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Wilbur Bowne

TitleProfessor
InstitutionThomas Jefferson University
DepartmentSurgery
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Thadi A, Morano WF, Khalili M, Babcock BD, Shaikh MF, Foster DS, Piazza Y, Gleeson EM, Goldstein E, Steele L, Campbell PM, Lin BO, Pincus MR, Bowne WB. Molecular Targeting of H/MDM-2 Oncoprotein in Human Colon Cancer Cells and Stem-like Colonic Epithelial-derived Progenitor Cells. Anticancer Res. 2021 Jan; 41(1):27-42. PMID: 33419797.
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    2. van Rhee F, Oksenhendler E, Srkalovic G, Voorhees P, Lim M, Dispenzieri A, Ide M, Parente S, Schey S, Streetly M, Wong R, Wu D, Maillard I, Brandstadter J, Munshi N, Bowne W, Elenitoba-Johnson KS, Fössa A, Lechowicz MJ, Chandrakasan S, Pierson SK, Greenway A, Nasta S, Yoshizaki K, Kurzrock R, Uldrick TS, Casper C, Chadburn A, Fajgenbaum DC. International evidence-based consensus diagnostic and treatment guidelines for unicentric Castleman disease. Blood Adv. 2020 Dec 08; 4(23):6039-6050. PMID: 33284946.
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    3. Thadi A, Lewis L, Goldstein E, Aggarwal A, Khalili M, Steele L, Polyak B, Seydafkan S, Bluth MH, Ward KA, Styler M, Campbell PM, Pincus MR, Bowne WB. Targeting Membrane HDM-2 by PNC-27 Induces Necrosis in Leukemia Cells But Not in Normal Hematopoietic Cells. Anticancer Res. 2020 Sep; 40(9):4857-4867. PMID: 32878773.
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    4. Thadi A, Gleeson EM, Khalili M, Shaikh MF, Goldstein E, Morano WF, Daniels LM, Grandhi N, Glatthorn H, Richard SD, Campbell PM, Sarafraz-Yazdi E, Pincus MR, Bowne WB. Anti-Cancer Tumor Cell Necrosis of Epithelial Ovarian Cancer Cell Lines Depends on High Expression of HDM-2 Protein in Their Membranes. Ann Clin Lab Sci. 2020 Sep; 50(5):611-624. PMID: 33067207.
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    5. Daniels LM, Khalili M, Morano WF, Simoncini M, Mapow BC, Leaf A, Bowne WB. Case report: optimal tumor cytoreduction and octreotide with durable disease control in a patient with MEN-1 and Zollinger-Ellison syndrome-over a decade of follow-up. World J Surg Oncol. 2019 Dec 09; 17(1):213. PMID: 31818296.
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    6. Li L, Khalili M, Johannes G, Baratam P, Morano WF, Styler M, Bowne WB, Hou JS. Case report of rhabdomyosarcomatous transformation of a primary gastrointestinal stromal tumor (GIST). BMC Cancer. 2019 Sep 13; 19(1):913. PMID: 31514735.
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    7. Altinok O, Poggio JL, Stein DE, Bowne WB, Shieh AC, Snyder NW, Orynbayeva Z. Malate-aspartate shuttle promotes l-lactate oxidation in mitochondria. J Cell Physiol. 2020 Mar; 235(3):2569-2581. PMID: 31490559.
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    8. Khalili M, Daniels L, Lin A, Krebs FC, Snook AE, Bekeschus S, Bowne WB, Miller V. Non-Thermal Plasma-Induced Immunogenic Cell Death in Cancer: A Topical Review. J Phys D Appl Phys. 2019 Oct 22; 52(42). PMID: 31485083.
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    9. Castaneda SA, Khalili M, Emrich J, Zoghbi VM, Weingarten MS, Rivard MJ, Bowne WB, Poli J. Report of the First Patient Treated for Pelvic Sarcoma With a Directional 103Pd Brachytherapy Device. Adv Radiat Oncol. 2020 Jan-Feb; 5(1):127-133. PMID: 32051899.
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    10. Khalili M, Zhou H, Thadi A, Daniels L, Fan Z, Morano WF, Ang J, Goldstein E, Polyak B, Mapow BC, Cheng H, Bowne WB. Slippery Nanoparticles as a Diffusion Platform for Mucin Producing Gastrointestinal Tumors. Ann Surg Oncol. 2020 Jan; 27(1):76-84. PMID: 31187366.
