Computational design and biophysical characterization of aggregation-resistant point mutations for ?D crystallin illustrate a balance of conformational stability and intrinsic aggregation propensity.

Sahin E, Jordan JL, Spatara ML, Naranjo A, Costanzo JA, Weiss WF, Robinson AS, Fernandez EJ, Roberts CJ. Computational design and biophysical characterization of aggregation-resistant point mutations for ?D crystallin illustrate a balance of conformational stability and intrinsic aggregation propensity. Biochemistry. 2011 Feb 8; 50(5):628-39.

View in: PubMed

subject areas

authors with profiles

Anne Skaja Robinson

The Thomas Jefferson University web site, its contents and programs, is provided for informational and educational purposes only and is not intended as medical advice nor is it intended to create any physician-patient relationship. Please remember that this information should not substitute for a visit or a consultation with a health care provider. The views or opinions expressed in the resources provided do not necessarily reflect those of Thomas Jefferson University, Thomas Jefferson University Hospital, or the Jefferson Health System or staff.
Please read our Privacy Statement