Claudio Giraudo

TitleAssoc Professor
InstitutionThomas Jefferson University
DepartmentMicrobiology
Address233 S. 10th Street
Philadelphia PA 19107
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ouahed J, Kelsen JR, Spessott WA, Kooshesh K, Sanmillan ML, Dawany N, Sullivan KE, Hamilton K, Slowik V, Nejentsev S, Neves JF, Flores H, Chung WK, Wilson A, Yeboa KA, Wou K, Jain P, Field M, Tollefson S, Dent MH, Li D, Naito T, McGovern DPB, Kwong AC, Taliaferro F, Ordovas-Montanes J, Horwitz B, Kotlarz D, Klein C, Evans J, Dorsey J, Warner N, Elkadri A, Muise AM, Goldsmith J, Thompson B, Engelhardt KR, Cant AJ, Hambleton S, Barclay A, Toth-Petroczy A, Vuzman D, Carmichael N, Bodea C, Cassa CA, Devoto M, Maas RL, Behrens EM, Giraudo CG, Snapper SB. Variants in STXBP3 Are Associated With Very Early Onset Inflammatory Bowel Disease, Bilateral Sensorineural Hearing Loss and Immune Dysregulation. J Crohns Colitis. 2021 Apr 23. PMID: 33891011.
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    2. Nichols KE, Giraudo CG. RHOG: Rac1-ing up another HLH gene. Blood. 2021 Apr 15; 137(15):1990-1991. PMID: 33856445.
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    3. Benavides N, Spessott WA, Sanmillan ML, Vargas M, Livingston MS, Erickson N, Pozos TC, McCormick ME, Scharrig E, Messinger YH, Giraudo CG. STXBP2-R190C Variant in a Patient With Neonatal Hemophagocytic Lymphohistiocytosis (HLH) and G6PD Deficiency Reveals a Critical Role of STXBP2 Domain 2 on Granule Exocytosis. Front Immunol. 2020; 11:545414. PMID: 33162974.
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    4. Kelsen JR, Dawany N, Conrad MA, Karakasheva TA, Maurer K, Wei JM, Uman S, Dent MH, Behera R, Bryant LM, Ma X, Moreira L, Chatterji P, Shraim R, Merz A, Mizuno R, Simon LA, Muir AB, Giraudo C, Behrens EM, Whelan KA, Devoto M, Russo PA, Andres SF, Sullivan KE, Hamilton KE. Colonoids From Patients With Pediatric Inflammatory Bowel Disease Exhibit Decreased Growth Associated With Inflammation Severity and Durable Upregulation of Antigen Presentation Genes. Inflamm Bowel Dis. 2020 Jun 19. PMID: 32556182.
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    5. Kou X, Xu X, Chen C, Sanmillan ML, Cai T, Zhou Y, Giraudo C, Le A, Shi S. The Fas/Fap-1/Cav-1 complex regulates IL-1RA secretion in mesenchymal stem cells to accelerate wound healing. Sci Transl Med. 2018 Mar 14; 10(432). PMID: 29540618.
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    6. Spessott WA, Sanmillan ML, Kulkarni VV, McCormick ME, Giraudo CG. Syntaxin 4 mediates endosome recycling for lytic granule exocytosis in cytotoxic T-lymphocytes. Traffic. 2017 07; 18(7):442-452. PMID: 28471021.
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    7. Spessott WA, Sanmillan ML, McCormick ME, Kulkarni VV, Giraudo CG. SM protein Munc18-2 facilitates transition of Syntaxin 11-mediated lipid mixing to complete fusion for T-lymphocyte cytotoxicity. Proc Natl Acad Sci U S A. 2017 03 14; 114(11):E2176-E2185. PMID: 28265073.
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    8. Spessott WA, Sanmillan ML, McCormick ME, Patel N, Villanueva J, Zhang K, Nichols KE, Giraudo CG. Hemophagocytic lymphohistiocytosis caused by dominant-negative mutations in STXBP2 that inhibit SNARE-mediated membrane fusion. Blood. 2015 Mar 05; 125(10):1566-77. PMID: 25564401; PMCID: PMC4351505.
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    9. Shutova MS, Spessott WA, Giraudo CG, Svitkina T. Endogenous species of mammalian nonmuscle myosin IIA and IIB include activated monomers and heteropolymers. Curr Biol. 2014 Sep 08; 24(17):1958-68. PMID: 25131674; PMCID: PMC4160463.