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    11. Khalili M, Daniels L, Gleeson EM, Grandhi N, Thandoni A, Burg F, Holleran L, Morano WF, Bowne WB. Pancreaticoduodenectomy outcomes for locally advanced right colon cancers: A systematic review. Surgery. 2019 08; 166(2):223-229. PMID: 31182232.
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    12. Thadi A, Khalili M, Morano WF, Richard SD, Katz SC, Bowne WB. Erratum: Thadi A.; et al. Early Investigations and Recent Advances in Intraperitoneal Immunotherapy for Peritoneal Metastasis. Vaccines 2018, 6, 54. Vaccines (Basel). 2019 Jan 31; 7(1). PMID: 30708956.
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    13. Zhou H, Fan Z, Li PY, Deng J, Arhontoulis DC, Li CY, Bowne WB, Cheng H. Dense and Dynamic Polyethylene Glycol Shells Cloak Nanoparticles from Uptake by Liver Endothelial Cells for Long Blood Circulation. ACS Nano. 2018 10 23; 12(10):10130-10141. PMID: 30117736.
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    14. Gleeson EM, Clarke JR, Morano WF, Shaikh MF, Bowne WB, Pitt HA. Patient-specific predictors of failure to rescue after pancreaticoduodenectomy. HPB (Oxford). 2019 03; 21(3):283-290. PMID: 30143319.
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    15. Morano WF, Shaikh MF, Gleeson EM, Galvez A, Khalili M, Lieb J, Renza-Stingone EP, Bowne WB. Reconstruction options following pancreaticoduodenectomy after Roux-en-Y gastric bypass: a systematic review. World J Surg Oncol. 2018 Aug 13; 16(1):168. PMID: 30103758.
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    16. Thadi A, Khalili M, Morano WF, Richard SD, Katz SC, Bowne WB. Early Investigations and Recent Advances in Intraperitoneal Immunotherapy for Peritoneal Metastasis. Vaccines (Basel). 2018 Aug 10; 6(3). PMID: 30103457.
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    17. Gleeson EM, Feldman R, Mapow BL, Mackovick LT, Ward KM, Morano WF, Rubin RR, Bowne WB. Appendix-derived Pseudomyxoma Peritonei (PMP): Molecular Profiling Toward Treatment of a Rare Malignancy. Am J Clin Oncol. 2018 08; 41(8):777-783. PMID: 28263231.
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    18. Kemmerer EJ, Gleeson E, Poli J, Ownbey RT, Brady LW, Bowne WB. Benefit of Radiotherapy in Extraskeletal Myxoid Chondrosarcoma: A Propensity Score Weighted Population-based Analysis of the SEER Database. Am J Clin Oncol. 2018 Jul; 41(7):674-680. PMID: 27819877.
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    19. Khalili M, Morano WF, Marconcini L, Shaikh MF, Gleeson EM, Styler M, Zebrower M, Bowne WB. Multidisciplinary strategies in bloodless medicine and surgery for patients undergoing pancreatectomy. J Surg Res. 2018 09; 229:208-215. PMID: 29936992.
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    20. Morano WF, Gleeson EM, Sullivan SH, Padmanaban V, Mapow BL, Shewokis PA, Esquivel J, Bowne WB. Clinicopathological Features and Management of Appendiceal Mucoceles: A Systematic Review. Am Surg. 2018 Feb 01; 84(2):273-281. PMID: 29580358.
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    21. Platoff RM, Morano WF, Marconcini L, DeLeo N, Mapow BL, Styler M, Bowne WB. Recurrent Gastrointestinal Stromal Tumors in the Imatinib Mesylate Era: Treatment Strategies for an Incurable Disease. Case Rep Oncol Med. 2017; 2017:8349090. PMID: 29333308.
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    22. Morano WF, Khalili M, Chi DS, Bowne WB, Esquivel J. Clinical studies in CRS and HIPEC: Trials, tribulations, and future directions-A systematic review. J Surg Oncol. 2018 Feb; 117(2):245-259. PMID: 29120491.
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    23. Franchini L, Hager S, Edwards DC, Jofre S, Bowne W, Belkoff L. Intussusception of the Small Bowel Secondary to Benign Ectopic Prostate Tissue. Urology. 2018 Apr; 114:14-17. PMID: 29122623.
