Header Logo
Keywords
Last Name
Institution

Yohei Kirino

TitleAssoc Professor
InstitutionThomas Jefferson University
DepartmentComputational Med Center
Phone215-503-8648
vCardDownload vCard

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Vrettos N, Maragkakis M, Alexiou P, Sgourdou P, Ibrahim F, Palmieri D, Kirino Y, Mourelatos Z. Modulation of Aub-TDRD interactions elucidates piRNA amplification and germplasm formation. Life Sci Alliance. 2021 03; 4(3). PMID: 33376130.
      View in: PubMed
    2. Abe K, Chiba Y, Katsuse O, Takahashi Y, Suda A, Hattori S, Yoshimi R, Kirino Y, Kunii M, Yoshimi A, Asami T, Hishimoto A. Exploratory investigation on antibodies to GluN1 and cognitive dysfunction in patients with chronic autoimmune psychosis. Neurosci Lett. 2021 01 19; 743:135588. PMID: 33359543.
      View in: PubMed
    3. Pawar K, Shigematsu M, Sharbati S, Kirino Y. Infection-induced 5'-half molecules of tRNAHisGUG activate Toll-like receptor 7. PLoS Biol. 2020 12; 18(12):e3000982. PMID: 33332353.
      View in: PubMed
    4. Gono T, Masui K, Nishina N, Kawaguchi Y, Kawakami A, Ikeda K, Kirino Y, Sugiyama Y, Tanino Y, Nunokawa T, Kaneko Y, Sato S, Asakawa K, Ukichi T, Kaieda S, Naniwa T, Okano Y, Kuwana M. Risk prediction modeling based on a combination of initial serum biomarkers in myositis-associated interstitial lung disease. Arthritis Rheumatol. 2020 Oct 29. PMID: 33118321.
      View in: PubMed
    5. Hirahara L, Kirino Y, Soejima Y, Takeno M, Takase-Minegishi K, Yoshimi R, Takeuchi M, Mizuki N, Nakajima H. Efficacy and safety of apremilast for 3 months in Behçet's disease: A prospective observational study. Mod Rheumatol. 2020 Oct 16; 1-6. PMID: 32996801.
      View in: PubMed
    6. Maruyama A, Kokuzawa A, Yamauchi Y, Kirino Y, Nagai H, Inoue Y, Ota T, Chifu Y, Inokuchi S, Koarada S, Ohta A, Iwamoto M, Tada Y. Clinical features of elderly-onset Adult-onset Still's disease. Mod Rheumatol. 2020 Oct 13; 1-7. PMID: 32990106.
      View in: PubMed
    7. Suzuki T, Yashiro Y, Kikuchi I, Ishigami Y, Saito H, Matsuzawa I, Okada S, Mito M, Iwasaki S, Ma D, Zhao X, Asano K, Lin H, Kirino Y, Sakaguchi Y, Suzuki T. Complete chemical structures of human mitochondrial tRNAs. Nat Commun. 2020 08 28; 11(1):4269. PMID: 32859890.
      View in: PubMed
    8. Shigematsu M, Kirino Y. Oxidative stress enhances the expression of 2',3'-cyclic phosphate-containing RNAs. RNA Biol. 2020 Jun 18; 1-10. PMID: 32397797.
      View in: PubMed
    9. Kunishita Y, Yoshimi R, Kamiyama R, Kishimoto D, Yoshida K, Hashimoto E, Komiya T, Sakurai N, Sugiyama Y, Kirino Y, Ozato K, Nakajima H. TRIM21 Dysfunction Enhances Aberrant B-Cell Differentiation in Autoimmune Pathogenesis. Front Immunol. 2020; 11:98. PMID: 32117252.
      View in: PubMed
    10. Kato H, Takeuchi M, Horita N, Ishido T, Mizuki R, Kawagoe T, Shibuya E, Yuda K, Ishido M, Mizuki Y, Hayashi T, Meguro A, Kirino Y, Minegishi K, Nakano H, Yoshimi R, Kurosawa M, Fukumoto T, Takeno M, Hotta K, Kaneko T, Mizuki N. HLA-A26 is a risk factor for Behçet's disease ocular lesions. Mod Rheumatol. 2020 Jan 04; 1-5. PMID: 31851572.
      View in: PubMed
    11. Shigematsu M, Morichika K, Kawamura T, Honda S, Kirino Y. Genome-wide identification of short 2',3'-cyclic phosphate-containing RNAs and their regulation in aging. PLoS Genet. 2019 Nov; 15(11):e1008469. PMID: 31721758.
      View in: PubMed
    12. Pawar K, Shigematsu M, Loher P, Honda S, Rigoutsos I, Kirino Y. Exploration of CCA-added RNAs revealed the expression of mitochondrial non-coding RNAs regulated by CCA-adding enzyme. RNA Biol. 2019 Sep 12; 1-9. PMID: 31512554.
      View in: PubMed
    13. Komiya T, Takase-Minegishi K, Sakurai N, Nagai H, Hamada N, Soejima Y, Sugiyama Y, Tsuchida N, Kunishita Y, Kishimoto D, Kobayashi K, Kamiyama R, Yoshimi R, Kirino Y, Ohno S, Nakajima H. Dose down-titration of biological disease-modifying antirheumatic drugs in daily clinical practice: Shared decision-making and patient treatment preferences in Japanese patients with rheumatoid arthritis. Int J Rheum Dis. 2019 Sep 12. PMID: 31515933.
