"Receptors, Enterotoxin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Guanylate cyclase-coupled receptors that bind bacterial ENTEROTOXINS, as well as the endogenous peptides guanylin and uroguanylin. Ligand binding stimulates production of CYCLIC GMP by EPITHELIAL CELLS of the intestinal lumen, altering barrier permeability and mucus secretion. Mutations in the gene (GUCY2C) encoding this receptor are associated with some cases of hereditary diarrhea (Diarrhea 6) and MECONIUM ILEUS.
| Descriptor ID |
D000074261
|
| MeSH Number(s) |
D08.811.520.650.600.500.250 D12.776.543.750.700.250 D12.776.543.750.750.025
|
| Concept/Terms |
Receptors, Enterotoxin- Receptors, Enterotoxin
- Enterotoxin-Guanylin Receptors
- Enterotoxin Guanylin Receptors
- Receptors, Enterotoxin-Guanylin
- Receptors, Guanyl Cyclase-C
- Receptors, Guanyl Cyclase C
- Guanyl Cyclase-C Receptors
- Cyclase-C Receptors, Guanyl
- Guanyl Cyclase C Receptors
- Guanylin-Uroguanylin Receptors
- Guanylin Uroguanylin Receptors
- Receptors, Guanylin-Uroguanylin
- Heat-Stable Enterotoxin Receptors
- Enterotoxin Receptors, Heat-Stable
- Heat Stable Enterotoxin Receptors
- Receptors, Heat-Stable Enterotoxin
- Enterotoxin Receptors
- GC-C Receptors
- GC C Receptors
- Receptors, GC-C
Enterotoxin Receptor- Enterotoxin Receptor
- Enterotoxin-Guanylin Receptor
- Enterotoxin Guanylin Receptor
- Receptor, Enterotoxin-Guanylin
- Guanyl Cyclase-C Receptor
- Guanyl Cyclase C Receptor
- Receptor, Guanyl Cyclase-C
- Receptor, Guanyl Cyclase C
- Guanylyl Cyclase C
- Cyclase C, Guanylyl
- Heat-Stable Enterotoxin Receptor
- Enterotoxin Receptor, Heat-Stable
- Heat Stable Enterotoxin Receptor
- Receptor, Heat-Stable Enterotoxin
- Receptor, Enterotoxin
- GC-C Receptor
- GC C Receptor
- Receptor, GC-C
- Guanylin-Uroguanylin Receptor
- Guanylin Uroguanylin Receptor
- Receptor, Guanylin-Uroguanylin
|
Below are MeSH descriptors whose meaning is more general than "Receptors, Enterotoxin".
Below are MeSH descriptors whose meaning is more specific than "Receptors, Enterotoxin".
This graph shows the total number of publications written about "Receptors, Enterotoxin" by people in this website by year, and whether "Receptors, Enterotoxin" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 2 | 2 |
| 2006 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
| 2022 | 0 | 2 | 2 |
| 2024 | 0 | 1 | 1 |
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click here.
Below are the most recent publications written about "Receptors, Enterotoxin" by people in Profiles.
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Baybutt TR, Entezari AA, Caspi A, Staudt RE, Carlson RD, Waldman SA, Snook AE. CD8a Structural Domains Enhance GUCY2C CAR-T Cell Efficacy. Cancer Biol Ther. 2024 Dec 31; 25(1):2398801.
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Caspi A, Entezari AA, Crutcher M, Snook AE, Waldman SA. Guanylyl cyclase C as a diagnostic and therapeutic target in colorectal cancer. Per Med. 2022 09; 19(5):457-472.
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Flickinger JC, Singh J, Yarman Y, Carlson RD, Barton JR, Waldman SA, Snook AE. T-Cell Responses to Immunodominant Listeria Epitopes Limit Vaccine-Directed Responses to the Colorectal Cancer Antigen, Guanylyl Cyclase C. Front Immunol. 2022; 13:855759.
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Merlino DJ, Barton JR, Charsar BA, Byrne MD, Rappaport JA, Smeyne RJ, Lepore AC, Snook AE, Waldman SA. Two distinct GUCY2C circuits with PMV (hypothalamic) and SN/VTA (midbrain) origin. Brain Struct Funct. 2019 Nov; 224(8):2983-2999.
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Li P, Wuthrick E, Rappaport JA, Kraft C, Lin JE, Marszalowicz G, Snook AE, Zhan T, Hyslop TM, Waldman SA. GUCY2C Signaling Opposes the Acute Radiation-Induced GI Syndrome. Cancer Res. 2017 Sep 15; 77(18):5095-5106.
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Elitsur N, Lorenz JN, Hawkins JA, Rudolph JA, Witte D, Yang LE, McDonough AA, Cohen MB. The proximal convoluted tubule is a target for the uroguanylin-regulated natriuretic response. J Pediatr Gastroenterol Nutr. 2006 Jul; 43 Suppl 1:S74-81.
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Di Guglielmo MD, Park J, Schulz S, Waldman SA. Nucleotide requirements for CDX2 binding to the cis promoter element mediating intestine-specific expression of guanylyl cyclase C. FEBS Lett. 2001 Oct 26; 507(2):128-32.
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Pitari GM, Di Guglielmo MD, Park J, Schulz S, Waldman SA. Guanylyl cyclase C agonists regulate progression through the cell cycle of human colon carcinoma cells. Proc Natl Acad Sci U S A. 2001 Jul 03; 98(14):7846-51.