4-related Multifocal Fibrosclerosis. Intern Med. 2016; 55(17):2497-502. PMID: 27580557.
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    48. Toyota Y, Tamura M, Kirino Y, Sugiyama Y, Tsuchida N, Kunishita Y, Kishimoto D, Kamiyama R, Miura Y, Minegishi K, Yoshimi R, Ueda A, Nakajima H. Musculoskeletal ultrasonography delineates ankle symptoms in rheumatoid arthritis. Mod Rheumatol. 2016 Sep 1; 1-5. PMID: 27539651.
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    49. Yoshimi R, Takeno M, Toyota Y, Tsuchida N, Sugiyama Y, Kunishita Y, Kishimoto D, Kamiyama R, Minegishi K, Hama M, Kirino Y, Ishigatsubo Y, Ohno S, Ueda A, Nakajima H. On-demand ultrasonography assessment in the most symptomatic joint supports the 8-joint score system for management of rheumatoid arthritis patients. Mod Rheumatol. 2016 Jul 13; 1-9. PMID: 27409294.
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    50. Takeuchi M, Ombrello MJ, Kirino Y, Erer B, Tugal-Tutkun I, Seyahi E, Özyazgan Y, Watts NR, Gül A, Kastner DL, Remmers EF. A single endoplasmic reticulum aminopeptidase-1 protein allotype is a strong risk factor for Behçet's disease in HLA-B*51 carriers. Ann Rheum Dis. 2016 Dec; 75(12):2208-2211. PMID: 27217550.
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    51. Sakai H, Kirino Y, Katsuma S, Aoki F, Suzuki MG. Morphological and histomorphological structures of testes and ovaries in early developmental stages of the silkworm, Bombyx mori. J Insect Biotechnol Sericology. 2016; 85(1):15-20. PMID: 28943775.
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    52. Telonis AG, Loher P, Kirino Y, Rigoutsos I. Consequential considerations when mapping tRNA fragments. BMC Bioinformatics. 2016; 17(1):123. PMID: 26961774.
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    53. Izumi N, Shoji K, Sakaguchi Y, Honda S, Kirino Y, Suzuki T, Katsuma S, Tomari Y. Identification and Functional Analysis of the Pre-piRNA 3' Trimmer in Silkworms. Cell. 2016 Feb 25; 164(5):962-73. PMID: 26919431.
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    54. Honda S, Morichika K, Kirino Y. Selective amplification and sequencing of cyclic phosphate-containing RNAs by the cP-RNA-seq method. Nat Protoc. 2016 Mar; 11(3):476-89. PMID: 26866791.
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    55. Honda S, Kirino Y. SHOT-RNAs: A novel class of tRNA-derived functional RNAs expressed in hormone-dependent cancers. Mol Cell Oncol. 2016 Mar; 3(2):e1079672. PMID: 27308603; PMCID: PMC4905382.
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    56. Telonis AG, Loher P, Honda S, Jing Y, Palazzo J, Kirino Y, Rigoutsos I. Dissecting tRNA-derived fragment complexities using personalized transcriptomes reveals novel fragment classes and unexpected dependencies. Oncotarget. 2015 Sep 22; 6(28):24797-822. PMID: 26325506.
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    57. Shigematsu M, Kirino Y. tRNA-Derived Short Non-coding RNA as Interacting Partners of Argonaute Proteins. Gene Regul Syst Bio. 2015; 9:27-33. PMID: 26401098; PMCID: PMC4567038.
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    58. Watanabe T, Takase-Minegishi K, Ihata A, Kunishita Y, Kishimoto D, Kamiyama R, Hama M, Yoshimi R, Kirino Y, Asami Y, Suda A, Ohno S, Tateishi U, Ueda A, Takeno M, Ishigatsubo Y. (18)F-FDG and (18)F-NaF PET/CT demonstrate coupling of inflammation and accelerated bone turnover in rheumatoid arthritis. Mod Rheumatol. 2016; 26(2):180-7. PMID: 26140472.
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    59. Honda S, Loher P, Shigematsu M, Palazzo JP, Suzuki R, Imoto I, Rigoutsos I, Kirino Y. Sex hormone-dependent tRNA halves enhance cell proliferation in breast and prostate cancers. Proc Natl Acad Sci U S A. 2015 Jul 21; 112(29):E3816-25. PMID: 26124144.