      View in: PubMed
    14. Sugiyama Y, Yoshimi R, Takeno M, Kunishita Y, Kishimoto D, Kamiyama R, Kirino Y, Ohno S, Nakajima H. miR-1 Is a Novel Biomarker for Polymyositis/dermatomyositis-associated Interstitial Lung Disease. Mod Rheumatol. 2019 Sep 04; 1-16. PMID: 31483179.
      View in: PubMed
    15. Mitsuhashi M, Yoshimi R, Kishimoto D, Hidekawa C, Iizuka Y, Sakurai N, Kamiyama R, Kirino Y, Kondo Y, Mizuki N, Nakajima H. Refractory optic perineuritis related to granulomatosis with polyangiitis treated with intensive immunosuppressive therapy combined with plasma exchange. Mod Rheumatol Case Rep. 2020 01; 4(1):84-89. PMID: 33086977.
      View in: PubMed
    16. Mizuki Y, Horita N, Horie Y, Takeuchi M, Ishido T, Mizuki R, Kawagoe T, Shibuya E, Yuda K, Ishido M, Minegishi K, Yoshimi R, Kirino Y, Kato S, Arimoto J, Fukumoto T, Kurosawa M, Kitaichi N, Takeno M, Kaneko T, Mizuki N. The influence of HLA-B51 on clinical manifestations among Japanese patients with Behçet's disease: A nationwide survey. Mod Rheumatol. 2019 Aug 06; 1-7. PMID: 31386589.
      View in: PubMed
    17. Rigoutsos I, Londin E, Kirino Y. Short RNA regulators: the past, the present, the future, and implications for precision medicine and health disparities. Curr Opin Biotechnol. 2019 Aug; 58:202-210. PMID: 31323485.
      View in: PubMed
    18. Tsuchida N, Kirino Y, Soejima Y, Onodera M, Arai K, Tamura E, Ishikawa T, Kawai T, Uchiyama T, Nomura S, Kobayashi D, Taguri M, Mitsuhashi S, Mizuguchi T, Takata A, Miyake N, Nakajima H, Miyatake S, Matsumoto N. Haploinsufficiency of A20 caused by a novel nonsense variant or entire deletion of TNFAIP3 is clinically distinct from Behçet's disease. Arthritis Res Ther. 2019 Jun 04; 21(1):137. PMID: 31164164.
      View in: PubMed
    19. Telonis AG, Loher P, Magee R, Pliatsika V, Londin E, Kirino Y, Rigoutsos I. tRNA Fragments Show Intertwining with mRNAs of Specific Repeat Content and Have Links to Disparities. Cancer Res. 2019 Apr 17. PMID: 30996049.
      View in: PubMed
    20. Kirino Y, Nakajima H. Clinical and Genetic Aspects of Behçet's Disease in Japan. Intern Med. 2019 Jan 10. PMID: 30626832.
      View in: PubMed
    21. Terao C, Yoshifuji H, Matsumura T, Naruse TK, Ishii T, Nakaoka Y, Kirino Y, Matsuo K, Origuchi T, Shimizu M, Maejima Y, Amiya E, Tamura N, Kawaguchi T, Takahashi M, Setoh K, Ohmura K, Watanabe R, Horita T, Atsumi T, Matsukura M, Miyata T, Kochi Y, Suda T, Tanemoto K, Meguro A, Okada Y, Ogimoto A, Yamamoto M, Takahashi H, Nakayamada S, Saito K, Kuwana M, Mizuki N, Tabara Y, Ueda A, Komuro I, Kimura A, Isobe M, Mimori T, Matsuda F. Genetic determinants and an epistasis of LILRA3 and HLA-B*52 in Takayasu arteritis. Proc Natl Acad Sci U S A. 2018 12 18; 115(51):13045-13050. PMID: 30498034.
      View in: PubMed
    22. Shigematsu M, Kawamura T, Kirino Y. Generation of 2',3'-Cyclic Phosphate-Containing RNAs as a Hidden Layer of the Transcriptome. Front Genet. 2018; 9:562. PMID: 30538719.
      View in: PubMed
    23. Suzuki T, Horita N, Takeuchi M, Ishido T, Mizuki Y, Mizuki R, Kawagoe T, Shibuya E, Yuta K, Yamane T, Hayashi T, Meguro A, Ishido M, Minegishi K, Yoshimi R, Kirino Y, Kato S, Arimoto J, Fukumoto T, Ishigatsubo Y, Kurosawa M, Takeno M, Kaneko T, Mizuki N. Clinical features of early-stage possible Behçet's disease patients with a variant-type major organ involvement in Japan. Mod Rheumatol. 2018 Jun 28; 1-18. PMID: 29954241.
      View in: PubMed
    24. Nakano H, Kirino Y, Takeno M, Higashitani K, Nagai H, Yoshimi R, Yamaguchi Y, Kato I, Aoki I, Nakajima H. GWAS-identified CCR1 and IL10 loci contribute to M1 macrophage-predominant inflammation in Behçet's disease. Arthritis Res Ther. 2018 Jun 12; 20(1):124. PMID: 29895319.
      View in: PubMed
    25. Kishimoto D, Kirino Y, Tamura M, Takeno M, Kunishita Y, Takase-Minegishi K, Nakano H, Kato I, Nagahama K, Yoshimi R, Igarashi K, Aoki I, Nakajima H. Dysregulated heme oxygenase-1low M2-like macrophages augment lupus nephritis via Bach1 induced by type I interferons. Arthritis Res Ther. 2018 Apr 10; 20(1):64. PMID: 29636091.
