"Germinal Center" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The activated center of a lymphoid follicle in secondary lymphoid tissue where B-LYMPHOCYTES are stimulated by antigens and helper T cells (T-LYMPHOCYTES, HELPER-INDUCER) are stimulated to generate memory cells.
| Descriptor ID |
D018858
|
| MeSH Number(s) |
A10.549.400.500 A15.382.520.604.412.500
|
| Concept/Terms |
Germinal Center- Germinal Center
- Center, Germinal
- Centers, Germinal
- Germinal Centers
|
Below are MeSH descriptors whose meaning is more general than "Germinal Center".
Below are MeSH descriptors whose meaning is more specific than "Germinal Center".
This graph shows the total number of publications written about "Germinal Center" by people in this website by year, and whether "Germinal Center" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 2 | 1 | 3 |
| 2003 | 1 | 0 | 1 |
| 2004 | 2 | 0 | 2 |
| 2005 | 2 | 0 | 2 |
| 2007 | 2 | 0 | 2 |
| 2009 | 2 | 0 | 2 |
| 2010 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Germinal Center" by people in Profiles.
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Lederer K, Castaño D, Gómez Atria D, Oguin TH, Wang S, Manzoni TB, Muramatsu H, Hogan MJ, Amanat F, Cherubin P, Lundgreen KA, Tam YK, Fan SHY, Eisenlohr LC, Maillard I, Weissman D, Bates P, Krammer F, Sempowski GD, Pardi N, Locci M. SARS-CoV-2 mRNA Vaccines Foster Potent Antigen-Specific Germinal Center Responses Associated with Neutralizing Antibody Generation. Immunity. 2020 12 15; 53(6):1281-1295.e5.
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Heiser RA, Snyder CM, St Clair J, Wysocki LJ. Aborted germinal center reactions and B cell memory by follicular T cells specific for a B cell receptor V region peptide. J Immunol. 2011 Jul 1; 187(1):212-21.
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Coffey F, Manser T. Expression of cellular FLIP by B cells is required for their participation in an immune response. J Immunol. 2010 May 1; 184(9):4871-9.
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Vuyyuru R, Mohan C, Manser T, Rahman ZS. The lupus susceptibility locus Sle1 breaches peripheral B cell tolerance at the antibody-forming cell and germinal center checkpoints. J Immunol. 2009 Nov 1; 183(9):5716-27.
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Coffey F, Alabyev B, Manser T. Initial clonal expansion of germinal center B cells takes place at the perimeter of follicles. Immunity. 2009 Apr 17; 30(4):599-609.
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Alabyev B, Rahman ZS, Manser T. Quantitatively reduced participation of anti-nuclear antigen B cells that down-regulate B cell receptor during primary development in the germinal center/memory B cell response to foreign antigen. J Immunol. 2007 May 1; 178(9):5623-34.
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Rahman ZS, Alabyev B, Manser T. FcgammaRIIB regulates autoreactive primary antibody-forming cell, but not germinal center B cell, activity. J Immunol. 2007 Jan 15; 178(2):897-907.
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Heltemes-Harris L, Liu X, Manser T. An antibody VH gene that promotes marginal zone B cell development and heavy chain allelic inclusion. Int Immunol. 2005 Nov; 17(11):1447-61.
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Rahman ZS, Manser T. Failed up-regulation of the inhibitory IgG Fc receptor Fc gamma RIIB on germinal center B cells in autoimmune-prone mice is not associated with deletion polymorphisms in the promoter region of the Fc gamma RIIB gene. J Immunol. 2005 Aug 1; 175(3):1440-9.
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Rahman ZS, Manser T. B cells expressing Bcl-2 and a signaling-impaired BAFF-specific receptor fail to mature and are deficient in the formation of lymphoid follicles and germinal centers. J Immunol. 2004 Nov 15; 173(10):6179-88.