Lipoxygenase Inhibitors

"Lipoxygenase Inhibitors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Compounds that bind to and inhibit that enzymatic activity of LIPOXYGENASES. Included under this category are inhibitors that are specific for lipoxygenase subtypes and act to reduce the production of LEUKOTRIENES.

Descriptor ID	D016859
MeSH Number(s)	D27.505.519.389.480
Concept/Terms	Lipoxygenase Inhibitors Lipoxygenase Inhibitors Inhibitors, Lipoxygenase Arachidonate 15-Lipoxygenase Inhibitors Arachidonate 15-Lipoxygenase Inhibitors 15-Lipoxygenase Inhibitors, Arachidonate Arachidonate 15 Lipoxygenase Inhibitors Inhibitors, Arachidonate 15-Lipoxygenase 15-Lipoxygenase Inhibitors 15 Lipoxygenase Inhibitors Inhibitors, 15-Lipoxygenase Arachidonate 5-Lipoxygenase Inhibitors Arachidonate 5-Lipoxygenase Inhibitors 5-Lipoxygenase Inhibitors, Arachidonate Arachidonate 5 Lipoxygenase Inhibitors Inhibitors, Arachidonate 5-Lipoxygenase 5-Lipoxygenase Inhibitors 5 Lipoxygenase Inhibitors Inhibitors, 5-Lipoxygenase Arachidonate 12-Lipoxygenase Inhibitors Arachidonate 12-Lipoxygenase Inhibitors 12-Lipoxygenase Inhibitors, Arachidonate Arachidonate 12 Lipoxygenase Inhibitors Inhibitors, Arachidonate 12-Lipoxygenase 12-Lipoxygenase Inhibitors 12 Lipoxygenase Inhibitors Inhibitors, 12-Lipoxygenase

Below are MeSH descriptors whose meaning is more general than "Lipoxygenase Inhibitors".

Chemicals and Drugs [D]
Chemical Actions and Uses [D27]
Pharmacologic Actions [D27.505]
Molecular Mechanisms of Pharmacological Action [D27.505.519]
Enzyme Inhibitors [D27.505.519.389]
Lipoxygenase Inhibitors [D27.505.519.389.480]

Below are MeSH descriptors whose meaning is related to "Lipoxygenase Inhibitors".

Below are MeSH descriptors whose meaning is more specific than "Lipoxygenase Inhibitors".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Lipoxygenase Inhibitors" by people in this website by year, and whether "Lipoxygenase Inhibitors" was a major or minor topic of these publications.

Bar chart showing 13 publications over 8 distinct years, with a maximum of 3 publications in 2011

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	2	0	2
2005	0	1	1
2008	2	0	2
2009	0	1	1
2011	2	1	3
2014	1	0	1
2017	2	0	2
2023	0	1	1

Below are the most recent publications written about "Lipoxygenase Inhibitors" by people in Profiles.

Yamaguchi A, van Hoorebeke C, Tourdot BE, Perry SC, Lee G, Rhoads N, Rickenberg A, Green AR, Sorrentino J, Yeung J, Freedman JC, Holman TR, Holinstat M. Fatty acids negatively regulate platelet function through formation of noncanonical 15-lipoxygenase-derived eicosanoids. Pharmacol Res Perspect. 2023 02; 11(1):e01056.

View in: PubMed
Tourdot BE, Holinstat M. Targeting 12-Lipoxygenase as a Potential Novel Antiplatelet Therapy. Trends Pharmacol Sci. 2017 11; 38(11):1006-1015.

View in: PubMed
Adili R, Tourdot BE, Mast K, Yeung J, Freedman JC, Green A, Luci DK, Jadhav A, Simeonov A, Maloney DJ, Holman TR, Holinstat M. First Selective 12-LOX Inhibitor, ML355, Impairs Thrombus Formation and Vessel Occlusion In Vivo With Minimal Effects on Hemostasis. Arterioscler Thromb Vasc Biol. 2017 10; 37(10):1828-1839.

View in: PubMed
Luci DK, Jameson JB, Yasgar A, Diaz G, Joshi N, Kantz A, Markham K, Perry S, Kuhn N, Yeung J, Kerns EH, Schultz L, Holinstat M, Nadler JL, Taylor-Fishwick DA, Jadhav A, Simeonov A, Holman TR, Maloney DJ. Synthesis and structure-activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase. J Med Chem. 2014 Jan 23; 57(2):495-506.

View in: PubMed
Yeung J, Apopa PL, Vesci J, Kenyon V, Rai G, Jadhav A, Simeonov A, Holman TR, Maloney DJ, Boutaud O, Holinstat M. Protein kinase C regulation of 12-lipoxygenase-mediated human platelet activation. Mol Pharmacol. 2012 Mar; 81(3):420-30.

View in: PubMed
Kenyon V, Rai G, Jadhav A, Schultz L, Armstrong M, Jameson JB, Perry S, Joshi N, Bougie JM, Leister W, Taylor-Fishwick DA, Nadler JL, Holinstat M, Simeonov A, Maloney DJ, Holman TR. Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase. J Med Chem. 2011 Aug 11; 54(15):5485-97.

View in: PubMed
Yeung J, Holinstat M. 12-lipoxygenase: a potential target for novel anti-platelet therapeutics. Cardiovasc Hematol Agents Med Chem. 2011 Jul 01; 9(3):154-64.

View in: PubMed
de Godoy MA, Rattan N, Rattan S. Arachidonic acid metabolites follow the preferential course of cyclooxygenase pathway for the basal tone in the internal anal sphincter. Am J Physiol Gastrointest Liver Physiol. 2009 Apr; 296(4):G727-34.

View in: PubMed
Melstrom LG, Bentrem DJ, Salabat MR, Kennedy TJ, Ding XZ, Strouch M, Rao SM, Witt RC, Ternent CA, Talamonti MS, Bell RH, Adrian TA. Overexpression of 5-lipoxygenase in colon polyps and cancer and the effect of 5-LOX inhibitors in vitro and in a murine model. Clin Cancer Res. 2008 Oct 15; 14(20):6525-30.

View in: PubMed
Edelman MJ, Watson D, Wang X, Morrison C, Kratzke RA, Jewell S, Hodgson L, Mauer AM, Gajra A, Masters GA, Bedor M, Vokes EE, Green MJ. Eicosanoid modulation in advanced lung cancer: cyclooxygenase-2 expression is a positive predictive factor for celecoxib + chemotherapy--Cancer and Leukemia Group B Trial 30203. J Clin Oncol. 2008 Feb 20; 26(6):848-55.

View in: PubMed

People

Explore

Similar Concepts

Top Journals

The Thomas Jefferson University web site, its contents and programs, is provided for informational and educational purposes only and is not intended as medical advice nor is it intended to create any physician-patient relationship. Please remember that this information should not substitute for a visit or a consultation with a health care provider. The views or opinions expressed in the resources provided do not necessarily reflect those of Thomas Jefferson University, Thomas Jefferson University Hospital, or the Jefferson Health System or staff.
Please read our Privacy Statement