      View in: PubMed
    26. Suwa A, Horita N, Ishido T, Takeuchi M, Kawagoe T, Shibuya E, Yamane T, Hayashi T, Meguro A, Ishido M, Minegishi K, Yoshimi R, Kirino Y, Kato S, Arimoto J, Fukumoto T, Ishigatsubo Y, Kurosawa M, Kaneko T, Takeno M, Mizuki N. The ocular involvement did not accompany with the genital ulcer or the gastrointestinal symptoms at the early stage of Behçet's disease. Mod Rheumatol. 2018 Mar 27; 1-17. PMID: 29583036.
      View in: PubMed
    27. Kamiyama R, Yoshimi R, Takeno M, Iribe Y, Tsukahara T, Kishimoto D, Kunishita Y, Sugiyama Y, Tsuchida N, Nakano H, Minegishi K, Tamura M, Asami Y, Kirino Y, Ishigatsubo Y, Ozato K, Nakajima H. Dysfunction of TRIM21 in interferon signature of systemic lupus erythematosus. Mod Rheumatol. 2018 Feb 23; 1-11. PMID: 29385873.
      View in: PubMed
    28. Sugiyama Y, Yoshimi R, Tamura M, Takeno M, Kunishita Y, Kishimoto D, Yoshioka Y, Kobayashi K, Takase-Minegishi K, Watanabe T, Hamada N, Nagai H, Tsuchida N, Soejima Y, Nakano H, Kamiyama R, Uehara T, Kirino Y, Sekiguchi A, Ihata A, Ohno S, Nagaoka S, Nakajima H. The predictive prognostic factors for polymyositis/dermatomyositis-associated interstitial lung disease. Arthritis Res Ther. 2018 Jan 11; 20(1):7. PMID: 29325580.
      View in: PubMed
    29. Kirino Y, Kawaguchi Y, Tada Y, Tsukamoto H, Ota T, Iwamoto M, Takahashi H, Nagasawa K, Takei S, Horiuchi T, Ichida H, Minota S, Ueda A, Ohta A, Ishigatsubo Y. Beneficial use of serum ferritin and heme oxygenase-1 as biomarkers in adult-onset Still's disease: A multicenter retrospective study. Mod Rheumatol. 2018 Jan 11; 1-7. PMID: 29278009.
      View in: PubMed
    30. Pliatsika V, Loher P, Magee R, Telonis AG, Londin E, Shigematsu M, Kirino Y, Rigoutsos I. MINTbase v2.0: a comprehensive database for tRNA-derived fragments that includes nuclear and mitochondrial fragments from all The Cancer Genome Atlas projects. Nucleic Acids Res. 2018 Jan 04; 46(D1):D152-D159. PMID: 29186503.
      View in: PubMed
    31. Shigematsu M, Honda S, Kirino Y. Dumbbell-PCR for Discriminative Quantification of a Small RNA Variant. Methods Mol Biol. 2018; 1680:65-73. PMID: 29030841.
      View in: PubMed
    32. Ishido T, Horita N, Takeuchi M, Kawagoe T, Shibuya E, Yamane T, Hayashi T, Meguro A, Ishido M, Minegishi K, Yoshimi R, Kirino Y, Kato S, Arimoto J, Ishigatsubo Y, Takeno M, Kurosawa M, Kaneko T, Mizuki N. Clinical manifestations of Behçet's disease depending on sex and age: results from Japanese nationwide registration. Rheumatology (Oxford). 2017 Nov 01; 56(11):1918-1927. PMID: 28968732.
      View in: PubMed
    33. Ishido M, Horita N, Takeuchi M, Shibuya E, Yamane T, Kawagoe T, Ishido T, Minegishi K, Yoshimi R, Kirino Y, Hirohata S, Ishigatsubo Y, Takeno M, Kaneko T, Mizuki N. Distinct clinical features between acute and chronic progressive parenchymal neuro-Behçet disease: meta-analysis. Sci Rep. 2017 Aug 31; 7(1):10196. PMID: 28860590.
      View in: PubMed
    34. Honda S, Loher P, Morichika K, Shigematsu M, Kawamura T, Kirino Y, Rigoutsos I, Kirino Y. Increasing cell density globally enhances the biogenesis of Piwi-interacting RNAs in Bombyx mori germ cells. Sci Rep. 2017 Jun 23; 7(1):4110. PMID: 28646211.
      View in: PubMed
    35. Honda S, Kawamura T, Loher P, Morichika K, Rigoutsos I, Kirino Y. The biogenesis pathway of tRNA-derived piRNAs in Bombyx germ cells. Nucleic Acids Res. 2017 Jun 22. PMID: 28645172.
      View in: PubMed
    36. Saito T, Tamura M, Chiba Y, Katsuse O, Suda A, Kamada A, Ikura T, Abe K, Ogawa M, Minegishi K, Yoshimi R, Kirino Y, Ihata A, Hirayasu Y. Regional cerebral glucose metabolism in systemic lupus erythematosus patients with major depressive disorder. J Neurol Sci. 2017 Aug 15; 379:127-130. PMID: 28716225.
      View in: PubMed
    37. Shigematsu M, Honda S, Loher P, Telonis AG, Rigoutsos I, Kirino Y. YAMAT-seq: an efficient method for high-throughput sequencing of mature transfer RNAs. Nucleic Acids Res. 2017 May 19; 45(9):e70. PMID: 28108659.
      View in: PubMed
    38. Takase-Minegishi K, Horita N, Kobayashi K, Yoshimi R, Kirino Y, Ohno S, Kaneko T, Nakajima H, Wakefield RJ, Emery P. Diagnostic test accuracy of ultrasound for synovitis in rheumatoid arthritis: systematic review and meta-analysis. Rheumatology (Oxford). 2017 Mar 03. PMID: 28340066.
