Microglia

"Microglia" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The third type of glial cell, along with astrocytes and oligodendrocytes (which together form the macroglia). Microglia vary in appearance depending on developmental stage, functional state, and anatomical location; subtype terms include ramified, perivascular, ameboid, resting, and activated. Microglia clearly are capable of phagocytosis and play an important role in a wide spectrum of neuropathologies. They have also been suggested to act in several other roles including in secretion (e.g., of cytokines and neural growth factors), in immunological processing (e.g., antigen presentation), and in central nervous system development and remodeling.

Descriptor ID	D017628
MeSH Number(s)	A08.637.400 A11.650.400
Concept/Terms	Microglia Microglia

Below are MeSH descriptors whose meaning is more general than "Microglia".

Anatomy [A]
Nervous System [A08]
Neuroglia [A08.637]
Microglia [A08.637.400]
Cells [A11]
Neuroglia [A11.650]
Microglia [A11.650.400]

Below are MeSH descriptors whose meaning is related to "Microglia".

Below are MeSH descriptors whose meaning is more specific than "Microglia".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Microglia" by people in this website by year, and whether "Microglia" was a major or minor topic of these publications.

Bar chart showing 61 publications over 28 distinct years, with a maximum of 5 publications in 2009

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	0	1	1
1996	1	0	1
1998	0	1	1
1999	1	1	2
2001	1	0	1
2002	2	0	2
2003	2	0	2
2004	4	0	4
2005	0	2	2
2006	2	1	3
2007	1	3	4
2008	1	2	3
2009	2	3	5
2010	1	0	1
2011	0	1	1
2012	3	0	3
2013	2	0	2
2014	0	1	1
2015	1	0	1
2016	2	0	2
2017	2	1	3
2018	2	1	3
2019	1	1	2
2020	2	2	4
2021	0	1	1
2022	1	0	1
2024	1	2	3
2025	2	0	2

Below are the most recent publications written about "Microglia" by people in Profiles.

Fu Z, Ganesana M, Hwang P, Tan X, Kinkaid MM, Sun YY, Bian E, Weybright A, Chen HR, Sol-Church K, Eyo UB, Pridans C, Quintana FJ, Robson SC, Kumar P, Venton BJ, Schaefer A, Kuan CY. Microglia modulate the cerebrovascular reactivity through ectonucleotidase CD39. Nat Commun. 2025 Jan 22; 16(1):956.

View in: PubMed
Hao H, Yin T, Li T, Zhou X, Ren H, Liu M, Huang H, Qi C, Xiu Y, Qiu W, Wang D, Shi M, Wang X, Dumont AS, Liu Q. Inhibition of Bruton's tyrosine kinase restricts neuroinflammation following intracerebral hemorrhage. Theranostics. 2025; 15(2):494-508.

View in: PubMed
Lemanski EA, Collins BA, Ebenezer AT, Anilkumar S, Langdon VA, Zheng Q, Ding S, Franke KR, Schwarz JM, Wright-Jin EC. A Novel Non-Invasive Murine Model of Neonatal Hypoxic-Ischemic Encephalopathy Demonstrates Developmental Delay and Motor Deficits with Activation of Inflammatory Pathways in Monocytes. Cells. 2024 Sep 14; 13(18).

View in: PubMed
Pan X, Caillon A, Fan S, Khan S, Tomatsu S, Pshezhetsky AV. Heterologous HSPC Transplantation Rescues Neuroinflammation and Ameliorates Peripheral Manifestations in the Mouse Model of Lysosomal Transmembrane Enzyme Deficiency, MPS IIIC. Cells. 2024 May 20; 13(10).

View in: PubMed
Ji XY, Guo YX, Wang LB, Wu WC, Wang JQ, He J, Gao R, Rasouli J, Gao MY, Wang ZH, Xiao D, Zhang WF, Ciric B, Zhang Y, Li X. Microglia-derived exosomes modulate myelin regeneration via miR-615-5p/MYRF axis. J Neuroinflammation. 2024 Jan 22; 21(1):29.

View in: PubMed
Liu N, Li Y, Jiang Y, Shi S, Niamnud A, Vodovoz SJ, Katakam PVG, Vidoudez C, Dumont AS, Wang X. Establishment and Application of a Novel In Vitro Model of Microglial Activation in Traumatic Brain Injury. J Neurosci. 2023 Jan 11; 43(2):319-332.

View in: PubMed
Yokubaitis CG, Jessani HN, Li H, Amodea AK, Ward SJ. Effects of Cannabidiol and Beta-Caryophyllene Alone or in Combination in a Mouse Model of Permanent Ischemia. Int J Mol Sci. 2021 Mar 11; 22(6).

View in: PubMed
Das Sarma J, Burrows A, Rayman P, Hwang MH, Kundu S, Sharma N, Bergmann C, Sen GC. Ifit2 deficiency restricts microglial activation and leukocyte migration following murine coronavirus (m-CoV) CNS infection. PLoS Pathog. 2020 11; 16(11):e1009034.

View in: PubMed
Sanfilippo C, Castrogiovanni P, Imbesi R, Nunnari G, Di Rosa M. Postsynaptic damage and microglial activation in AD patients could be linked CXCR4/CXCL12 expression levels. Brain Res. 2020 12 15; 1749:147127.

View in: PubMed
Elmadany N, Logiacco F, Buonfiglioli A, Haage VC, Wright-Jin EC, Schattenberg A, Papawassiliou RM, Kettenmann H, Semtner M, Gutmann DH. Neurofibromatosis 1 - Mutant microglia exhibit sexually-dimorphic cyclic AMP-dependent purinergic defects. Neurobiol Dis. 2020 10; 144:105030.

View in: PubMed

People

Explore

Similar Concepts

Top Journals

The Thomas Jefferson University web site, its contents and programs, is provided for informational and educational purposes only and is not intended as medical advice nor is it intended to create any physician-patient relationship. Please remember that this information should not substitute for a visit or a consultation with a health care provider. The views or opinions expressed in the resources provided do not necessarily reflect those of Thomas Jefferson University, Thomas Jefferson University Hospital, or the Jefferson Health System or staff.
Please read our Privacy Statement