Richard Pomerantz

TitleProfessor
InstitutionThomas Jefferson University
DepartmentBiochem & Molecular Biology
Address233 S. 10th Street
Philadelphia PA 19107
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Calbert ML, Chandramouly G, Adams CM, Saez-Ayala M, Kent T, Tyagi M, Ayyadevara VSSA, Wang Y, Krais JJ, Gordon J, Atkins J, Toma MM, Betzi S, Boghossian AS, Rees MG, Ronan MM, Roth JA, Goldman AR, Gorman N, Mitra R, Childers WE, Gra?a X, Skorski T, Johnson N, Hurtz C, Morelli X, Eischen CM, Pomerantz RT. 4'-Ethynyl-2'-Deoxycytidine (EdC) Preferentially Targets Lymphoma and Leukemia Subtypes by Inducing Replicative Stress. Mol Cancer Ther. 2023 Dec 08. PMID: 38064712.
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    2. Krais JJ, Glass DJ, Chudoba I, Wang Y, Feng W, Simpson D, Patel P, Liu Z, Neumann-Domer R, Betsch RG, Bernhardy AJ, Bradbury AM, Conger J, Yueh WT, Nacson J, Pomerantz RT, Gupta GP, Testa JR, Johnson N. Genetic separation of Brca1 functions reveal mutation-dependent Pol? vulnerabilities. Nat Commun. 2023 Nov 24; 14(1):7714. PMID: 38001070.
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    3. Demidova EV, Serebriiskii IG, Vlasenkova R, Kelow S, Andrake MD, Hartman TR, Kent T, Virtucio J, Rosen GL, Pomerantz RT, Dunbrack RL, Golemis EA, Hall MJ, Chen DYT, Daly MB, Arora S. Correction: Candidate variants in?DNA replication and?repair genes in?early-onset renal cell carcinoma patients referred for?germline testing. BMC Genomics. 2023 Jul 10; 24(1):388. PMID: 37430226.
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    4. Tredinnick TN, Kent T, Minakhin L, Li Z, Madzo J, Chen XS, Pomerantz RT. Promoter-Independent Synthesis of Chemically Modified RNA by Polymerase ? Variants. RNA. 2023 Apr 27. PMID: 37105714.
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    5. Demidova EV, Serebriiskii IG, Vlasenkova R, Kelow S, Andrake MD, Hartman TR, Kent T, Virtucio J, Rosen GL, Pomerantz RT, Dunbrack RL, Golemis EA, Hall MJ, Chen DYT, Daly MB, Arora S. Candidate variants in DNA replication and repair genes in early-onset renal cell carcinoma patients referred for germline testing. BMC Genomics. 2023 Apr 24; 24(1):212. PMID: 37095444.
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    6. Chandramouly G, Jamsen J, Borisonnik N, Tyagi M, Calbert ML, Tredinnick T, Ozdemir AY, Kent T, Demidova EV, Arora S, Wilson SH, Pomerantz RT. Author Correction: Pol? promotes microhomology-mediated end-joining. Nat Struct Mol Biol. 2023 Apr 14. PMID: 37059901.
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    7. Vekariya U, Toma MM, Nieborowska-Skorska M, Le BV, Caron MC, Kukuyan AM, Sullivan-Reed K, Podszywalow-Bartnicka P, Chitrala KN, Atkins J, Drzewiecka M, Feng W, Chan J, Chatla S, Golovine K, Jelinek J, Sliwinski T, Ghosh J, Matlawska-Wasowska K, Chandramouly G, Nejati R, Wasik MA, Sykes S, Piwocka K, Hadzijusufovic E, Valent P, Pomerantz RT, Morton G, Childers W, Zhao H, Paietta E, Levine RL, Tallman MS, Fernandez H, Litzow MR, Gupta G, Masson JY, Skorski T. DNA polymerase theta protects leukemia cells from metabolic-induced DNA damage. Blood. 2022 Dec 29. PMID: 36580665.
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    8. Chandramouly G, Jamsen J, Borisonnik N, Tyagi M, Calbert ML, Tredinnick T, Ozdemir AY, Kent T, Demidova EV, Arora S, Wilson SH, Pomerantz RT. Pol? promotes microhomology-mediated end-joining. Nat Struct Mol Biol. 2023 Jan; 30(1):107-114. PMID: 36536104.
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    9. Chen XS, Pomerantz RT. DNA Polymerase ?: A Cancer Drug Target with Reverse Transcriptase Activity. Genes (Basel). 2021 Jul 27; 12(8). PMID: 34440316.
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    10. Chandramouly G, Zhao J, McDevitt S, Rusanov T, Hoang T, Borisonnik N, Treddinick T, Lopezcolorado FW, Kent T, Siddique LA, Mallon J, Huhn J, Shoda Z, Kashkina E, Brambati A, Stark JM, Chen XS, Pomerantz RT. Pol? reverse transcribes RNA and promotes RNA-templated DNA repair. Sci Adv. 2021 Jun; 7(24). PMID: 34117057.
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    11. Chandramouly G, Liao S, Rusanov T, Borisonnik N, Calbert ML, Kent T, Sullivan-Reed K, Vekariya U, Kashkina E, Skorski T, Yan H, Pomerantz RT. Pol? promotes the repair of 5'-DNA-protein crosslinks by microhomology-mediated end-joining. Cell Rep. 2021 Mar 09; 34(10):108820. PMID: 33691100.
