Thomas Jefferson University

Paul Nyirjesy

TitleProfessor
InstitutionThomas Jefferson University
DepartmentObstetrics-Gynecology
Address833 Chestnut Street
Philadelphia PA 19107
Phone215-503-6702
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Schwebke JR, Nyirjesy P, Dsouza M, Getman D. Vaginitis and risk of sexually transmitted infections: results of a multi-center U.S. clinical study using STI nucleic acid amplification testing. J Clin Microbiol. 2024 Aug 14; e0081624. PMID: 39140739.
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    2. Powell A, Goje O, Nyirjesy P. A Comparison of Newer and Traditional Approaches to Diagnosing Vaginal Infections. Obstet Gynecol. 2024 Feb 13. PMID: 38350107.
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    3. File B, Sobel R, Becker M, Nyirjesy P. Fluconazole-Resistant Candida Albicans Vaginal Infections at a Referral Center and Treated With Boric Acid. J Low Genit Tract Dis. 2023 Mar 24. PMID: 36961480.
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    4. Goje O, Sobel R, Nyirjesy P, Goldstein SR, Spitzer M, Faught B, Larson S, King T, Azie NE, Angulo D, Sobel JD. Oral Ibrexafungerp for Vulvovaginal Candidiasis Treatment: An Analysis of VANISH 303 and VANISH 306. J Womens Health (Larchmt). 2022 Oct 17. PMID: 36255448.
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    5. Nyirjesy P, Brookhart C, Lazenby G, Schwebke J, Sobel JD. Vulvovaginal Candidiasis: A Review of the Evidence for the 2021 Centers for Disease Control and Prevention of Sexually Transmitted Infections Treatment Guidelines. Clin Infect Dis. 2022 04 13; 74(Suppl_2):S162-S168. PMID: 35416967.
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    6. Sobel JD, Nyirjesy P. Oteseconazole: an advance in treatment of recurrent vulvovaginal candidiasis. Future Microbiol. 2021 Dec; 16:1453-1461. PMID: 34783586.
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    7. Goje OT, Brown H, Nyirjesy P, London RS, Muzny C, Arrindell D. Diagnosis of Vaginitis: New Thinking for a New Era. Popul Health Manag. 2021 Oct; 24(5):616-621. PMID: 34590887.
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    8. Nyirjesy P, Schwebke JR, Angulo DA, Harriott IA, Azie NE, Sobel JD. Phase 2 randomized study of oral ibrexafungerp vs fluconazole in vulvovaginal candidiasis. Clin Infect Dis. 2021 Sep 23. PMID: 34555149.
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    9. Schwebke JR, Sobel R, Gersten JK, Sussman SA, Lederman SN, Jacobs MA, Chappell BT, Weinstein DL, Moffett AH, Azie NE, Angulo DA, Harriott IA, Borroto-Esoda K, Ghannoum MA, Nyirjesy P, Sobel JD. Ibrexafungerp versus placebo for vulvovaginal candidiasis treatment: a phase 3, randomized, controlled superiority trial (VANISH 303). Clin Infect Dis. 2021 Sep 01. PMID: 34467969.
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    10. Muzny CA, Schwebke JR, Nyirjesy P, Kaufman G, Mena LA, Lazenby GB, Van Gerwen OT, Graves KJ, Arbuckle J, Carter BA, McMahon CP, Eder S, Shaw J, Pandey B, Chavoustie SE. Efficacy and Safety of Single Oral Dosing of Secnidazole for Trichomoniasis in Women: Results of a Phase 3, Randomized, Double-Blind, Placebo-Controlled, Delayed-Treatment Study. Clin Infect Dis. 2021 Mar 26. PMID: 33768237.
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    11. Nyirjesy P, Banker WM, Bonus TM. Physician Awareness and Adherence to Clinical Practice Guidelines in the Diagnosis of Vaginitis Patients: A Retrospective Chart Review. Popul Health Manag. 2020 Oct; 23(S1):S13-S21. PMID: 32985960.
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    12. Brand SR, Sobel JD, Nyirjesy P, Ghannoum MA, Schotzinger RJ, Degenhardt TP. Randomized Phase 2 Study of VT-1161 for the Treatment of Acute Vulvovaginal Candidiasis. Clin Infect Dis. 2020 Aug 20. PMID: 32818963.
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    13. Rinko R, Spector C, Cook E, Mancenido B, Gracely EJ, Nyirjesy P. Sequence of Pelvic Examination Does Not Affect Patients With Baseline Vulvovaginal Syndromes: A Randomized Clinical Trial. Female Pelvic Med Reconstr Surg. 2020 Apr 21. PMID: 32332423.
