"GABA Modulators" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Substances that do not act as agonists or antagonists but do affect the GAMMA-AMINOBUTYRIC ACID receptor-ionophore complex. GABA-A receptors (RECEPTORS, GABA-A) appear to have at least three allosteric sites at which modulators act: a site at which BENZODIAZEPINES act by increasing the opening frequency of GAMMA-AMINOBUTYRIC ACID-activated chloride channels; a site at which BARBITURATES act to prolong the duration of channel opening; and a site at which some steroids may act. GENERAL ANESTHETICS probably act at least partly by potentiating GABAergic responses, but they are not included here.
| Descriptor ID |
D018757
|
| MeSH Number(s) |
D27.505.519.625.240.500 D27.505.696.577.240.500
|
| Concept/Terms |
GABA Modulators- GABA Modulators
- Modulators, GABA
- GABAergic Modulators
- Modulators, GABAergic
- gamma-Aminobutyric Acid Modulators
- Acid Modulators, gamma-Aminobutyric
- Modulators, gamma-Aminobutyric Acid
- gamma Aminobutyric Acid Modulators
|
Below are MeSH descriptors whose meaning is more general than "GABA Modulators".
Below are MeSH descriptors whose meaning is more specific than "GABA Modulators".
This graph shows the total number of publications written about "GABA Modulators" by people in this website by year, and whether "GABA Modulators" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 2 | 1 | 3 |
| 2004 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2013 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "GABA Modulators" by people in Profiles.
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Gurrell R, Gorman D, Whitlock M, Ogden A, Reynolds DS, DiVentura B, Abou-Khalil B, Gelfand M, Pollard J, Hogan RE, Krauss G, Sperling M, Vazquez B, Wechsler RT, Friedman D, Butt RP, French J. Photosensitive epilepsy: Robust clinical efficacy of a selective GABA potentiator. Neurology. 2019 04 09; 92(15):e1786-e1795.
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Chugani HT, Kumar A, Muzik O. GABA(A) receptor imaging with positron emission tomography in the human newborn: a unique binding pattern. Pediatr Neurol. 2013 Jun; 48(6):459-62.
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Ramdas S, Riesenberg LA, Jasani N. Drug overdose with refractory bradycardia and hypotension. Del Med J. 2011 Jun; 83(6):169-72.
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Spaeth GL, Mantravadi AV. Topiramate as treatment for alcohol dependence. JAMA. 2008 Jan 30; 299(4):405; author reply 406-7.
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Couper FJ, Logan BK. Addicted to driving under the influence--a GHB/GBL case report. J Anal Toxicol. 2004 Sep; 28(6):512-5.
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Juh?sz C, Nagy F, Watson C, da Silva EA, Muzik O, Chugani DC, Shah J, Chugani HT. Glucose and [11C]flumazenil positron emission tomography abnormalities of thalamic nuclei in temporal lobe epilepsy. Neurology. 1999 Dec 10; 53(9):2037-45.
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Levy LM, Dalakas MC, Floeter MK. The stiff-person syndrome: an autoimmune disorder affecting neurotransmission of gamma-aminobutyric acid. Ann Intern Med. 1999 Oct 05; 131(7):522-30.
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Nagy F, Chugani DC, Juh?sz C, da Silva EA, Muzik O, Kupsky W, Canady A, Watson C, Shah J, Chugani HT. Altered in vitro and in vivo flumazenil binding in human epileptogenic neocortex. J Cereb Blood Flow Metab. 1999 Sep; 19(9):939-47.