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    12. Black SJ, Ozdemir AY, Kashkina E, Kent T, Rusanov T, Ristic D, Shin Y, Suma A, Hoang T, Chandramouly G, Siddique LA, Borisonnik N, Sullivan-Reed K, Mallon JS, Skorski T, Carnevale V, Murakami KS, Wyman C, Pomerantz RT. Publisher Correction: Molecular basis of microhomology-mediated end-joining by purified full-length Pol?. Nat Commun. 2020 Apr 09; 11(1):1831. PMID: 32273507.
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    13. Black SJ, Ozdemir AY, Kashkina E, Kent T, Rusanov T, Ristic D, Shin Y, Suma A, Hoang T, Chandramouly G, Siddique LA, Borisonnik N, Sullivan-Reed K, Mallon JS, Skorski T, Carnevale V, Murakami KS, Wyman C, Pomerantz RT. Molecular basis of microhomology-mediated end-joining by purified full-length Pol?. Nat Commun. 2019 09 27; 10(1):4423. PMID: 31562312.
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    14. Thomas C, Rusanov T, Hoang T, Augustin T, Kent T, Gaspar I, Pomerantz RT. One-step enzymatic modification of RNA 3' termini using polymerase ?. Nucleic Acids Res. 2019 04 23; 47(7):3272-3283. PMID: 30818397.
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    15. Rusanov T, Kent T, Saeed M, Hoang TM, Thomas C, Rice CM, Pomerantz RT. Identification of a Small Interface between the Methyltransferase and RNA Polymerase of NS5 that is Essential for Zika Virus Replication. Sci Rep. 2018 11 26; 8(1):17384. PMID: 30478404.
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    16. McDevitt S, Rusanov T, Kent T, Chandramouly G, Pomerantz RT. How RNA transcripts coordinate DNA recombination and repair. Nat Commun. 2018 03 15; 9(1):1091. PMID: 29545568.
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    17. Ozdemir AY, Rusanov T, Kent T, Siddique LA, Pomerantz RT. Polymerase ?-helicase efficiently unwinds DNA and RNA-DNA hybrids. J Biol Chem. 2018 04 06; 293(14):5259-5269. PMID: 29444826.
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    18. Mateos-Gomez PA, Kent T, Deng SK, McDevitt S, Kashkina E, Hoang TM, Pomerantz RT, Sfeir A. The helicase domain of Pol? counteracts RPA to promote alt-NHEJ. Nat Struct Mol Biol. 2017 Dec; 24(12):1116-1123. PMID: 29058711.
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    19. Hoang TM, Kent T, Pomerantz RT. Modification of 3' Terminal Ends of DNA and RNA Using DNA Polymerase ? Terminal Transferase Activity. Bio Protoc. 2017 Jun 20; 7(12). PMID: 28824932.
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    20. Lupey-Green LN, Moquin SA, Martin KA, McDevitt SM, Hulse M, Caruso LB, Pomerantz RT, Miranda JL, Tempera I. PARP1 restricts Epstein Barr Virus lytic reactivation by binding the BZLF1 promoter. Virology. 2017 07; 507:220-230. PMID: 28456021.
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    21. Black SJ, Kashkina E, Kent T, Pomerantz RT. DNA Polymerase ?: A Unique Multifunctional End-Joining Machine. Genes (Basel). 2016 Sep 21; 7(9). PMID: 27657134.
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    22. Kent T, Rusanov TD, Hoang TM, Velema WA, Krueger AT, Copeland WC, Kool ET, Pomerantz RT. DNA polymerase ? specializes in incorporating synthetic expanded-size (xDNA) nucleotides. Nucleic Acids Res. 2016 Nov 02; 44(19):9381-9392. PMID: 27591252.
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    23. Kent T, Mateos-Gomez PA, Sfeir A, Pomerantz RT. Polymerase ? is a robust terminal transferase that oscillates between three different mechanisms during end-joining. Elife. 2016 06 17; 5. PMID: 27311885.
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    24. Chandramouly G, McDevitt S, Sullivan K, Kent T, Luz A, Glickman JF, Andrake M, Skorski T, Pomerantz RT. Small-Molecule Disruption of RAD52 Rings as a Mechanism for Precision Medicine in BRCA-Deficient Cancers. Chem Biol. 2015 Nov 19; 22(11):1491-1504. PMID: 26548611.
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    25. Kent T, Chandramouly G, McDevitt SM, Ozdemir AY, Pomerantz RT. Mechanism of microhomology-mediated end-joining promoted by human DNA polymerase ?. Nat Struct Mol Biol. 2015 Mar; 22(3):230-7. PMID: 25643323.
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    26. Pomerantz RT, Goodman MF, O'Donnell ME. DNA polymerases are error-prone at RecA-mediated recombination intermediates. . 2013 Aug 15; 12(16):2558-63. PMID: 23907132.
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    27. Pomerantz RT, Kurth I, Goodman MF, O'Donnell ME. Preferential D-loop extension by a translesion DNA polymerase underlies error-prone recombination. Nat Struct Mol Biol. 2013 Jun; 20(6):748-55. PMID: 23686288.
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    28. Pomerantz RT, O'Donnell M. Direct restart of a replication fork stalled by a head-on RNA polymerase. Science. 2010 Jan 29; 327(5965):590-2. PMID: 20110508.
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    29. Pomerantz RT, Temiakov D, Anikin M, Vassylyev DG, McAllister WT. A mechanism of nucleotide misincorporation during transcription due to template-strand misalignment. Mol Cell. 2006 Oct 20; 24(2):245-55. PMID: 17052458; PMCID: PMC2810628.
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    30. Kashkina E, Anikin M, Brueckner F, Pomerantz RT, McAllister WT, Cramer P, Temiakov D. Template misalignment in multisubunit RNA polymerases and transcription fidelity. Mol Cell. 2006 Oct 20; 24(2):257-66. PMID: 17052459.
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