      View in: PubMed
    39. Takeuchi M, Mizuki N, Meguro A, Ombrello MJ, Kirino Y, Satorius C, Le J, Blake M, Erer B, Kawagoe T, Ustek D, Tugal-Tutkun I, Seyahi E, Ozyazgan Y, Sousa I, Davatchi F, Francisco V, Shahram F, Abdollahi BS, Nadji A, Shafiee NM, Ghaderibarmi F, Ohno S, Ueda A, Ishigatsubo Y, Gadina M, Oliveira SA, Gül A, Kastner DL, Remmers EF. Dense genotyping of immune-related loci implicates host responses to microbial exposure in Behçet's disease susceptibility. Nat Genet. 2017 Mar; 49(3):438-443. PMID: 28166214.
      View in: PubMed
    40. Shigematsu M, Kirino Y. 5'-terminal nucleotide variations in human cytoplasmic tRNAHisGUG and its 5'-halves. RNA. 2016 Nov 22. PMID: 27879434.
      View in: PubMed
    41. Kirino Y, Ideguchi H, Takeno M, Suda A, Higashitani K, Kunishita Y, Takase-Minegishi K, Tamura M, Watanabe T, Asami Y, Uehara T, Yoshimi R, Yamazaki T, Sekiguchi A, Ihata A, Ohno S, Ueda A, Igarashi T, Nagaoka S, Ishigatsubo Y, Nakajima H. Continuous evolution of clinical phenotype in 578 Japanese patients with Behçet's disease: a retrospective observational study. Arthritis Res Ther. 2016 Oct 3; 18(1):217. PMID: 27716399.
      View in: PubMed
    42. Kunishita Y, Yoshimi R, Takeno M, Yamanaka S, Sugiyama Y, Tsuchida N, Kishimoto D, Kamiyama R, Minegishi K, Hama M, Kirino Y, Ishigatsubo Y, Ueda A, Nakajima H. Non-IgG4-related Multifocal Fibrosclerosis. Intern Med. 2016; 55(17):2497-502. PMID: 27580557.
      View in: PubMed
    43. Toyota Y, Tamura M, Kirino Y, Sugiyama Y, Tsuchida N, Kunishita Y, Kishimoto D, Kamiyama R, Miura Y, Minegishi K, Yoshimi R, Ueda A, Nakajima H. Musculoskeletal ultrasonography delineates ankle symptoms in rheumatoid arthritis. Mod Rheumatol. 2016 Sep 1; 1-5. PMID: 27539651.
      View in: PubMed
    44. Yoshimi R, Takeno M, Toyota Y, Tsuchida N, Sugiyama Y, Kunishita Y, Kishimoto D, Kamiyama R, Minegishi K, Hama M, Kirino Y, Ishigatsubo Y, Ohno S, Ueda A, Nakajima H. On-demand ultrasonography assessment in the most symptomatic joint supports the 8-joint score system for management of rheumatoid arthritis patients. Mod Rheumatol. 2016 Jul 13; 1-9. PMID: 27409294.
      View in: PubMed
    45. Takeuchi M, Ombrello MJ, Kirino Y, Erer B, Tugal-Tutkun I, Seyahi E, Özyazgan Y, Watts NR, Gül A, Kastner DL, Remmers EF. A single endoplasmic reticulum aminopeptidase-1 protein allotype is a strong risk factor for Behçet's disease in HLA-B*51 carriers. Ann Rheum Dis. 2016 Dec; 75(12):2208-2211. PMID: 27217550.
      View in: PubMed
    46. Sakai H, Kirino Y, Katsuma S, Aoki F, Suzuki MG. Morphological and histomorphological structures of testes and ovaries in early developmental stages of the silkworm, Bombyx mori. J Insect Biotechnol Sericology. 2016; 85(1):15-20. PMID: 28943775.
      View in: PubMed
    47. Telonis AG, Loher P, Kirino Y, Rigoutsos I. Consequential considerations when mapping tRNA fragments. BMC Bioinformatics. 2016; 17(1):123. PMID: 26961774.
      View in: PubMed
    48. Izumi N, Shoji K, Sakaguchi Y, Honda S, Kirino Y, Suzuki T, Katsuma S, Tomari Y. Identification and Functional Analysis of the Pre-piRNA 3' Trimmer in Silkworms. Cell. 2016 Feb 25; 164(5):962-73. PMID: 26919431.
      View in: PubMed
    49. Honda S, Morichika K, Kirino Y. Selective amplification and sequencing of cyclic phosphate-containing RNAs by the cP-RNA-seq method. Nat Protoc. 2016 Mar; 11(3):476-89. PMID: 26866791.
      View in: PubMed
    50. Honda S, Kirino Y. SHOT-RNAs: A novel class of tRNA-derived functional RNAs expressed in hormone-dependent cancers. Mol Cell Oncol. 2016 Mar; 3(2):e1079672. PMID: 27308603; PMCID: PMC4905382 [Available on 11/23/16].
    51. Telonis AG, Loher P, Honda S, Jing Y, Palazzo J, Kirino Y, Rigoutsos I. Dissecting tRNA-derived fragment complexities using personalized transcriptomes reveals novel fragment classes and unexpected dependencies. Oncotarget. 2015 Sep 22; 6(28):24797-822. PMID: 26325506.
      View in: PubMed
    52. Shigematsu M, Kirino Y. tRNA-Derived Short Non-coding RNA as Interacting Partners of Argonaute Proteins. Gene Regul Syst Bio. 2015; 9:27-33. PMID: 26401098; PMCID: PMC4567038.
