Alpha-Ketoglutarate-Dependent Dioxygenase FTO
"Alpha-Ketoglutarate-Dependent Dioxygenase FTO" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. It has highest activity towards single-stranded RNA containing 3-methyluracil, followed by SINGLE-STRANDED DNA containing 3-methylthymine and specifically demethylates N(6)-methyladenosine (m6A) RNA, the most common internal modification of MESSENGER RNA (mRNA) in higher EUKARYOTES. It contributes to the regulation of the global metabolic rate, energy HOMEOSTASIS, as well as body fat accumulation by regulating the differentiation of ADIPOCYTES into BROWN FAT CELLS or WHITE FAT CELLS.
| Descriptor ID |
D000071516
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| MeSH Number(s) |
D08.811.074.062.968 D08.811.682.662.582.242 D08.811.682.690.416.139.992
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| Concept/Terms |
Alpha-Ketoglutarate-Dependent Dioxygenase FTO- Alpha-Ketoglutarate-Dependent Dioxygenase FTO
- Alpha Ketoglutarate Dependent Dioxygenase FTO
- FTO, Alpha-Ketoglutarate-Dependent Dioxygenase
- Fat Mass and Obesity Associated (FTO) Protein
- Alpha-Ketoglutarate-Dependent Dioxygenase
- Alpha Ketoglutarate Dependent Dioxygenase
- Dioxygenase, Alpha-Ketoglutarate-Dependent
- Fat Mass and Obesity Associated Protein
- AlkB Homolog 9 Protein
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Below are MeSH descriptors whose meaning is more general than "Alpha-Ketoglutarate-Dependent Dioxygenase FTO".
Below are MeSH descriptors whose meaning is more specific than "Alpha-Ketoglutarate-Dependent Dioxygenase FTO".
This graph shows the total number of publications written about "Alpha-Ketoglutarate-Dependent Dioxygenase FTO" by people in this website by year, and whether "Alpha-Ketoglutarate-Dependent Dioxygenase FTO" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Alpha-Ketoglutarate-Dependent Dioxygenase FTO" by people in Profiles.
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Lee S, Lasky-Su J, Won S, Laurie C, Celed?n JC, Lange C, Weiss S, Hecker J. Novel recessive locus for body mass index in childhood asthma. Thorax. 2021 12; 76(12):1227-1230.
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Peters U, North KE, Sethupathy P, Buyske S, Haessler J, Jiao S, Fesinmeyer MD, Jackson RD, Kuller LH, Rajkovic A, Lim U, Cheng I, Schumacher F, Wilkens L, Li R, Monda K, Ehret G, Nguyen KD, Cooper R, Lewis CE, Leppert M, Irvin MR, Gu CC, Houston D, Buzkova P, Ritchie M, Matise TC, Le Marchand L, Hindorff LA, Crawford DC, Haiman CA, Kooperberg C. A systematic mapping approach of 16q12.2/FTO and BMI in more than 20,000 African Americans narrows in on the underlying functional variation: results from the Population Architecture using Genomics and Epidemiology (PAGE) study. PLoS Genet. 2013; 9(1):e1003171.
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Ahmad T, Chasman DI, Mora S, Par? G, Cook NR, Buring JE, Ridker PM, Lee IM. The fat-mass and obesity-associated (FTO) gene, physical activity, and risk of incident cardiovascular events in white women. Am Heart J. 2010 Dec; 160(6):1163-9.