"MELAS Syndrome" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A mitochondrial disorder characterized by focal or generalized seizures, episodes of transient or persistent neurologic dysfunction resembling strokes, and ragged-red fibers on muscle biopsy. Affected individuals tend to be normal at birth through early childhood, then experience growth failure, episodic vomiting, and recurrent cerebral insults resulting in visual loss and hemiparesis. The cortical lesions tend to occur in the parietal and occipital lobes and are not associated with vascular occlusion. VASCULAR HEADACHE is frequently associated and the disorder tends to be familial. (From Joynt, Clinical Neurology, 1992, Ch56, p117)
| Descriptor ID |
D017241
|
| MeSH Number(s) |
C05.651.460.620.520 C10.228.140.163.100.535 C10.228.140.300.275.500 C10.668.491.500.500.500 C14.907.253.329.500 C16.320.565.189.535 C18.452.132.100.535 C18.452.648.189.535 C18.452.660.560.620.520
|
| Concept/Terms |
MELAS Syndrome- MELAS Syndrome
- Syndrome, MELAS
- Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Episodes
- Mitochondrial Myopathy, Lactic Acidosis, Stroke-Like Episode
- Myopathy, Mitochondrial-Encephalopathy-Lactic Acidosis-Stroke
- MELAS
- Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes
|
Below are MeSH descriptors whose meaning is more general than "MELAS Syndrome".
- Diseases [C]
- Musculoskeletal Diseases [C05]
- Muscular Diseases [C05.651]
- Mitochondrial Myopathies [C05.651.460]
- Mitochondrial Encephalomyopathies [C05.651.460.620]
- MELAS Syndrome [C05.651.460.620.520]
- Nervous System Diseases [C10]
- Central Nervous System Diseases [C10.228]
- Brain Diseases [C10.228.140]
- Brain Diseases, Metabolic [C10.228.140.163]
- Brain Diseases, Metabolic, Inborn [C10.228.140.163.100]
- MELAS Syndrome [C10.228.140.163.100.535]
- Cerebrovascular Disorders [C10.228.140.300]
- Cerebral Small Vessel Diseases [C10.228.140.300.275]
- MELAS Syndrome [C10.228.140.300.275.500]
- Neuromuscular Diseases [C10.668]
- Muscular Diseases [C10.668.491]
- Mitochondrial Myopathies [C10.668.491.500]
- Mitochondrial Encephalomyopathies [C10.668.491.500.500]
- MELAS Syndrome [C10.668.491.500.500.500]
- Cardiovascular Diseases [C14]
- Vascular Diseases [C14.907]
- Cerebrovascular Disorders [C14.907.253]
- Cerebral Small Vessel Diseases [C14.907.253.329]
- MELAS Syndrome [C14.907.253.329.500]
- Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
- Genetic Diseases, Inborn [C16.320]
- Metabolism, Inborn Errors [C16.320.565]
- Brain Diseases, Metabolic, Inborn [C16.320.565.189]
- MELAS Syndrome [C16.320.565.189.535]
- Nutritional and Metabolic Diseases [C18]
- Metabolic Diseases [C18.452]
- Brain Diseases, Metabolic [C18.452.132]
- Brain Diseases, Metabolic, Inborn [C18.452.132.100]
- MELAS Syndrome [C18.452.132.100.535]
- Metabolism, Inborn Errors [C18.452.648]
- Brain Diseases, Metabolic, Inborn [C18.452.648.189]
- MELAS Syndrome [C18.452.648.189.535]
- Mitochondrial Diseases [C18.452.660]
- Mitochondrial Myopathies [C18.452.660.560]
- Mitochondrial Encephalomyopathies [C18.452.660.560.620]
- MELAS Syndrome [C18.452.660.560.620.520]
Below are MeSH descriptors whose meaning is more specific than "MELAS Syndrome".
This graph shows the total number of publications written about "MELAS Syndrome" by people in this website by year, and whether "MELAS Syndrome" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2003 | 1 | 0 | 1 |
| 2004 | 1 | 0 | 1 |
| 2005 | 1 | 1 | 2 |
| 2006 | 1 | 0 | 1 |
| 2012 | 1 | 0 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "MELAS Syndrome" by people in Profiles.
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Treff NR, Campos J, Tao X, Levy B, Ferry KM, Scott RT. Blastocyst preimplantation genetic diagnosis (PGD) of a mitochondrial DNA disorder. Fertil Steril. 2012 Nov; 98(5):1236-40.
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Kirino Y, Yasukawa T, Marjavaara SK, Jacobs HT, Holt IJ, Watanabe K, Suzuki T. Acquisition of the wobble modification in mitochondrial tRNALeu(CUN) bearing the G12300A mutation suppresses the MELAS molecular defect. Hum Mol Genet. 2006 Mar 15; 15(6):897-904.
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Kirino Y, Goto Y, Campos Y, Arenas J, Suzuki T. Specific correlation between the wobble modification deficiency in mutant tRNAs and the clinical features of a human mitochondrial disease. Proc Natl Acad Sci U S A. 2005 May 17; 102(20):7127-32.
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Kirino Y, Suzuki T. Human mitochondrial diseases associated with tRNA wobble modification deficiency. RNA Biol. 2005 Apr; 2(2):41-4.
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Kirino Y, Yasukawa T, Ohta S, Akira S, Ishihara K, Watanabe K, Suzuki T. Codon-specific translational defect caused by a wobble modification deficiency in mutant tRNA from a human mitochondrial disease. Proc Natl Acad Sci U S A. 2004 Oct 19; 101(42):15070-5.
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Park H, Davidson E, King MP. The pathogenic A3243G mutation in human mitochondrial tRNALeu(UUR) decreases the efficiency of aminoacylation. Biochemistry. 2003 Feb 04; 42(4):958-64.
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Carvalho KS, Garg BP. Arterial strokes in children. Neurol Clin. 2002 Nov; 20(4):1079-100, vii.