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    60. Toyoda H, Miyagawa T, Koike A, Kanbayashi T, Imanishi A, Sagawa Y, Kotorii N, Kotorii T, Hashizume Y, Ogi K, Hiejima H, Kamei Y, Hida A, Miyamoto M, Imai M, Fujimura Y, Tamura Y, Ikegami A, Wada Y, Moriya S, Furuya H, Takeuchi M, Kirino Y, Meguro A, Remmers EF, Kawamura Y, Otowa T, Miyashita A, Kashiwase K, Khor SS, Yamasaki M, Kuwano R, Sasaki T, Ishigooka J, Kuroda K, Kume K, Chiba S, Yamada N, Okawa M, Hirata K, Mizuki N, Uchimura N, Shimizu T, Inoue Y, Honda Y, Mishima K, Honda M, Tokunaga K. A polymorphism in CCR1/CCR3 is associated with narcolepsy. Brain Behav Immun. 2015 Oct; 49:148-55. PMID: 25986216.
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    61. Terao C, Matsumura T, Yoshifuji H, Kirino Y, Maejima Y, Nakaoka Y, Takahashi M, Amiya E, Tamura N, Nakajima T, Origuchi T, Horita T, Matsukura M, Kochi Y, Ogimoto A, Yamamoto M, Takahashi H, Nakayamada S, Saito K, Wada Y, Narita I, Kawaguchi Y, Yamanaka H, Ohmura K, Atsumi T, Tanemoto K, Miyata T, Kuwana M, Komuro I, Tabara Y, Ueda A, Isobe M, Mimori T, Matsuda F. Takayasu arteritis and ulcerative colitis: high rate of co-occurrence and genetic overlap. Arthritis Rheumatol. 2015 May; 67(8):2226-32. PMID: 25931203.
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    62. Kirino Y, Hama M, Takase-Minegishi K, Kunishita Y, Kishimoto D, Yoshimi R, Asami Y, Ihata A, Oba MS, Tsunoda S, Ohno S, Ueda A, Takeno M, Ishigatsubo Y. Predicting joint destruction in rheumatoid arthritis with power Doppler, anti-citrullinated peptide antibody, and joint swelling. Mod Rheumatol. 2015; 25(6):842-8. PMID: 25736364.
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    63. Kirino Y, Remmers EF. Genetic architectures of seropositive and seronegative rheumatic diseases. Nat Rev Rheumatol. 2015 Jul; 11(7):401-14. PMID: 25907699.
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    64. Telonis AG, Kirino Y, Rigoutsos I. Mitochondrial tRNA-lookalikes in nuclear chromosomes: Could they be functional? RNA Biol. 2015 Apr 3; 12(4):375-80. PMID: 25849196.
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    65. Honda S, Kirino Y. Dumbbell-PCR: a method to quantify specific small RNA variants with a single nucleotide resolution at terminal sequences. Nucleic Acids Res. 2015 Jul 13; 43(12):e77. PMID: 25779041.
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    66. Londin E, Loher P, Telonis AG, Quann K, Clark P, Jing Y, Hatzimichael E, Kirino Y, Honda S, Lally M, Ramratnam B, Comstock CE, Knudsen KE, Gomella L, Spaeth GL, Hark L, Katz LJ, Witkiewicz A, Rostami A, Jimenez SA, Hollingsworth MA, Yeh JJ, Shaw CA, McKenzie SE, Bray P, Nelson PT, Zupo S, Van Roosbroeck K, Keating MJ, Calin GA, Yeo C, Jimbo M, Cozzitorto J, Brody JR, Delgrosso K, Mattick JS, Fortina P, Rigoutsos I. Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- and tissue-specific microRNAs. Proc Natl Acad Sci U S A. 2015 Mar 10; 112(10):E1106-15. PMID: 25713380.
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    67. Honda S, Shigematsu M, Morichika K, Telonis AG, Kirino Y. Four-leaf clover qRT-PCR: A convenient method for selective quantification of mature tRNA. RNA Biol. 2015; 12(5):501-8. PMID: 25833336.
