Timothy Stalker

TitleAsst Professor
InstitutionThomas Jefferson University
DepartmentHematology
Address1020 Locust St.
Philadelphia PA 19107
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    R01HL119070     (BRASS, LAWRENCE F)Jul 15, 2013 - May 15, 2014
    NIH
    Subcellular mechanisms of platelet activation
    Role: Co-Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Poventud-Fuentes I, Kwon KW, Seo J, Tomaiuolo M, Stalker TJ, Brass LF, Huh D. A Human Vascular Injury-on-a-Chip Model of Hemostasis. Small. 2020 Nov 04; e2004889. PMID: 33150735.
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    2. Tomaiuolo M, Litvinov RI, Weisel JW, Stalker TJ. Use of electron microscopy to study platelets and thrombi. Platelets. 2020 Jul 03; 31(5):580-588. PMID: 32423268.
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    3. Stalker TJ. Mouse laser injury models: variations on a theme. Platelets. 2020 May 18; 31(4):423-431. PMID: 32297542.
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    4. Stalker TJ. Mouse models of platelet function in vivo. Platelets. 2020 05 18; 31(4):415-416. PMID: 32243224.
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    5. Chen X, Gupta S, Cooper M, DeHelian D, Zhao X, Naik MU, Wurtzel JGT, Stalker TJ, Goldfinger LE, Benovic J, Brass LF, McKenzie SE, Naik UP, Ma P. GRK6 regulates the hemostatic response to injury through its rate-limiting effects on GPCR signaling in platelets. Blood Adv. 2020 Jan 14; 4(1):76-86. PMID: 31899801.
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    6. Tomaiuolo M, Matzko CN, Poventud-Fuentes I, Weisel JW, Brass LF, Stalker TJ. Interrelationships between structure and function during the hemostatic response to injury. Proc Natl Acad Sci U S A. 2019 02 05; 116(6):2243-2252. PMID: 30674670.
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    7. Ma P, Gupta S, Sampietro S, DeHelian D, Tutwiler V, Tang A, Stalker TJ, Brass LF. RGS10 shapes the hemostatic response to injury through its differential effects on intracellular signaling by platelet agonists. Blood Adv. 2018 08 28; 2(16):2145-2155. PMID: 30150297.
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    8. Shen J, Sampietro S, Wu J, Tang J, Gupta S, Matzko CN, Tang C, Yu Y, Brass LF, Zhu L, Stalker TJ. Coordination of platelet agonist signaling during the hemostatic response in vivo. Blood Adv. 2017 Dec 26; 1(27):2767-2775. PMID: 29296928.
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    9. Zhao B, Mei Y, Cao L, Zhang J, Sumagin R, Yang J, Gao J, Schipma MJ, Wang Y, Thorsheim C, Zhao L, Stalker T, Stein B, Wen QJ, Crispino JD, Abrams CS, Ji P. Loss of pleckstrin-2 reverts lethality and vascular occlusions in JAK2V617F-positive myeloproliferative neoplasms. J Clin Invest. 2018 01 02; 128(1):125-140. PMID: 29202466.
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    10. Zhao L, Thorsheim CL, Suzuki A, Stalker TJ, Min SH, Lian L, Fairn GD, Cockcroft S, Durham A, Krishnaswamy S, Abrams CS. Phosphatidylinositol transfer protein-a in platelets is inconsequential for thrombosis yet is utilized for tumor metastasis. Nat Commun. 2017 10 31; 8(1):1216. PMID: 29084966.
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    11. Kastelowitz N, Tamura R, Onasoga A, Stalker TJ, White OR, Brown PN, Brodsky GL, Brass LF, Branchford BR, Di Paola J, Yin H. Peptides derived from MARCKS block coagulation complex assembly on phosphatidylserine. Sci Rep. 2017 06 27; 7(1):4275. PMID: 28655899.
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    12. Tomaiuolo M, Brass LF, Stalker TJ. Regulation of Platelet Activation and Coagulation and Its Role in Vascular Injury and Arterial Thrombosis. Interv Cardiol Clin. 2017 01; 6(1):1-12. PMID: 27886814.
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    13. Brass LF, Diamond SL, Stalker TJ. Platelets and hemostasis: a new perspective on an old subject. Blood Adv. 2016 Nov 29; 1(1):5-9. PMID: 29296690.
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    14. Welsh JD, Muthard RW, Stalker TJ, Taliaferro JP, Diamond SL, Brass LF. A systems approach to hemostasis: 4. How hemostatic thrombi limit the loss of plasma-borne molecules from the microvasculature. Blood. 2016 Mar 24; 127(12):1598-605. PMID: 26738537.
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    15. Meng R, Wu J, Harper DC, Wang Y, Kowalska MA, Abrams CS, Brass LF, Poncz M, Stalker TJ, Marks MS. Defective release of a granule and lysosome contents from platelets in mouse Hermansky-Pudlak syndrome models. Blood. 2015 Mar 05; 125(10):1623-32. PMID: 25477496.