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    14. Balchander D, Nyirjesy P. Fractionated CO2 Laser as Therapy in Recalcitrant Lichen Sclerosus. J Low Genit Tract Dis. 2020 Feb 14. PMID: 32068618.
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    15. Schwebke JR, Taylor SN, Ackerman R, Schlaberg R, Quigley NB, Gaydos CA, Chavoustie SE, Nyirjesy P, Remillard CV, Estes P, McKinney B, Getman DK, Clark C. Clinical validation of the Aptima Bacterial Vaginosis and Aptima Candida/Trichomonas Vaginitis Assays: results from a prospective multi-center clinical study. J Clin Microbiol. 2019 Nov 20. PMID: 31748322.
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    16. Alessio C, Nyirjesy P. Management of Resistant Trichomoniasis. Curr Infect Dis Rep. 2019 Aug 06; 21(9):31. PMID: 31388764.
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    17. Nyirjesy P, Alessio C, Jandourek A, Lee JD, Sandison T, Sobel JD. CD101 Topical Compared With Oral Fluconazole for Acute Vulvovaginal Candidiasis: A Randomized Controlled Trial. J Low Genit Tract Dis. 2019 Jul; 23(3):226-229. PMID: 30893271.
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    18. Nyirjesy P, Sobel JD. Re: A systematic review of drug treatment of vulvodynia: evidence of a strong placebo effect. BJOG. 2019 06; 126(7):945-946. PMID: 30957400.
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    19. Yano J, Sobel JD, Nyirjesy P, Sobel R, Williams VL, Yu Q, Noverr MC, Fidel PL. Current patient perspectives of vulvovaginal candidiasis: incidence, symptoms, management and post-treatment outcomes. BMC Womens Health. 2019 03 29; 19(1):48. PMID: 30925872.
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    20. Henien M, Nyirjesy P, Smith K. Metronidazole-Resistant Trichomoniasis: Beneficial Pharmacodynamic Relationship With High-Dose Oral Tinidazole and Vaginal Paromomycin Combination Therapy. Sex Transm Dis. 2019 01; 46(1):e1-e2. PMID: 30106840.
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    21. Crouss T, Sobel JD, Smith K, Nyirjesy P. Long-Term Outcomes of Women With Recurrent Vulvovaginal Candidiasis After a Course of Maintenance Antifungal Therapy. J Low Genit Tract Dis. 2018 Oct; 22(4):382-386. PMID: 29975334.
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    22. Edwards JE, Schwartz MM, Schmidt CS, Sobel JD, Nyirjesy P, Schodel F, Marchus E, Lizakowski M, DeMontigny EA, Hoeg J, Holmberg T, Cooke MT, Hoover K, Edwards L, Jacobs M, Sussman S, Augenbraun M, Drusano M, Yeaman MR, Ibrahim AS, Filler SG, Hennessey JP. A Fungal Immunotherapeutic Vaccine (NDV-3A) for Treatment of Recurrent Vulvovaginal Candidiasis-A Phase 2 Randomized, Double-Blind, Placebo-Controlled Trial. Clin Infect Dis. 2018 06 01; 66(12):1928-1936. PMID: 29697768.
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    23. Schwebke JR, Gaydos CA, Nyirjesy P, Paradis S, Kodsi S, Cooper CK. Diagnostic Performance of a Molecular Test versus Clinician Assessment of Vaginitis. J Clin Microbiol. 2018 06; 56(6). PMID: 29643195.
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    24. Brand SR, Degenhardt TP, Person K, Sobel JD, Nyirjesy P, Schotzinger RJ, Tavakkol A. A phase 2, randomized, double-blind, placebo-controlled, dose-ranging study to evaluate the efficacy and safety of orally administered VT-1161 in the treatment of recurrent vulvovaginal candidiasis. Am J Obstet Gynecol. 2018 06; 218(6):624.e1-624.e9. PMID: 29534874.
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    25. Nyirjesy P, Schwebke JR. Secnidazole: next-generation antimicrobial agent for bacterial vaginosis treatment. Future Microbiol. 2018 04; 13:507-524. PMID: 29327947.
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    26. Schwebke JR, Morgan FG, Koltun W, Nyirjesy P. A phase-3, double-blind, placebo-controlled study of the effectiveness and safety of single oral doses of secnidazole 2 g for the treatment of women with bacterial vaginosis. Am J Obstet Gynecol. 2017 12; 217(6):678.e1-678.e9. PMID: 28867602.