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    68. Yoshimi R, Ihata A, Kunishita Y, Kishimoto D, Kamiyama R, Minegishi K, Hama M, Kirino Y, Asami Y, Ohno S, Ueda A, Takeno M, Ishigatsubo Y. A novel 8-joint ultrasound score is useful in daily practice for rheumatoid arthritis. Mod Rheumatol. 2015 May; 25(3):379-85. PMID: 25401228.
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    69. Telonis AG, Loher P, Kirino Y, Rigoutsos I. Nuclear and mitochondrial tRNA-lookalikes in the human genome. Front Genet. 2014; 5:344. PMID: 25339973.
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    70. Ombrello MJ, Kirino Y, de Bakker PI, Gül A, Kastner DL, Remmers EF. Behçet disease-associated MHC class I residues implicate antigen binding and regulation of cell-mediated cytotoxicity. Proc Natl Acad Sci U S A. 2014 Jun 17; 111(24):8867-72. PMID: 24821759.
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    71. Honda S, Kirino Y, Kirino Y. Analysis of sDMA modifications of PIWI proteins. Methods Mol Biol. 2014; 1093:137-48. PMID: 24178562.
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    72. Shigematsu M, Honda S, Kirino Y. Transfer RNA as a source of small functional RNA. J Mol Biol Mol Imaging. 2014; 1(2). PMID: 26389128.
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    73. Yoshimi R, Hama M, Minegishi K, Kishimoto D, Watanabe T, Kamiyama R, Kirino Y, Asami Y, Ihata A, Tsunoda S, Ueda A, Takeno M, Ishigatsubo Y. Ultrasonography predicts achievement of Boolean remission after DAS28-based clinical remission of rheumatoid arthritis. Mod Rheumatol. 2014 Jul; 24(4):590-8. PMID: 24289200.
      Citations:    
    74. Honda S, Kirino Y, Maragkakis M, Alexiou P, Ohtaki A, Murali R, Mourelatos Z, Kirino Y. Mitochondrial protein BmPAPI modulates the length of mature piRNAs. RNA. 2013 Oct; 19(10):1405-18. PMID: 23970546.
      Citations:    
    75. Kirino Y, Zhou Q, Ishigatsubo Y, Mizuki N, Tugal-Tutkun I, Seyahi E, Özyazgan Y, Ugurlu S, Erer B, Abaci N, Ustek D, Meguro A, Ueda A, Takeno M, Inoko H, Ombrello MJ, Satorius CL, Maskeri B, Mullikin JC, Sun HW, Gutierrez-Cruz G, Kim Y, Wilson AF, Kastner DL, Gül A, Remmers EF. Targeted resequencing implicates the familial Mediterranean fever gene MEFV and the toll-like receptor 4 gene TLR4 in Behçet disease. Proc Natl Acad Sci U S A. 2013 May 14; 110(20):8134-9. PMID: 23633568.
      Citations:    
    76. Kirino Y, Bertsias G, Ishigatsubo Y, Mizuki N, Tugal-Tutkun I, Seyahi E, Ozyazgan Y, Sacli FS, Erer B, Inoko H, Emrence Z, Cakar A, Abaci N, Ustek D, Satorius C, Ueda A, Takeno M, Kim Y, Wood GM, Ombrello MJ, Meguro A, Gül A, Remmers EF, Kastner DL. Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1. Nat Genet. 2013 Feb; 45(2):202-7. PMID: 23291587.
      Citations:    
    77. Suzuki R, Honda S, Kirino Y. PIWI Expression and Function in Cancer. Front Genet. 2012; 3:204. PMID: 23087701.
      Citations:    
    78. Vourekas A, Zheng Q, Alexiou P, Maragkakis M, Kirino Y, Gregory BD, Mourelatos Z. Mili and Miwi target RNA repertoire reveals piRNA biogenesis and function of Miwi in spermiogenesis. Nat Struct Mol Biol. 2012 Aug; 19(8):773-81. PMID: 22842725.
      Citations:    
    79. Hama M, Kirino Y, Takeno M, Takase K, Miyazaki T, Yoshimi R, Ueda A, Itoh-Nakadai A, Muto A, Igarashi K, Ishigatsubo Y. Bach1 regulates osteoclastogenesis in a mouse model via both heme oxygenase 1-dependent and heme oxygenase 1-independent pathways. Arthritis Rheum. 2012 May; 64(5):1518-28. PMID: 22127667.