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    24. Pompa TA, Morano WF, Jeurkar C, Li H, Soundararajan S, Poli J, Bowne WB, Styler M. Complete Response after Treatment with Neoadjuvant Chemoradiation with Prolonged Chemotherapy for Locally Advanced, Unresectable Adenocarcinoma of the Pancreas. Case Rep Oncol Med. 2017; 2017:7834702. PMID: 28373919.
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    25. Shaikh MF, Morano WF, Lee J, Gleeson E, Babcock BD, Michl J, Sarafraz-Yazdi E, Pincus MR, Bowne WB. Emerging Role of MDM2 as Target for Anti-Cancer Therapy: A Review. Ann Clin Lab Sci. 2016 Dec; 46(6):627-634. PMID: 27993876.
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    26. Morano WF, Aggarwal A, Love P, Richard SD, Esquivel J, Bowne WB. Intraperitoneal immunotherapy: historical perspectives and modern therapy. Cancer Gene Ther. 2016 Nov; 23(11):373-381. PMID: 27834358.
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    27. Padmanaban V, Morano WF, Gleeson E, Aggarwal A, Mapow BL, Stein DE, Bowne WB. Incidentally discovered low-grade appendiceal mucinous neoplasm: a precursor to pseudomyxoma peritonei. Clin Case Rep. 2016 Dec; 4(12):1112-1116. PMID: 27980743.
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    28. Gleeson EM, Shaikh MF, Shewokis PA, Clarke JR, Meyers WC, Pitt HA, Bowne WB. WHipple-ABACUS, a simple, validated risk score for 30-day mortality after pancreaticoduodenectomy developed using the ACS-NSQIP database. Surgery. 2016 11; 160(5):1279-1287. PMID: 27544541.
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    29. Pietrantonio F, Perrone F, Mennitto A, Gleeson EM, Milione M, Tamborini E, Busico A, Settanni G, Berenato R, Caporale M, Morano F, Bossi I, Pellegrinelli A, Di Bartolomeo M, de Braud F, Baratti D, Bowne WB, Kusamura S, Deraco M. Toward the molecular dissection of peritoneal pseudomyxoma. Ann Oncol. 2016 11; 27(11):2097-2103. PMID: 27502722.
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    30. Moaven O, Raziee H, Bowne W, Abbaszadegan MR, Fuchs BC. Disease Biomarkers in Gastrointestinal Malignancies. Dis Markers. 2016; 2016:4714910. PMID: 27445424.
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    31. Zhou H, Fan Z, Deng J, Lemons PK, Arhontoulis DC, Bowne WB, Cheng H. Hyaluronidase Embedded in Nanocarrier PEG Shell for Enhanced Tumor Penetration and Highly Efficient Antitumor Efficacy. Nano Lett. 2016 05 11; 16(5):3268-77. PMID: 27057591.
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    32. Foster D, Shaikh MF, Gleeson E, Babcock BD, Ringold D, Bowne WB. Palliative Surgery for Advanced Cancer: Identifying Evidence-Based Criteria for Patient Selection: Case Report and Review of Literature. J Palliat Med. 2016 Jan; 19(1):22-9. PMID: 26565437.
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    33. Foster D, Shaikh MF, Gleeson E, Babcock BD, Lin J, Ownbey RT, Hysell ME, Ringold D, Bowne WB. Pancreatic mucinous cystic neoplasm in a transgender patient. World J Surg Oncol. 2015 Jun 24; 13:205. PMID: 26104783.
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    34. Sarafraz-Yazdi E, Gorelick C, Wagreich AR, Salame G, Angert M, Gartman CH, Gupta V, Bowne WB, Lee YC, Abulafia O, Pincus MR, Michl J. Ex vivo Efficacy of Anti-Cancer Drug PNC-27 in the Treatment of Patient-Derived Epithelial Ovarian Cancer. Ann Clin Lab Sci. 2015; 45(6):650-8. PMID: 26663795.
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    35. Williams AD, Sanchez A, Hou JS, Rubin RR, Hysell ME, Babcock BD, Shaikh MF, Weingarten MS, Bowne WB. Retroperitoneal Castleman's disease: advocating a multidisciplinary approach for a rare clinical entity. World J Surg Oncol. 2014 Feb 04; 12:30. PMID: 24495409.
