Mudit Tyagi

TitleAssoc Professor
InstitutionThomas Jefferson University
DepartmentCenter for Translational Medic
Address1020 Locust St.
Philadelphia PA 19107
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    1. Hokello J, Tyagi K, Owor RO, Sharma AL, Bhushan A, Daniel R, Tyagi M. New Insights into HIV Life Cycle, Th1/Th2 Shift during HIV Infection and Preferential Virus Infection of Th2 Cells: Implications of Early HIV Treatment Initiation and Care. Life (Basel). 2024 Jan 09; 14(1). PMID: 38255719.
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    2. Tyagi M, Reddy NG, Sahoo NK. Fibrin-Glue-Assisted Surgery for Idiopathic Macular Holes. Semin Ophthalmol. 2023 Oct 21; 1-4. PMID: 37864463.
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    3. Sheng Y, Jain M, Sahoo N, Reddy N, Tyagi M, Narula R, Stewart MW, Narayanan R. Medical Therapy for Large Idiopathic Full-Thickness Macular Holes. Retin Cases Brief Rep. 2023 Jun 19. PMID: 37343512.
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    4. Hokello J, Tyagi P, Dimri S, Sharma AL, Tyagi M. Comparison of the Biological Basis for Non-HIV Transmission to HIV-Exposed Seronegative Individuals, Disease Non-Progression in HIV Long-Term Non-Progressors and Elite Controllers. Viruses. 2023 06 13; 15(6). PMID: 37376660.
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    5. Ramamurthy S, Raval V, Ali H, Tyagi M, Narayanan R, Reddy R, Das AV. GIANT RETINAL TEAR DETACHMENT: Clinical Presentation and Treatment Outcomes in 396 Patients. Retina. 2023 05 01; 43(5):784-792. PMID: 36728871.
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    6. Jacob N, Tyagi M, Chhablani J, Narayanan R, Kelgaonkar A, Jain M, Singh SR, Sahoo NK. Retinal Pigment Epithelial Characteristics in Acute and Resolved Vogt-Koyanagi-Harada Disease. J Clin Med. 2023 Mar 19; 12(6). PMID: 36983367.
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    7. Sahoo NK, Suresh A, Patil A, Ong J, Kazi E, Tyagi M, Narayanan R, Nayak S, Jacob N, Venkatesh R, Chhablani J. Novel En Face OCT-Based Closure Patterns in Idiopathic Macular Holes. Ophthalmol Retina. 2023 06; 7(6):503-508. PMID: 36584899.
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    8. Tyagi M, Sahoo NK, Belenje AS, Desai A. Fovea sparing internal limiting membrane peeling for idiopathic macular holes-Report of unfavourable outcomes of a surgical technique. Eur J Ophthalmol. 2023 May; 33(3):1467-1472. PMID: 36524252.
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    9. Sharma AL, Shafer D, Netting D, Tyagi M. Cocaine sensitizes the CD4+ T?cells for HIV infection by co-stimulating NFAT and AP-1. iScience. 2022 Dec 22; 25(12):105651. PMID: 36483012.
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    10. Bhargava A, Sahoo NK, Das AV, Tyagi M, Kammari P, Sheth J, Kurada J, Shukla S. From Scylla to Charybdis: Fixed drug combinations for tuberculosis and increased ethambutol-induced optic neuropathy in India. Indian J Ophthalmol. 2022 08; 70(8):3073-3076. PMID: 35918975.
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    11. Sharma AL, Wang H, Zhang Z, Millien G, Tyagi M, Hongpaisan J. HIV Promotes Neurocognitive Impairment by Damaging the Hippocampal Microvessels. Mol Neurobiol. 2022 Jun 04. PMID: 35665894.
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    12. Belenje A, Takkar B, Agarwal K, Tyagi M, Aggarwal V, Padhi TR, Narayanan R. Jet stream related iatrogenic retinal breaks during vitreo-retinal surgery. Indian J Ophthalmol. 2022 Mar; 70(3):902-907. PMID: 35225540.
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    13. Sonti S, Tyagi K, Pande A, Daniel R, Sharma AL, Tyagi M. Crossroads of Drug Abuse and HIV Infection: Neurotoxicity and CNS Reservoir. Vaccines (Basel). 2022 Jan 27; 10(2). PMID: 35214661.
