The TLR7 agonist, imiquimod, increases IFN-beta production and reduces the severity of experimental autoimmune encephalomyelitis.
O'Brien K, Fitzgerald D, Rostami A, Gran B. The TLR7 agonist, imiquimod, increases IFN-beta production and reduces the severity of experimental autoimmune encephalomyelitis. J Neuroimmunol. 2010 Apr 15; 221(1-2):107-11.
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Adjuvants, Immunologic
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Aminoquinolines
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Animals
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Cell Proliferation
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Dose-Response Relationship, Drug
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Encephalomyelitis, Autoimmune, Experimental
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Female
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Interferon-beta
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Leukocytes, Mononuclear
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Mice
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Mice, Inbred C57BL
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Mice, Knockout
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Receptor, Interferon alpha-beta
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RNA, Messenger
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Severity of Illness Index
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Statistics, Nonparametric
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T-Lymphocytes