Tryptophan

"Tryptophan" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals.

Descriptor ID	D014364
MeSH Number(s)	D12.125.072.050.850 D12.125.142.875
Concept/Terms	Tryptophan Tryptophan L-Tryptophan L Tryptophan Levotryptophan Ardeydorm Ardeydorm Ardeytropin L-Tryptophan-ratiopharm L-Tryptophan-ratiopharm L Tryptophan ratiopharm ratio-Tryptophan ratio Tryptophan Tryptophan Metabolism Alterations Tryptophan Metabolism Alterations PMS-Tryptophan PMS-Tryptophan PMS Tryptophan Trofan Trofan Tryptacin Tryptacin Tryptan Tryptan Optimax Optimax Lyphan Lyphan Naturruhe

Below are MeSH descriptors whose meaning is more general than "Tryptophan".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Amino Acids [D12.125]
Amino Acids, Cyclic [D12.125.072]
Amino Acids, Aromatic [D12.125.072.050]
Tryptophan [D12.125.072.050.850]
Amino Acids, Essential [D12.125.142]
Tryptophan [D12.125.142.875]

Below are MeSH descriptors whose meaning is related to "Tryptophan".

Below are MeSH descriptors whose meaning is more specific than "Tryptophan".

Tryptophan
5-Hydroxytryptophan

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Tryptophan" by people in this website by year, and whether "Tryptophan" was a major or minor topic of these publications.

Bar chart showing 74 publications over 29 distinct years, with a maximum of 6 publications in 2003 and 2007

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	2	0	2
1996	1	0	1
1997	2	2	4
1998	2	1	3
2000	1	0	1
2001	1	2	3
2002	2	0	2
2003	3	3	6
2004	1	1	2
2005	3	1	4
2006	1	1	2
2007	4	2	6
2008	0	3	3
2009	0	4	4
2010	2	1	3
2011	3	2	5
2012	2	0	2
2013	1	1	2
2014	1	2	3
2015	2	2	4
2016	0	1	1
2017	1	1	2
2018	0	1	1
2019	1	1	2
2020	1	0	1
2021	1	1	2
2022	0	1	1
2023	0	1	1
2025	1	0	1

Below are the most recent publications written about "Tryptophan" by people in Profiles.

Stauff E, Xu W, Kecskemethy HH, Langhans SA, Kandula VVR, Averill LW, Yue X. Tryptophan Kynurenine Pathway-Based Imaging Agents for Brain Disorders and Oncology-From Bench to Bedside. Biomolecules. 2025 Jan 01; 15(1).

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Van NT, Zhang K, Wigmore RM, Kennedy AI, DaSilva CR, Huang J, Ambelil M, Villagomez JH, O'Connor GJ, Longman RS, Cao M, Snook AE, Platten M, Kasenty G, Sigal LJ, Prendergast GC, Kim SV. Dietary L-Tryptophan consumption determines the number of colonic regulatory T cells and susceptibility to colitis via GPR15. Nat Commun. 2023 11 14; 14(1):7363.

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Chen YF, Lu HC, Hou PC, Lin YC, Aala WJ, Onoufriadis A, McGrath JA, Chen YL, Hsu CK. Plasma metabolomic profiling reflects the malnourished and chronic inflammatory state in recessive dystrophic epidermolysis bullosa. J Dermatol Sci. 2022 Aug; 107(2):82-88.

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Yue X, Nikam RM, Kecskemethy HH, Kandula VVR, Falchek SJ, Averill LW, Langhans SA. Radiosynthesis of 1-(2-[18F]Fluoroethyl)-L-Tryptophan using a One-pot, Two-step Protocol. J Vis Exp. 2021 09 21; (175).

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Cai Y, Kim DJ, Takahashi T, Broadhurst DI, Yan H, Ma S, Rattray NJW, Casanovas-Massana A, Israelow B, Klein J, Lucas C, Mao T, Moore AJ, Muenker MC, Oh JE, Silva J, Wong P, Ko AI, Khan SA, Iwasaki A, Johnson CH. Kynurenic acid may underlie sex-specific immune responses to COVID-19. Sci Signal. 2021 07 06; 14(690).

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Xin Y, Yue X, Li H, Li Z, Cai H, Choudhary AK, Zhang S, Chugani DC, Langhans SA. PET imaging of medulloblastoma with an 18F-labeled tryptophan analogue in a transgenic mouse model. Sci Rep. 2020 03 02; 10(1):3800.

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Yue X, Xin Y, Zhang S, Nikam R, Kandula V, Choudhary AK, Chugani HT, Chugani DC. Automated production of 1-(2-[18F]fluoroethyl)-l-tryptophan for imaging of tryptophan metabolism. Appl Radiat Isot. 2020 Feb; 156:109022.

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Thomas S, Laury-Kleintop L, Prendergast GC. Reliable detection of indoleamine 2,3 dioxygenase-1 in murine cells and tissues. Methods Enzymol. 2019; 629:219-233.

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Muller AJ, Manfredi MG, Zakharia Y, Prendergast GC. Inhibiting IDO pathways to treat cancer: lessons from the ECHO-301 trial and beyond. Semin Immunopathol. 2019 01; 41(1):41-48.

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Prendergast GC, Mondal A, Dey S, Laury-Kleintop LD, Muller AJ. Inflammatory Reprogramming with IDO1 Inhibitors: Turning Immunologically Unresponsive 'Cold' Tumors 'Hot'. Trends Cancer. 2018 01; 4(1):38-58.

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