Robert Fleming

TitleProfessor
InstitutionJefferson University - East Falls Campus
DepartmentSustainable Design
Address4201 Henry Ave
Philadelphia PA 19144
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Parrow NL, Violet PC, George NA, Ali F, Bhanvadia S, Wong R, Tisdale JF, Fitzhugh C, Levine M, Thein SL, Fleming RE. Dietary iron restriction improves markers of disease severity in murine sickle cell anemia. Blood. 2021 Mar 18; 137(11):1553-1555. PMID: 33512468.
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    2. Fleming RE, Parrow NL. Maternal hepcidin: the only player on the field? Blood. 2020 Nov 05; 136(19):2099-2100. PMID: 33152087.
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    3. Verhaeghe R, George K, Westerman M, Olbina G, McCann D, Parrow N, Pincus E, Havranek T, Fleming RE. Hepcidin Status at 2 Months in Infants Fed Breast Milk Compared with Formula. Neonatology. 2020 Aug 20; 1-6. PMID: 32818935.
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    4. Parrow NL, Fleming RE. The selfishly selfless placenta. J Clin Invest. 2019 Dec 17. PMID: 31845907.
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    5. Casu C, Chessa R, Liu A, Gupta R, Drakesmith H, Fleming R, Ginzburg YZ, MacDonald B, Rivella S. Minihepcidins improve ineffective erythropoiesis and splenomegaly in a new mouse model of adult beta-thalassemia major. Haematologica. 2019 Oct 03. PMID: 31582543.
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    6. Parrow NL, Li Y, Feola M, Guerra A, Casu C, Prasad P, Mammen L, Ali F, Vaicikauskas E, Rivella S, Ginzburg YZ, Fleming RE. Lobe specificity of iron-binding to transferrin modulates murine erythropoiesis and iron homeostasis. Blood. 2019 Aug 21. PMID: 31434707.
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    7. Delaney KM, Guillet R, Fleming RE, Ru Y, Pressman EK, Vermeylen F, Nemeth E, O'Brien KO. Umbilical Cord Serum Ferritin Concentration is Inversely Associated with Umbilical Cord Hemoglobin in Neonates Born to Adolescents Carrying Singletons and Women Carrying Multiples. J Nutr. 2019 Mar 01; 149(3):406-415. PMID: 30770543.
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    8. Ginzburg YZ, Fleming RE. Tfr2 suppression benefits ß-thalassemic erythropoiesis. Blood. 2018 Nov 22; 132(21):2215-2216. PMID: 30467188.
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    9. Parrow NL, Violet PC, Tu H, Nichols J, Pittman CA, Fitzhugh C, Fleming RE, Mohandas N, Tisdale JF, Levine M. Measuring Deformability and Red Cell Heterogeneity in Blood by Ektacytometry. J Vis Exp. 2018 Jan 12; (131). PMID: 29364234.
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    10. Parrow NL, Fleming RE. Releasing the FKBP12 brake on hepcidin. Blood. 2017 11 09; 130(19):2049-2050. PMID: 29122771.
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    11. Khalil S, Holy M, Grado S, Fleming R, Kurita R, Nakamura Y, Goldfarb A. A specialized pathway for erythroid iron delivery through lysosomal trafficking of transferrin receptor 2. Blood Adv. 2017 Jun 27; 1(15):1181-1194. PMID: 29296759.
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    12. MacQueen BC, Baer VL, Scott DM, Ling CY, O'Brien EA, Boyer C, Henry E, Fleming RE, Christensen RD. Iron Supplements for Infants at Risk for Iron Deficiency. Glob Pediatr Health. 2017; 4:2333794X17703836. PMID: 28491927.
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    13. Parrow NL, Tu H, Nichols J, Violet PC, Pittman CA, Fitzhugh C, Fleming RE, Mohandas N, Tisdale JF, Levine M. Measurements of red cell deformability and hydration reflect HbF and HbA2 in blood from patients with sickle cell anemia. Blood Cells Mol Dis. 2017 Jun; 65:41-50. PMID: 28472705.
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    14. Li H, Choesang T, Bao W, Chen H, Feola M, Garcia-Santos D, Li J, Sun S, Follenzi A, Pham P, Liu J, Zhang J, Ponka P, An X, Mohandas N, Fleming RE, Rivella S, Li G, Ginzburg YZ. Decreasing TfR1 expression reverses anemia and hepcidin suppression in ß-thalassemic mice. Blood. 2017 Mar 16; 129(11):1514-1526. PMID: 28151426.
