"NEDD8 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A ubiquitin-like protein that functions in CELL CYCLE regulation and embryogenesis. It is attached covalently to its substrates following activation by the UBIQUITIN-ACTIVATING ENZYME E1-UBA3 enzyme complex. NEDD8 attaches to CULLINS, activating their E3 UBIQUITIN LIGASE activity, to promote polyubiquitination and degradation of CYCLINS and regulatory proteins
| Descriptor ID |
D000075687
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| MeSH Number(s) |
D12.776.947.218
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| Concept/Terms |
NEDD8 Protein- NEDD8 Protein
- Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 8
- Neural Precursor Cell Expressed Developmentally Down Regulated Protein 8
- NEDD-8 Protein
- NEDD 8 Protein
- Ubiquitin-like Protein NEDD8
- NEDD8, Ubiquitin-like Protein
- Ubiquitin like Protein NEDD8
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Below are MeSH descriptors whose meaning is more general than "NEDD8 Protein".
Below are MeSH descriptors whose meaning is more specific than "NEDD8 Protein".
This graph shows the total number of publications written about "NEDD8 Protein" by people in this website by year, and whether "NEDD8 Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
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Below are the most recent publications written about "NEDD8 Protein" by people in Profiles.
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Huang G, Towe CW, Choi L, Yonekawa Y, Bommelj? CC, Bains S, Rechler W, Hao B, Ramanathan Y, Singh B. The ubiquitin-associated (UBA) domain of SCCRO/DCUN1D1 protein serves as a feedback regulator of biochemical and oncogenic activity. J Biol Chem. 2015 Jan 02; 290(1):296-309.
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Smith MA, Maris JM, Gorlick R, Kolb EA, Lock R, Carol H, Keir ST, Reynolds CP, Kang MH, Morton CL, Wu J, Smith PG, Yu J, Houghton PJ. Initial testing of the investigational NEDD8-activating enzyme inhibitor MLN4924 by the pediatric preclinical testing program. Pediatr Blood Cancer. 2012 Aug; 59(2):246-53.
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Kim AY, Bommelj? CC, Lee BE, Yonekawa Y, Choi L, Morris LG, Huang G, Kaufman A, Ryan RJ, Hao B, Ramanathan Y, Singh B. SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation. J Biol Chem. 2008 Nov 28; 283(48):33211-20.