"Fibrinogens, Abnormal" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Fibrinogens which have a functional defect as the result of one or more amino acid substitutions in the amino acid sequence of normal fibrinogen. Abnormalities of the fibrinogen molecule may impair any of the major steps involved in the conversion of fibrinogen into stabilized fibrin, such as cleavage of the fibrinopeptides by thrombin, polymerization and cross-linking of fibrin. The resulting dysfibrinogenemias can be clinically silent or can be associated with bleeding, thrombosis or defective wound healing.
| Descriptor ID |
D015241
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| MeSH Number(s) |
D12.776.124.050.250.265 D12.776.124.125.500.265 D23.119.490.265
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Fibrinogens, Abnormal".
Below are MeSH descriptors whose meaning is more specific than "Fibrinogens, Abnormal".
This graph shows the total number of publications written about "Fibrinogens, Abnormal" by people in this website by year, and whether "Fibrinogens, Abnormal" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 1 | 1 | 2 |
| 2005 | 1 | 0 | 1 |
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Below are the most recent publications written about "Fibrinogens, Abnormal" by people in Profiles.
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Keller MA, Martinez J, Baradet TC, Nagaswami C, Chernysh IN, Borowski MK, Surrey S, Weisel JW. Fibrinogen Philadelphia, a hypodysfibrinogenemia characterized by abnormal polymerization and fibrinogen hypercatabolism due to gamma S378P mutation. Blood. 2005 Apr 15; 105(8):3162-8.
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Deering SH, Landy HJ, Tchabo N, Kessler C. Hypodysfibrinogenemia during pregnancy, labor, and delivery. Obstet Gynecol. 2003 May; 101(5 Pt 2):1092-4.
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Moster ML. Coagulopathies and arterial stroke. J Neuroophthalmol. 2003 Mar; 23(1):63-71.
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De Cristofaro R, Furlan M, Landolfi R. Fibrinogen Milano IV (A alpha 16 Arg-->His): characterization of its abnormal interaction with human alpha-thrombin. Biochem J. 1994 Sep 01; 302 ( Pt 2):623-4.
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Pasquale LR, Moster ML, Schmaier A. Dural sinus thrombosis with abnormalities of protein S and fibrinogen. Arch Ophthalmol. 1990 May; 108(5):644.