Serine Peptidase Inhibitor Kazal-Type 5

"Serine Peptidase Inhibitor Kazal-Type 5" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

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A secreted serine peptidase inhibitor that consists of 15 KAZAL MOTIFS and inhibits KALLIKREINS KLK5, KLK7, and KLK14 as well as TRYPSIN. It plays important roles in protecting MUCOSA against infection and inflammation, and in maintaining the integrity of the skin. Mutations in the SPINK5 gene are associated with NETHERTON SYNDROME.

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Bar chart showing 1 publications over 1 distinct years, with a maximum of 1 publications in 2005
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