Receptors, Enterotoxin

"Receptors, Enterotoxin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Guanylate cyclase-coupled receptors that bind bacterial ENTEROTOXINS, as well as the endogenous peptides guanylin and uroguanylin. Ligand binding stimulates production of CYCLIC GMP by EPITHELIAL CELLS of the intestinal lumen, altering barrier permeability and mucus secretion. Mutations in the gene (GUCY2C) encoding this receptor are associated with some cases of hereditary diarrhea (Diarrhea 6) and MECONIUM ILEUS.

Descriptor ID	D000074261
MeSH Number(s)	D08.811.520.650.600.500.250 D12.776.543.750.700.250 D12.776.543.750.750.025
Concept/Terms	Receptors, Enterotoxin Receptors, Enterotoxin Enterotoxin-Guanylin Receptors Enterotoxin Guanylin Receptors Receptors, Enterotoxin-Guanylin Receptors, Guanyl Cyclase-C Receptors, Guanyl Cyclase C Guanyl Cyclase-C Receptors Cyclase-C Receptors, Guanyl Guanyl Cyclase C Receptors Guanylin-Uroguanylin Receptors Guanylin Uroguanylin Receptors Receptors, Guanylin-Uroguanylin Heat-Stable Enterotoxin Receptors Enterotoxin Receptors, Heat-Stable Heat Stable Enterotoxin Receptors Receptors, Heat-Stable Enterotoxin Enterotoxin Receptors GC-C Receptors GC C Receptors Receptors, GC-C Enterotoxin Receptor Enterotoxin Receptor Enterotoxin-Guanylin Receptor Enterotoxin Guanylin Receptor Receptor, Enterotoxin-Guanylin Guanyl Cyclase-C Receptor Guanyl Cyclase C Receptor Receptor, Guanyl Cyclase-C Receptor, Guanyl Cyclase C Guanylyl Cyclase C Cyclase C, Guanylyl Heat-Stable Enterotoxin Receptor Enterotoxin Receptor, Heat-Stable Heat Stable Enterotoxin Receptor Receptor, Heat-Stable Enterotoxin Receptor, Enterotoxin GC-C Receptor GC C Receptor Receptor, GC-C Guanylin-Uroguanylin Receptor Guanylin Uroguanylin Receptor Receptor, Guanylin-Uroguanylin

Below are MeSH descriptors whose meaning is more general than "Receptors, Enterotoxin".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Lyases [D08.811.520]
Phosphorus-Oxygen Lyases [D08.811.520.650]
Guanylate Cyclase [D08.811.520.650.600]
Receptors, Guanylate Cyclase-Coupled [D08.811.520.650.600.500]
Receptors, Enterotoxin [D08.811.520.650.600.500.250]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Membrane Proteins [D12.776.543]
Receptors, Cell Surface [D12.776.543.750]
Receptors, Guanylate Cyclase-Coupled [D12.776.543.750.700]
Receptors, Enterotoxin [D12.776.543.750.700.250]
Receptors, Peptide [D12.776.543.750.750]
Receptors, Enterotoxin [D12.776.543.750.750.025]

Below are MeSH descriptors whose meaning is more specific than "Receptors, Enterotoxin".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Receptors, Enterotoxin" by people in this website by year, and whether "Receptors, Enterotoxin" was a major or minor topic of these publications.

Bar chart showing 99 publications over 27 distinct years, with a maximum of 11 publications in 2009

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	3	3
1997	0	1	1
1998	0	2	2
1999	0	1	1
2000	0	2	2
2001	0	3	3
2002	0	3	3
2003	0	1	1
2005	0	5	5
2006	0	5	5
2007	0	4	4
2008	0	6	6
2009	0	11	11
2010	0	4	4
2011	0	4	4
2012	0	3	3
2013	0	5	5
2014	0	4	4
2016	0	6	6
2017	1	5	6
2018	1	0	1
2019	4	0	4
2020	4	0	4
2021	2	3	5
2022	0	2	2
2023	1	2	3
2024	0	1	1

Below are the most recent publications written about "Receptors, Enterotoxin" by people in Profiles.

Baybutt TR, Entezari AA, Caspi A, Staudt RE, Carlson RD, Waldman SA, Snook AE. CD8a Structural Domains Enhance GUCY2C CAR-T Cell Efficacy. Cancer Biol Ther. 2024 Dec 31; 25(1):2398801.

View in: PubMed
Londregan A, Alexander TD, Covarrubias M, Waldman SA. Fundamental Neurochemistry Review: The role of enteroendocrine cells in visceral pain. J Neurochem. 2023 12; 167(6):719-732.

View in: PubMed
Barton JR, Londregan AK, Alexander TD, Entezari AA, Bar-Ad S, Cheng L, Lepore AC, Snook AE, Covarrubias M, Waldman SA. Intestinal neuropod cell GUCY2C regulates visceral pain. J Clin Invest. 2023 02 15; 133(4).

View in: PubMed
Di Guglielmo MD, Holbrook J, Stabley D, Robbins KM, Boyce B, Hardy H, Adeyemi A. The Intestinal Tract Brush Border in Young Children Uniformly Expresses Guanylate Cyclase C. Appl Immunohistochem Mol Morphol. 2023 03 01; 31(3):154-162.

View in: PubMed
Caspi A, Entezari AA, Crutcher M, Snook AE, Waldman SA. Guanylyl cyclase C as a diagnostic and therapeutic target in colorectal cancer. Per Med. 2022 09; 19(5):457-472.

View in: PubMed
Flickinger JC, Singh J, Yarman Y, Carlson RD, Barton JR, Waldman SA, Snook AE. T-Cell Responses to Immunodominant Listeria Epitopes Limit Vaccine-Directed Responses to the Colorectal Cancer Antigen, Guanylyl Cyclase C. Front Immunol. 2022; 13:855759.

View in: PubMed
Rappaport JA, Entezari AA, Caspi A, Caksa S, Jhaveri AV, Stanek TJ, Ertel A, Kupper J, Fortina PM, McMahon SB, Jaynes JB, Snook AE, Waldman SA. A ?-Catenin-TCF-Sensitive Locus Control Region Mediates GUCY2C Ligand Loss in Colorectal Cancer. Cell Mol Gastroenterol Hepatol. 2022; 13(4):1276-1296.

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Weinberg DS, Foster NR, Della'Zanna G, McMurray RP, Kraft WK, Pallotto A, Kastenberg DM, Katz LC, Henry CH, Moleski SM, Limburg PJ, Waldman SA. Phase I double-blind, placebo-controlled trial of dolcanatide (SP-333) 27 mg to explore colorectal bioactivity in healthy volunteers. Cancer Biol Ther. 2021 12 02; 22(10-12):544-553.

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Entezari AA, Snook AE, Waldman SA. Guanylyl cyclase 2C (GUCY2C) in gastrointestinal cancers: recent innovations and therapeutic potential. Expert Opin Ther Targets. 2021 05; 25(5):335-346.

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Kopenhaver J, Crutcher M, Waldman SA, Snook AE. The shifting paradigm of colorectal cancer treatment: a look into emerging cancer stem cell-directed therapeutics to lead the charge toward complete remission. Expert Opin Biol Ther. 2021 10; 21(10):1335-1345.

View in: PubMed

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