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    14. Takkar B, Sahoo NK, Tyagi M, Dave VP. Observations on Six Rare Cases of Chorioretinitis Sclopetaria. Nepal J Ophthalmol. 2022 Jan; 14(27):152-161. PMID: 35996913.
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    15. Nayak S, Das T, Parameswarappa D, Sharma S, Jakati S, Jalali S, Narayanan R, Basu S, Tyagi M, Dave VP, Pappuru RR, Pathengay A, Kaza H, Rani PK, Behera S, Sahoo NK, Kapoor A, Agrawal H, Agarwal K, Takkar B, Raval VR. Sight-threatening intraocular infection in patients with COVID-19 in India. Indian J Ophthalmol. 2021 Dec; 69(12):3664-3676. PMID: 34827019.
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    16. Hokello J, Sharma AL, Tyagi P, Bhushan A, Tyagi M. Human Immunodeficiency Virus Type-1 (HIV-1) Transcriptional Regulation, Latency and Therapy in the Central Nervous System. Vaccines (Basel). 2021 Nov 03; 9(11). PMID: 34835203.
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    17. Narayanan R, Tyagi M, Sahoo NK, Reddy S, Pathengay A. Accidental Self-Inflicted Handheld Laser-Induced Maculopathy. Ocul Immunol Inflamm. 2021 Oct 12; 1-4. PMID: 34637668.
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    18. Sahoo NK, Ranjan R, Tyagi M, Agrawal H, Reddy S. Radiation Retinopathy: Detection and Management Strategies. Clin Ophthalmol. 2021; 15:3797-3809. PMID: 34526764.
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    19. Sonti S, Sharma AL, Tyagi M. HIV-1 persistence in the CNS: Mechanisms of latency, pathogenesis and an update on eradication strategies. Virus Res. 2021 Oct 02; 303:198523. PMID: 34314771.
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    20. Sharma AL, Hokello J, Tyagi M. Circumcision as an Intervening Strategy against HIV Acquisition in the Male Genital Tract. Pathogens. 2021 Jun 25; 10(7). PMID: 34201976.
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    21. Hokello J, Sharma AL, Tyagi M. An Update on the HIV DNA Vaccine Strategy. Vaccines (Basel). 2021 Jun 05; 9(6). PMID: 34198789.
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    22. Soni A, Parameswarappa DC, Tyagi M, Sahoo NK, Dogra A, Pappuru RR, Chhablani J. Brilliant Blue G toxicity in macular hole surgeries: A report on combined phototoxicity and dye-induced macular damage. Semin Ophthalmol. 2022 Jan 02; 37(1):117-122. PMID: 34010087.
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    23. Soni A, Narayanan R, Tyagi M, Belenje A, Basu S. Acute Retinal Necrosis as a presenting ophthalmic manifestation in COVID 19 recovered patients. Ocul Immunol Inflamm. 2021 May 19; 29(4):722-725. PMID: 34228583.
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    24. Hokello J, Sharma AL, Tyagi M. Combinatorial Use of Both Epigenetic and Non-Epigenetic Mechanisms to Efficiently Reactivate HIV Latency. Int J Mol Sci. 2021 Apr 02; 22(7). PMID: 33918134.
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    25. Narayanan R, Tyagi M, Gupta SR, Nayaka A, Jayadev C. Immediate onset of sterile endophthalmitis with hypopyon after intravitreal Brolucizumab in a case of polypoidal choroidal vasculopathy. Indian J Ophthalmol. 2021 02; 69(2):469-470. PMID: 33463623.
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    26. Hokello J, Sharma AL, Tyagi M. AP-1 and NF-?B synergize to transcriptionally activate latent HIV upon T-cell receptor activation. FEBS Lett. 2021 Jan 09. PMID: 33421101.
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    27. Dave VP, Tyagi M, Narayanan R, Pappuru RR. Intraocular endoscopy: A review. Indian J Ophthalmol. 2021 01; 69(1):14-25. PMID: 33323565.
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    28. Hokello J, Sharma AL, Shukla GC, Tyagi M. A narrative review on the basic and clinical aspects of the novel SARS-CoV-2, the etiologic agent of COVID-19. Ann Transl Med. 2020 Dec; 8(24):1686. PMID: 33490198.
