"Forkhead Box Protein O1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A forkhead box transcription factor that is a major target of INSULIN signaling and regulator of metabolic homeostasis in response to OXIDATIVE STRESS. It binds to the insulin RESPONSE ELEMENT (IRE) and the related Daf-16 family binding element (DBE). Its activity is suppressed by insulin and it also regulates OSTEOBLAST proliferation, controls bone mass, and skeletal regulation of GLUCOSE metabolism. It promotes GLUCONEOGENESIS in HEPATOCYTES and regulates gene expression in ADIPOSE TISSUE. It is also an important CELL DEATH regulator. Chromosomal aberrations involving the FOXO1 gene occur in RHABDOMYOSARCOMA.
| Descriptor ID |
D000071161
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| MeSH Number(s) |
D12.776.260.950.249.250 D12.776.930.977.249.250
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Forkhead Box Protein O1".
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This graph shows the total number of publications written about "Forkhead Box Protein O1" by people in this website by year, and whether "Forkhead Box Protein O1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 0 | 1 | 1 |
| 1995 | 0 | 2 | 2 |
| 1996 | 0 | 1 | 1 |
| 2000 | 0 | 2 | 2 |
| 2001 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
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Below are the most recent publications written about "Forkhead Box Protein O1" by people in Profiles.
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Pandey PR, Chatterjee B, Olanich ME, Khan J, Miettinen MM, Hewitt SM, Barr FG. PAX3-FOXO1 is essential for tumour initiation and maintenance but not recurrence in a human myoblast model of rhabdomyosarcoma. J Pathol. 2017 04; 241(5):626-637.
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Wu W, Kong Z, Duan X, Zhu H, Li S, Zeng S, Liang Y, Iliakis G, Gui Z, Yang D. Inhibition of PARP1 by small interfering RNA enhances docetaxel activity against human prostate cancer PC3 cells. Biochem Biophys Res Commun. 2013 Dec 06; 442(1-2):127-32.
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Ehlers JP, Penne RB, Eagle RC, Carrasco JR. Alveolar rhabdomyosarcoma presenting as an acute orbital mass in the medial rectus muscle. Ophthalmic Plast Reconstr Surg. 2007 Mar-Apr; 23(2):149-51.
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Fredericks WJ, Ayyanathan K, Rauscher FJ. Regulating the neoplastic phenotype using engineered transcriptional repressors. Cancer Lett. 2001 Jan; 162 Suppl:S23-S32.
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Ayyanathan K, Fredericks WJ, Berking C, Herlyn M, Balakrishnan C, Gunther E, Rauscher FJ. Hormone-dependent tumor regression in vivo by an inducible transcriptional repressor directed at the PAX3-FKHR oncogene. Cancer Res. 2000 Oct 15; 60(20):5803-14.
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Fredericks WJ, Ayyanathan K, Herlyn M, Friedman JR, Rauscher FJ. An engineered PAX3-KRAB transcriptional repressor inhibits the malignant phenotype of alveolar rhabdomyosarcoma cells harboring the endogenous PAX3-FKHR oncogene. Mol Cell Biol. 2000 Jul; 20(14):5019-31.
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Scheidler S, Fredericks WJ, Rauscher FJ, Barr FG, Vogt PK. The hybrid PAX3-FKHR fusion protein of alveolar rhabdomyosarcoma transforms fibroblasts in culture. Proc Natl Acad Sci U S A. 1996 Sep 3; 93(18):9805-9.
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Bennicelli JL, Fredericks WJ, Wilson RB, Rauscher FJ, Barr FG. Wild type PAX3 protein and the PAX3-FKHR fusion protein of alveolar rhabdomyosarcoma contain potent, structurally distinct transcriptional activation domains. Oncogene. 1995 Jul 6; 11(1):119-30.
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Fredericks WJ, Galili N, Mukhopadhyay S, Rovera G, Bennicelli J, Barr FG, Rauscher FJ. The PAX3-FKHR fusion protein created by the t(2;13) translocation in alveolar rhabdomyosarcomas is a more potent transcriptional activator than PAX3. Mol Cell Biol. 1995 Mar; 15(3):1522-35.
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Galili N, Davis RJ, Fredericks WJ, Mukhopadhyay S, Rauscher FJ, Emanuel BS, Rovera G, Barr FG. Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma. Nat Genet. 1993 Nov; 5(3):230-5.