      Citations:    
    80. Kirino Y. [Role of arginine methylation in the Piwi-interacting RNA pathway]. Seikagaku. 2011 Apr; 83(4):312-6. PMID: 21626884.
      Citations:    
    81. Kirino Y, Vourekas A, Khandros E, Mourelatos Z. Immunoprecipitation of piRNPs and directional, next generation sequencing of piRNAs. Methods Mol Biol. 2011; 725:281-93. PMID: 21528460.
      Citations:    
    82. Mimaki M, Hatakeyama H, Komaki H, Yokoyama M, Arai H, Kirino Y, Suzuki T, Nishino I, Nonaka I, Goto Y. Reversible infantile respiratory chain deficiency: a clinical and molecular study. Ann Neurol. 2010 Dec; 68(6):845-54. PMID: 21194154.
      Citations:    
    83. Vourekas A, Kirino Y, Mourelatos Z. Elective affinities: a Tudor-Aubergine tale of germline partnership. Genes Dev. 2010 Sep 15; 24(18):1963-6. PMID: 20844011.
      Citations:    
    84. Remmers EF, Cosan F, Kirino Y, Ombrello MJ, Abaci N, Satorius C, Le JM, Yang B, Korman BD, Cakiris A, Aglar O, Emrence Z, Azakli H, Ustek D, Tugal-Tutkun I, Akman-Demir G, Chen W, Amos CI, Dizon MB, Kose AA, Azizlerli G, Erer B, Brand OJ, Kaklamani VG, Kaklamanis P, Ben-Chetrit E, Stanford M, Fortune F, Ghabra M, Ollier WE, Cho YH, Bang D, O'Shea J, Wallace GR, Gadina M, Kastner DL, Gül A. Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease. Nat Genet. 2010 Aug; 42(8):698-702. PMID: 20622878.
      Citations:    
    85. Miyazaki T, Kirino Y, Takeno M, Samukawa S, Hama M, Tanaka M, Yamaji S, Ueda A, Tomita N, Fujita H, Ishigatsubo Y. Expression of heme oxygenase-1 in human leukemic cells and its regulation by transcriptional repressor Bach1. Cancer Sci. 2010 Jun; 101(6):1409-16. PMID: 20345481.
      Citations:    
    86. Ishigatsubo Y, Ihata A, Kobayashi H, Hama M, Kirino Y, Ueda A, Takeno M, Shirai A, Ohno S. Therapeutic angiogenesis in patients with systemic sclerosis by autologous transplantation of bone-marrow-derived cells. Mod Rheumatol. 2010 Jun; 20(3):263-72. PMID: 20169390.
      Citations:    
    87. Ideguchi H, Suda A, Takeno M, Kirino Y, Ihata A, Ueda A, Ohno S, Baba Y, Kuroiwa Y, Ishigatsubo Y. Neurological manifestations of Behçet's disease in Japan: a study of 54 patients. J Neurol. 2010 Jun; 257(6):1012-20. PMID: 20127350.
      Citations:    
    88. Miyazaki T, Kirino Y, Takeno M, Hama M, Ushihama A, Watanabe R, Takase K, Tachibana T, Matsumoto K, Tanaka M, Yamaji S, Ideguchi H, Tomita N, Fujita H, Ohno S, Ueda A, Ishigatsubo Y. Serum HO-1 is useful to make differential diagnosis of secondary hemophagocytic syndrome from other similar hematological conditions. Int J Hematol. 2010 Mar; 91(2):229-37. PMID: 20091384.
      Citations:    
    89. Kirino Y, Vourekas A, Kim N, de Lima Alves F, Rappsilber J, Klein PS, Jongens TA, Mourelatos Z. Arginine methylation of vasa protein is conserved across phyla. J Biol Chem. 2010 Mar 12; 285(11):8148-54. PMID: 20080973.
      Citations:    
    90. Kirino Y, Vourekas A, Sayed N, de Lima Alves F, Thomson T, Lasko P, Rappsilber J, Jongens TA, Mourelatos Z. Arginine methylation of Aubergine mediates Tudor binding and germ plasm localization. RNA. 2010 Jan; 16(1):70-8. PMID: 19926723.