    53. Watanabe T, Takase-Minegishi K, Ihata A, Kunishita Y, Kishimoto D, Kamiyama R, Hama M, Yoshimi R, Kirino Y, Asami Y, Suda A, Ohno S, Tateishi U, Ueda A, Takeno M, Ishigatsubo Y. (18)F-FDG and (18)F-NaF PET/CT demonstrate coupling of inflammation and accelerated bone turnover in rheumatoid arthritis. Mod Rheumatol. 2016; 26(2):180-7. PMID: 26140472.
      View in: PubMed
    54. Honda S, Loher P, Shigematsu M, Palazzo JP, Suzuki R, Imoto I, Rigoutsos I, Kirino Y. Sex hormone-dependent tRNA halves enhance cell proliferation in breast and prostate cancers. Proc Natl Acad Sci U S A. 2015 Jul 21; 112(29):E3816-25. PMID: 26124144.
      View in: PubMed
    55. Toyoda H, Miyagawa T, Koike A, Kanbayashi T, Imanishi A, Sagawa Y, Kotorii N, Kotorii T, Hashizume Y, Ogi K, Hiejima H, Kamei Y, Hida A, Miyamoto M, Imai M, Fujimura Y, Tamura Y, Ikegami A, Wada Y, Moriya S, Furuya H, Takeuchi M, Kirino Y, Meguro A, Remmers EF, Kawamura Y, Otowa T, Miyashita A, Kashiwase K, Khor SS, Yamasaki M, Kuwano R, Sasaki T, Ishigooka J, Kuroda K, Kume K, Chiba S, Yamada N, Okawa M, Hirata K, Mizuki N, Uchimura N, Shimizu T, Inoue Y, Honda Y, Mishima K, Honda M, Tokunaga K. A polymorphism in CCR1/CCR3 is associated with narcolepsy. Brain Behav Immun. 2015 Oct; 49:148-55. PMID: 25986216.
      View in: PubMed
    56. Terao C, Matsumura T, Yoshifuji H, Kirino Y, Maejima Y, Nakaoka Y, Takahashi M, Amiya E, Tamura N, Nakajima T, Origuchi T, Horita T, Matsukura M, Kochi Y, Ogimoto A, Yamamoto M, Takahashi H, Nakayamada S, Saito K, Wada Y, Narita I, Kawaguchi Y, Yamanaka H, Ohmura K, Atsumi T, Tanemoto K, Miyata T, Kuwana M, Komuro I, Tabara Y, Ueda A, Isobe M, Mimori T, Matsuda F. Takayasu arteritis and ulcerative colitis: high rate of co-occurrence and genetic overlap. Arthritis Rheumatol. 2015 May; 67(8):2226-32. PMID: 25931203.
      View in: PubMed
    57. Kirino Y, Hama M, Takase-Minegishi K, Kunishita Y, Kishimoto D, Yoshimi R, Asami Y, Ihata A, Oba MS, Tsunoda S, Ohno S, Ueda A, Takeno M, Ishigatsubo Y. Predicting joint destruction in rheumatoid arthritis with power Doppler, anti-citrullinated peptide antibody, and joint swelling. Mod Rheumatol. 2015; 25(6):842-8. PMID: 25736364.
      View in: PubMed
    58. Kirino Y, Remmers EF. Genetic architectures of seropositive and seronegative rheumatic diseases. Nat Rev Rheumatol. 2015 Jul; 11(7):401-14. PMID: 25907699.
      View in: PubMed
    59. Telonis AG, Kirino Y, Rigoutsos I. Mitochondrial tRNA-lookalikes in nuclear chromosomes: Could they be functional? RNA Biol. 2015 Apr 3; 12(4):375-80. PMID: 25849196.
      View in: PubMed
    60. Honda S, Kirino Y. Dumbbell-PCR: a method to quantify specific small RNA variants with a single nucleotide resolution at terminal sequences. Nucleic Acids Res. 2015 Jul 13; 43(12):e77. PMID: 25779041.
      View in: PubMed
    61. Londin E, Loher P, Telonis AG, Quann K, Clark P, Jing Y, Hatzimichael E, Kirino Y, Honda S, Lally M, Ramratnam B, Comstock CE, Knudsen KE, Gomella L, Spaeth GL, Hark L, Katz LJ, Witkiewicz A, Rostami A, Jimenez SA, Hollingsworth MA, Yeh JJ, Shaw CA, McKenzie SE, Bray P, Nelson PT, Zupo S, Van Roosbroeck K, Keating MJ, Calin GA, Yeo C, Jimbo M, Cozzitorto J, Brody JR, Delgrosso K, Mattick JS, Fortina P, Rigoutsos I. Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- and tissue-specific microRNAs. Proc Natl Acad Sci U S A. 2015 Mar 10; 112(10):E1106-15. PMID: 25713380.
      View in: PubMed
    62. Honda S, Shigematsu M, Morichika K, Telonis AG, Kirino Y. Four-leaf clover qRT-PCR: A convenient method for selective quantification of mature tRNA. RNA Biol. 2015; 12(5):501-8. PMID: 25833336.
      View in: PubMed
    63. Yoshimi R, Ihata A, Kunishita Y, Kishimoto D, Kamiyama R, Minegishi K, Hama M, Kirino Y, Asami Y, Ohno S, Ueda A, Takeno M, Ishigatsubo Y. A novel 8-joint ultrasound score is useful in daily practice for rheumatoid arthritis. Mod Rheumatol. 2015 May; 25(3):379-85. PMID: 25401228.
      View in: PubMed
    64. Telonis AG, Loher P, Kirino Y, Rigoutsos I. Nuclear and mitochondrial tRNA-lookalikes in the human genome. Front Genet. 2014; 5:344. PMID: 25339973.