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    29. Sharma AL, Hokello J, Sonti S, Zicari S, Sun L, Alqatawni A, Bukrinsky M, Simon G, Chauhan A, Daniel R, Tyagi M. CBF-1 Promotes the Establishment and Maintenance of HIV Latency by Recruiting Polycomb Repressive Complexes, PRC1 and PRC2, at HIV LTR. Viruses. 2020 09 18; 12(9). PMID: 32961937.
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    30. Dave VP, Chakurkar R, Tyagi M, Narayanan R, Pappuru RR. Intraocular endoscopy in the management of ocular trauma: clinical settings and treatment outcomes at a tertiary eye care centre. Eye (Lond). 2021 Jul; 35(7):1904-1908. PMID: 32918042.
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    31. Hokello J, Sharma AL, Tyagi M. Efficient Non-Epigenetic Activation of HIV Latency through the T-Cell Receptor Signalosome. Viruses. 2020 Aug 08; 12(8). PMID: 32784426.
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    32. Alqatawni A, Sharma AL, Attilus B, Tyagi M, Daniel R. Shedding Light on the Role of Extracellular Vesicles in HIV Infection and Wound Healing. Viruses. 2020 May 27; 12(6). PMID: 32471020.
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    33. Dave VP, Pathengay A, Braimah IZ, Panchal B, Sharma S, Pappuru RR, Mathai A, Tyagi M, Narayanan R, Jalali S, Das T. ENTEROCOCCUS ENDOPHTHALMITIS: Clinical Settings, Antimicrobial Susceptibility, and Management Outcomes. Retina. 2020 May; 40(5):898-902. PMID: 30681640.
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    34. Zicari S, Sharma AL, Sahu G, Dubrovsky L, Sun L, Yue H, Jada T, Ochem A, Simon G, Bukrinsky M, Tyagi M. DNA dependent protein kinase (DNA-PK) enhances HIV transcription by promoting RNA polymerase II activity and recruitment of transcription machinery at HIV LTR. Oncotarget. 2020 Feb 18; 11(7):699-726. PMID: 32133046.
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    35. Hokello J, Sharma AL, Dimri M, Tyagi M. Insights into the HIV Latency and the Role of Cytokines. Pathogens. 2019 Sep 04; 8(3). PMID: 31487807.
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    36. Narayanan R, Singh SR, Taylor S, Berrocal MH, Chhablani J, Tyagi M, Ohno-Matsui K, Pappuru RR, Apte RS. SURGICAL OUTCOMES AFTER INVERTED INTERNAL LIMITING MEMBRANE FLAP VERSUS CONVENTIONAL PEELING FOR VERY LARGE MACULAR HOLES. Retina. 2019 Aug; 39(8):1465-1469. PMID: 29689027.
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    37. Deshmukh D, Joseph J, Chakrabarti M, Sharma S, Jayasudha R, Sama KC, Sontam B, Tyagi M, Narayanan R, Shivaji S. New insights into culture negative endophthalmitis by unbiased next generation sequencing. Sci Rep. 2019 01 29; 9(1):844. PMID: 30696908.
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    38. Dave VP, Pappuru RR, Pathengay A, Tyagi M, Narayanan R, Jalali S. Vitrectomy with Silicone Oil Tamponade in Rhegmatogenous Retinal Detachment following Acute Retinal Necrosis: Clinical Outcomes and Prognostic Factors. Semin Ophthalmol. 2019; 34(1):47-51. PMID: 30496028.
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    39. Dave VP, Pathengay A, Budhiraja I, Sharma S, Pappuru RR, Tyagi M, Narayanan R, Jalali S, Chhablani J, Das T. CLINICAL PRESENTATION, MICROBIOLOGIC PROFILE AND FACTORS PREDICTING OUTCOMES IN BACILLUS ENDOPHTHALMITIS. Retina. 2018 May; 38(5):1019-1023. PMID: 28406861.
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    40. Pappuru RR, Dave VP, Pathengay A, Gangakhedkar S, Sharma S, Narayanan R, Tyagi M, Grzybowski A, Das T. Endophthalmitis Progressing to Panophthalmitis: Clinical Features, Demographic Profile, and Factors Predicting Outcome. Semin Ophthalmol. 2018; 33(5):671-674. PMID: 29256717.
