John Kostyak

TitleAsst Professor
InstitutionThomas Jefferson University
DepartmentHematology
Address1020 Locust St.
Philadelphia PA 19107
Phone09250002
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Kostyak JC, Mauri B, Patel A, Dangelmaier C, Reddy H, Kunapuli SP. Phosphorylation of protein kinase Cd positively regulates thromboxane generation in platelets. J Biol Chem. 2021 Apr 28; 100720. PMID: 33932405.
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    2. Kolpakov MA, Guo X, Rafiq K, Vlasenko L, Hooshdaran B, Seqqat R, Wang T, Fan X, Tilley DG, Kostyak JC, Kunapuli SP, Houser SR, Sabri A. Loss of Protease-Activated Receptor 4 Prevents Inflammation Resolution and Predisposes the Heart to Cardiac Rupture after Myocardial Infarction. Circulation. 2020 Jun 03. PMID: 32489148.
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    3. Inamdar VV, Reddy H, Dangelmaier C, Kostyak JC, Kunapuli SP. The protein tyrosine phosphatase PTPN7 is a negative regulator of ERK activation and thromboxane generation in platelets. J Biol Chem. 2019 08 16; 294(33):12547-12554. PMID: 31266805.
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    4. Inamdar VV, Kostyak JC, Badolia R, Dangelmaier CA, Manne BK, Patel A, Kim S, Kunapuli SP. Impaired Glycoprotein VI-Mediated Signaling and Platelet Functional Responses in CD45 Knockout Mice. Thromb Haemost. 2019 Aug; 119(8):1321-1331. PMID: 31226719.
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    5. Patel A, Kostyak J, Dangelmaier C, Badolia R, Bhavanasi D, Aslan JE, Merali S, Kim S, Eble JA, Goldfinger L, Kunapuli S. ELMO1 deficiency enhances platelet function. Blood Adv. 2019 Feb 26; 3(4):575-587. PMID: 30787021.
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    6. Kostyak JC, Mauri BR, Dangelmaier C, Patel A, Zhou Y, Eble JA, Tsygankov AY, McKenzie SE, Kunapuli SP. TULA-2 Deficiency Enhances Platelet Functional Responses to CLEC-2 Agonists. TH Open. 2018 Oct; 2(4):e411-e419. PMID: 31249969.
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    7. Kostyak JC, Liverani E, Kunapuli SP. PKC-epsilon deficiency alters progenitor cell populations in favor of megakaryopoiesis. PLoS One. 2017; 12(8):e0182867. PMID: 28783756.
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    8. Badolia R, Kostyak JC, Dangelmaier C, Kunapuli SP. Syk Activity Is Dispensable for Platelet GP1b-IX-V Signaling. Int J Mol Sci. 2017 Jun 09; 18(6). PMID: 28598382.
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    9. Kosoff RE, Aslan JE, Kostyak JC, Dulaimi E, Chow HY, Prudnikova TY, Radu M, Kunapuli SP, McCarty OJ, Chernoff J. Pak2 restrains endomitosis during megakaryopoiesis and alters cytoskeleton organization. Blood. 2015 May 07; 125(19):2995-3005. PMID: 25824689.
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    10. Kostyak JC, Bhavanasi D, Liverani E, McKenzie SE, Kunapuli SP. Protein Kinase C d Deficiency Enhances Megakaryopoiesis and Recovery From Thrombocytopenia. Arterioscler Thromb Vasc Biol. 2014 Dec; 34(12):2579-85. PMID: 25359855.
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    11. Kostyak JC, Kunapuli SP. PKC? is dispensable for megakaryopoiesis. Platelets. 2015; 26(6):610-1. PMID: 24955517.
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    12. Bhavanasi D, Kostyak JC, Swindle J, Kilpatrick LE, Kunapuli SP. CGX1037 is a novel PKC isoform delta selective inhibitor in platelets. Platelets. 2015; 26(1):2-9. PMID: 24433221.
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    13. Kostyak JC, Naik MU, Naik UP. Calcium- and integrin-binding protein 1 regulates megakaryocyte ploidy, adhesion, and migration. Blood. 2012 Jan 19; 119(3):838-46. PMID: 22128142.
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    14. Kostyak JC, Naik UP. Calcium- and integrin-binding protein 1 regulates endomitosis and its interaction with Polo-like kinase 3 is enhanced in endomitotic Dami cells. PLoS One. 2011; 6(1):e14513. PMID: 21264284.
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    15. Kostyak JC, Kris-Etherton P, Bagshaw D, DeLany JP, Farrell PA. Relative fat oxidation is higher in children than adults. Nutr J. 2007 Aug 16; 6:19. PMID: 17705825.
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    16. Korzick DH, Kostyak JC, Hunter JC, Saupe KW. Local delivery of PKCepsilon-activating peptide mimics ischemic preconditioning in aged hearts through GSK-3beta but not F1-ATPase inactivation. . 2007 Oct; 293(4):H2056-63. PMID: 17675573.
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    17. Kostyak JC, Naik UP. Megakaryopoiesis: transcriptional insights into megakaryocyte maturation. Front Biosci. 2007; 12:2050-62. PMID: 17127443.
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    18. Kostyak JC, Hunter JC, Korzick DH. Acute PKCdelta inhibition limits ischaemia-reperfusion injury in the aged rat heart: role of GSK-3beta. Cardiovasc Res. 2006 May 01; 70(2):325-34. PMID: 16542646.
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