      Citations:    
    91. Kirino Y, Ihata A, Shizukuishi K, Hama M, Takase K, Suda A, Ueda A, Ohno S, Takeno M, Ishigatsubo Y. Multiple extra-articular synovial cysts complicated with rheumatoid arthritis. Mod Rheumatol. 2009; 19(5):563-6. PMID: 19526305.
      Citations:    
    92. Kirino Y, Kim N, de Planell-Saguer M, Khandros E, Chiorean S, Klein PS, Rigoutsos I, Jongens TA, Mourelatos Z. Arginine methylation of Piwi proteins catalysed by dPRMT5 is required for Ago3 and Aub stability. Nat Cell Biol. 2009 May; 11(5):652-8. PMID: 19377467.
      Citations:    
    93. Murakami S, Takeno M, Kirino Y, Kobayashi M, Watanabe R, Kudo M, Ihata A, Ueda A, Ohno S, Watanuki Y, Kaneko T, Ishigatsubo Y. Screening of tuberculosis by interferon-gamma assay before biologic therapy for rheumatoid arthritis. Tuberculosis (Edinb). 2009 Mar; 89(2):136-41. PMID: 19211305.
      Citations:    
    94. Kobayashi M, Miyazawa N, Takeno M, Murakami S, Kirino Y, Okouchi A, Kaneko T, Ishigatsubo Y. Circulating carbon monoxide level is elevated after sleep in patients with obstructive sleep apnea. Chest. 2008 Nov; 134(5):904-10. PMID: 18988776.
      Citations:    
    95. Kirino Y, Mourelatos Z. Site-specific crosslinking of human microRNPs to RNA targets. RNA. 2008 Oct; 14(10):2254-9. PMID: 18719246.
      Citations:    
    96. Kirino M, Kirino Y, Takeno M, Nagashima Y, Takahashi K, Kobayashi M, Murakami S, Hirasawa T, Ueda A, Aihara M, Ikezawa Z, Ishigatsubo Y. Heme oxygenase 1 attenuates the development of atopic dermatitis-like lesions in mice: implications for human disease. J Allergy Clin Immunol. 2008 Aug; 122(2):290-7, 297.e1-8. PMID: 18582925.
      Citations:    
    97. Kurata S, Weixlbaumer A, Ohtsuki T, Shimazaki T, Wada T, Kirino Y, Takai K, Watanabe K, Ramakrishnan V, Suzuki T. Modified uridines with C5-methylene substituents at the first position of the tRNA anticodon stabilize U.G wobble pairing during decoding. J Biol Chem. 2008 Jul 4; 283(27):18801-11. PMID: 18456657.
      Citations:    
    98. Kirino Y, Takeno M, Watanabe R, Murakami S, Kobayashi M, Ideguchi H, Ihata A, Ohno S, Ueda A, Mizuki N, Ishigatsubo Y. Association of reduced heme oxygenase-1 with excessive Toll-like receptor 4 expression in peripheral blood mononuclear cells in Behçet's disease. Arthritis Res Ther. 2008; 10(1):R16. PMID: 18234118.
      Citations:    
    99. Kirino Y, Mourelatos Z. The mouse homolog of HEN1 is a potential methylase for Piwi-interacting RNAs. RNA. 2007 Sep; 13(9):1397-401. PMID: 17652135.
      Citations:    
    100. Kirino Y, Mourelatos Z. Mouse Piwi-interacting RNAs are 2'-O-methylated at their 3' termini. Nat Struct Mol Biol. 2007 Apr; 14(4):347-8. PMID: 17384647.
      Citations:    
    101. Kirino Y, Takeno M, Murakami S, Kobayashi M, Kobayashi H, Miura K, Ideguchi H, Ohno S, Ueda A, Ishigatsubo Y. Tumor necrosis factor alpha acceleration of inflammatory responses by down-regulating heme oxygenase 1 in human peripheral monocytes. Arthritis Rheum. 2007 Feb; 56(2):464-75. PMID: 17265482.
      Citations:    
    102. Kirino Y, Mourelatos Z. 2'-O-methyl modification in mouse piRNAs and its methylase. Nucleic Acids Symp Ser (Oxf). 2007; (51):417-8. PMID: 18029764.
