Protein Tyrosine Phosphatases
"Protein Tyrosine Phosphatases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme group that specifically dephosphorylates phosphotyrosyl residues in selected proteins. Together with PROTEIN-TYROSINE KINASE, it regulates tyrosine phosphorylation and dephosphorylation in cellular signal transduction and may play a role in cell growth control and carcinogenesis.
| Descriptor ID |
D017027
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| MeSH Number(s) |
D08.811.277.352.650.775
|
| Concept/Terms |
Protein Tyrosine Phosphatases- Protein Tyrosine Phosphatases
- Phosphatases, Protein Tyrosine
- Tyrosine Phosphatases, Protein
- Phosphotyrosyl Protein Phosphatase
- Phosphatase, Phosphotyrosyl Protein
- Protein Phosphatase, Phosphotyrosyl
- Protein-Tyrosine Phosphatase
- Phosphatase, Protein-Tyrosine
- PTPase
- Tyrosyl Phosphoprotein Phosphatase
- Phosphatase, Tyrosyl Phosphoprotein
- Phosphoprotein Phosphatase, Tyrosyl
- Phosphotyrosine Phosphatase
- Phosphatase, Phosphotyrosine
- Protein-Tyrosine-Phosphatase
- Protein Tyrosine Phosphatase
|
Below are MeSH descriptors whose meaning is more general than "Protein Tyrosine Phosphatases".
Below are MeSH descriptors whose meaning is more specific than "Protein Tyrosine Phosphatases".
This graph shows the total number of publications written about "Protein Tyrosine Phosphatases" by people in this website by year, and whether "Protein Tyrosine Phosphatases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2002 | 1 | 1 | 2 |
| 2003 | 3 | 0 | 3 |
| 2004 | 1 | 0 | 1 |
| 2005 | 2 | 1 | 3 |
| 2006 | 3 | 2 | 5 |
| 2007 | 1 | 1 | 2 |
| 2012 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2018 | 1 | 1 | 2 |
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Below are the most recent publications written about "Protein Tyrosine Phosphatases" by people in Profiles.
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Moise G, Morales Y, Beaumont V, Caradonna T, Loria JP, Johnson SJ, Hengge AC. A YopH PTP1B Chimera Shows the Importance of the WPD-Loop Sequence to the Activity, Structure, and Dynamics of Protein Tyrosine Phosphatases. Biochemistry. 2018 09 11; 57(36):5315-5326.
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Cui Q, Kong D, Li Z, Ahiable P, Wang K, Wu K, Wu G. Dachshund 1 is Differentially Expressed Between Male and Female Breast Cancer: A Matched Case-Control Study of Clinical Characteristics and Prognosis. Clin Breast Cancer. 2018 10; 18(5):e875-e882.
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Reppschläger K, Gosselin J, Dangelmaier CA, Thomas DH, Carpino N, McKenzie SE, Kunapuli SP, Tsygankov AY. TULA-2 Protein Phosphatase Suppresses Activation of Syk through the GPVI Platelet Receptor for Collagen by Dephosphorylating Tyr(P)346, a Regulatory Site of Syk. J Biol Chem. 2016 Oct 21; 291(43):22427-22441.
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Moise G, Gallup NM, Alexandrova AN, Hengge AC, Johnson SJ. Conservative tryptophan mutants of the protein tyrosine phosphatase YopH exhibit impaired WPD-loop function and crystallize with divanadate esters in their active sites. Biochemistry. 2015 Oct 27; 54(42):6490-500.
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Jiao Y, Ye DZ, Li Z, Teta-Bissett M, Peng Y, Taub R, Greenbaum LE, Kaestner KH. Protein tyrosine phosphatase of liver regeneration-1 is required for normal timing of cell cycle progression during liver regeneration. Am J Physiol Gastrointest Liver Physiol. 2015 Jan 15; 308(2):G85-91.
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Hurt JK, Coleman JL, Fitzpatrick BJ, Taylor-Blake B, Bridges AS, Vihko P, Zylka MJ. Prostatic acid phosphatase is required for the antinociceptive effects of thiamine and benfotiamine. PLoS One. 2012; 7(10):e48562.
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Ganguly N, Giang PH, Basu SK, Mir FA, Siddiqui I, Sharma P. Mycobacterium tuberculosis 6-kDa early secreted antigenic target (ESAT-6) protein downregulates lipopolysaccharide induced c-myc expression by modulating the extracellular signal regulated kinases 1/2. BMC Immunol. 2007 Oct 03; 8:24.
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Wang H, Lu Y, Huang W, Papoutsakis ET, Fuhrken P, Eklund EA. HoxA10 activates transcription of the gene encoding mitogen-activated protein kinase phosphatase 2 (Mkp2) in myeloid cells. J Biol Chem. 2007 Jun 1; 282(22):16164-76.
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Tresini M, Lorenzini A, Torres C, Cristofalo VJ. Modulation of replicative senescence of diploid human cells by nuclear ERK signaling. J Biol Chem. 2007 Feb 9; 282(6):4136-51.
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Wu JH, Goswami R, Cai X, Exum ST, Huang X, Zhang L, Brian L, Premont RT, Peppel K, Freedman NJ. Regulation of the platelet-derived growth factor receptor-beta by G protein-coupled receptor kinase-5 in vascular smooth muscle cells involves the phosphatase Shp2. J Biol Chem. 2006 Dec 8; 281(49):37758-72.