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    16. Min SH, Suzuki A, Stalker TJ, Zhao L, Wang Y, McKennan C, Riese MJ, Guzman JF, Zhang S, Lian L, Joshi R, Meng R, Seeholzer SH, Choi JK, Koretzky G, Marks MS, Abrams CS. Loss of PIKfyve in platelets causes a lysosomal disease leading to inflammation and thrombosis in mice. Nat Commun. 2014 Sep 02; 5:4691. PMID: 25178411.
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    17. Stalker TJ, Welsh JD, Brass LF. Shaping the platelet response to vascular injury. Curr Opin Hematol. 2014 Sep; 21(5):410-7. PMID: 25023471.
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    18. Welsh JD, Stalker TJ, Voronov R, Muthard RW, Tomaiuolo M, Diamond SL, Brass LF. A systems approach to hemostasis: 1. The interdependence of thrombus architecture and agonist movements in the gaps between platelets. Blood. 2014 Sep 11; 124(11):1808-15. PMID: 24951424.
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    19. Tomaiuolo M, Stalker TJ, Welsh JD, Diamond SL, Sinno T, Brass LF. A systems approach to hemostasis: 2. Computational analysis of molecular transport in the thrombus microenvironment. Blood. 2014 Sep 11; 124(11):1816-23. PMID: 24951425.
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    20. Stalker TJ, Welsh JD, Tomaiuolo M, Wu J, Colace TV, Diamond SL, Brass LF. A systems approach to hemostasis: 3. Thrombus consolidation regulates intrathrombus solute transport and local thrombin activity. Blood. 2014 Sep 11; 124(11):1824-31. PMID: 24951426.
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    21. Brass LF, Tomaiuolo M, Stalker TJ. Harnessing the platelet signaling network to produce an optimal hemostatic response. Hematol Oncol Clin North Am. 2013 Jun; 27(3):381-409. PMID: 23714305.
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    22. Voronov RS, Stalker TJ, Brass LF, Diamond SL. Simulation of intrathrombus fluid and solute transport using in vivo clot structures with single platelet resolution. Ann Biomed Eng. 2013 Jun; 41(6):1297-307. PMID: 23423707.
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    23. Wang Y, Zhao L, Suzuki A, Lian L, Min SH, Wang Z, Litvinov RI, Stalker TJ, Yago T, Klopocki AG, Schmidtke DW, Yin H, Choi JK, McEver RP, Weisel JW, Hartwig JH, Abrams CS. Platelets lacking PIP5KI? have normal integrin activation but impaired cytoskeletal-membrane integrity and adhesion. Blood. 2013 Apr 04; 121(14):2743-52. PMID: 23372168.
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    24. Stalker TJ, Traxler EA, Wu J, Wannemacher KM, Cermignano SL, Voronov R, Diamond SL, Brass LF. Hierarchical organization in the hemostatic response and its relationship to the platelet-signaling network. Blood. 2013 Mar 07; 121(10):1875-85. PMID: 23303817.
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    25. Wang QM, Stalker TJ, Gong Y, Rikitake Y, Scalia R, Liao JK. Inhibition of Rho-kinase attenuates endothelial-leukocyte interaction during ischemia-reperfusion injury. Vasc Med. 2012 Dec; 17(6):379-85. PMID: 23015643.
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    26. Brass LF, Stalker TJ. Minding the gaps--and the junctions, too. Circulation. 2012 May 22; 125(20):2414-6. PMID: 22528525.
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    27. Naik MU, Stalker TJ, Brass LF, Naik UP. JAM-A protects from thrombosis by suppressing integrin aIIbß3-dependent outside-in signaling in platelets. Blood. 2012 Apr 5; 119(14):3352-60. PMID: 22271446.
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    28. Stalker TJ, Newman DK, Ma P, Wannemacher KM, Brass LF. Platelet signaling. Handb Exp Pharmacol. 2012; (210):59-85. PMID: 22918727.
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    29. Ma P, Cierniewska A, Signarvic R, Cieslak M, Kong H, Sinnamon AJ, Neubig RR, Newman DK, Stalker TJ, Brass LF. A newly identified complex of spinophilin and the tyrosine phosphatase, SHP-1, modulates platelet activation by regulating G protein-dependent signaling. Blood. 2012 Feb 23; 119(8):1935-45. PMID: 22210881.
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    30. Schmaier AA, Stalker TJ, Runge JJ, Lee D, Nagaswami C, Mericko P, Chen M, Cliché S, Gariépy C, Brass LF, Hammer DA, Weisel JW, Rosenthal K, Kahn ML. Occlusive thrombi arise in mammals but not birds in response to arterial injury: evolutionary insight into human cardiovascular disease. Blood. 2011 Sep 29; 118(13):3661-9. PMID: 21816834.
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    31. Wannemacher KM, Zhu L, Jiang H, Fong KP, Stalker TJ, Lee D, Tran AN, Neeves KB, Maloney S, Kumanogoh A, Kikutani H, Hammer DA, Diamond SL, Brass LF. Diminished contact-dependent reinforcement of Syk activation underlies impaired thrombus growth in mice lacking Semaphorin 4D. Blood. 2010 Dec 16; 116(25):5707-15. PMID: 20855865.