      Citations:    
    103. Noma A, Kirino Y, Ikeuchi Y, Suzuki T. Biosynthesis of wybutosine, a hyper-modified nucleoside in eukaryotic phenylalanine tRNA. EMBO J. 2006 May 17; 25(10):2142-54. PMID: 16642040.
      Citations:    
    104. Kobayashi H, Takeno M, Saito T, Takeda Y, Kirino Y, Noyori K, Hayashi T, Ueda A, Ishigatsubo Y. Regulatory role of heme oxygenase 1 in inflammation of rheumatoid arthritis. Arthritis Rheum. 2006 Apr; 54(4):1132-42. PMID: 16572448.
      Citations:    
    105. Kirino Y, Yasukawa T, Marjavaara SK, Jacobs HT, Holt IJ, Watanabe K, Suzuki T. Acquisition of the wobble modification in mitochondrial tRNALeu(CUN) bearing the G12300A mutation suppresses the MELAS molecular defect. Hum Mol Genet. 2006 Mar 15; 15(6):897-904. PMID: 16446307.
      Citations:    
    106. Yoshimi R, Takeno M, Yamanaka S, Shiina M, Kirino Y, Takeda Y, Sekiguchi A, Kobayashi H, Ihata A, Motoji K, Ohno S, Ueda A, Soga T, Ishigatsubo Y. Systemic sclerosis and pseudomesotheliomatous adenocarcinoma of the lung. Mod Rheumatol. 2006; 16(3):165-8. PMID: 16767555.
      Citations:    
    107. Yasukawa T, Kirino Y, Ishii N, Holt IJ, Jacobs HT, Makifuchi T, Fukuhara N, Ohta S, Suzuki T, Watanabe K. Wobble modification deficiency in mutant tRNAs in patients with mitochondrial diseases. FEBS Lett. 2005 May 23; 579(13):2948-52. PMID: 15893315.
      Citations:    
    108. Kirino Y, Goto Y, Campos Y, Arenas J, Suzuki T. Specific correlation between the wobble modification deficiency in mutant tRNAs and the clinical features of a human mitochondrial disease. Proc Natl Acad Sci U S A. 2005 May 17; 102(20):7127-32. PMID: 15870203.
      Citations:    
    109. Kirino Y, Suzuki T. Human mitochondrial diseases associated with tRNA wobble modification deficiency. RNA Biol. 2005 Apr; 2(2):41-4. PMID: 17132941.
      Citations:    
    110. Kirino Y, Takeno M, Iwasaki M, Ueda A, Ohno S, Shirai A, Kanamori H, Tanaka K, Ishigatsubo Y. Increased serum HO-1 in hemophagocytic syndrome and adult-onset Still's disease: use in the differential diagnosis of hyperferritinemia. Arthritis Res Ther. 2005; 7(3):R616-24. PMID: 15899048.
      Citations:    
    111. Aoki A, Kirino Y, Ishigatsubo Y, Senuma A, Nagaoka S. [Liver involvement in primary Sjogren's syndrome]. Nihon Rinsho Meneki Gakkai Kaishi. 2004 Dec; 27(6):397-401. PMID: 15678893.
      Citations:    
    112. Kirino Y, Yasukawa T, Ohta S, Akira S, Ishihara K, Watanabe K, Suzuki T. Codon-specific translational defect caused by a wobble modification deficiency in mutant tRNA from a human mitochondrial disease. Proc Natl Acad Sci U S A. 2004 Oct 19; 101(42):15070-5. PMID: 15477592.
      Citations:    
    113. Kirino Y, Tsuji T, Ohno S, Yoshimi R, Takeda Y, Misumi M, Inoue Y, Ueda A, Takeno M, Ishigatsubo Y. [A solitary lung lesion in Wegener's granulomatosis, which was difficult to differentiate from lung neoplasm]. Ryumachi. 2003 Feb; 43(1):39-43. PMID: 12692988.
      Citations:    
    114. Kurata S, Ohtsuki T, Wada T, Kirino Y, Takai K, Saigo K, Watanabe K, Suzuki T. Decoding property of C5 uridine modification at the wobble position of tRNA anticodon. Nucleic Acids Res Suppl. 2003; (3):245-6. PMID: 14510472.
      Citations:    
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