Lawrence Goldfinger

TitleAssoc Professor
InstitutionThomas Jefferson University
DepartmentHematology
Address1020 Locust St.
Philadelphia PA 19107
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Lazar S, Goldfinger LE. Platelets and extracellular vesicles and their cross-talk with cancer. Blood. 2021 May 03. PMID: 33940593.
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    2. Lazar S, Wurtzel JGT, Chen X, Ma P, Goldfinger LE. High-efficiency unassisted transfection of platelets with naked double-stranded miRNAs modulates signal-activated translation and platelet function. Platelets. 2020 Aug 25; 1-13. PMID: 32838617.
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    3. Chen X, Gupta S, Cooper M, DeHelian D, Zhao X, Naik MU, Wurtzel JGT, Stalker TJ, Goldfinger LE, Benovic J, Brass LF, McKenzie SE, Naik UP, Ma P. GRK6 regulates the hemostatic response to injury through its rate-limiting effects on GPCR signaling in platelets. Blood Adv. 2020 Jan 14; 4(1):76-86. PMID: 31899801.
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    4. Goldfinger LE, Edelstein LC. Horizontal RNA transfer goes deep: platelet consumption and microRNA utilization by vascular smooth muscle cells. J Thromb Haemost. 2019 Jul; 17(7):1014-1017. PMID: 31257731.
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    5. Goldfinger LE. GPVI inhibitor as antitumor gateway drug. Blood. 2019 Jun 20; 133(25):2633-2634. PMID: 31221792.
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    6. Patel A, Kostyak J, Dangelmaier C, Badolia R, Bhavanasi D, Aslan JE, Merali S, Kim S, Eble JA, Goldfinger L, Kunapuli S. ELMO1 deficiency enhances platelet function. Blood Adv. 2019 Feb 26; 3(4):575-587. PMID: 30787021.
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    7. Janapati S, Wurtzel J, Dangelmaier C, Manne BK, Bhavanasi D, Kostyak JC, Kim S, Holinstat M, Kunapuli SP, Goldfinger LE. TC21/RRas2 regulates glycoprotein VI-FcR?-mediated platelet activation and thrombus stability. J Thromb Haemost. 2018 Jun 08. PMID: 29883056.
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    8. Jalagadugula G, Goldfinger LE, Mao G, Lambert MP, Rao AK. Defective RAB1B-related megakaryocytic ER-to-Golgi transport in RUNX1 haplodeficiency: impact on von Willebrand factor. Blood Adv. 2018 04 10; 2(7):797-806. PMID: 29632235.
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    9. Lazar S, Goldfinger LE. Platelet Microparticles and miRNA Transfer in Cancer Progression: Many Targets, Modes of Action, and Effects Across Cancer Stages. Front Cardiovasc Med. 2018; 5:13. PMID: 29564336.
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    10. Michael JV, Goldfinger LE. Concepts and advances in cancer therapeutic vulnerabilities in RAS membrane targeting. Semin Cancer Biol. 2017 Dec 01. PMID: 29203271.
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    11. Mao G, Songdej N, Voora D, Goldfinger LE, Del Carpio-Cano FE, Myers RA, Rao AK. Transcription Factor RUNX1 Regulates Platelet PCTP (Phosphatidylcholine Transfer Protein): Implications for Cardiovascular Events: Differential Effects of RUNX1 Variants. Circulation. 2017 Sep 05; 136(10):927-939. PMID: 28676520.
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    12. Michael JV, Wurtzel JGT, Mao GF, Rao AK, Kolpakov MA, Sabri A, Hoffman NE, Rajan S, Tomar D, Madesh M, Nieman MT, Yu J, Edelstein LC, Rowley JW, Weyrich AS, Goldfinger LE. Platelet microparticles infiltrating solid tumors transfer miRNAs that suppress tumor growth. Blood. 2017 May 12. PMID: 28500171.
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    13. Mao GF, Goldfinger LE, Fan DC, Lambert MP, Jalagadugula G, Freishtat R, Rao AK. Dysregulation of PLDN (pallidin) is a mechanism for platelet dense granule deficiency in RUNX1 haplodeficiency. J Thromb Haemost. 2017 04; 15(4):792-801. PMID: 28075530.
