"Polymyositis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Diseases characterized by inflammation involving multiple muscles. This may occur as an acute or chronic condition associated with medication toxicity (DRUG TOXICITY); CONNECTIVE TISSUE DISEASES; infections; malignant NEOPLASMS; and other disorders. The term polymyositis is frequently used to refer to a specific clinical entity characterized by subacute or slowly progressing symmetrical weakness primarily affecting the proximal limb and trunk muscles. The illness may occur at any age, but is most frequent in the fourth to sixth decade of life. Weakness of pharyngeal and laryngeal muscles, interstitial lung disease, and inflammation of the myocardium may also occur. Muscle biopsy reveals widespread destruction of segments of muscle fibers and an inflammatory cellular response. (Adams et al., Principles of Neurology, 6th ed, pp1404-9)
Descriptor ID |
D017285
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MeSH Number(s) |
C05.651.594.819 C10.668.491.562.575
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Concept/Terms |
Polymyositis- Polymyositis
- Polymyositides
- Myositis, Multiple
- Multiple Myositis
- Myositides, Multiple
Polymyositis, Idiopathic- Polymyositis, Idiopathic
- Idiopathic Polymyositides
- Idiopathic Polymyositis
- Polymyositides, Idiopathic
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Below are MeSH descriptors whose meaning is more general than "Polymyositis".
Below are MeSH descriptors whose meaning is more specific than "Polymyositis".
This graph shows the total number of publications written about "Polymyositis" by people in this website by year, and whether "Polymyositis" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2003 | 2 | 1 | 3 |
2004 | 1 | 0 | 1 |
2006 | 1 | 1 | 2 |
2008 | 0 | 1 | 1 |
2010 | 2 | 0 | 2 |
2011 | 1 | 0 | 1 |
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Below are the most recent publications written about "Polymyositis" by people in Profiles.
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Dalakas MC. Pathophysiology of inflammatory and autoimmune myopathies. Presse Med. 2011 Apr; 40(4 Pt 2):e237-47.
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Dalakas MC. Inflammatory muscle diseases: a critical review on pathogenesis and therapies. Curr Opin Pharmacol. 2010 Jun; 10(3):346-52.
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Dalakas MC. Immunotherapy of myositis: issues, concerns and future prospects. Nat Rev Rheumatol. 2010 Mar; 6(3):129-37.
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Schmidt J, Barthel K, Wrede A, Salajegheh M, Bähr M, Dalakas MC. Interrelation of inflammation and APP in sIBM: IL-1 beta induces accumulation of beta-amyloid in skeletal muscle. Brain. 2008 May; 131(Pt 5):1228-40.
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Gidron A, Quadrini M, Dimov N, Argiris A. Malignant thymoma associated with fatal myocarditis and polymyositis in a 32-year-old woman with a history of hairy cell leukemia. Am J Clin Oncol. 2006 Apr; 29(2):213-4.
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Dalakas MC. Therapeutic targets in patients with inflammatory myopathies: present approaches and a look to the future. Neuromuscul Disord. 2006 Apr; 16(4):223-36.
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Dalakas MC. Inflammatory disorders of muscle: progress in polymyositis, dermatomyositis and inclusion body myositis. Curr Opin Neurol. 2004 Oct; 17(5):561-7.
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Dalakas MC, Hohlfeld R. Polymyositis and dermatomyositis. Lancet. 2003 Sep 20; 362(9388):971-82.
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Dalakas MC. Therapeutic approaches in patients with inflammatory myopathies. Semin Neurol. 2003 Jun; 23(2):199-206.
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Nemoto H, Bhopale MK, Constantinescu CS, Schotland D, Rostami A. Skeletal muscle myosin is the autoantigen for experimental autoimmune myositis. Exp Mol Pathol. 2003 Jun; 74(3):238-43.