"Leucine Zippers" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
DNA-binding motifs formed from two alpha-helixes which intertwine for about eight turns into a coiled coil and then bifurcate to form Y shaped structures. Leucines occurring in heptad repeats end up on the same sides of the helixes and are adjacent to each other in the stem of the Y (the "zipper" region). The DNA-binding residues are located in the bifurcated region of the Y.
Descriptor ID |
D016350
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MeSH Number(s) |
G02.111.570.820.709.275.500.520
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Concept/Terms |
Leucine Zippers- Leucine Zippers
- Leucine Zipper
- Zipper, Leucine
- Zippers, Leucine
|
Below are MeSH descriptors whose meaning is more general than "Leucine Zippers".
Below are MeSH descriptors whose meaning is more specific than "Leucine Zippers".
This graph shows the total number of publications written about "Leucine Zippers" by people in this website by year, and whether "Leucine Zippers" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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1999 | 0 | 1 | 1 |
2002 | 1 | 1 | 2 |
2004 | 1 | 0 | 1 |
2005 | 1 | 0 | 1 |
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Below are the most recent publications written about "Leucine Zippers" by people in Profiles.
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Daniele LL, Lillo C, Lyubarsky AL, Nikonov SS, Philp N, Mears AJ, Swaroop A, Williams DS, Pugh EN. Cone-like morphological, molecular, and electrophysiological features of the photoreceptors of the Nrl knockout mouse. Invest Ophthalmol Vis Sci. 2005 Jun; 46(6):2156-67.
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Qian Y, Gatesman AS, Baisden JM, Zot HG, Cherezova L, Qazi I, Mazloum N, Lee MY, Guappone-Koay A, Flynn DC. Analysis of the role of the leucine zipper motif in regulating the ability of AFAP-110 to alter actin filament integrity. J Cell Biochem. 2004 Feb 15; 91(3):602-20.
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Wu FY, Tang QQ, Chen H, ApRhys C, Farrell C, Chen J, Fujimuro M, Lane MD, Hayward GS. Lytic replication-associated protein (RAP) encoded by Kaposi sarcoma-associated herpesvirus causes p21CIP-1-mediated G1 cell cycle arrest through CCAAT/enhancer-binding protein-alpha. Proc Natl Acad Sci U S A. 2002 Aug 6; 99(16):10683-8.
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Qian Y, Baisden JM, Cherezova L, Summy JM, Guappone-Koay A, Shi X, Mast T, Pustula J, Zot HG, Mazloum N, Lee MY, Flynn DC. PC phosphorylation increases the ability of AFAP-110 to cross-link actin filaments. Mol Biol Cell. 2002 Jul; 13(7):2311-22.
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Beier F, Lee RJ, Taylor AC, Pestell RG, LuValle P. Identification of the cyclin D1 gene as a target of activating transcription factor 2 in chondrocytes. Proc Natl Acad Sci U S A. 1999 Feb 16; 96(4):1433-8.