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    36. Davitt K, Babcock BD, Fenelus M, Poon CK, Sarkar A, Trivigno V, Zolkind PA, Matthew SM, Grin'kina N, Orynbayeva Z, Shaikh MF, Adler V, Michl J, Sarafraz-Yazdi E, Pincus MR, Bowne WB. The anti-cancer peptide, PNC-27, induces tumor cell necrosis of a poorly differentiated non-solid tissue human leukemia cell line that depends on expression of HDM-2 in the plasma membrane of these cells. Ann Clin Lab Sci. 2014; 44(3):241-8. PMID: 25117093.
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    37. Pincus MR, Fenelus M, Sarafraz-Yazdi E, Adler V, Bowne W, Michl J. Anti-cancer peptides from ras-p21 and p53 proteins. Curr Pharm Des. 2011; 17(25):2677-98. PMID: 21728981.
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    38. Sookraj KA, Bowne WB, Adler V, Sarafraz-Yazdi E, Michl J, Pincus MR. The anti-cancer peptide, PNC-27, induces tumor cell lysis as the intact peptide. Cancer Chemother Pharmacol. 2010 Jul; 66(2):325-31. PMID: 20182728.
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    39. Sarafraz-Yazdi E, Bowne WB, Adler V, Sookraj KA, Wu V, Shteyler V, Patel H, Oxbury W, Brandt-Rauf P, Zenilman ME, Michl J, Pincus MR. Anticancer peptide PNC-27 adopts an HDM-2-binding conformation and kills cancer cells by binding to HDM-2 in their membranes. Proc Natl Acad Sci U S A. 2010 Feb 02; 107(5):1918-23. PMID: 20080680.
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    40. Sookraj KA, Bowne WB, Ghosh BC. Perforated appendicitis presenting as a thigh abscess. J Am Coll Surg. 2009 Jun; 208(6):1142. PMID: 19476904.
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    41. Bowne WB, Sookraj KA, Vishnevetsky M, Adler V, Sarafraz-Yazdi E, Lou S, Koenke J, Shteyler V, Ikram K, Harding M, Bluth MH, Ng M, Brandt-Rauf PW, Hannan R, Bradu S, Zenilman ME, Michl J, Pincus MR. The penetratin sequence in the anticancer PNC-28 peptide causes tumor cell necrosis rather than apoptosis of human pancreatic cancer cells. Ann Surg Oncol. 2008 Dec; 15(12):3588-600. PMID: 18931881.
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    42. Fu SL, Pierre J, Smith-Norowitz TA, Hagler M, Bowne W, Pincus MR, Mueller CM, Zenilman ME, Bluth MH. Immunoglobulin E antibodies from pancreatic cancer patients mediate antibody-dependent cell-mediated cytotoxicity against pancreatic cancer cells. Clin Exp Immunol. 2008 Sep; 153(3):401-9. PMID: 18803764.
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    43. Chiu A, Bowne WB, Sookraj KA, Zenilman ME, Fingerhut A, Ferzli GS. The role of the assistant in laparoscopic surgery: important considerations for the apprentice-in-training. Surg Innov. 2008 Sep; 15(3):229-36. PMID: 18757384.
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    44. Fu SL, Wallner SR, Bowne WB, Hagler MD, Zenilman ME, Gross R, Bluth MH. Sophorolipids and their derivatives are lethal against human pancreatic cancer cells. J Surg Res. 2008 Jul; 148(1):77-82. PMID: 18570934.
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    45. Adler V, Bowne W, Michl J, Sookraj KA, Ikram K, Pestka S, Izotova L, Zenilman M, Friedman FK, Qu Y, Pincus MR. Site-specific phosphorylation of raf in cells containing oncogenic ras-p21 is likely mediated by jun-N-terminal kinase. Ann Clin Lab Sci. 2008; 38(1):47-56. PMID: 18316782.
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    46. Adler V, Bowne W, Kamran I, Michl J, Friedman FK, Chin E, Zenilman M, Pincus MR. Two peptides derived from ras-p21 induce either phenotypic reversion or tumor cell necrosis of ras-transformed human cancer cells. Cancer Chemother Pharmacol. 2008 Aug; 62(3):491-8. PMID: 18066549.
