H-ras inhibits RhoA/ROCK leading to a decrease in the basal tone in the internal anal sphincter.
de Godoy MA, Patel CA, Waldman SA, Katsuki M, Regan RF, Rattan S. H-ras inhibits RhoA/ROCK leading to a decrease in the basal tone in the internal anal sphincter. Gastroenterology. 2007 Apr; 132(4):1401-9.