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    14. Goldfinger LE, Michael JV. Regulation of Ras signaling and function by plasma membrane microdomains. Biosci Trends. 2017 Mar 22; 11(1):23-40. PMID: 28179601.
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    15. Michael JV, Wurtzel JG, Goldfinger LE. Inhibition of Galectin-1 Sensitizes HRAS-driven Tumor Growth to Rapamycin Treatment. Anticancer Res. 2016 10; 36(10):5053-5061. PMID: 27798864.
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    16. Michael JV, Wurtzel JG, Goldfinger LE. Regulation of H-Ras-driven MAPK signaling, transformation and tumorigenesis, but not PI3K signaling and tumor progression, by plasma membrane microdomains. Oncogenesis. 2016 May 30; 5(5):e228. PMID: 27239960.
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    17. Rowley JW, Chappaz S, Corduan A, Chong MM, Campbell R, Khoury A, Manne BK, Wurtzel JG, Michael JV, Goldfinger LE, Mumaw MM, Nieman MT, Kile BT, Provost P, Weyrich AS. Dicer1-mediated miRNA processing shapes the mRNA profile and function of murine platelets. Blood. 2016 Apr 07; 127(14):1743-51. PMID: 26773046; PMCID: PMC4825412.
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    18. Wurtzel JG, Lee S, Singhal SS, Awasthi S, Ginsberg MH, Goldfinger LE. RLIP76 regulates Arf6-dependent cell spreading and migration by linking ARNO with activated R-Ras at recycling endosomes. Biochem Biophys Res Commun. 2015 Nov 27; 467(4):785-91. PMID: 26498519; PMCID: PMC4644438.
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    19. Lee S, Wurtzel JG, Goldfinger LE. The RLIP76 N-terminus binds ARNO to regulate PI 3-kinase, Arf6 and Rac signaling, cell spreading and migration. Biochem Biophys Res Commun. 2014 11 28; 454(4):560-5. PMID: 25450693; PMCID: PMC4254618.
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    20. Lee S, Goldfinger LE. RLIP76 regulates HIF-1 activity, VEGF expression and secretion in tumor cells, and secretome transactivation of endothelial cells. FASEB J. 2014 Sep; 28(9):4158-68. PMID: 24928198; PMCID: PMC4139904.
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    21. Silver L, Michael JV, Goldfinger LE, Gallo G. Activation of PI3K and R-Ras signaling promotes the extension of sensory axons on inhibitory chondroitin sulfate proteoglycans. Dev Neurobiol. 2014 Sep; 74(9):918-33. PMID: 24578264; PMCID: PMC4235675.
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    22. Lee S, Barbe MF, Scalia R, Goldfinger LE. Three-dimensional reconstruction of neovasculature in solid tumors and basement membrane matrix using ex vivo X-ray microcomputed tomography. Microcirculation. 2014 Feb; 21(2):159-70. PMID: 25279426; PMCID: PMC4185970.
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    23. Kim S, Dangelmaier C, Bhavanasi D, Meng S, Wang H, Goldfinger LE, Kunapuli SP. RhoG protein regulates glycoprotein VI-Fc receptor ?-chain complex-mediated platelet activation and thrombus formation. J Biol Chem. 2013 Nov 22; 288(47):34230-8. PMID: 24106269; PMCID: PMC3837163.
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    24. Goldfinger LE, Lee S. Emerging treatments in lung cancer - targeting the RLIP76 molecular transporter. Lung Cancer (Auckl). 2013; 2013(4):61-69. PMID: 25419163.
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    25. Lee S, Wurtzel JG, Singhal SS, Awasthi S, Goldfinger LE. RALBP1/RLIP76 depletion in mice suppresses tumor growth by inhibiting tumor neovascularization. Cancer Res. 2012 Oct 15; 72(20):5165-73. PMID: 22902412; PMCID: PMC3473090.
