"Mercaptopurine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.
| Descriptor ID |
D015122
|
| MeSH Number(s) |
D02.886.489.534 D03.633.100.759.534
|
| Concept/Terms |
Mercaptopurine- Mercaptopurine
- 6-Thiopurine
- 6 Thiopurine
- 6-Mercaptopurine Monohydrate
- 6 Mercaptopurine Monohydrate
- 1,7-Dihydro-6H-purine-6-thione
- 6-Thiohypoxanthine
- 6 Thiohypoxanthine
|
Below are MeSH descriptors whose meaning is more general than "Mercaptopurine".
Below are MeSH descriptors whose meaning is more specific than "Mercaptopurine".
This graph shows the total number of publications written about "Mercaptopurine" by people in this website by year, and whether "Mercaptopurine" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Mercaptopurine" by people in Profiles.
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Karadag AS, Parish LC. Sarcoidosis: A great imitator. Clin Dermatol. 2019 May - Jun; 37(3):240-254.
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Rohan JM, Fukuda T, Alderfer MA, Wetherington Donewar C, Ewing L, Katz ER, Muriel AC, Vinks AA, Drotar D. Measuring Medication Adherence in Pediatric Cancer: An Approach to Validation. J Pediatr Psychol. 2017 Mar 01; 42(2):232-244.
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Rohan JM, Drotar D, Alderfer M, Donewar CW, Ewing L, Katz ER, Muriel A. Electronic monitoring of medication adherence in early maintenance phase treatment for pediatric leukemia and lymphoma: identifying patterns of nonadherence. J Pediatr Psychol. 2015 Jan-Feb; 40(1):75-84.
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El-Bitar MK, Muwakkit SA, Dabbagh O. Severe hypoglycemic seizures in a child receiving 6-mercaptopurine. J Pediatr Hematol Oncol. 2011 Mar; 33(2):e75-6.
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Klinger A, Schursky M, Rosh J, Starker I, Mercer GO, Rolandelli RH. Combination biological and surgical therapy in an adolescent presenting with highly destructive perianal Crohn disease. J Pediatr Gastroenterol Nutr. 2010 Dec; 51(6):784-6.
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Caver TE, Slobod KS, Flynn PM, Behm FG, Hudson MM, Turner EV, Webster RG, Boyett JM, Tassie TL, Pui CH, Hurwitz JL. Profound abnormality of the B/T lymphocyte ratio during chemotherapy for pediatric acute lymphoblastic leukemia. Leukemia. 1998 Apr; 12(4):619-22.
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Arbeter AM, Granowetter L, Starr SE, Lange B, Wimmer R, Plotkin SA. Immunization of children with acute lymphoblastic leukemia with live attenuated varicella vaccine without complete suspension of chemotherapy. Pediatrics. 1990 Mar; 85(3):338-44.
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Leone G, Pagano L, Marra R, Landolfi R, Cudillo L, Storti S, Mango G, Alfano G, D'Onofrio G. Combination of 6-mercaptopurine, vincristine, methotrexate, and prednisone in resistant or relapsed acute nonlymphoid leukemia. Cancer Treat Rep. 1987 Jul-Aug; 71(7-8):751-3.
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Wiernik PH, Glidewell OJ, Hoagland HC, Brunner KW, Spurr CL, Cuttner J, Silver RT, Carey RW, DelDuca V, Kung FH, Holland JF. A comparative trial of daunorubicin, cytosine arabinoside, and thioguanine, and a combination of the three agents for the treatment of acute myelocytic leukemia. Med Pediatr Oncol. 1979; 6(3):261-77.
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Israel HL, Patchefsky AS. Wegener's granulomatosis of lung: diagnosis and treatment. Experience with 12 cases. Ann Intern Med. 1971 Jun; 74(6):881-91.