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    27. Hillier SL, Nyirjesy P, Waldbaum AS, Schwebke JR, Morgan FG, Adetoro NA, Braun CJ. Secnidazole Treatment of Bacterial Vaginosis: A Randomized Controlled Trial. Obstet Gynecol. 2017 08; 130(2):379-386. PMID: 28697102.
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    28. Gaydos CA, Beqaj S, Schwebke JR, Lebed J, Smith B, Davis TE, Fife KH, Nyirjesy P, Spurrell T, Furgerson D, Coleman J, Paradis S, Cooper CK. Clinical Validation of a Test for the Diagnosis of Vaginitis. Obstet Gynecol. 2017 07; 130(1):181-189. PMID: 28594779.
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    29. Chavoustie SE, Eder SE, Koltun WD, Lemon TR, Mitchell C, Nyirjesy P, Sobel JD, Sobel R, Villanueva R. Experts explore the state of bacterial vaginosis and the unmet needs facing women and providers. Int J Gynaecol Obstet. 2017 05; 137(2):107-109. PMID: 28262922.
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    30. Mattson SK, Polk JP, Nyirjesy P. Chronic Cervicitis: Presenting Features and Response to Therapy. J Low Genit Tract Dis. 2016 Jul; 20(3):e30-3. PMID: 27243142.
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    31. Powell AM, Gracely E, Nyirjesy P. Non-albicans Candida Vulvovaginitis: Treatment Experience at a Tertiary Care Vaginitis Center. J Low Genit Tract Dis. 2016 Jan; 20(1):85-9. PMID: 26083330.
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    32. Meites E, Gaydos CA, Hobbs MM, Kissinger P, Nyirjesy P, Schwebke JR, Secor WE, Sobel JD, Workowski KA. A Review of Evidence-Based Care of Symptomatic Trichomoniasis and Asymptomatic Trichomonas vaginalis Infections. Clin Infect Dis. 2015 Dec 15; 61 Suppl 8:S837-48. PMID: 26602621.
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    33. Powell AM, Nyirjesy P. New Perspectives on the Normal Vagina and Noninfectious Causes of Discharge. Clin Obstet Gynecol. 2015 Sep; 58(3):453-63. PMID: 26125958.
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    34. Keating MA, Nyirjesy P. Trichomonas vaginalis Infection in a Tertiary Care Vaginitis Center. Sex Transm Dis. 2015 Sep; 42(9):482-5. PMID: 26267873.
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    35. Chavoustie SE, Jacobs M, Reisman HA, Waldbaum AS, Levy SF, Hillier SL, Nyirjesy P. Metronidazole vaginal gel 1.3% in the treatment of bacterial vaginosis: a dose-ranging study. J Low Genit Tract Dis. 2015 Apr; 19(2):129-34. PMID: 24983350.
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    36. Reichman O, Moyal-Barracco M, Nyirjesy P. Comment on "Vulvovaginal candidiasis as a chronic disease: diagnostic criteria and definition". J Low Genit Tract Dis. 2015 Jan; 19(1):e23-4. PMID: 24769654.
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    37. Nyirjesy P. Management of persistent vaginitis. Obstet Gynecol. 2014 Dec; 124(6):1135-46. PMID: 25415165.
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    38. Powell AM, Nyirjesy P. Recurrent vulvovaginitis. Best Pract Res Clin Obstet Gynaecol. 2014 Oct; 28(7):967-76. PMID: 25220102.
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    39. Pereira N, Bardawil EC, Patel MA, Brannon RK, Podolsky ML, Nyirjesy P. Iliopsoas abscess: an unexpected sequela of dilation and evacuation. J Low Genit Tract Dis. 2014 Apr; 18(2):E34-7. PMID: 23994946.
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    40. Nyirjesy P, Sobel JD, Fung A, Mayer C, Capuano G, Ways K, Usiskin K. Genital mycotic infections with canagliflozin, a sodium glucose co-transporter 2 inhibitor, in patients with type 2 diabetes mellitus: a pooled analysis of clinical studies. Curr Med Res Opin. 2014 Jun; 30(6):1109-19. PMID: 24517339.
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    41. Pereira N, Powell AM, Nyirjesy P, Plante LA. Vaginorectal Streptococcus porcinus in pregnancy: an emerging pathogen? J Low Genit Tract Dis. 2013 Oct; 17(4):e18-21. PMID: 23595037.
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    42. Nyirjesy P, Sobel JD. Genital mycotic infections in patients with diabetes. Postgrad Med. 2013 May; 125(3):33-46. PMID: 23748505.
