"Complement C1q" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A subcomponent of complement C1, composed of six copies of three polypeptide chains (A, B, and C), each encoded by a separate gene (C1QA; C1QB; C1QC). This complex is arranged in nine subunits (six disulfide-linked dimers of A and B, and three disulfide-linked homodimers of C). C1q has binding sites for antibodies (the heavy chain of IMMUNOGLOBULIN G or IMMUNOGLOBULIN M). The interaction of C1q and immunoglobulin activates the two proenzymes COMPLEMENT C1R and COMPLEMENT C1S, thus initiating the cascade of COMPLEMENT ACTIVATION via the CLASSICAL COMPLEMENT PATHWAY.
| Descriptor ID |
D015922
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| MeSH Number(s) |
D12.776.124.486.274.050.270
|
| Concept/Terms |
Complement C1q- Complement C1q
- C1q, Complement
- Complement Component 1q
- Component 1q, Complement
- C1q Complement
- Complement, C1q
- Complement 1q
|
Below are MeSH descriptors whose meaning is more general than "Complement C1q".
Below are MeSH descriptors whose meaning is more specific than "Complement C1q".
This graph shows the total number of publications written about "Complement C1q" by people in this website by year, and whether "Complement C1q" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 1 | 0 | 1 |
| 2015 | 2 | 1 | 3 |
| 2017 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Complement C1q" by people in Profiles.
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Yan Z, Wang C, Meng Z, Gan L, Guo R, Liu J, Bond Lau W, Xie D, Zhao J, Lopez BL, Christopher TA, Naik UP, Ma X, Wang Y. C1q/TNF-Related Protein 3 Prevents Diabetic Retinopathy via AMPK-Dependent Stabilization of Blood-Retinal Barrier Tight Junctions. Cells. 2022 02 23; 11(5).
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Liu J, Meng Z, Gan L, Guo R, Gao J, Liu C, Zhu D, Liu D, Zhang L, Zhang Z, Xie D, Jiao X, Lau WB, Lopez BL, Christopher TA, Ma X, Cao J, Wang Y. C1q/TNF-related protein 5 contributes to diabetic vascular endothelium dysfunction through promoting Nox-1 signaling. Redox Biol. 2020 07; 34:101476.
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Kozlowski T, Weimer ET, Andreoni K, Schmitz J. C1q Test for Identification of Sensitized Liver Recipients at Risk of Early Acute Antibody-Mediated Rejection. Ann Transplant. 2017 Aug 25; 22:518-523.
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Shah D, Romero F, Zhu Y, Duong M, Sun J, Walsh K, Summer R. C1q Deficiency Promotes Pulmonary Vascular Inflammation and Enhances the Susceptibility of the Lung Endothelium to Injury. J Biol Chem. 2015 Dec 04; 290(49):29642-51.
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Quast I, Keller CW, Maurer MA, Giddens JP, Tackenberg B, Wang LX, M?nz C, Nimmerjahn F, Dalakas MC, L?nemann JD. Sialylation of IgG Fc domain impairs complement-dependent cytotoxicity. J Clin Invest. 2015 Nov 02; 125(11):4160-70.
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Filippone EJ, Farber JL. Humoral immunity in renal transplantation: epitopes, Cw and DP, and complement-activating capability--an update. Clin Transplant. 2015 Apr; 29(4):279-87.
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Breitbart SI, Bielory L. Acquired angioedema: Autoantibody associations and C1q utility as a diagnostic tool. Allergy Asthma Proc. 2010 Sep-Oct; 31(5):428-34.
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Dietzschold B, Schwaeble W, Sch?fer MK, Hooper DC, Zehng YM, Petry F, Sheng H, Fink T, Loos M, Koprowski H, Weihe E. Expression of C1q, a subcomponent of the rat complement system, is dramatically enhanced in brains of rats with either Borna disease or experimental allergic encephalomyelitis. J Neurol Sci. 1995 May; 130(1):11-6.
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Bielory L, Kemeny DM, Richards D, Lessof MH. IgG subclass antibody production in human serum sickness. J Allergy Clin Immunol. 1990 Mar; 85(3):573-7.
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Lawley TJ, Bielory L, Gascon P, Yancey KB, Young NS, Frank MM. Human serum sickness. Trans Assoc Am Physicians. 1984; 97:49-55.