"Pentostatin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A potent inhibitor of ADENOSINE DEAMINASE. The drug induces APOPTOSIS of LYMPHOCYTES, and is used in the treatment of many lymphoproliferative malignancies, particularly HAIRY CELL LEUKEMIA. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.
Descriptor ID |
D015649
|
MeSH Number(s) |
D03.383.742.680.350.200.700 D13.570.230.677 D13.570.685.350.200.700
|
Concept/Terms |
Pentostatin- Pentostatin
- Deoxycoformycin
- Co-Vidarabine
- 2'-Deoxycoformycin
- 2' Deoxycoformycin
|
Below are MeSH descriptors whose meaning is more general than "Pentostatin".
Below are MeSH descriptors whose meaning is more specific than "Pentostatin".
This graph shows the total number of publications written about "Pentostatin" by people in this website by year, and whether "Pentostatin" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2003 | 2 | 0 | 2 |
2006 | 0 | 2 | 2 |
2008 | 1 | 0 | 1 |
2009 | 0 | 1 | 1 |
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Below are the most recent publications written about "Pentostatin" by people in Profiles.
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Ravandi F, Aribi A, O'Brien S, Faderl S, Jones D, Ferrajoli A, Huang X, York S, Pierce S, Wierda W, Kontoyiannis D, Verstovsek S, Pro B, Fayad L, Keating M, Kantarjian H. Phase II study of alemtuzumab in combination with pentostatin in patients with T-cell neoplasms. J Clin Oncol. 2009 Nov 10; 27(32):5425-30.
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Sauter C, Lamanna N, Weiss MA. Pentostatin in chronic lymphocytic leukemia. Expert Opin Drug Metab Toxicol. 2008 Sep; 4(9):1217-22.
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Lamanna N, Weiss MA. Purine analogue-based chemotherapy regimens for second-line therapy in patients with chronic lymphocytic leukemia. Semin Hematol. 2006 Apr; 43(2 Suppl 2):S44-9.
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Lamanna N, Kalaycio M, Maslak P, Jurcic JG, Heaney M, Brentjens R, Zelenetz AD, Horgan D, Gencarelli A, Panageas KS, Scheinberg DA, Weiss MA. Pentostatin, cyclophosphamide, and rituximab is an active, well-tolerated regimen for patients with previously treated chronic lymphocytic leukemia. J Clin Oncol. 2006 Apr 1; 24(10):1575-81.
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Dang NH, Hagemeister FB, Duvic M, Romaguera JE, Younes A, Jones D, Samuels B, Fayad LE, Pro B, Samaniego F, Sarris A, Goy A, McLaughlin P, Tong AT, Walker PL, Tiongson LP, Smith TL, Huh YO, Morimoto C, Rodriguez MA. Pentostatin in T-non-Hodgkin's lymphomas: efficacy and effect on CD26+ T lymphocytes. Oncol Rep. 2003 Sep-Oct; 10(5):1513-8.
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Weiss MA, Maslak PG, Jurcic JG, Scheinberg DA, Aliff TB, Lamanna N, Frankel SR, Kossman SE, Horgan D. Pentostatin and cyclophosphamide: an effective new regimen in previously treated patients with chronic lymphocytic leukemia. J Clin Oncol. 2003 Apr 1; 21(7):1278-84.