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    15. Parrow NL, Fleming RE. Liver sinusoidal endothelial cells as iron sensors. Blood. 2017 Jan 26; 129(4):397-398. PMID: 28126953.
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    16. Glick JB, Craiglow BG, Choate KA, Kato H, Fleming RE, Siegfried E, Glick SA. Improved Management of Harlequin Ichthyosis With Advances in Neonatal Intensive Care. Pediatrics. 2017 Jan; 139(1). PMID: 27999114.
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    17. Casu C, Oikonomidou PR, Chen H, Nandi V, Ginzburg Y, Prasad P, Fleming RE, Shah YM, Valore EV, Nemeth E, Ganz T, MacDonald B, Rivella S. Minihepcidin peptides as disease modifiers in mice affected by ß-thalassemia and polycythemia vera. Blood. 2016 Jul 14; 128(2):265-76. PMID: 27154187; PMCID: PMC4946204.
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    18. Chen H, Choesang T, Li H, Sun S, Pham P, Bao W, Feola M, Westerman M, Li G, Follenzi A, Blanc L, Rivella S, Fleming RE, Ginzburg YZ. Increased hepcidin in transferrin-treated thalassemic mice correlates with increased liver BMP2 expression and decreased hepatocyte ERK activation. Haematologica. 2016 Mar; 101(3):297-308. PMID: 26635037; PMCID: PMC4815721.
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    19. Lee SM, Loguinov A, Fleming RE, Vulpe CD. Effects of strain and age on hepatic gene expression profiles in murine models of HFE-associated hereditary hemochromatosis. Genes Nutr. 2015 Jan; 10(1):443. PMID: 25427953; PMCID: PMC4245401.
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    20. Parrow NL, Fleming RE. Bone morphogenetic proteins as regulators of iron metabolism. Annu Rev Nutr. 2014; 34:77-94. PMID: 24995692.
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    21. Parrow NL, Fleming RE, Minnick MF. Sequestration and scavenging of iron in infection. Infect Immun. 2013 Oct; 81(10):3503-14. PMID: 23836822; PMCID: PMC3811770.
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    22. Galesloot TE, Geurts-Moespot AJ, den Heijer M, Sweep FC, Fleming RE, Kiemeney LA, Vermeulen SH, Swinkels DW. Associations of common variants in HFE and TMPRSS6 with iron parameters are independent of serum hepcidin in a general population: a replication study. J Med Genet. 2013 Sep; 50(9):593-8. PMID: 23794717.
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    23. Vujic Spasic M, Sparla R, Mleczko-Sanecka K, Migas MC, Breitkopf-Heinlein K, Dooley S, Vaulont S, Fleming RE, Muckenthaler MU. Smad6 and Smad7 are co-regulated with hepcidin in mouse models of iron overload. Biochim Biophys Acta. 2013 Jan; 1832(1):76-84. PMID: 22960056.
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    24. Feng Q, Migas MC, Waheed A, Britton RS, Fleming RE. Ferritin upregulates hepatic expression of bone morphogenetic protein 6 and hepcidin in mice. Am J Physiol Gastrointest Liver Physiol. 2012 Jun 15; 302(12):G1397-404. PMID: 22517766; PMCID: PMC3378091.
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    25. Parrow NL, Gardenghi S, Ramos P, Casu C, Grady RW, Anderson ER, Shah YM, Li H, Ginzburg YZ, Fleming RE, Rivella S. Decreased hepcidin expression in murine ß-thalassemia is associated with suppression of Bmp/Smad signaling. Blood. 2012 Mar 29; 119(13):3187-9. PMID: 22461476.
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    26. Fleming RE, Ponka P. Iron overload in human disease. N Engl J Med. 2012 Jan 26; 366(4):348-59. PMID: 22276824.
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    27. Kroot JJ, Tjalsma H, Fleming RE, Swinkels DW. Hepcidin in human iron disorders: diagnostic implications. Clin Chem. 2011 Dec; 57(12):1650-69. PMID: 21989113.
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    28. Fleming RE, Feng Q, Britton RS. Knockout mouse models of iron homeostasis. Annu Rev Nutr. 2011 Aug 21; 31:117-37. PMID: 21548776.
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    29. Corradini E, Rozier M, Meynard D, Odhiambo A, Lin HY, Feng Q, Migas MC, Britton RS, Babitt JL, Fleming RE. Iron regulation of hepcidin despite attenuated Smad1,5,8 signaling in mice without transferrin receptor 2 or Hfe. Gastroenterology. 2011 Nov; 141(5):1907-14. PMID: 21745449; PMCID: PMC3634343.
