Protein Synthesis Inhibitors

"Protein Synthesis Inhibitors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Compounds which inhibit the synthesis of proteins. They are usually ANTI-BACTERIAL AGENTS or toxins. Mechanism of the action of inhibition includes the interruption of peptide-chain elongation, the blocking the A site of ribosomes, the misreading of the genetic code or the prevention of the attachment of oligosaccharide side chains to glycoproteins.

Descriptor ID	D011500
MeSH Number(s)	D27.505.519.389.760
Concept/Terms	Protein Synthesis Inhibitors Protein Synthesis Inhibitors Inhibitors, Protein Synthesis Protein Synthesis Antagonists Antagonists, Protein Synthesis

Below are MeSH descriptors whose meaning is more general than "Protein Synthesis Inhibitors".

Chemicals and Drugs [D]
Chemical Actions and Uses [D27]
Pharmacologic Actions [D27.505]
Molecular Mechanisms of Pharmacological Action [D27.505.519]
Enzyme Inhibitors [D27.505.519.389]
Protein Synthesis Inhibitors [D27.505.519.389.760]

Below are MeSH descriptors whose meaning is related to "Protein Synthesis Inhibitors".

Below are MeSH descriptors whose meaning is more specific than "Protein Synthesis Inhibitors".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Protein Synthesis Inhibitors" by people in this website by year, and whether "Protein Synthesis Inhibitors" was a major or minor topic of these publications.

Bar chart showing 34 publications over 17 distinct years, with a maximum of 6 publications in 2002

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	3	3
1997	1	2	3
1998	0	1	1
1999	0	1	1
2000	0	1	1
2001	0	4	4
2002	0	6	6
2004	1	1	2
2005	1	1	2
2007	1	1	2
2008	0	1	1
2011	0	1	1
2012	2	0	2
2013	0	2	2
2015	1	0	1
2017	0	1	1
2018	0	1	1

Below are the most recent publications written about "Protein Synthesis Inhibitors" by people in Profiles.

MacGibeny MA, Koyuncu OO, Wirblich C, Schnell MJ, Enquist LW. Retrograde axonal transport of rabies virus is unaffected by interferon treatment but blocked by emetine locally in axons. PLoS Pathog. 2018 07; 14(7):e1007188.

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Ohguchi Y, Nomura T, Suzuki S, Takeda M, Miyauchi T, Mizuno O, Shinkuma S, Fujita Y, Nemoto O, Ono K, McLean WHI, Shimizu H. Gentamicin-Induced Readthrough and Nonsense-Mediated mRNA Decay of SERPINB7 Nonsense Mutant Transcripts. J Invest Dermatol. 2018 04; 138(4):836-843.

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Lamb R, Harrison H, Smith DL, Townsend PA, Jackson T, Ozsvari B, Martinez-Outschoorn UE, Pestell RG, Howell A, Lisanti MP, Sotgia F. Targeting tumor-initiating cells: eliminating anabolic cancer stem cells with inhibitors of protein synthesis or by mimicking caloric restriction. Oncotarget. 2015 Mar 10; 6(7):4585-601.

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Pucci MJ, Bush K. Investigational antimicrobial agents of 2013. Clin Microbiol Rev. 2013 Oct; 26(4):792-821.

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Abbas T, Mueller AC, Shibata E, Keaton M, Rossi M, Dutta A. CRL1-FBXO11 promotes Cdt2 ubiquitylation and degradation and regulates Pr-Set7/Set8-mediated cellular migration. Mol Cell. 2013 Mar 28; 49(6):1147-58.

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Kurata S, Shen B, Liu JO, Takeuchi N, Kaji A, Kaji H. Possible steps of complete disassembly of post-termination complex by yeast eEF3 deduced from inhibition by translocation inhibitors. Nucleic Acids Res. 2013 Jan 07; 41(1):264-76.

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Liu T, Nair SJ, Lescarbeau A, Belani J, Peluso S, Conley J, Tillotson B, O'Hearn P, Smith S, Slocum K, West K, Helble J, Douglas M, Bahadoor A, Ali J, McGovern K, Fritz C, Palombella VJ, Wylie A, Castro AC, Tremblay MR. Synthetic silvestrol analogues as potent and selective protein synthesis inhibitors. J Med Chem. 2012 Oct 25; 55(20):8859-78.

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Bush K, Pucci MJ. New antimicrobial agents on the horizon. Biochem Pharmacol. 2011 Dec 01; 82(11):1528-39.

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G?ller M, Toualbi-Abed K, Legrand A, Michel L, Mauviel A, Bernuau D, Daniel F. c-Fos overexpression increases the proliferation of human hepatocytes by stabilizing nuclear Cyclin D1. World J Gastroenterol. 2008 Nov 07; 14(41):6339-46.

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Pyrko P, Kardosh A, Sch?nthal AH. Celecoxib transiently inhibits cellular protein synthesis. Biochem Pharmacol. 2008 Jan 15; 75(2):395-404.

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