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    47. Wang H, Wieczorek RL, Zenilman ME, Desoto-Lapaix F, Ghosh BC, Bowne WB. Castleman's disease in the head of the pancreas: report of a rare clinical entity and current perspective on diagnosis, treatment, and outcome. World J Surg Oncol. 2007 Nov 20; 5:133. PMID: 18028547.
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    48. Hardin RE, Ferzli GS, Zenilman ME, Gadangi PK, Bowne WB. Invasive amebiasis and ameboma formation presenting as a rectal mass: An uncommon case of malignant masquerade at a western medical center. World J Gastroenterol. 2007 Nov 14; 13(42):5659-61. PMID: 17948943.
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    49. Qu Y, Adler V, Izotova L, Pestka S, Bowne W, Michl J, Boutjdir M, Friedman FK, Pincus MR. The dual-specificity kinases, TOPK and DYRK1A, are critical for oocyte maturation induced by wild-type--but not by oncogenic--ras-p21 protein. Front Biosci. 2007 Sep 01; 12:5089-97. PMID: 17569632.
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    50. Kim J, Edwards E, Bowne W, Castro A, Moon V, Gadangi P, Ferzli G. Medial-to-lateral laparoscopic colon resection: a view beyond the learning curve. Surg Endosc. 2007 Sep; 21(9):1503-7. PMID: 17641928.
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    51. Katz SC, Bowne WB, Wolchok JD, Busam KJ, Jaques DP, Coit DG. Surgical management of melanoma of the gallbladder: a report of 13 cases and review of the literature. Am J Surg. 2007 Apr; 193(4):493-7. PMID: 17368297.
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    52. Bowne WB, Morgenthal CB, Castro AE, Shah P, Ferzli GS. The role of endoscopic extraperitoneal herniorrhaphy: where do we stand in 2005? Surg Endosc. 2007 May; 21(5):707-12. PMID: 17279303.
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    53. Bowne WB, Michl J, Bluth MH, Zenilman ME, Pincus MR. Novel peptides from the RAS-p21 and p53 proteins for the treatment of cancer. Cancer Ther. 2007; 5B:331-344. PMID: 18007958.
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    54. Bowne WB, Julliard K, Castro AE, Shah P, Morgenthal CB, Ferzli GS. Laparoscopic gastric bypass is superior to adjustable gastric band in super morbidly obese patients: A prospective, comparative analysis. Arch Surg. 2006 Jul; 141(7):683-9. PMID: 16847241.
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    55. Bowne WB, Lee B, Wong WD, Ben-Porat L, Shia J, Cohen AM, Enker WE, Guillem JG, Paty PB, Weiser MR. Operative salvage for locoregional recurrent colon cancer after curative resection: an analysis of 100 cases. Dis Colon Rectum. 2005 May; 48(5):897-909. PMID: 15785892.
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    56. Jarnagin WR, Bowne W, Klimstra DS, Ben-Porat L, Roggin K, Cymes K, Fong Y, DeMatteo RP, D'Angelica M, Koea J, Blumgart LH. Papillary phenotype confers improved survival after resection of hilar cholangiocarcinoma. Ann Surg. 2005 May; 241(5):703-12; discussion 712-4. PMID: 15849506.
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    57. Allen PJ, Bowne WB, Jaques DP, Brennan MF, Busam K, Coit DG. Merkel cell carcinoma: prognosis and treatment of patients from a single institution. J Clin Oncol. 2005 Apr 01; 23(10):2300-9. PMID: 15800320.
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    58. Florman S, Bowne W, Kim-Schluger L, Sung MW, Huang R, Fotino M, Thung S, Schwartz M, Miller C. Unresectable squamous cell carcinoma of donor origin treated with immunosuppression withdrawal and liver retransplantation. Am J Transplant. 2004 Feb; 4(2):278-82. PMID: 14974952.
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    59. Allen PJ, Jaques DP, D'Angelica M, Bowne WB, Conlon KC, Brennan MF. Cystic lesions of the pancreas: selection criteria for operative and nonoperative management in 209 patients. J Gastrointest Surg. 2003 Dec; 7(8):970-7. PMID: 14675706.
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    60. Hawkins WG, Trcka J, Segal N, Blachere NE, Gold JS, Moroi Y, Bowne WB, Lewis JJ, Wolchok JD, Houghton AN. The role of lipopolysaccharide in T-cell responses following DNA vaccination. Vaccine. 2003 Mar 28; 21(13-14):1548-53. PMID: 12615452.