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    26. Wurtzel JG, Kumar P, Goldfinger LE. Palmitoylation regulates vesicular trafficking of R-Ras to membrane ruffles and effects on ruffling and cell spreading. Small GTPases. 2012 Jul-Sep; 3(3):139-53. PMID: 22751447; PMCID: PMC3442799.
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    27. Bhavanasi D, Kim S, Goldfinger LE, Kunapuli SP. Protein kinase Cd mediates the activation of protein kinase D2 in platelets. Biochem Pharmacol. 2011 Oct 01; 82(7):720-7. PMID: 21736870; PMCID: PMC3156373.
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    28. Jalagadugula G, Mao G, Kaur G, Goldfinger LE, Dhanasekaran DN, Rao AK. Regulation of platelet myosin light chain (MYL9) by RUNX1: implications for thrombocytopenia and platelet dysfunction in RUNX1 haplodeficiency. Blood. 2010 Dec 23; 116(26):6037-45. PMID: 20876458; PMCID: PMC3031389.
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    29. Lim CJ, Kain KH, Tkachenko E, Goldfinger LE, Gutierrez E, Allen MD, Groisman A, Zhang J, Ginsberg MH. Integrin-mediated protein kinase A activation at the leading edge of migrating cells. Mol Biol Cell. 2008 Nov; 19(11):4930-41. PMID: 18784251.
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    30. Goldfinger LE, Tzima E, Stockton R, Kiosses WB, Kinbara K, Tkachenko E, Gutierrez E, Groisman A, Nguyen P, Chien S, Ginsberg MH. Localized alpha4 integrin phosphorylation directs shear stress-induced endothelial cell alignment. Circ Res. 2008 Jul 18; 103(2):177-85. PMID: 18583710; PMCID: PMC2669779.
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    31. Lee J, Hong J, Nam TG, Peters EC, Orth AP, Geierstanger BH, Goldfinger LE, Ginsberg MH, Cho CY, Schultz PG. A small molecule inhibitor of alpha4 integrin-dependent cell migration. Bioorg Med Chem. 2009 Feb 01; 17(3):977-80. PMID: 18329275; PMCID: PMC2951142.
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    32. Goldfinger LE. Choose your own path: specificity in Ras GTPase signaling. Mol Biosyst. 2008 Apr; 4(4):293-9. PMID: 18354782.
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    33. Goldfinger LE, Ptak C, Jeffery ED, Shabanowitz J, Han J, Haling JR, Sherman NE, Fox JW, Hunt DF, Ginsberg MH. An experimentally derived database of candidate Ras-interacting proteins. J Proteome Res. 2007 May; 6(5):1806-11. PMID: 17439166; PMCID: PMC4627692.
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    34. Goldfinger LE, Ptak C, Jeffery ED, Shabanowitz J, Hunt DF, Ginsberg MH. RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration. J Cell Biol. 2006 Sep 11; 174(6):877-88. PMID: 16966426; PMCID: PMC2064341.
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    35. Kinbara K, Goldfinger LE, Hansen M, Chou FL, Ginsberg MH. Ras GTPases: integrins' friends or foes? Nat Rev Mol Cell Biol. 2003 Oct; 4(10):767-76. PMID: 14570053.
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    36. Goldfinger LE, Han J, Kiosses WB, Howe AK, Ginsberg MH. Spatial restriction of alpha4 integrin phosphorylation regulates lamellipodial stability and alpha4beta1-dependent cell migration. J Cell Biol. 2003 Aug 18; 162(4):731-41. PMID: 12913113; PMCID: PMC2173787.
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    37. Han J, Rose DM, Woodside DG, Goldfinger LE, Ginsberg MH. Integrin alpha 4 beta 1-dependent T cell migration requires both phosphorylation and dephosphorylation of the alpha 4 cytoplasmic domain to regulate the reversible binding of paxillin. J Biol Chem. 2003 Sep 12; 278(37):34845-53. PMID: 12837751.
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    38. Goldfinger LE, Jiang L, Hopkinson SB, Stack MS, Jones JC. Spatial regulation and activity modulation of plasmin by high affinity binding to the G domain of the alpha 3 subunit of laminin-5. J Biol Chem. 2000 Nov 10; 275(45):34887-93. PMID: 10956663.
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