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    43. Pereira N, Edlind TD, Schlievert PM, Nyirjesy P. Vaginal toxic shock reaction triggering desquamative inflammatory vaginitis. J Low Genit Tract Dis. 2013 Jan; 17(1):88-91. PMID: 23222054.
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    44. Nyirjesy P, Zhao Y, Ways K, Usiskin K. Evaluation of vulvovaginal symptoms and Candida colonization in women with type 2 diabetes mellitus treated with canagliflozin, a sodium glucose co-transporter 2 inhibitor. Curr Med Res Opin. 2012 Jul; 28(7):1173-8. PMID: 22632452.
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    45. Subramanian C, Nyirjesy P, Sobel JD. Genital malodor in women: a modern reappraisal. J Low Genit Tract Dis. 2012 Jan; 16(1):49-55. PMID: 21964208.
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    46. Nyirjesy P, Leigh RD, Mathew L, Lev-Sagie A, Culhane JF. Chronic vulvovaginitis in women older than 50 years: analysis of a prospective database. J Low Genit Tract Dis. 2012 Jan; 16(1):24-9. PMID: 21964206.
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    47. Miller MR, Nyirjesy P. Refractory Trichomoniasis in HIV-positive and HIV-negative Subjects. Curr Infect Dis Rep. 2011 Dec; 13(6):595-603. PMID: 21922351.
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    48. Nyirjesy P, Gilbert J, Mulcahy LJ. Resistant trichomoniasis: successful treatment with combination therapy. Sex Transm Dis. 2011 Oct; 38(10):962-3. PMID: 21934573.
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    49. Nyirjesy P, Robinson J, Mathew L, Lev-Sagie A, Reyes I, Culhane JF. Alternative therapies in women with chronic vaginitis. Obstet Gynecol. 2011 Apr; 117(4):856-61. PMID: 21422856.
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    50. Patel MA, Nyirjesy P. Role of Mycoplasma and ureaplasma species in female lower genital tract infections. Curr Infect Dis Rep. 2010 Nov; 12(6):417-22. PMID: 21308549.
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    51. Asemota OA, Nyirjesy P, Fox R, Sobel JD. Candida glabrata complicating in vitro pregnancy: successful management of subsequent pregnancy. Fertil Steril. 2011 Feb; 95(2):803.e1-2. PMID: 20840882.
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    52. Leigh R, Nyirjesy P. Genitourinary manifestations of epstein-barr virus infections. Curr Infect Dis Rep. 2009 Nov; 11(6):449-56. PMID: 19857384.
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    53. Sobel JD, Nyirjesy P, Kessary H, Ferris DG. Use of the VS-sense swab in diagnosing vulvovaginitis. J Womens Health (Larchmt). 2009 Sep; 18(9):1467-70. PMID: 19743911.
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    54. Lev-Sagie A, Nyirjesy P, Tarangelo N, Bongiovanni AM, Bayer C, Linhares IM, Giraldo PC, Ledger WJ, Witkin SS. Hyaluronan in vaginal secretions: association with recurrent vulvovaginal candidiasis. Am J Obstet Gynecol. 2009 Aug; 201(2):206.e1-5. PMID: 19646572.
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    55. Nyirjesy P. Vulvovaginal candidiasis and bacterial vaginosis. Infect Dis Clin North Am. 2008 Dec; 22(4):637-652. PMID: 18954756.
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    56. Culhane JF, Nyirjesy P, McCollum K, Casabellata G, Di Santolo M, Cauci S. Evaluation of semen detection in vaginal secretions: comparison of four methods. Am J Reprod Immunol. 2008 Sep; 60(3):274-81. PMID: 18647289.
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    57. Podolsky ML, Desai NA, Waters TP, Nyirjesy P. Hysteroscopic tubal occlusion: sterilization after failed laparoscopic or abdominal approaches. Obstet Gynecol. 2008 Feb; 111(2 Pt 2):513-5. PMID: 18239004.
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    58. Nyirjesy P. Postmenopausal vaginitis. Curr Infect Dis Rep. 2007 Nov; 9(6):480-4. PMID: 17999884.
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    59. Livengood CH, Ferris DG, Wiesenfeld HC, Hillier SL, Soper DE, Nyirjesy P, Marrazzo J, Chatwani A, Fine P, Sobel J, Taylor SN, Wood L, Kanalas JJ. Effectiveness of two tinidazole regimens in treatment of bacterial vaginosis: a randomized controlled trial. Obstet Gynecol. 2007 Aug; 110(2 Pt 1):302-9. PMID: 17666604.
