"Gene Products, vpr" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Trans-acting proteins which accelerate retroviral virus replication. The vpr proteins act in trans to increase the levels of specified proteins. vpr is short for viral protein R, where R is undefined.
Descriptor ID |
D016336
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MeSH Number(s) |
D12.776.964.925.984.430
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Concept/Terms |
Gene Products, vpr- Gene Products, vpr
- vpr Gene Products
- Viral Protein R (vpr)
- vpr Protein
- Viral Protein R
- Protein R, Viral
- Gene Product, vpr
- vpr Gene Product
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Below are MeSH descriptors whose meaning is more general than "Gene Products, vpr".
Below are MeSH descriptors whose meaning is more specific than "Gene Products, vpr".
This graph shows the total number of publications written about "Gene Products, vpr" by people in this website by year, and whether "Gene Products, vpr" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2000 | 0 | 1 | 1 |
2004 | 2 | 0 | 2 |
2005 | 1 | 0 | 1 |
2006 | 1 | 0 | 1 |
2007 | 1 | 0 | 1 |
2008 | 1 | 0 | 1 |
2009 | 1 | 0 | 1 |
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Below are the most recent publications written about "Gene Products, vpr" by people in Profiles.
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Muthumani K, Lambert VM, Shanmugam M, Thieu KP, Choo AY, Chung JC, Satishchandran A, Kim JJ, Weiner DB, Ugen KE. Anti-tumor activity mediated by protein and peptide transduction of HIV viral protein R (Vpr). Cancer Biol Ther. 2009 Jan; 8(2):180-7.
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Srinivasan A, Ayyavoo V, Mahalingam S, Kannan A, Boyd A, Datta D, Kalyanaraman VS, Cristillo A, Collman RG, Morellet N, Sawaya BE, Murali R. A comprehensive analysis of the naturally occurring polymorphisms in HIV-1 Vpr: potential impact on CTL epitopes. Virol J. 2008 Aug 23; 5:99.
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Cheng X, Cheng X, Mukhtar M, Acheampong EA, Srinivasan A, Rafi M, Pomerantz RJ, Parveen Z. HIV-1 Vpr potently induces programmed cell death in the CNS in vivo. DNA Cell Biol. 2007 Feb; 26(2):116-31.
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Muthumani K, Choo AY, Zong WX, Madesh M, Hwang DS, Premkumar A, Thieu KP, Emmanuel J, Kumar S, Thompson CB, Weiner DB. The HIV-1 Vpr and glucocorticoid receptor complex is a gain-of-function interaction that prevents the nuclear localization of PARP-1. Nat Cell Biol. 2006 Feb; 8(2):170-9.
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Muthumani K, Choo AY, Hwang DS, Dayes NS, Chattergoon M, Mayilvahanan S, Thieu KP, Buckley PT, Emmanuel J, Premkumar A, Weiner DB. HIV-1 Viral protein-r (Vpr) protects against lethal superantigen challenge while maintaining homeostatic T cell levels in vivo. Mol Ther. 2005 Nov; 12(5):910-21.
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Muthumani K, Hwang DS, Choo AY, Mayilvahanan S, Dayes NS, Thieu KP, Weiner DB. HIV-1 Vpr inhibits the maturation and activation of macrophages and dendritic cells in vitro. Int Immunol. 2005 Feb; 17(2):103-16.
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Muthumani K, Desai BM, Hwang DS, Choo AY, Laddy DJ, Thieu KP, Rao RG, Weiner DB. HIV-1 Vpr and anti-inflammatory activity. DNA Cell Biol. 2004 Apr; 23(4):239-47.
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Kulkosky J, Bouhamdan M, Geist A, Nunnari G, Phinney DG, Pomerantz RJ. Pathogenesis of HIV-1 infection within bone marrow cells. Leuk Lymphoma. 2000 May; 37(5-6):497-515.