Patch-Clamp Techniques

"Patch-Clamp Techniques" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An electrophysiologic technique for studying cells, cell membranes, and occasionally isolated organelles. All patch-clamp methods rely on a very high-resistance seal between a micropipette and a membrane; the seal is usually attained by gentle suction. The four most common variants include on-cell patch, inside-out patch, outside-out patch, and whole-cell clamp. Patch-clamp methods are commonly used to voltage clamp, that is control the voltage across the membrane and measure current flow, but current-clamp methods, in which the current is controlled and the voltage is measured, are also used.

Descriptor ID	D018408
MeSH Number(s)	E05.200.500.905 E05.242.800
Concept/Terms	Patch-Clamp Techniques Patch-Clamp Techniques Patch Clamp Techniques Patch-Clamp Technique Technique, Patch-Clamp Techniques, Patch-Clamp Patch-Clamp Technics Patch Clamp Technics Patch-Clamp Technic Technic, Patch-Clamp Technics, Patch-Clamp Whole-Cell Recording Whole-Cell Recording Recording, Whole-Cell Recordings, Whole-Cell Whole Cell Recording Whole-Cell Recordings Voltage-Clamp Techniques Voltage-Clamp Techniques Technique, Voltage-Clamp Techniques, Voltage-Clamp Voltage Clamp Techniques Voltage-Clamp Technique Voltage-Clamp Technics Technic, Voltage-Clamp Technics, Voltage-Clamp Voltage Clamp Technics Voltage-Clamp Technic

Below are MeSH descriptors whose meaning is more general than "Patch-Clamp Techniques".

Analytical, Diagnostic and Therapeutic Techniques and Equipment [E]
Investigative Techniques [E05]
Clinical Laboratory Techniques [E05.200]
Cytological Techniques [E05.200.500]
Patch-Clamp Techniques [E05.200.500.905]
Cytological Techniques [E05.242]
Patch-Clamp Techniques [E05.242.800]

Below are MeSH descriptors whose meaning is more specific than "Patch-Clamp Techniques".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Patch-Clamp Techniques" by people in this website by year, and whether "Patch-Clamp Techniques" was a major or minor topic of these publications.

Bar chart showing 76 publications over 16 distinct years, with a maximum of 11 publications in 2011

To see the data from this visualization as text, click here.

Year	Minor Topic	Total
2002	6	6
2003	4	4
2004	4	4
2005	3	3
2006	7	7
2007	7	7
2008	4	4
2009	5	5
2010	10	10
2011	11	11
2012	4	4
2013	3	3
2014	3	3
2015	1	1
2017	3	3
2020	1	1

Below are the most recent publications written about "Patch-Clamp Techniques" by people in Profiles.

Elmadany N, Logiacco F, Buonfiglioli A, Haage VC, Wright-Jin EC, Schattenberg A, Papawassiliou RM, Kettenmann H, Semtner M, Gutmann DH. Neurofibromatosis 1 - Mutant microglia exhibit sexually-dimorphic cyclic AMP-dependent purinergic defects. Neurobiol Dis. 2020 10; 144:105030.

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Wu M, White HV, Boehm BA, Meriney CJ, Kerrigan K, Frasso M, Liang M, Gotway EM, Wilcox MR, Johnson JW, Wipf P, Meriney SD. New Cav2 calcium channel gating modifiers with agonist activity and therapeutic potential to treat neuromuscular disease. Neuropharmacology. 2018 03 15; 131:176-189.

View in: PubMed
Aimino MA, Coker CR, Silberman Y. Acute ethanol modulation of neurocircuit function in the nucleus of the tractus solitarius. Brain Res Bull. 2018 04; 138:5-11.

View in: PubMed
Møller RS, Wuttke TV, Helbig I, Marini C, Johannesen KM, Brilstra EH, Vaher U, Borggraefe I, Talvik I, Talvik T, Kluger G, Francois LL, Lesca G, de Bellescize J, Blichfeldt S, Chatron N, Holert N, Jacobs J, Swinkels M, Betzler C, Syrbe S, Nikanorova M, Myers CT, Larsen LH, Vejzovic S, Pendziwiat M, von Spiczak S, Hopkins S, Dubbs H, Mang Y, Mukhin K, Holthausen H, van Gassen KL, Dahl HA, Tommerup N, Mefford HC, Rubboli G, Guerrini R, Lemke JR, Lerche H, Muhle H, Maljevic S. Mutations in GABRB3: From febrile seizures to epileptic encephalopathies. Neurology. 2017 Jan 31; 88(5):483-492.

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Johnson AA, Bachman LA, Gilles BJ, Cross SD, Stelzig KE, Resch ZT, Marmorstein LY, Pulido JS, Marmorstein AD. Autosomal Recessive Bestrophinopathy Is Not Associated With the Loss of Bestrophin-1 Anion Channel Function in a Patient With a Novel BEST1 Mutation. Invest Ophthalmol Vis Sci. 2015 Jul; 56(8):4619-30.

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Tian J, Tep C, Benedick A, Saidi N, Ryu JC, Kim ML, Sadasivan S, Oberdick J, Smeyne R, Zhu MX, Yoon SO. p75 regulates Purkinje cell firing by modulating SK channel activity through Rac1. J Biol Chem. 2014 Nov 07; 289(45):31458-72.

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Burashnikov A, Di Diego JM, Barajas-Mart?nez H, Hu D, Zygmunt AC, Cordeiro JM, Moise NS, Kornreich BG, Belardinelli L, Antzelevitch C. Ranolazine effectively suppresses atrial fibrillation in the setting of heart failure. Circ Heart Fail. 2014 Jul; 7(4):627-33.

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Guo D, Yu M, Liu Q, Cox RH, Liu T, Yan GX. Ventricular hypertrophy amplifies transmural dispersion of repolarization by preferentially increasing the late sodium current in endocardium. J Electrocardiol. 2014 Sep-Oct; 47(5):642-8.

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Cordeiro JM, Panama BK, Goodrow R, Zygmunt AC, White C, Treat JA, Zeina T, Nesterenko VV, Di Diego JM, Burashnikov A, Antzelevitch C. Developmental changes in expression and biophysics of ion channels in the canine ventricle. J Mol Cell Cardiol. 2013 Nov; 64:79-89.

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Alzayady KJ, Wagner LE, Chandrasekhar R, Monteagudo A, Godiska R, Tall GG, Joseph SK, Yule DI. Functional inositol 1,4,5-trisphosphate receptors assembled from concatenated homo- and heteromeric subunits. J Biol Chem. 2013 Oct 11; 288(41):29772-84.

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