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    60. Della Badia C, Nyirjesy P, Atogho A. Endometrial ablation devices: review of a manufacturer and user facility device experience database. J Minim Invasive Gynecol. 2007 Jul-Aug; 14(4):436-41. PMID: 17630160.
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    61. Nyirjesy P, McIntosh MJ, Steinmetz JI, Schumacher RJ, Joffrion JL. The effects of intravaginal clindamycin and metronidazole therapy on vaginal mobiluncus morphotypes in patients with bacterial vaginosis. Sex Transm Dis. 2007 Apr; 34(4):197-202. PMID: 17179772.
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    62. Nyirjesy P, Peyton C, Weitz MV, Mathew L, Culhane JF. Causes of chronic vaginitis: analysis of a prospective database of affected women. Obstet Gynecol. 2006 Nov; 108(5):1185-91. PMID: 17077241.
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    63. Culhane JF, Nyirjesy P, McCollum K, Goldenberg RL, Gelber SE, Cauci S. Variation in vaginal immune parameters and microbial hydrolytic enzymes in bacterial vaginosis positive pregnant women with and without Mobiluncus species. Am J Obstet Gynecol. 2006 Aug; 195(2):516-21. PMID: 16643824.
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    64. Nyirjesy P, McIntosh MJ, Gattermeir DJ, Schumacher RJ, Steinmetz JI, Joffrion JL. The effects of intravaginal clindamycin and metronidazole therapy on vaginal lactobacilli in patients with bacterial vaginosis. Am J Obstet Gynecol. 2006 May; 194(5):1277-82. PMID: 16647910.
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    65. Sobel JD, Ferris D, Schwebke J, Nyirjesy P, Wiesenfeld HC, Peipert J, Soper D, Ohmit SE, Hillier SL. Suppressive antibacterial therapy with 0.75% metronidazole vaginal gel to prevent recurrent bacterial vaginosis. Am J Obstet Gynecol. 2006 May; 194(5):1283-9. PMID: 16647911.
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    66. Nyirjesy P, Sobel JD. Advances in diagnosing vaginitis: development of a new algorithm. Curr Infect Dis Rep. 2005 Nov; 7(6):458-62. PMID: 16225784.
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    67. Pereira L, Culhane J, McCollum K, Agnew K, Nyirjesy P. Variation in microbiologic profiles among pregnant women with bacterial vaginosis. Am J Obstet Gynecol. 2005 Sep; 193(3 Pt 1):746-51. PMID: 16150269.
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    68. Nunnari G, Sullivan J, Xu Y, Nyirjesy P, Kulkosky J, Cavert W, Frank I, Pomerantz RJ. HIV type 1 cervicovaginal reservoirs in the era of HAART. AIDS Res Hum Retroviruses. 2005 Aug; 21(8):714-8. PMID: 16131311.
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    69. Nyirjesy P, Alexander AB, Weitz MV. Vaginal Candida parapsilosis: pathogen or bystander? Infect Dis Obstet Gynecol. 2005 Mar; 13(1):37-41. PMID: 16040326.
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    70. Baylson FA, Nyirjesy P, Weitz MV. Treatment of recurrent bacterial vaginosis with tinidazole. Obstet Gynecol. 2004 Nov; 104(5 Pt 1):931-2. PMID: 15516381.
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    71. Patel DA, Gillespie B, Sobel JD, Leaman D, Nyirjesy P, Weitz MV, Foxman B. Risk factors for recurrent vulvovaginal candidiasis in women receiving maintenance antifungal therapy: results of a prospective cohort study. Am J Obstet Gynecol. 2004 Mar; 190(3):644-53. PMID: 15041994.
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    72. Nyirjesy P, Sobel JD. Vulvovaginal candidiasis. Obstet Gynecol Clin North Am. 2003 Dec; 30(4):671-84. PMID: 14719844.
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    73. Nyirjesy P. Lichen Sclerosus and Other Conditions Mimicking Vulvovaginal Candidiasis. Curr Infect Dis Rep. 2002 Dec; 4(6):520-524. PMID: 12433328.
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    74. Ferris DG, Nyirjesy P, Sobel JD, Soper D, Pavletic A, Litaker MS. Over-the-counter antifungal drug misuse associated with patient-diagnosed vulvovaginal candidiasis. Obstet Gynecol. 2002 Mar; 99(3):419-25. PMID: 11864668.
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    75. Nyirjesy P. Nongonococcal and Nonchlamydial Cervicitis. Curr Infect Dis Rep. 2001 Dec; 3(6):540-545. PMID: 11722812.
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