"Nicotinic Antagonists" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Drugs that bind to nicotinic cholinergic receptors (RECEPTORS, NICOTINIC) and block the actions of acetylcholine or cholinergic agonists. Nicotinic antagonists block synaptic transmission at autonomic ganglia, the skeletal neuromuscular junction, and at central nervous system nicotinic synapses.
| Descriptor ID |
D018733
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| MeSH Number(s) |
D27.505.519.625.120.200.700 D27.505.696.577.120.200.700
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Nicotinic Antagonists".
Below are MeSH descriptors whose meaning is more specific than "Nicotinic Antagonists".
This graph shows the total number of publications written about "Nicotinic Antagonists" by people in this website by year, and whether "Nicotinic Antagonists" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 1 | 0 | 1 |
| 2004 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
| 2014 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Nicotinic Antagonists" by people in Profiles.
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Hahn B, Harvey AN, Concheiro-Guisan M, Huestis MA, Ross TJ, Stein EA. Nicotinic receptor modulation of the default mode network. Psychopharmacology (Berl). 2021 Feb; 238(2):589-597.
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Klassen SA, Moir ME, Limberg JK, Baker SE, Nicholson WT, Curry TB, Joyner MJ, Shoemaker JK. Asynchronous action potential discharge in human muscle sympathetic nerve activity. Am J Physiol Heart Circ Physiol. 2019 10 01; 317(4):H754-H764.
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Paul RK, Singh NS, Khadeer M, Moaddel R, Sanghvi M, Green CE, O'Loughlin K, Torjman MC, Bernier M, Wainer IW. (R,S)-Ketamine metabolites (R,S)-norketamine and (2S,6S)-hydroxynorketamine increase the mammalian target of rapamycin function. Anesthesiology. 2014 Jul; 121(1):149-59.
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Singh NS, Paul RK, Ramamoorthy A, Torjman MC, Moaddel R, Bernier M, Wainer IW. Nicotinic acetylcholine receptor antagonists alter the function and expression of serine racemase in PC-12 and 1321N1 cells. Cell Signal. 2013 Dec; 25(12):2634-45.
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Hruska M, Keefe J, Wert D, Tekinay AB, Hulce JJ, Ibañez-Tallon I, Nishi R. Prostate stem cell antigen is an endogenous lynx1-like prototoxin that antagonizes alpha7-containing nicotinic receptors and prevents programmed cell death of parasympathetic neurons. J Neurosci. 2009 Nov 25; 29(47):14847-54.
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Shytle RD, Mori T, Townsend K, Vendrame M, Sun N, Zeng J, Ehrhart J, Silver AA, Sanberg PR, Tan J. Cholinergic modulation of microglial activation by alpha 7 nicotinic receptors. J Neurochem. 2004 Apr; 89(2):337-43.
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Wang DX, Sheu SS, Sharma VK, Rubin L, Journet M, Kende AS, Abood LG. [3H]benzylpempidine, a new radioligand for probing a putative channel site on nicotinic cholinergic receptors. Life Sci. 1997; 60(15):1271-7.