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    32. Signarvic RS, Cierniewska A, Stalker TJ, Fong KP, Chatterjee MS, Hess PR, Ma P, Diamond SL, Neubig RR, Brass LF. RGS/Gi2alpha interactions modulate platelet accumulation and thrombus formation at sites of vascular injury. Blood. 2010 Dec 23; 116(26):6092-100. PMID: 20852125.
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    33. Zhu L, Stalker TJ, Fong KP, Jiang H, Tran A, Crichton I, Lee EK, Neeves KB, Maloney SF, Kikutani H, Kumanogoh A, Pure E, Diamond SL, Brass LF. Disruption of SEMA4D ameliorates platelet hypersensitivity in dyslipidemia and confers protection against the development of atherosclerosis. Arterioscler Thromb Vasc Biol. 2009 Jul; 29(7):1039-45. PMID: 19390055.
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    34. Wang Y, Chen X, Lian L, Tang T, Stalker TJ, Sasaki T, Kanaho Y, Brass LF, Choi JK, Hartwig JH, Abrams CS. Loss of PIP5KIbeta demonstrates that PIP5KI isoform-specific PIP2 synthesis is required for IP3 formation. Proc Natl Acad Sci U S A. 2008 Sep 16; 105(37):14064-9. PMID: 18772378.
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    35. Brass LF, Zhu L, Stalker TJ. Novel therapeutic targets at the platelet vascular interface. Arterioscler Thromb Vasc Biol. 2008 Mar; 28(3):s43-50. PMID: 18174448.
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    36. Kahner BN, Dorsam RT, Mada SR, Kim S, Stalker TJ, Brass LF, Daniel JL, Kitamura D, Kunapuli SP. Hematopoietic lineage cell specific protein 1 (HS1) is a functionally important signaling molecule in platelet activation. Blood. 2007 Oct 01; 110(7):2449-56. PMID: 17579181.
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    37. Zhu L, Bergmeier W, Wu J, Jiang H, Stalker TJ, Cieslak M, Fan R, Boumsell L, Kumanogoh A, Kikutani H, Tamagnone L, Wagner DD, Milla ME, Brass LF. Regulated surface expression and shedding support a dual role for semaphorin 4D in platelet responses to vascular injury. Proc Natl Acad Sci U S A. 2007 Jan 30; 104(5):1621-6. PMID: 17244710.
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    38. Brass LF, Jiang H, Wu J, Stalker TJ, Zhu L. Contact-dependent signaling events that promote thrombus formation. Blood Cells Mol Dis. 2006 Mar-Apr; 36(2):157-61. PMID: 16473534.
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    39. Brass LF, Zhu L, Stalker TJ. Minding the gaps to promote thrombus growth and stability. J Clin Invest. 2005 Dec; 115(12):3385-92. PMID: 16322784.
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    40. Prévost N, Woulfe DS, Jiang H, Stalker TJ, Marchese P, Ruggeri ZM, Brass LF. Eph kinases and ephrins support thrombus growth and stability by regulating integrin outside-in signaling in platelets. Proc Natl Acad Sci U S A. 2005 Jul 12; 102(28):9820-5. PMID: 15994237.
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    41. Stalker TJ, Gong Y, Scalia R. The calcium-dependent protease calpain causes endothelial dysfunction in type 2 diabetes. Diabetes. 2005 Apr; 54(4):1132-40. PMID: 15793253.
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    42. Wolfrum S, Dendorfer A, Rikitake Y, Stalker TJ, Gong Y, Scalia R, Dominiak P, Liao JK. Inhibition of Rho-kinase leads to rapid activation of phosphatidylinositol 3-kinase/protein kinase Akt and cardiovascular protection. Arterioscler Thromb Vasc Biol. 2004 Oct; 24(10):1842-7. PMID: 15319269.
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    43. Brass LF, Stalker TJ, Zhu L, Lu B, Woulfe DS, Prevost N. Boundary events: contact-dependent and contact-facilitated signaling between platelets. Semin Thromb Hemost. 2004 Aug; 30(4):399-410. PMID: 15354261.
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    44. Stalker TJ, Skvarka CB, Scalia R. A novel role for calpains in the endothelial dysfunction of hyperglycemia. FASEB J. 2003 Aug; 17(11):1511-3. PMID: 12824289.
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    45. Wu X, Motoshima H, Mahadev K, Stalker TJ, Scalia R, Goldstein BJ. Involvement of AMP-activated protein kinase in glucose uptake stimulated by the globular domain of adiponectin in primary rat adipocytes. Diabetes. 2003 Jun; 52(6):1355-63. PMID: 12765944.
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    46. Scalia R, Stalker TJ. Microcirculation as a target for the anti-inflammatory properties of statins. Microcirculation. 2002 Dec; 9(6):431-42. PMID: 12483541.
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    47. Booth G, Stalker TJ, Lefer AM, Scalia R. Mechanisms of amelioration of glucose-induced endothelial dysfunction following inhibition of protein kinase C in vivo. Diabetes. 2002 May; 51(5):1556-64. PMID: 11978656.
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