Thomas Jefferson University

John Kostyak

TitleAsst Professor
InstitutionThomas Jefferson University
DepartmentHematology
Address1020 Locust St.
Philadelphia PA 19107
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Kostyak JC, McKenzie SE, Naik UP. The Function of ASK1 in Sepsis and Stress-Induced Disorders. Int J Mol Sci. 2023 Dec 22; 25(1). PMID: 38203381.
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    2. Dangelmaier CA, Patchin M, Vajipayajula DN, Vari HR, Singh PK, Wright MN, Kostyak JC, Tsygankov AY, Kunapuli SP. Phosphorylation of spleen tyrosine kinase at Y346 negatively regulates ITAM-mediated signaling and function in platelets. J Biol Chem. 2023 Jun 01; 299(7):104865. PMID: 37268160.
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    3. Dangelmaier C, Mauri B, Patel A, Kunapuli SP, Kostyak JC. D121 Located within the DRY Motif of P2Y12 Is Essential for P2Y12-Mediated Platelet Function. Int J Mol Sci. 2022 Sep 29; 23(19). PMID: 36232816.
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    4. Kostyak JC, Mauri B, Dangelmaier C, Vari HR, Patel A, Wright M, Reddy H, Tsygankov AY, Kunapuli SP. Phosphorylation on Y342 Syk is important for both ITAM and hemITAM signaling in platelets. J Biol Chem. 2022 Jun 23; 102189. PMID: 35753354.
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    5. Dangelmaier C, Vari HR, Wright M, Kostyak JC, Kunapuli SP. Clustering extent-dependent differential signaling by CLEC-2 receptors in platelets. Res Pract Thromb Haemost. 2022 Mar; 6(3):e12710. PMID: 35573643.
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    6. Kostyak JC, Mauri B, Patel A, Dangelmaier C, Reddy H, Kunapuli SP. Phosphorylation of protein kinase Cd positively regulates thromboxane generation in platelets. J Biol Chem. 2021 Apr 28; 100720. PMID: 33932405.
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    7. Kolpakov MA, Guo X, Rafiq K, Vlasenko L, Hooshdaran B, Seqqat R, Wang T, Fan X, Tilley DG, Kostyak JC, Kunapuli SP, Houser SR, Sabri A. Loss of Protease-Activated Receptor 4 Prevents Inflammation Resolution and Predisposes the Heart to Cardiac Rupture after Myocardial Infarction. Circulation. 2020 Jun 03. PMID: 32489148.
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    8. Inamdar VV, Reddy H, Dangelmaier C, Kostyak JC, Kunapuli SP. The protein tyrosine phosphatase PTPN7 is a negative regulator of ERK activation and thromboxane generation in platelets. J Biol Chem. 2019 08 16; 294(33):12547-12554. PMID: 31266805.
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    9. Inamdar VV, Kostyak JC, Badolia R, Dangelmaier CA, Manne BK, Patel A, Kim S, Kunapuli SP. Impaired Glycoprotein VI-Mediated Signaling and Platelet Functional Responses in CD45 Knockout Mice. Thromb Haemost. 2019 Aug; 119(8):1321-1331. PMID: 31226719.
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    10. Patel A, Kostyak J, Dangelmaier C, Badolia R, Bhavanasi D, Aslan JE, Merali S, Kim S, Eble JA, Goldfinger L, Kunapuli S. ELMO1 deficiency enhances platelet function. Blood Adv. 2019 Feb 26; 3(4):575-587. PMID: 30787021.
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    11. Kostyak JC, Mauri BR, Dangelmaier C, Patel A, Zhou Y, Eble JA, Tsygankov AY, McKenzie SE, Kunapuli SP. TULA-2 Deficiency Enhances Platelet Functional Responses to CLEC-2 Agonists. TH Open. 2018 Oct; 2(4):e411-e419. PMID: 31249969.
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    12. Kostyak JC, Liverani E, Kunapuli SP. PKC-epsilon deficiency alters progenitor cell populations in favor of megakaryopoiesis. PLoS One. 2017; 12(8):e0182867. PMID: 28783756.
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    13. Badolia R, Kostyak JC, Dangelmaier C, Kunapuli SP. Syk Activity Is Dispensable for Platelet GP1b-IX-V Signaling. Int J Mol Sci. 2017 Jun 09; 18(6). PMID: 28598382.
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    14. Kosoff RE, Aslan JE, Kostyak JC, Dulaimi E, Chow HY, Prudnikova TY, Radu M, Kunapuli SP, McCarty OJ, Chernoff J. Pak2 restrains endomitosis during megakaryopoiesis and alters cytoskeleton organization. Blood. 2015 May 07; 125(19):2995-3005. PMID: 25824689.
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    15. Kostyak JC, Bhavanasi D, Liverani E, McKenzie SE, Kunapuli SP. Protein Kinase C d Deficiency Enhances Megakaryopoiesis and Recovery From Thrombocytopenia. Arterioscler Thromb Vasc Biol. 2014 Dec; 34(12):2579-85. PMID: 25359855.
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    16. Kostyak JC, Kunapuli SP. PKC? is dispensable for megakaryopoiesis. Platelets. 2015; 26(6):610-1. PMID: 24955517.
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    17. Bhavanasi D, Kostyak JC, Swindle J, Kilpatrick LE, Kunapuli SP. CGX1037 is a novel PKC isoform delta selective inhibitor in platelets. Platelets. 2015; 26(1):2-9. PMID: 24433221.
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    18. Kostyak JC, Naik MU, Naik UP. Calcium- and integrin-binding protein 1 regulates megakaryocyte ploidy, adhesion, and migration. Blood. 2012 Jan 19; 119(3):838-46. PMID: 22128142.
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    19. Kostyak JC, Naik UP. Calcium- and integrin-binding protein 1 regulates endomitosis and its interaction with Polo-like kinase 3 is enhanced in endomitotic Dami cells. PLoS One. 2011; 6(1):e14513. PMID: 21264284.
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    20. Kostyak JC, Kris-Etherton P, Bagshaw D, DeLany JP, Farrell PA. Relative fat oxidation is higher in children than adults. Nutr J. 2007 Aug 16; 6:19. PMID: 17705825.
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    21. Korzick DH, Kostyak JC, Hunter JC, Saupe KW. Local delivery of PKCepsilon-activating peptide mimics ischemic preconditioning in aged hearts through GSK-3beta but not F1-ATPase inactivation. . 2007 Oct; 293(4):H2056-63. PMID: 17675573.
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    22. Kostyak JC, Naik UP. Megakaryopoiesis: transcriptional insights into megakaryocyte maturation. Front Biosci. 2007; 12:2050-62. PMID: 17127443.
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    23. Kostyak JC, Hunter JC, Korzick DH. Acute PKCdelta inhibition limits ischaemia-reperfusion injury in the aged rat heart: role of GSK-3beta. Cardiovasc Res. 2006 May 01; 70(2):325-34. PMID: 16542646.
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