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    30. Swinkels DW, Fleming RE. Novel observations in hereditary hemochromatosis: potential implications for clinical strategies. Haematologica. 2011 Apr; 96(4):485-8. PMID: 21454877; PMCID: PMC3069220.
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    31. Castoldi M, Vujic Spasic M, Altamura S, Elmén J, Lindow M, Kiss J, Stolte J, Sparla R, D'Alessandro LA, Klingmüller U, Fleming RE, Longerich T, Gröne HJ, Benes V, Kauppinen S, Hentze MW, Muckenthaler MU. The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice. J Clin Invest. 2011 Apr; 121(4):1386-96. PMID: 21364282; PMCID: PMC3069782.
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    32. Tjalsma H, Laarakkers CM, van Swelm RP, Theurl M, Theurl I, Kemna EH, van der Burgt YE, Venselaar H, Dutilh BE, Russel FG, Weiss G, Masereeuw R, Fleming RE, Swinkels DW. Mass spectrometry analysis of hepcidin peptides in experimental mouse models. PLoS One. 2011 Mar 08; 6(3):e16762. PMID: 21408141; PMCID: PMC3050808.
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    33. Gao J, Chen J, De Domenico I, Koeller DM, Harding CO, Fleming RE, Koeberl DD, Enns CA. Hepatocyte-targeted HFE and TFR2 control hepcidin expression in mice. Blood. 2010 Apr 22; 115(16):3374-81. PMID: 20177050; PMCID: PMC2858491.
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    34. Chua AC, Delima RD, Morgan EH, Herbison CE, Tirnitz-Parker JE, Graham RM, Fleming RE, Britton RS, Bacon BR, Olynyk JK, Trinder D. Iron uptake from plasma transferrin by a transferrin receptor 2 mutant mouse model of haemochromatosis. J Hepatol. 2010 Mar; 52(3):425-31. PMID: 20133002; PMCID: PMC2880807.
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    35. Rodriguez A, Luukkaala T, Fleming RE, Britton RS, Bacon BR, Parkkila S. Global transcriptional response to Hfe deficiency and dietary iron overload in mouse liver and duodenum. PLoS One. 2009 Sep 29; 4(9):e7212. PMID: 19787063; PMCID: PMC2747280.
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    36. Hänninen MM, Haapasalo J, Haapasalo H, Fleming RE, Britton RS, Bacon BR, Parkkila S. Expression of iron-related genes in human brain and brain tumors. BMC Neurosci. 2009 Apr 22; 10:36. PMID: 19386095; PMCID: PMC2679039.
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    37. John BK, Dang NC, Hussain SA, Yang GC, Cham MD, Yantiss R, Joseph AS, Giashuddin SM, Lee PC, Fleming R, Somnay K. Multifocal granular cell tumor presenting as an esophageal stricture. J Gastrointest Cancer. 2008; 39(1-4):107-13. PMID: 19340612.
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    38. Fleming RE. Iron sensing as a partnership: HFE and transferrin receptor 2. Cell Metab. 2009 Mar; 9(3):211-2. PMID: 19254564.
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    39. Lesnikov V, Gorden N, Fausto N, Spaulding E, Campbell J, Shulman H, Fleming RE, Deeg HJ. Transferrin fails to provide protection against Fas-induced hepatic injury in mice with deletion of functional transferrin-receptor type 2. Apoptosis. 2008 Aug; 13(8):1005-12. PMID: 18561026; PMCID: PMC2574612.
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    40. Fleming RE. Iron and inflammation: cross-talk between pathways regulating hepcidin. J Mol Med (Berl). 2008 May; 86(5):491-4. PMID: 18425494.
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    41. Waheed A, Britton RS, Grubb JH, Sly WS, Fleming RE. HFE association with transferrin receptor 2 increases cellular uptake of transferrin-bound iron. Arch Biochem Biophys. 2008 Jun 01; 474(1):193-7. PMID: 18353247.
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    42. Rodriguez A, Hilvo M, Kytömäki L, Fleming RE, Britton RS, Bacon BR, Parkkila S. Effects of iron loading on muscle: genome-wide mRNA expression profiling in the mouse. BMC Genomics. 2007 Oct 19; 8:379. PMID: 17949489; PMCID: PMC2151772.
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    43. Fleming RE. Hepcidin activation during inflammation: make it STAT. Gastroenterology. 2007 Jan; 132(1):447-9. PMID: 17241894.
