"Veratrum Alkaloids" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Alkaloids with powerful hypotensive effects isolated from American or European Hellebore (Veratrum viride Ait. Liliaceae and Veratrum album L. Liliaceae). They increase cholinergic and decrease adrenergic tone with appropriate side effects and at higher doses depress respiration and produce cardiac arrhythmias; only the ester alkaloids have been used as hypotensive agents in specific instances. They have been generally replaced by drugs with fewer adverse effects.
| Descriptor ID |
D014704
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| MeSH Number(s) |
D03.132.920
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Veratrum Alkaloids".
Below are MeSH descriptors whose meaning is more specific than "Veratrum Alkaloids".
This graph shows the total number of publications written about "Veratrum Alkaloids" by people in this website by year, and whether "Veratrum Alkaloids" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
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Below are the most recent publications written about "Veratrum Alkaloids" by people in Profiles.
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Vorobyeva AG, Lee R, Miller S, Longen C, Sharoni M, Kandelwal PJ, Kim FJ, Marenda DR, Saunders AJ. Cyclopamine modulates ?-secretase-mediated cleavage of amyloid precursor protein by altering its subcellular trafficking and lysosomal degradation. J Biol Chem. 2014 Nov 28; 289(48):33258-74.
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Sims-Mourtada J, Yang D, Tworowska I, Larson R, Smith D, Tsao N, Opdenaker L, Mourtada F, Woodward W. Detection of canonical hedgehog signaling in breast cancer by 131-iodine-labeled derivatives of the sonic hedgehog protein. J Biomed Biotechnol. 2012; 2012:639562.
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Dennler S, Andr? J, Alexaki I, Li A, Magnaldo T, ten Dijke P, Wang XJ, Verrecchia F, Mauviel A. Induction of sonic hedgehog mediators by transforming growth factor-beta: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo. Cancer Res. 2007 Jul 15; 67(14):6981-6.
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Riobo NA, Saucy B, Dilizio C, Manning DR. Activation of heterotrimeric G proteins by Smoothened. Proc Natl Acad Sci U S A. 2006 Aug 15; 103(33):12607-12.