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    61. Hawkins WG, Gold JS, Blachere NE, Bowne WB, Hoos A, Lewis JJ, Houghton AN. Xenogeneic DNA immunization in melanoma models for minimal residual disease. J Surg Res. 2002 Feb; 102(2):137-43. PMID: 11796010.
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    62. Wolchok JD, Srinivasan R, Perales MA, Houghton AN, Bowne WB, Blachere NE. Alternative roles for interferon-gamma in the immune response to DNA vaccines encoding related melanosomal antigens. Cancer Immun. 2001 Aug 16; 1:9. PMID: 12747770.
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    63. Brooks AD, Bowne WB, Delgado R, Leung DH, Woodruff J, Lewis JJ, Brennan MF. Soft tissue sarcomas of the groin: diagnosis, management, and prognosis. J Am Coll Surg. 2001 Aug; 193(2):130-6. PMID: 11491442.
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    64. Bowne WB, Hawkins WG, Lewis JJ. Immunotherapeutic approach to cancer with cutaneous DNA vaccination. Methods Mol Med. 2001; 53:313-21. PMID: 21318804.
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    65. Hawkins WG, Gold JS, Dyall R, Wolchok JD, Hoos A, Bowne WB, Srinivasan R, Houghton AN, Lewis JJ. Immunization with DNA coding for gp100 results in CD4 T-cell independent antitumor immunity. Surgery. 2000 Aug; 128(2):273-80. PMID: 10923004.
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    66. Bowne WB, Antonescu CR, Leung DH, Katz SC, Hawkins WG, Woodruff JM, Brennan MF, Lewis JJ. Dermatofibrosarcoma protuberans: A clinicopathologic analysis of patients treated and followed at a single institution. Cancer. 2000 Jun 15; 88(12):2711-20. PMID: 10870053.
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    67. Bowne WB, Srinivasan R, Wolchok JD, Hawkins WG, Blachere NE, Dyall R, Lewis JJ, Houghton AN. Coupling and uncoupling of tumor immunity and autoimmunity. J Exp Med. 1999 Dec 06; 190(11):1717-22. PMID: 10587362.
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    68. Bowne WB, Wolchok JD, Hawkins WG, Srinivasan R, Gregor P, Blachere NE, Moroi Y, Engelhorn ME, Houghton AN, Lewis JJ. Injection of DNA encoding granulocyte-macrophage colony-stimulating factor recruits dendritic cells for immune adjuvant effects. Cytokines Cell Mol Ther. 1999 Dec; 5(4):217-25. PMID: 10850386.
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    69. Linehan DC, Bowne WB, Lewis JJ. Immunotherapeutic approaches to sarcoma. Semin Surg Oncol. 1999 Jul-Aug; 17(1):72-7. PMID: 10402640.
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    70. Bowne WB, Lewis JJ, Filippa DA, Niesvizky R, Brooks AD, Burt ME, Brennan MF. The management of unicentric and multicentric Castleman's disease: a report of 16 cases and a review of the literature. Cancer. 1999 Feb 01; 85(3):706-17. PMID: 10091744.
      View in: PubMed
    71. Dyall R, Bowne WB, Weber LW, LeMaoult J, Szabo P, Moroi Y, Piskun G, Lewis JJ, Houghton AN, Nikolic-Zugic J. Heteroclitic immunization induces tumor immunity. J Exp Med. 1998 Nov 02; 188(9):1553-61. PMID: 9802967.
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    72. Weber LW, Bowne WB, Wolchok JD, Srinivasan R, Qin J, Moroi Y, Clynes R, Song P, Lewis JJ, Houghton AN. Tumor immunity and autoimmunity induced by immunization with homologous DNA. J Clin Invest. 1998 Sep 15; 102(6):1258-64. PMID: 9739060.
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    73. Hirschowitz EA, Leonard S, Song W, Ferris B, Leopold PL, Lewis JJ, Bowne WB, Wang S, Houghton AN, Crystal RG. Adenovirus-mediated expression of melanoma antigen gp75 as immunotherapy for metastatic melanoma. Gene Ther. 1998 Jul; 5(7):975-83. PMID: 9813669.
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