"Protein Prenylation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A post-translational modification of proteins by the attachment of an isoprenoid to the C-terminal cysteine residue. The isoprenoids used, farnesyl diphosphate or geranylgeranyl diphosphate, are derived from the same biochemical pathway that produces cholesterol.
| Descriptor ID |
D017368
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| MeSH Number(s) |
G02.111.660.871.790.600.400 G02.111.672.500 G02.111.691.600.400 G03.734.871.790.600.400 G03.804.500 G05.308.670.600.400
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Protein Prenylation".
Below are MeSH descriptors whose meaning is more specific than "Protein Prenylation".
This graph shows the total number of publications written about "Protein Prenylation" by people in this website by year, and whether "Protein Prenylation" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2007 | 1 | 1 | 2 |
| 2012 | 0 | 1 | 1 |
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Below are the most recent publications written about "Protein Prenylation" by people in Profiles.
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Wang Y, Ostlund C, Choi JC, Swayne TC, Gundersen GG, Worman HJ. Blocking farnesylation of the prelamin A variant in Hutchinson-Gilford progeria syndrome alters the distribution of A-type lamins. Nucleus. 2012 Sep-Oct; 3(5):452-62.
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Marrari Y, Crouthamel M, Irannejad R, Wedegaertner PB. Assembly and trafficking of heterotrimeric G proteins. Biochemistry. 2007 Jul 3; 46(26):7665-77.
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Patel CA, Rattan S. RhoA prenylation inhibitor produces relaxation of tonic smooth muscle of internal anal sphincter. J Pharmacol Exp Ther. 2007 May; 321(2):501-8.
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Takida S, Wedegaertner PB. Heterotrimer formation, together with isoprenylation, is required for plasma membrane targeting of Gbetagamma. J Biol Chem. 2003 May 9; 278(19):17284-90.
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Camera M, Toschi V, Comparato C, Baetta R, Rossi F, Fuortes M, Ezekowitz MD, Paoletti R, Tremoli E. Cholesterol-induced thrombogenicity of the vessel wall: inhibitory effect of fluvastatin. Thromb Haemost. 2002 Apr; 87(4):748-55.