"Spermine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A biogenic polyamine formed from spermidine. It is found in a wide variety of organisms and tissues and is an essential growth factor in some bacteria. It is found as a polycation at all pH values. Spermine is associated with nucleic acids, particularly in viruses, and is thought to stabilize the helical structure.
| Descriptor ID |
D013096
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| MeSH Number(s) |
D02.092.211.415.701.801.821 D02.092.782.802
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Spermine".
Below are MeSH descriptors whose meaning is more specific than "Spermine".
This graph shows the total number of publications written about "Spermine" by people in this website by year, and whether "Spermine" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 1 | 0 | 1 |
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Below are the most recent publications written about "Spermine" by people in Profiles.
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Smith MA, Maris JM, Lock R, Kolb EA, Gorlick R, Keir ST, Carol H, Morton CL, Reynolds CP, Kang MH, Houghton PJ. Initial testing (stage 1) of the polyamine analog PG11047 by the pediatric preclinical testing program. Pediatr Blood Cancer. 2011 Aug; 57(2):268-74.
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Chen Y, Weeks RS, Burns MR, Boorman DW, Klein-Szanto A, O'Brien TG. Combination therapy with 2-difluoromethylornithine and a polyamine transport inhibitor against murine squamous cell carcinoma. Int J Cancer. 2006 May 01; 118(9):2344-9.
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Lewis JS, Vijayanathan V, Thomas TJ, Pestell RG, Albanese C, Gallo MA, Thomas T. Activation of cyclin D1 by estradiol and spermine in MCF-7 breast cancer cells: a mechanism involving the p38 MAP kinase and phosphorylation of ATF-2. Oncol Res. 2005; 15(3):113-28.
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Shangguan T, Cabral-Lilly D, Purandare U, Godin N, Ahl P, Janoff A, Meers P. A novel N-acyl phosphatidylethanolamine-containing delivery vehicle for spermine-condensed plasmid DNA. Gene Ther. 2000 May; 7(9):769-83.
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Shah N, Antony T, Haddad S, Amenta P, Shirahata A, Thomas TJ, Thomas T. Antitumor effects of bis(ethyl)polyamine analogs on mammary tumor development in FVB/NTgN (MMTVneu) transgenic mice. Cancer Lett. 1999 Nov 01; 146(1):15-23.
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Sparagna GC, Gunter KK, Sheu SS, Gunter TE. Mitochondrial calcium uptake from physiological-type pulses of calcium. A description of the rapid uptake mode. J Biol Chem. 1995 Nov 17; 270(46):27510-5.
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Kuo BS, Korner G, Dryjski M, Bjornsson TD. Role of polyamines in the stimulation of synthesis and secretion of plasminogen activator from bovine aortic endothelial cells. J Cell Physiol. 1988 Oct; 137(1):192-8.
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Bachrach U, Brem S, Wertman SB, Schnur LF, Greenblatt CL. Leishmania spp.: cellular levels and synthesis of polyamines during growth cycles. Exp Parasitol. 1979 Dec; 48(3):457-63.