      View in: PubMed
    65. Ombrello MJ, Kirino Y, de Bakker PI, Gül A, Kastner DL, Remmers EF. Behçet disease-associated MHC class I residues implicate antigen binding and regulation of cell-mediated cytotoxicity. Proc Natl Acad Sci U S A. 2014 Jun 17; 111(24):8867-72. PMID: 24821759.
      View in: PubMed
    66. Honda S, Kirino Y, Kirino Y. Analysis of sDMA modifications of PIWI proteins. Methods Mol Biol. 2014; 1093:137-48. PMID: 24178562.
      View in: PubMed
    67. Shigematsu M, Honda S, Kirino Y. Transfer RNA as a source of small functional RNA. J Mol Biol Mol Imaging. 2014; 1(2). PMID: 26389128.
      View in: PubMed
    68. Yoshimi R, Hama M, Minegishi K, Kishimoto D, Watanabe T, Kamiyama R, Kirino Y, Asami Y, Ihata A, Tsunoda S, Ueda A, Takeno M, Ishigatsubo Y. Ultrasonography predicts achievement of Boolean remission after DAS28-based clinical remission of rheumatoid arthritis. Mod Rheumatol. 2014 Jul; 24(4):590-8. PMID: 24289200.
      View in: PubMed
    69. Honda S, Kirino Y, Maragkakis M, Alexiou P, Ohtaki A, Murali R, Mourelatos Z, Kirino Y. Mitochondrial protein BmPAPI modulates the length of mature piRNAs. RNA. 2013 Oct; 19(10):1405-18. PMID: 23970546.
      View in: PubMed
    70. Kirino Y, Zhou Q, Ishigatsubo Y, Mizuki N, Tugal-Tutkun I, Seyahi E, Özyazgan Y, Ugurlu S, Erer B, Abaci N, Ustek D, Meguro A, Ueda A, Takeno M, Inoko H, Ombrello MJ, Satorius CL, Maskeri B, Mullikin JC, Sun HW, Gutierrez-Cruz G, Kim Y, Wilson AF, Kastner DL, Gül A, Remmers EF. Targeted resequencing implicates the familial Mediterranean fever gene MEFV and the toll-like receptor 4 gene TLR4 in Behçet disease. Proc Natl Acad Sci U S A. 2013 May 14; 110(20):8134-9. PMID: 23633568.
      View in: PubMed
    71. Kirino Y, Bertsias G, Ishigatsubo Y, Mizuki N, Tugal-Tutkun I, Seyahi E, Ozyazgan Y, Sacli FS, Erer B, Inoko H, Emrence Z, Cakar A, Abaci N, Ustek D, Satorius C, Ueda A, Takeno M, Kim Y, Wood GM, Ombrello MJ, Meguro A, Gül A, Remmers EF, Kastner DL. Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1. Nat Genet. 2013 Feb; 45(2):202-7. PMID: 23291587.
      View in: PubMed
    72. Suzuki R, Honda S, Kirino Y. PIWI Expression and Function in Cancer. Front Genet. 2012; 3:204. PMID: 23087701.
      View in: PubMed
    73. Vourekas A, Zheng Q, Alexiou P, Maragkakis M, Kirino Y, Gregory BD, Mourelatos Z. Mili and Miwi target RNA repertoire reveals piRNA biogenesis and function of Miwi in spermiogenesis. Nat Struct Mol Biol. 2012 Aug; 19(8):773-81. PMID: 22842725.
      View in: PubMed
    74. Hama M, Kirino Y, Takeno M, Takase K, Miyazaki T, Yoshimi R, Ueda A, Itoh-Nakadai A, Muto A, Igarashi K, Ishigatsubo Y. Bach1 regulates osteoclastogenesis in a mouse model via both heme oxygenase 1-dependent and heme oxygenase 1-independent pathways. Arthritis Rheum. 2012 May; 64(5):1518-28. PMID: 22127667.
      View in: PubMed
    75. Kirino Y. [Role of arginine methylation in the Piwi-interacting RNA pathway]. Seikagaku. 2011 Apr; 83(4):312-6. PMID: 21626884.
      View in: PubMed
    76. Kirino Y, Vourekas A, Khandros E, Mourelatos Z. Immunoprecipitation of piRNPs and directional, next generation sequencing of piRNAs. Methods Mol Biol. 2011; 725:281-93. PMID: 21528460.
      View in: PubMed
    77. Mimaki M, Hatakeyama H, Komaki H, Yokoyama M, Arai H, Kirino Y, Suzuki T, Nishino I, Nonaka I, Goto Y. Reversible infantile respiratory chain deficiency: a clinical and molecular study. Ann Neurol. 2010 Dec; 68(6):845-54. PMID: 21194154.
      View in: PubMed
    78. Vourekas A, Kirino Y, Mourelatos Z. Elective affinities: a Tudor-Aubergine tale of germline partnership. Genes Dev. 2010 Sep 15; 24(18):1963-6. PMID: 20844011.
      View in: PubMed
    79. Remmers EF, Cosan F, Kirino Y, Ombrello MJ, Abaci N, Satorius C, Le JM, Yang B, Korman BD, Cakiris A, Aglar O, Emrence Z, Azakli H, Ustek D, Tugal-Tutkun I, Akman-Demir G, Chen W, Amos CI, Dizon MB, Kose AA, Azizlerli G, Erer B, Brand OJ, Kaklamani VG, Kaklamanis P, Ben-Chetrit E, Stanford M, Fortune F, Ghabra M, Ollier WE, Cho YH, Bang D, O'Shea J, Wallace GR, Gadina M, Kastner DL, Gül A. Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease. Nat Genet. 2010 Aug; 42(8):698-702. PMID: 20622878.
