HIV Envelope Protein gp120
"HIV Envelope Protein gp120" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
External envelope protein of the human immunodeficiency virus which is encoded by the HIV env gene. It has a molecular weight of 120 kDa and contains numerous glycosylation sites. Gp120 binds to cells expressing CD4 cell-surface antigens, most notably T4-lymphocytes and monocytes/macrophages. Gp120 has been shown to interfere with the normal function of CD4 and is at least partly responsible for the cytopathic effect of HIV.
Descriptor ID |
D015699
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MeSH Number(s) |
D12.776.964.775.325.164.249 D12.776.964.775.562.500.500 D12.776.964.970.880.325.164.249 D23.050.327.520.350
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Concept/Terms |
HIV Envelope Protein gp120- HIV Envelope Protein gp120
- Envelope Glycoprotein gp120, HIV
- gp120 Envelope Glycoprotein, HIV
- HIV Envelope Glycoprotein gp120
- HTLV-III gp120
- HTLV III gp120
- gp120, HTLV-III
- env Protein gp120, HIV
- gp120(HIV)
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Below are MeSH descriptors whose meaning is more general than "HIV Envelope Protein gp120".
Below are MeSH descriptors whose meaning is more specific than "HIV Envelope Protein gp120".
This graph shows the total number of publications written about "HIV Envelope Protein gp120" by people in this website by year, and whether "HIV Envelope Protein gp120" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2002 | 1 | 1 | 2 |
2003 | 3 | 0 | 3 |
2005 | 2 | 3 | 5 |
2006 | 0 | 1 | 1 |
2007 | 1 | 0 | 1 |
2009 | 4 | 0 | 4 |
2010 | 1 | 1 | 2 |
2011 | 1 | 0 | 1 |
2012 | 2 | 1 | 3 |
2013 | 1 | 0 | 1 |
2015 | 1 | 0 | 1 |
2016 | 1 | 0 | 1 |
2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "HIV Envelope Protein gp120" by people in Profiles.
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Schapiro HM, Khasnis MD, Ahn K, Karagiaridi A, Hayden S, Cilento ME, Root MJ. Regulation of epitope exposure in the gp41 membrane-proximal external region through interactions at the apex of HIV-1 Env. PLoS Pathog. 2022 May; 18(5):e1010531.
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Huwe PJ, Xu Q, Shapovalov MV, Modi V, Andrake MD, Dunbrack RL. Biological function derived from predicted structures in CASP11. Proteins. 2016 Sep; 84 Suppl 1:370-91.
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Sealy RE, Jones BG, Surman SL, Branum K, Howlett NM, Flynn PM, Hurwitz JL. Murine Monoclonal Antibodies for Antigenic Discrimination of HIV-1 Envelope Proteins. Viral Immunol. 2016 Jan-Feb; 29(1):64-70.
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Pinzone MR, Di Rosa M, Celesia BM, Condorelli F, Malaguarnera M, Madeddu G, Martellotta F, Castronuovo D, Gussio M, Coco C, Palermo F, Cosentino S, Cacopardo B, Nunnari G. LPS and HIV gp120 modulate monocyte/macrophage CYP27B1 and CYP24A1 expression leading to vitamin D consumption and hypovitaminosis D in HIV-infected individuals. Eur Rev Med Pharmacol Sci. 2013 Jul; 17(14):1938-50.
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Nath S, Bachani M, Harshavardhana D, Steiner JP. Catechins protect neurons against mitochondrial toxins and HIV proteins via activation of the BDNF pathway. J Neurovirol. 2012 Dec; 18(6):445-55.
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Danial M, Root MJ, Klok HA. Polyvalent side chain peptide-synthetic polymer conjugates as HIV-1 entry inhibitors. Biomacromolecules. 2012 May 14; 13(5):1438-47.
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Louboutin JP, Strayer DS. Blood-brain barrier abnormalities caused by HIV-1 gp120: mechanistic and therapeutic implications. ScientificWorldJournal. 2012; 2012:482575.
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Louboutin JP, Reyes BA, Agrawal L, Van Bockstaele EJ, Strayer DS. HIV-1 gp120 upregulates matrix metalloproteinases and their inhibitors in a rat model of HIV encephalopathy. Eur J Neurosci. 2011 Dec; 34(12):2015-23.
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Louboutin JP, Agrawal L, Reyes BA, Van Bockstaele EJ, Strayer DS. HIV-1 gp120-induced injury to the blood-brain barrier: role of metalloproteinases 2 and 9 and relationship to oxidative stress. J Neuropathol Exp Neurol. 2010 Aug; 69(8):801-16.
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Louboutin JP, Reyes BA, Agrawal L, Maxwell CR, Van Bockstaele EJ, Strayer DS. Blood-brain barrier abnormalities caused by exposure to HIV-1 gp120--protection by gene delivery of antioxidant enzymes. Neurobiol Dis. 2010 May; 38(2):313-25.