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    41. Ambiya V, Rani PK, Narayanan R, Balakrishnan D, Chhablani J, Jalali S, Tyagi M, Pappuru RR. Outcomes of Recurrent Retinal Detachment Surgery following Pars Plana Vitrectomy for Rhegmatogenous Retinal Detachment. Semin Ophthalmol. 2018; 33(5):657-663. PMID: 29125779.
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    42. Ambiya V, Khodani M, Goud A, Narayanan R, Tyagi M, Rani PK, Chhablani J. Early Focal Laser Photocoagulation in Acute Central Serous Chorioretinopathy: A Prospective, Randomized Study. Ophthalmic Surg Lasers Imaging Retina. 2017 07 01; 48(7):564-571. PMID: 28728183.
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    43. Dave VP, Pathengay A, Relhan N, Sharma P, Jalali S, Pappuru RR, Tyagi M, Narayanan R, Chhablani J, Das T, Flynn HW. Endophthalmitis and Concurrent or Delayed-Onset Rhegmatogenous Retinal Detachment Managed With Pars Plana Vitrectomy, Intravitreal Antibiotics, and Silicone Oil. Ophthalmic Surg Lasers Imaging Retina. 2017 07 01; 48(7):546-551. PMID: 28728182.
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    44. Reddy Pappuru RR, Tyagi M, Paulose RM, Dave VP, Das T, Chhablani J, Narayanan R, Saxena RK, Balakrishnan D, Basu S, Sangwan VS. Role of Diagnostic Endoscopy in Posterior Segment Evaluation for Definitive Prognostication in Eyes With Corneal Opacification. Am J Ophthalmol. 2017 Apr; 176:9-14. PMID: 28040528.
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    45. Dave VP, Pathengay A, Basu S, Gupta N, Basu S, Raval V, Das T, Sharma S, Mathai A, Narayanan R, Chhablani J, Sharma P, Tyagi M, Balakrishnan D, Jalali S, Rani PK, Pappuru RR. Endophthalmitis After Pars Plana Vitrectomy: Clinical Features, Risk Factors, and Management Outcomes. Asia Pac J Ophthalmol (Phila). 2016 May; 5(3):192-5. PMID: 27003734.
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    46. Narayanan R, Tyagi M, Hussein A, Chhablani J, Apte RS. SCLERAL BUCKLING WITH WIDE-ANGLED ENDOILLUMINATION AS A SURGICAL EDUCATIONAL TOOL. Retina. 2016 Apr; 36(4):830-3. PMID: 26447399.
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    47. Das T, Aurora A, Chhablani J, Giridhar A, Kumar A, Raman R, Nagpal M, Narayanan R, Natarajan S, Ramasamay K, Tyagi M, Verma L. Evidence-based review of diabetic macular edema management: Consensus statement on Indian treatment guidelines. Indian J Ophthalmol. 2016 Jan; 64(1):14-25. PMID: 26953019.
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    48. Tyagi M, Bukrinsky M, Simon GL. Mechanisms of HIV Transcriptional Regulation by Drugs of Abuse. Curr HIV Res. 2016; 14(5):442-454. PMID: 27009097.
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    49. Tyagi M, Weber J, Bukrinsky M, Simon GL. The effects of cocaine on HIV transcription. J Neurovirol. 2016 06; 22(3):261-74. PMID: 26572787.
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    50. Tyagi M, Ambiya V, Mathai A, Narayanan R. Atypical cytomegalovirus retinitis in non-Hodgkin's lymphoma. BMJ Case Rep. 2015 Aug 03; 2015. PMID: 26240105.
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    51. Patil-Chhablani P, Tyagi M, Kekunnaya R, Narayanan R. Acute unilateral vision loss with optic disc oedema in retinitis pigmentosa. BMJ Case Rep. 2015 Aug 03; 2015. PMID: 26240107.