      View in: PubMed
    80. Miyazaki T, Kirino Y, Takeno M, Samukawa S, Hama M, Tanaka M, Yamaji S, Ueda A, Tomita N, Fujita H, Ishigatsubo Y. Expression of heme oxygenase-1 in human leukemic cells and its regulation by transcriptional repressor Bach1. Cancer Sci. 2010 Jun; 101(6):1409-16. PMID: 20345481.
      View in: PubMed
    81. Ishigatsubo Y, Ihata A, Kobayashi H, Hama M, Kirino Y, Ueda A, Takeno M, Shirai A, Ohno S. Therapeutic angiogenesis in patients with systemic sclerosis by autologous transplantation of bone-marrow-derived cells. Mod Rheumatol. 2010 Jun; 20(3):263-72. PMID: 20169390.
      View in: PubMed
    82. Ideguchi H, Suda A, Takeno M, Kirino Y, Ihata A, Ueda A, Ohno S, Baba Y, Kuroiwa Y, Ishigatsubo Y. Neurological manifestations of Behçet's disease in Japan: a study of 54 patients. J Neurol. 2010 Jun; 257(6):1012-20. PMID: 20127350.
      View in: PubMed
    83. Miyazaki T, Kirino Y, Takeno M, Hama M, Ushihama A, Watanabe R, Takase K, Tachibana T, Matsumoto K, Tanaka M, Yamaji S, Ideguchi H, Tomita N, Fujita H, Ohno S, Ueda A, Ishigatsubo Y. Serum HO-1 is useful to make differential diagnosis of secondary hemophagocytic syndrome from other similar hematological conditions. Int J Hematol. 2010 Mar; 91(2):229-37. PMID: 20091384.
      View in: PubMed
    84. Kirino Y, Vourekas A, Kim N, de Lima Alves F, Rappsilber J, Klein PS, Jongens TA, Mourelatos Z. Arginine methylation of vasa protein is conserved across phyla. J Biol Chem. 2010 Mar 12; 285(11):8148-54. PMID: 20080973.
      View in: PubMed
    85. Kirino Y, Vourekas A, Sayed N, de Lima Alves F, Thomson T, Lasko P, Rappsilber J, Jongens TA, Mourelatos Z. Arginine methylation of Aubergine mediates Tudor binding and germ plasm localization. RNA. 2010 Jan; 16(1):70-8. PMID: 19926723.
      View in: PubMed
    86. Kirino Y, Ihata A, Shizukuishi K, Hama M, Takase K, Suda A, Ueda A, Ohno S, Takeno M, Ishigatsubo Y. Multiple extra-articular synovial cysts complicated with rheumatoid arthritis. Mod Rheumatol. 2009; 19(5):563-6. PMID: 19526305.
      View in: PubMed
    87. Kirino Y, Kim N, de Planell-Saguer M, Khandros E, Chiorean S, Klein PS, Rigoutsos I, Jongens TA, Mourelatos Z. Arginine methylation of Piwi proteins catalysed by dPRMT5 is required for Ago3 and Aub stability. Nat Cell Biol. 2009 May; 11(5):652-8. PMID: 19377467.
      View in: PubMed
    88. Murakami S, Takeno M, Kirino Y, Kobayashi M, Watanabe R, Kudo M, Ihata A, Ueda A, Ohno S, Watanuki Y, Kaneko T, Ishigatsubo Y. Screening of tuberculosis by interferon-gamma assay before biologic therapy for rheumatoid arthritis. Tuberculosis (Edinb). 2009 Mar; 89(2):136-41. PMID: 19211305.
      View in: PubMed
    89. Kobayashi M, Miyazawa N, Takeno M, Murakami S, Kirino Y, Okouchi A, Kaneko T, Ishigatsubo Y. Circulating carbon monoxide level is elevated after sleep in patients with obstructive sleep apnea. Chest. 2008 Nov; 134(5):904-10. PMID: 18988776.
      View in: PubMed
    90. Kirino Y, Mourelatos Z. Site-specific crosslinking of human microRNPs to RNA targets. RNA. 2008 Oct; 14(10):2254-9. PMID: 18719246.
      View in: PubMed
    91. Kirino M, Kirino Y, Takeno M, Nagashima Y, Takahashi K, Kobayashi M, Murakami S, Hirasawa T, Ueda A, Aihara M, Ikezawa Z, Ishigatsubo Y. Heme oxygenase 1 attenuates the development of atopic dermatitis-like lesions in mice: implications for human disease. J Allergy Clin Immunol. 2008 Aug; 122(2):290-7, 297.e1-8. PMID: 18582925.
      View in: PubMed
    92. Kurata S, Weixlbaumer A, Ohtsuki T, Shimazaki T, Wada T, Kirino Y, Takai K, Watanabe K, Ramakrishnan V, Suzuki T. Modified uridines with C5-methylene substituents at the first position of the tRNA anticodon stabilize U.G wobble pairing during decoding. J Biol Chem. 2008 Jul 4; 283(27):18801-11. PMID: 18456657.
      View in: PubMed
    93. Kirino Y, Takeno M, Watanabe R, Murakami S, Kobayashi M, Ideguchi H, Ihata A, Ohno S, Ueda A, Mizuki N, Ishigatsubo Y. Association of reduced heme oxygenase-1 with excessive Toll-like receptor 4 expression in peripheral blood mononuclear cells in Behçet's disease. Arthritis Res Ther. 2008; 10(1):R16. PMID: 18234118.
