"MutL Protein Homolog 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Eukaryotic homolog of the bacterial MutL DNA MISMATCH REPAIR protein. It heterodimerizes with MISMATCH REPAIR ENDONUCLEASE PMS2 to form MutL alpha, which is recruited to DNA mismatch sites by the MUTS DNA MISMATCH-BINDING PROTEIN. Mutations in the human MLH1 gene are associated with COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS.
| Descriptor ID |
D000070957
|
| MeSH Number(s) |
D08.811.074.766.500 D08.811.277.040.025.215.500 D12.776.260.540.500
|
| Concept/Terms |
MutL Protein Homolog 1- MutL Protein Homolog 1
- MLH1 Protein
- Colon Cancer, Nonpolyposis Type 2 Protein
- MutL Homolog 1
- COCA2 Protein
|
Below are MeSH descriptors whose meaning is more general than "MutL Protein Homolog 1".
Below are MeSH descriptors whose meaning is more specific than "MutL Protein Homolog 1".
This graph shows the total number of publications written about "MutL Protein Homolog 1" by people in this website by year, and whether "MutL Protein Homolog 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
| 2019 | 1 | 1 | 2 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "MutL Protein Homolog 1" by people in Profiles.
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Dondi G, Coluccelli S, De Leo A, Ferrari S, Gruppioni E, Bovicelli A, Godino L, Coada CA, Morganti AG, Giordano A, Santini D, Ceccarelli C, Turchetti D, De Iaco P, Perrone AM. An Analysis of Clinical, Surgical, Pathological and Molecular Characteristics of Endometrial Cancer According to Mismatch Repair Status. A Multidisciplinary Approach. Int J Mol Sci. 2020 Sep 29; 21(19).
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Rao S, Peri S, Hoffmann J, Cai KQ, Harris B, Rhodes M, Connolly DC, Testa JR, Wiest DL. RPL22L1 induction in colorectal cancer is associated with poor prognosis and 5-FU resistance. PLoS One. 2019; 14(10):e0222392.
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Kobayashi M, Inaguma S, Raffeld M, Kato H, Suzuki S, Wakasugi T, Mitsui A, Kuwabara Y, Lasota J, Ikeda H, Miettinen M, Takahashi S. Epithelioid variant of gastrointestinal stromal tumor harboring PDGFRA mutation and MLH1 gene alteration: A case report. Pathol Int. 2019 Sep; 69(9):541-546.
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Hassen S, Ali AA, Kilaparty SP, Al-Anbaky QA, Majeed W, Boman BM, Fields JZ, Ali N. Interdependence of DNA mismatch repair proteins MLH1 and MSH2 in apoptosis in human colorectal carcinoma cell lines. Mol Cell Biochem. 2016 Jan; 412(1-2):297-305.
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Hassen S, Boman BM, Ali N, Parker M, Somerman C, Ali-Khan Catts ZJ, Ali AA, Fields JZ. Detection of DNA mismatch repair proteins in fresh human blood lymphocytes--towards a novel method for hereditary non-polyposis colorectal cancer (Lynch syndrome) screening. J Exp Clin Cancer Res. 2011 Oct 21; 30:100.
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Fields JZ, Gao Z, Gao Z, Lewis M, Maimonis P, Harvey J, Lynch HT, Boman BM. Immunoassay for wild-type protein in lymphocytes predicts germline mutations in patients at risk for hereditary colorectal cancer. J Lab Clin Med. 2004 Jan; 143(1):59-66.
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Weber TK, Chin HM, Rodriguez-Bigas M, Keitz B, Gilligan R, O'Malley L, Urf E, Diba N, Pazik J, Petrelli NJ. Novel hMLH1 and hMSH2 germline mutations in African Americans with colorectal cancer. JAMA. 1999 Jun 23-30; 281(24):2316-20.