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    44. Gouya L, Muzeau F, Robreau AM, Letteron P, Couchi E, Lyoumi S, Deybach JC, Puy H, Fleming R, Demant P, Beaumont C, Grandchamp B. Genetic study of variation in normal mouse iron homeostasis reveals ceruloplasmin as an HFE-hemochromatosis modifier gene. Gastroenterology. 2007 Feb; 132(2):679-86. PMID: 17258727.
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    45. Fleming RE, Britton RS. Iron Imports. VI. HFE and regulation of intestinal iron absorption. Am J Physiol Gastrointest Liver Physiol. 2006 Apr; 290(4):G590-4. PMID: 16537971.
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    46. Fleming RE, Britton RS, Waheed A, Sly WS, Bacon BR. Pathophysiology of hereditary hemochromatosis. Semin Liver Dis. 2005 Nov; 25(4):411-9. PMID: 16315135; PMCID: PMC2587012.
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    47. Fleming RE, Bacon BR. Orchestration of iron homeostasis. N Engl J Med. 2005 Apr 28; 352(17):1741-4. PMID: 15858181.
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    48. Fleming RE. Advances in understanding the molecular basis for the regulation of dietary iron absorption. Curr Opin Gastroenterol. 2005 Mar; 21(2):201-6. PMID: 15711214.
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    49. Fleming RE, Britton RS, Waheed A, Sly WS, Bacon BR. Pathogenesis of hereditary hemochromatosis. Clin Liver Dis. 2004 Nov; 8(4):755-73, vii. PMID: 15464654.
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    50. Kawabata H, Fleming RE, Gui D, Moon SY, Saitoh T, O'Kelly J, Umehara Y, Wano Y, Said JW, Koeffler HP. Expression of hepcidin is down-regulated in TfR2 mutant mice manifesting a phenotype of hereditary hemochromatosis. Blood. 2005 Jan 01; 105(1):376-81. PMID: 15345587.
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    51. Tomatsu S, Orii KO, Fleming RE, Holden CC, Waheed A, Britton RS, Gutierrez MA, Velez-Castrillon S, Bacon BR, Sly WS. Contribution of the H63D mutation in HFE to murine hereditary hemochromatosis. Proc Natl Acad Sci U S A. 2003 Dec 23; 100(26):15788-93. PMID: 14673107; PMCID: PMC307646.
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    52. Au M, Weber TR, Fleming RE. Successful use of somatostatin in a case of neonatal chylothorax. J Pediatr Surg. 2003 Jul; 38(7):1106-7. PMID: 12861552.
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    53. Hannuksela J, Parkkila S, Waheed A, Britton RS, Fleming RE, Bacon BR, Sly WS. Human platelets express hemochromatosis protein (HFE) and transferrin receptor 2. Eur J Haematol. 2003 Apr; 70(4):201-6. PMID: 12656741.
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    54. Ahmad KA, Ahmann JR, Migas MC, Waheed A, Britton RS, Bacon BR, Sly WS, Fleming RE. Decreased liver hepcidin expression in the Hfe knockout mouse. Blood Cells Mol Dis. 2002 Nov-Dec; 29(3):361-6. PMID: 12547226.
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    55. Fleming RE, Ahmann JR, Migas MC, Waheed A, Koeffler HP, Kawabata H, Britton RS, Bacon BR, Sly WS. Targeted mutagenesis of the murine transferrin receptor-2 gene produces hemochromatosis. Proc Natl Acad Sci U S A. 2002 Aug 06; 99(16):10653-8. PMID: 12134060; PMCID: PMC125003.
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    56. Britton RS, Fleming RE, Parkkila S, Waheed A, Sly WS, Bacon BR. Pathogenesis of hereditary hemochromatosis: genetics and beyond. Semin Gastrointest Dis. 2002 Apr; 13(2):68-79. PMID: 12064862.
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    57. Waheed A, Grubb JH, Zhou XY, Tomatsu S, Fleming RE, Costaldi ME, Britton RS, Bacon BR, Sly WS. Regulation of transferrin-mediated iron uptake by HFE, the protein defective in hereditary hemochromatosis. Proc Natl Acad Sci U S A. 2002 Mar 05; 99(5):3117-22. PMID: 11867720; PMCID: PMC122482.
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    58. Fleming RE. Cord serum ferritin levels, fetal iron status, and neurodevelopmental outcomes: correlations and confounding variables. J Pediatr. 2002 Feb; 140(2):145-8. PMID: 11865262.
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    59. Fleming RE, Sly WS. Mechanisms of iron accumulation in hereditary hemochromatosis. Annu Rev Physiol. 2002; 64:663-80. PMID: 11826284.
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