      View in: PubMed
    94. Kirino Y, Mourelatos Z. The mouse homolog of HEN1 is a potential methylase for Piwi-interacting RNAs. RNA. 2007 Sep; 13(9):1397-401. PMID: 17652135.
      View in: PubMed
    95. Kirino Y, Mourelatos Z. Mouse Piwi-interacting RNAs are 2'-O-methylated at their 3' termini. Nat Struct Mol Biol. 2007 Apr; 14(4):347-8. PMID: 17384647.
      View in: PubMed
    96. Kirino Y, Takeno M, Murakami S, Kobayashi M, Kobayashi H, Miura K, Ideguchi H, Ohno S, Ueda A, Ishigatsubo Y. Tumor necrosis factor alpha acceleration of inflammatory responses by down-regulating heme oxygenase 1 in human peripheral monocytes. Arthritis Rheum. 2007 Feb; 56(2):464-75. PMID: 17265482.
      View in: PubMed
    97. Kirino Y, Mourelatos Z. 2'-O-methyl modification in mouse piRNAs and its methylase. Nucleic Acids Symp Ser (Oxf). 2007; (51):417-8. PMID: 18029764.
      View in: PubMed
    98. Noma A, Kirino Y, Ikeuchi Y, Suzuki T. Biosynthesis of wybutosine, a hyper-modified nucleoside in eukaryotic phenylalanine tRNA. EMBO J. 2006 May 17; 25(10):2142-54. PMID: 16642040.
      View in: PubMed
    99. Kobayashi H, Takeno M, Saito T, Takeda Y, Kirino Y, Noyori K, Hayashi T, Ueda A, Ishigatsubo Y. Regulatory role of heme oxygenase 1 in inflammation of rheumatoid arthritis. Arthritis Rheum. 2006 Apr; 54(4):1132-42. PMID: 16572448.
      View in: PubMed
    100. Kirino Y, Yasukawa T, Marjavaara SK, Jacobs HT, Holt IJ, Watanabe K, Suzuki T. Acquisition of the wobble modification in mitochondrial tRNALeu(CUN) bearing the G12300A mutation suppresses the MELAS molecular defect. Hum Mol Genet. 2006 Mar 15; 15(6):897-904. PMID: 16446307.
      View in: PubMed
    101. Yoshimi R, Takeno M, Yamanaka S, Shiina M, Kirino Y, Takeda Y, Sekiguchi A, Kobayashi H, Ihata A, Motoji K, Ohno S, Ueda A, Soga T, Ishigatsubo Y. Systemic sclerosis and pseudomesotheliomatous adenocarcinoma of the lung. Mod Rheumatol. 2006; 16(3):165-8. PMID: 16767555.
      View in: PubMed
    102. Yasukawa T, Kirino Y, Ishii N, Holt IJ, Jacobs HT, Makifuchi T, Fukuhara N, Ohta S, Suzuki T, Watanabe K. Wobble modification deficiency in mutant tRNAs in patients with mitochondrial diseases. FEBS Lett. 2005 May 23; 579(13):2948-52. PMID: 15893315.
      View in: PubMed
    103. Kirino Y, Goto Y, Campos Y, Arenas J, Suzuki T. Specific correlation between the wobble modification deficiency in mutant tRNAs and the clinical features of a human mitochondrial disease. Proc Natl Acad Sci U S A. 2005 May 17; 102(20):7127-32. PMID: 15870203.
      View in: PubMed
    104. Kirino Y, Suzuki T. Human mitochondrial diseases associated with tRNA wobble modification deficiency. RNA Biol. 2005 Apr; 2(2):41-4. PMID: 17132941.
      View in: PubMed
    105. Kirino Y, Takeno M, Iwasaki M, Ueda A, Ohno S, Shirai A, Kanamori H, Tanaka K, Ishigatsubo Y. Increased serum HO-1 in hemophagocytic syndrome and adult-onset Still's disease: use in the differential diagnosis of hyperferritinemia. Arthritis Res Ther. 2005; 7(3):R616-24. PMID: 15899048.
      View in: PubMed
    106. Aoki A, Kirino Y, Ishigatsubo Y, Senuma A, Nagaoka S. [Liver involvement in primary Sjogren's syndrome]. Nihon Rinsho Meneki Gakkai Kaishi. 2004 Dec; 27(6):397-401. PMID: 15678893.
      View in: PubMed
    107. Kirino Y, Yasukawa T, Ohta S, Akira S, Ishihara K, Watanabe K, Suzuki T. Codon-specific translational defect caused by a wobble modification deficiency in mutant tRNA from a human mitochondrial disease. Proc Natl Acad Sci U S A. 2004 Oct 19; 101(42):15070-5. PMID: 15477592.
      View in: PubMed
    108. Kirino Y, Tsuji T, Ohno S, Yoshimi R, Takeda Y, Misumi M, Inoue Y, Ueda A, Takeno M, Ishigatsubo Y. [A solitary lung lesion in Wegener's granulomatosis, which was difficult to differentiate from lung neoplasm]. Ryumachi. 2003 Feb; 43(1):39-43. PMID: 12692988.
      View in: PubMed
    109. Kurata S, Ohtsuki T, Wada T, Kirino Y, Takai K, Saigo K, Watanabe K, Suzuki T. Decoding property of C5 uridine modification at the wobble position of tRNA anticodon. Nucleic Acids Res Suppl. 2003; (3):245-6. PMID: 14510472.
      View in: PubMed
    Kirino's Networks
    Click the "See All" links for more information and interactive visualizations!
    Same Department Expand Description