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    10. Antonny B, Audhya J, l Bagnat M, von Blume J, Briggs JA, Giraudo C, Kaeser PS, Miller E, Reinisch K, Sbalzarini IF, Schuldiner M, Shen J, Takamori S, Verstreken P, Walther T. Directing traffic into the future. Dev Cell. 2013 Dec 09; 27(5):480-4. PMID: 24482802.
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    11. Shi L, Kümmel D, Coleman J, Melia TJ, Giraudo CG. Dual roles of Munc18-1 rely on distinct binding modes of the central cavity with Stx1A and SNARE complex. Mol Biol Cell. 2011 Nov; 22(21):4150-60. PMID: 21900493; PMCID: PMC3204075.
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    12. Krishnakumar SS, Radoff DT, Kümmel D, Giraudo CG, Li F, Khandan L, Baguley SW, Coleman J, Reinisch KM, Pincet F, Rothman JE. A conformational switch in complexin is required for synaptotagmin to trigger synaptic fusion. Nat Struct Mol Biol. 2011 Jul 24; 18(8):934-40. PMID: 21785412; PMCID: PMC3668341.
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    13. Li F, Pincet F, Perez E, Giraudo CG, Tareste D, Rothman JE. Complexin activates and clamps SNAREpins by a common mechanism involving an intermediate energetic state. Nat Struct Mol Biol. 2011 Jul 24; 18(8):941-6. PMID: 21785413; PMCID: PMC3736826.
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    14. Kümmel D, Krishnakumar SS, Radoff DT, Li F, Giraudo CG, Pincet F, Rothman JE, Reinisch KM. Complexin cross-links prefusion SNAREs into a zigzag array. Nat Struct Mol Biol. 2011 Jul 24; 18(8):927-33. PMID: 21785414; PMCID: PMC3410656.
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    15. Quintero CA, Giraudo CG, Villarreal M, Montich G, Maccioni HJ. Identification of a site in Sar1 involved in the interaction with the cytoplasmic tail of glycolipid glycosyltransferases. J Biol Chem. 2010 Sep 24; 285(39):30340-6. PMID: 20650895; PMCID: PMC2943283.
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    16. Giraudo CG, Garcia-Diaz A, Eng WS, Chen Y, Hendrickson WA, Melia TJ, Rothman JE. Alternative zippering as an on-off switch for SNARE-mediated fusion. Science. 2009 Jan 23; 323(5913):512-6. PMID: 19164750; PMCID: PMC3736854.
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    17. Giraudo CG, Garcia-Diaz A, Eng WS, Yamamoto A, Melia TJ, Rothman JE. Distinct domains of complexins bind SNARE complexes and clamp fusion in vitro. J Biol Chem. 2008 Jul 25; 283(30):21211-9. PMID: 18499660; PMCID: PMC2475712.
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    18. Giraudo CG, Eng WS, Melia TJ, Rothman JE. A clamping mechanism involved in SNARE-dependent exocytosis. Science. 2006 Aug 04; 313(5787):676-80. PMID: 16794037.
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    19. Uliana AS, Giraudo CG, Maccioni HJ. Cytoplasmic tails of SialT2 and GalNAcT impose their respective proximal and distal Golgi localization. Traffic. 2006 May; 7(5):604-12. PMID: 16643282.
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    20. Giraudo CG, Hu C, You D, Slovic AM, Mosharov EV, Sulzer D, Melia TJ, Rothman JE. SNAREs can promote complete fusion and hemifusion as alternative outcomes. J Cell Biol. 2005 Jul 18; 170(2):249-60. PMID: 16027221; PMCID: PMC2171417.
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    21. Crespo PM, Zurita AR, Giraudo CG, Maccioni HJ, Daniotti JL. Ganglioside glycosyltransferases and newly synthesized gangliosides are excluded from detergent-insoluble complexes of Golgi membranes. Biochem J. 2004 Feb 01; 377(Pt 3):561-8. PMID: 14565845; PMCID: PMC1223901.
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    22. Giraudo CG, Maccioni HJ. Ganglioside glycosyltransferases organize in distinct multienzyme complexes in CHO-K1 cells. J Biol Chem. 2003 Oct 10; 278(41):40262-71. PMID: 12900410.
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    23. Giraudo CG, Maccioni HJ. Endoplasmic reticulum export of glycosyltransferases depends on interaction of a cytoplasmic dibasic motif with Sar1. Mol Biol Cell. 2003 Sep; 14(9):3753-66. PMID: 12972562.
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    24. Maccioni HJ, Giraudo CG, Daniotti JL. Understanding the stepwise synthesis of glycolipids. Neurochem Res. 2002 Aug; 27(7-8):629-36. PMID: 12374198.
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