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    52. Tyagi M, Iordanskiy S, Ammosova T, Kumari N, Smith K, Breuer D, Ilatovskiy AV, Kont YS, Ivanov A, Üren A, Kovalskyy D, Petukhov M, Kashanchi F, Nekhai S. Reactivation of latent HIV-1 provirus via targeting protein phosphatase-1. Retrovirology. 2015 Jul 16; 12:63. PMID: 26178009.
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    53. Sahu G, Farley K, El-Hage N, Aiamkitsumrit B, Fassnacht R, Kashanchi F, Ochem A, Simon GL, Karn J, Hauser KF, Tyagi M. Cocaine promotes both initiation and elongation phase of HIV-1 transcription by activating NF-?B and MSK1 and inducing selective epigenetic modifications at HIV-1 LTR. Virology. 2015 Sep; 483:185-202. PMID: 25980739.
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    54. Narayanan R, Chhablani J, Sinha M, Dave V, Tyagi M, Pappuru RR, Kuppermann BD. Efficacy of anti-vascular endothelial growth factor therapy in subretinal neovascularization secondary to macular telangiectasia type 2. Retina. 2012 Nov-Dec; 32(10):2001-5. PMID: 22990322.
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    55. Tyagi M, Bukrinsky M. Human immunodeficiency virus (HIV) latency: the major hurdle in HIV eradication. Mol Med. 2012 Sep 25; 18:1096-108. PMID: 22692576.
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    56. Tyagi M, Kashanchi F. New and novel intrinsic host repressive factors against HIV-1: PAF1 complex, HERC5 and others. Retrovirology. 2012 Mar 09; 9:19. PMID: 22405323.
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    57. Tyagi M, Romerio F. Models of HIV-1 persistence in the CD4+ T cell compartment: past, present and future. Curr HIV Res. 2011 Dec 01; 9(8):579-87. PMID: 22211662.
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    58. Tyagi M, Narayanan R. Diabetic retinopathy and cardiovascular disease. Ophthalmology. 2011 Dec; 118(12):2529-30; author reply 2530.e1. PMID: 22136686.
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    59. Van Duyne R, Guendel I, Narayanan A, Gregg E, Shafagati N, Tyagi M, Easley R, Klase Z, Nekhai S, Kehn-Hall K, Kashanchi F. Varying modulation of HIV-1 LTR activity by Baf complexes. J Mol Biol. 2011 Aug 19; 411(3):581-96. PMID: 21699904.
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    60. Lalonde MS, Lobritz MA, Ratcliff A, Chamanian M, Athanassiou Z, Tyagi M, Wong J, Robinson JA, Karn J, Varani G, Arts EJ. Inhibition of both HIV-1 reverse transcription and gene expression by a cyclic peptide that binds the Tat-transactivating response element (TAR) RNA. PLoS Pathog. 2011 May; 7(5):e1002038. PMID: 21625572.
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    61. Tyagi S, Ochem A, Tyagi M. DNA-dependent protein kinase interacts functionally with the RNA polymerase II complex recruited at the human immunodeficiency virus (HIV) long terminal repeat and plays an important role in HIV gene expression. J Gen Virol. 2011 Jul; 92(Pt 7):1710-1720. PMID: 21450944.
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    62. Tyagi M, Pearson RJ, Karn J. Establishment of HIV latency in primary CD4+ cells is due to epigenetic transcriptional silencing and P-TEFb restriction. J Virol. 2010 Jul; 84(13):6425-37. PMID: 20410271.
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    63. Pearson R, Kim YK, Hokello J, Lassen K, Friedman J, Tyagi M, Karn J. Epigenetic silencing of human immunodeficiency virus (HIV) transcription by formation of restrictive chromatin structures at the viral long terminal repeat drives the progressive entry of HIV into latency. J Virol. 2008 Dec; 82(24):12291-303. PMID: 18829756.
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    64. Tyagi M, Karn J. CBF-1 promotes transcriptional silencing during the establishment of HIV-1 latency. EMBO J. 2007 Dec 12; 26(24):4985-95. PMID: 18007589.
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    65. Kim YK, Bourgeois CF, Pearson R, Tyagi M, West MJ, Wong J, Wu SY, Chiang CM, Karn J. Recruitment of TFIIH to the HIV LTR is a rate-limiting step in the emergence of HIV from latency. EMBO J. 2006 Aug 09; 25(15):3596-604. PMID: 16874302.
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