Microglia

"Microglia" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The third type of glial cell, along with astrocytes and oligodendrocytes (which together form the macroglia). Microglia vary in appearance depending on developmental stage, functional state, and anatomical location; subtype terms include ramified, perivascular, ameboid, resting, and activated. Microglia clearly are capable of phagocytosis and play an important role in a wide spectrum of neuropathologies. They have also been suggested to act in several other roles including in secretion (e.g., of cytokines and neural growth factors), in immunological processing (e.g., antigen presentation), and in central nervous system development and remodeling.

Descriptor ID	D017628
MeSH Number(s)	A08.637.400 A11.650.400
Concept/Terms	Microglia Microglia

Below are MeSH descriptors whose meaning is more general than "Microglia".

Anatomy [A]
Nervous System [A08]
Neuroglia [A08.637]
Microglia [A08.637.400]
Cells [A11]
Neuroglia [A11.650]
Microglia [A11.650.400]

Below are MeSH descriptors whose meaning is related to "Microglia".

Below are MeSH descriptors whose meaning is more specific than "Microglia".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Microglia" by people in this website by year, and whether "Microglia" was a major or minor topic of these publications.

Bar chart showing 39 publications over 20 distinct years, with a maximum of 4 publications in 2012 and 2013 and 2018

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2001	1	0	1
2003	1	0	1
2005	0	1	1
2006	1	1	2
2007	0	3	3
2008	1	0	1
2009	1	2	3
2012	3	1	4
2013	3	1	4
2014	0	1	1
2015	2	0	2
2016	2	1	3
2017	1	1	2
2018	2	2	4
2020	0	1	1
2021	0	1	1
2022	0	1	1
2023	0	1	1
2024	1	1	2
2025	1	0	1

Below are the most recent publications written about "Microglia" by people in Profiles.

Fu Z, Ganesana M, Hwang P, Tan X, Kinkaid MM, Sun YY, Bian E, Weybright A, Chen HR, Sol-Church K, Eyo UB, Pridans C, Quintana FJ, Robson SC, Kumar P, Venton BJ, Schaefer A, Kuan CY. Microglia modulate the cerebrovascular reactivity through ectonucleotidase CD39. Nat Commun. 2025 Jan 22; 16(1):956.

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Ghosh S, Jana R, Jana S, Basu R, Chatterjee M, Ranawat N, Das Sarma J. Differential expression of cellular prion protein (PrPC) in mouse hepatitis virus induced neuroinflammation. J Neurovirol. 2024 06; 30(3):215-228.

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Pan X, Caillon A, Fan S, Khan S, Tomatsu S, Pshezhetsky AV. Heterologous HSPC Transplantation Rescues Neuroinflammation and Ameliorates Peripheral Manifestations in the Mouse Model of Lysosomal Transmembrane Enzyme Deficiency, MPS IIIC. Cells. 2024 05 20; 13(10).

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Rocha SM, Kirkley KS, Chatterjee D, Aboellail TA, Smeyne RJ, Tjalkens RB. Microglia-specific knock-out of NF-?B/IKK2 increases the accumulation of misfolded a-synuclein through the inhibition of p62/sequestosome-1-dependent autophagy in the rotenone model of Parkinson's disease. Glia. 2023 09; 71(9):2154-2179.

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Rocha SM, Bantle CM, Aboellail T, Chatterjee D, Smeyne RJ, Tjalkens RB. Rotenone induces regionally distinct a-synuclein protein aggregation and activation of glia prior to loss of dopaminergic neurons in C57Bl/6 mice. Neurobiol Dis. 2022 06 01; 167:105685.

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Yokubaitis CG, Jessani HN, Li H, Amodea AK, Ward SJ. Effects of Cannabidiol and Beta-Caryophyllene Alone or in Combination in a Mouse Model of Permanent Ischemia. Int J Mol Sci. 2021 Mar 11; 22(6).

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Das Sarma J, Burrows A, Rayman P, Hwang MH, Kundu S, Sharma N, Bergmann C, Sen GC. Ifit2 deficiency restricts microglial activation and leukocyte migration following murine coronavirus (m-CoV) CNS infection. PLoS Pathog. 2020 11; 16(11):e1009034.

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Ezquer F, Quintanilla ME, Morales P, Santapau D, Ezquer M, Kogan MJ, Salas-Huenuleo E, Herrera-Marschitz M, Israel Y. Intranasal delivery of mesenchymal stem cell-derived exosomes reduces oxidative stress and markedly inhibits ethanol consumption and post-deprivation relapse drinking. Addict Biol. 2019 09; 24(5):994-1007.

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Kozina E, Sadasivan S, Jiao Y, Dou Y, Ma Z, Tan H, Kodali K, Shaw T, Peng J, Smeyne RJ. Mutant LRRK2 mediates peripheral and central immune responses leading to neurodegeneration in vivo. Brain. 2018 06 01; 141(6):1753-1769.

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Cotto B, Li H, Tuma RF, Ward SJ, Langford D. Cocaine-mediated activation of microglia and microglial MeCP2 and BDNF production. Neurobiol Dis. 2018 09; 117:28-41.

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