Combined loss of INK4a and caveolin-1 synergistically enhances cell proliferation and oncogene-induced tumorigenesis: role of INK4a/CAV-1 in mammary epithelial cell hyperplasia.
Williams TM, Lee H, Cheung MW, Cohen AW, Razani B, Iyengar P, Scherer PE, Pestell RG, Lisanti MP. Combined loss of INK4a and caveolin-1 synergistically enhances cell proliferation and oncogene-induced tumorigenesis: role of INK4a/CAV-1 in mammary epithelial cell hyperplasia. J Biol Chem. 2004 Jun 4; 279(23):24745-56.
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Animals
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Blotting, Western
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Caveolin 1
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Caveolins
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Cell Division
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Cell Line, Transformed
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Cell Transformation, Neoplastic
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Cells, Cultured
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Crosses, Genetic
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Cyclin D1
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Cyclin-Dependent Kinase Inhibitor p16
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Cyclin-Dependent Kinase Inhibitor p21
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Cyclins
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Disease Progression
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Enzyme Activation
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Epithelial Cells
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Fibroblasts
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Flow Cytometry
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Gene Expression Regulation, Neoplastic
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Genes, Reporter
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Hyperplasia
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Immunoblotting
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Mammary Glands, Animal
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Mice
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Mice, Inbred C57BL
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Mice, Nude
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Mice, Transgenic
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Mitogen-Activated Protein Kinase 1
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Mitogen-Activated Protein Kinase 3
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Mitogen-Activated Protein Kinases
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Models, Genetic
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Neoplasm Transplantation
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Phenotype
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Retroviridae
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RNA, Messenger
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Signal Transduction
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src-Family Kinases
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Time Factors