Subacute Sclerosing Panencephalitis
"Subacute Sclerosing Panencephalitis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A rare, slowly progressive encephalitis caused by chronic infection with the MEASLES VIRUS. The condition occurs primarily in children and young adults, approximately 2-8 years after the initial infection. A gradual decline in intellectual abilities and behavioral alterations are followed by progressive MYOCLONUS; MUSCLE SPASTICITY; SEIZURES; DEMENTIA; autonomic dysfunction; and ATAXIA. DEATH usually occurs 1-3 years after disease onset. Pathologic features include perivascular cuffing, eosinophilic cytoplasmic inclusions, neurophagia, and fibrous gliosis. It is caused by the SSPE virus, which is a defective variant of MEASLES VIRUS. (From Adams et al., Principles of Neurology, 6th ed, pp767-8)
| Descriptor ID |
D013344
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| MeSH Number(s) |
C02.182.525.600 C02.290.700 C02.782.580.600.500.500.800 C02.839.862 C10.228.140.430.520.750.600 C10.228.228.245.340.600 C10.228.228.399.750.600
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| Concept/Terms |
Subacute Sclerosing Panencephalitis- Subacute Sclerosing Panencephalitis
- Sclerosing Panencephalitis, Subacute
- Panencephalitides, Subacute Sclerosing
- Sclerosing Panencephalitides, Subacute
- Subacute Sclerosing Panencephalitides
- Panencephalitis, Subacute Sclerosing
- Leukoencephalitis, Van Bogaert's
- Leukoencephalitis, Van Bogaert
- Leukoencephalitis, Van Bogaerts
- Inclusion Body Encephalitis, Measles
- Sclerosing Leukoencephalitis, Subacute
- Leukoencephalitides, Subacute Sclerosing
- Sclerosing Leukoencephalitides, Subacute
- Subacute Sclerosing Leukoencephalitides
- Subacute Sclerosing Leukoencephalitis
- Leukoencephalitis, Subacute Sclerosing
- Measles Inclusion Body Encephalitis
- Encephaltis, Inclusion Body, Measles
- SSPE
- Van Bogaert's Leukoencephalitis
- Van Bogaert Leukoencephalitis
- Van Bogaerts Leukoencephalitis
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Below are MeSH descriptors whose meaning is more general than "Subacute Sclerosing Panencephalitis".
Below are MeSH descriptors whose meaning is more specific than "Subacute Sclerosing Panencephalitis".
This graph shows the total number of publications written about "Subacute Sclerosing Panencephalitis" by people in this website by year, and whether "Subacute Sclerosing Panencephalitis" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
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Below are the most recent publications written about "Subacute Sclerosing Panencephalitis" by people in Profiles.
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Gosztonyi G, Koprowski H. The concept of neurotropism and selective vulnerability ("pathoclisis") in virus infections of the nervous system--a historical overview. Curr Top Microbiol Immunol. 2001; 253:1-13.
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Lawrence DM, Vaughn MM, Belman AR, Cole JS, Rall GF. Immune response-mediated protection of adult but not neonatal mice from neuron-restricted measles virus infection and central nervous system disease. J Virol. 1999 Mar; 73(3):1795-801.
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G?rny MK, Wr?blewska Z, Pleasure D, Miller SL, Wajgt A, Koprowski H. CSF antibodies to myelin basic protein and oligodendrocytes in multiple sclerosis and other neurological diseases. Acta Neurol Scand. 1983 Jun; 67(6):338-47.
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Croce CM, Linnenbach A, Hall W, Steplewski Z, Koprowski H. Production of human hybridomas secreting antibodies to measles virus. Nature. 1980 Dec 04; 288(5790):488-9.
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Iwasaki Y, Koprowski H. Cell to cell transmission of virus in the central nervous system. I. Subacute sclerosing panencephalitis. Lab Invest. 1974 Aug; 31(2):187-96.
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Katz M, K?ckell YM, M?ller D, ter Meulen V, Koprowski H. Immunohistological, microscopical and neurochemical studies on encephalitides. 7. Subacute sclerosing panencephalitis. Susceptibility of dogs to the virus, and characterization of host response. Acta Neuropathol. 1973 Jun 26; 25(1):81-8.
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M?ller D, Katz M, Rorke LB, ter Meulen V, Koprowski H. Immunohistological, microscopical and neurochemical studies on encephalitides. VI. Subacute sclerosing panencephalitis. Histopathological and histochemical analysis of experimental encephalitis induced in ferrets by SSPE viruses. Acta Neuropathol. 1973 Mar 30; 24(1):12-29.
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Katz M, Koprowski H, Moorhead PS. Transformation of cell cultures derived from human brains. Science. 1973 Mar 09; 179(4077):1019-20.
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Katz M, Koprowski H. The significance of failure to isolate infectious viruses in cases of subacute sclerosing panencephalitis. Brief report. Arch Gesamte Virusforsch. 1973; 41(4):390-3.
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Thein P, Mayr A, ter Muelen V, Koprowski H, K?ckell MY, M?ller D, Meyermann R. Subacute sclerosing panencephalitis. Transmission of the virus to calves and lambs. Arch Neurol. 1972 Dec; 27(6):540-8.